公开(公告)号：US20200264084A1

公开(公告)日：2020-08-20

申请号：US16647917

申请日：2018-09-21

Applicant: University of Saskatchewan

Inventor： Travis Kent Wiens ,  Jeremy William ven der Buhs

IPC: G01N3/30 ,  F17D5/06 ,  G01M3/24 ,  G01M5/00 ,  G01N3/20

Abstract: Methods of detecting pipeline weakening are described herein. The methods include creating a pressure wave in a fluid flowing in a pipeline using an input transducer located at a first position along the pipeline; measuring the pressure wave using an output transducer positioned at a second position along the pipeline that is spaced from the first position, and generating an output signal based on the pressure wave; analyzing the output signal to determine a stiffness of a sidewall of the pipeline positioned between the input transducer and output transducer; and determining if the sidewall includes a defect based on the stiffness of the sidewall, including analyzing a frequency response of the output signal to detect the defect.

公开(公告)号：US20200087405A1

公开(公告)日：2020-03-19

申请号：US16487673

申请日：2018-02-22

Applicant: University of Saskatchewan ,  The Governing Council of the University of Toronto

Inventor： Sachdev Sidhu ,  Shane Miersch ,  Clarence Ronald Geyer

IPC: C07K16/28 ,  A61K47/68 ,  A61K49/00 ,  G01N33/68

Abstract: An Epidermal Growth Factor Receptor (EGFR, HER1, ErbB1)-binding agent has a heavy chain and a light chain, wherein the dimerization loop from EGFR's Domain II is grafted within complementarity determining region 3 (CDR3) of the heavy chain, and the binding agent is affinity matured. The graft directs the binding agent to bind EGFR at its dimerization region, to thereby inhibit EGFR dimerization and activation. In another embodiment, an EGFR-binding agent is panned out of Library F, a Fab library. The binding agents are for detecting and/or quantifying EGFR expression, for targeting EGFR-expressing cells, and for decreasing levels of EGFR in EGFR-expressing cells.

公开(公告)号：US10543202B2

公开(公告)日：2020-01-28

申请号：US15987505

申请日：2018-05-23

Applicant: University of Saskatchewan

Inventor： Ellen K. Wasan

IPC: A61K31/4422 ,  A61K47/10 ,  A61K47/20 ,  A61K47/44 ,  A61K9/00 ,  A61K9/107 ,  A61P17/02 ,  A61K9/06 ,  A61K31/12 ,  A61K31/352

Abstract: The present application relates to topical formulations in the form of an oil-in-water emulsion comprising nifedipine and a photostabilizing effective amount of quercetin or a photostabilizing effective amount of a combination of quercetin and butyl methoxydibenzoylmethane (BMDBM). Such topical formulations may, for example, be used for the treatment of diseases, disorders or conditions that benefit from topical administration of nifedipine such as but not limited to Raynaud phenomenon, chilblains or wound healing.

公开(公告)号：US20190323033A1

公开(公告)日：2019-10-24

申请号：US16312869

申请日：2017-06-23

Applicant: University of Saskatchewan

Inventor： Suresh K. TIKOO ,  Xin ZHAO

IPC: C12N15/86 ,  A61K35/761 ,  A61K39/12 ,  A61K39/02 ,  A61K39/00

Abstract: The present application provided defective bovine adenovirus (BAV) vectors that lack pV function. Cell lines and methods of preparing such vectors are provided. In addition, the invention provides methods of treating a disease or disorder with a defective BAV lacking pV function as well as vaccine comprising a defective BAV lacking pV function.

公开(公告)号：US20190320610A1

公开(公告)日：2019-10-24

申请号：US16228640

申请日：2018-12-20

Applicant: UNIVERSITY OF SASKATCHEWAN

Inventor： Vladimir VUJANOVIC ,  James J. GERMIDA

IPC: A01H17/00 ,  A01N63/04 ,  B09C1/10 ,  A01N63/02 ,  A01N25/00 ,  C12R1/465 ,  C12R1/80 ,  A01N63/00 ,  C12R1/645

Abstract: The present disclosure provides novel endophyte strains or cultures thereof that have a symbiotic relationship with plants. The present disclosure further provides methods of improving seed vitality, biotic and abiotic stress resistance, plant health and yield under both stressed and unstressed environmental conditions, comprising inoculating a seed with the novel endophyte strains and cultivating a plant therefrom.

公开(公告)号：US20190274950A1

公开(公告)日：2019-09-12

申请号：US16291269

申请日：2019-03-04

Applicant: University of Saskatchewan

Inventor： Ellen K. Wasan ,  Ahmed Shoker ,  Holly G. Mansell ,  Kishor M. Wasan

IPC: A61K9/00 ,  A61K9/51 ,  A61K31/5377 ,  A61P37/06

Abstract: The present application discloses modified release mucoadhesive formulations of mycophenolate mofetil and pharmaceutical compositions thereof useful in the treatment of, for example, post-transplant organ rejection. Method of preparing the formulations is also disclosed.

公开(公告)号：US10302317B2

公开(公告)日：2019-05-28

申请号：US14957795

申请日：2015-12-03

Applicant: Nortek Air Solutions Canada, Inc. ,  University of Saskatchewan

Inventor： Blake Erb ,  Robert W. Besant ,  Carey J. Simonson ,  Howard Hemingson

IPC: F24F3/147 ,  F28D15/00 ,  F24F12/00 ,  B01D53/22 ,  F24F3/14 ,  F28D21/00 ,  F24F1/00

Abstract: An energy exchanger is provided. The exchanger includes a housing having a front and a back. A plurality of panels forming desiccant channels extend from the front to the back of the housing. Air channels are formed between adjacent panels. The air channels are configured to direct an air stream in a direction from the front of the housing to the back of the housing. A desiccant inlet is provided in flow communication with the desiccant channels. A desiccant outlet is provided in flow communication with the desiccant channels. The desiccant channels are configured to channel desiccant from the desiccant inlet to the desiccant outlet in at least one of a counter-flow or cross-flow direction with respect to the direction of the air stream.

公开(公告)号：US20190030153A1

公开(公告)日：2019-01-31

申请号：US15746770

申请日：2016-07-22

Applicant: UNIVERSITY OF SASKATCHEWAN ,  KENYA AGRICULTURE AND LIVESTOCK RESEARCH ORGANIZATION (KALRO) ,  INTERNATIONAL LIVESTOCK RESEARCH INSTITUTE (ILRI)

Inventor： Andrew POTTER ,  Volker GERDTS ,  Jose PEREZ-CASAL ,  Yejun WANG ,  Hezron WESONGA ,  Reuben SOI ,  Jan NAESSENS ,  Joerg JORES

IPC: A61K39/02 ,  A61P31/04 ,  C07K14/30 ,  C12N15/62

Abstract: Immunogenic proteins comprising Mycoplasma mycoides subsp. mycoides and M. mycoides subsp. capri proteins, encoding polynucleotides, a method for producing said proteins, and use of compositions to prevent M. mycoides subsp. mycoides infections are disclosed.

公开(公告)号：US20180321243A1

公开(公告)日：2018-11-08

申请号：US15737846

申请日：2016-06-30

Applicant: University of Saskatchewan

Inventor： Changiz Taghibiglou ,  Nathan Pham ,  Landon Pastushok ,  Clarence Ronald Geyer

IPC: G01N33/573 ,  C07K16/40

CPC classification number: G01N33/573 ,  C07K16/2896 ,  C07K16/40 ,  C12Y304/24081 ,  G01N33/6896 ,  G01N2333/96486 ,  G01N2800/28

Abstract: The present disclosure relates to a method for detecting a brain injury in a subject by comparing the amount of ADAM10 protein in a blood sample from the subject to a reference standard or to the amount of ADAM10 in a blood sample from a control. An increase in the amount of ADAM10 in the subject blood sample relative to the reference standard or control is indicative of the subject having sustained a brain injury, in particular a traumatic brain injury (TBI). The present disclosure also provides novel antibody and antibody fragments that bind to ADAM10 at different positions.

公开(公告)号：US10104862B2

公开(公告)日：2018-10-23

申请号：US14614193

申请日：2015-02-04

Applicant: University Of Saskatchewan

Inventor： Vladimir Vujanovic ,  James J. Germida ,  Michelle Hubbard

IPC: A01H17/00 ,  A01N63/04

Abstract: The present disclosure provides compositions comprising novel endophytes capable of promoting germination endophytes that have a symbiotic relationship with plants. The present disclosure further provides methods of improving seed vitality, biotic and abiotic stress resistance, plant health and yield under both stressed and unstressed environmental conditions, comprising inoculating a seed with the novel endophyte strains and cultivating a plant therefrom.