公开(公告)号：US06713059B2

公开(公告)日：2004-03-30

申请号：US10121207

申请日：2002-04-11

Applicant: Andrew S. Kende ,  Barbara H. Iglewski ,  Roger Smith ,  Richard P. Phipps ,  James P. Pearson

Inventor： Andrew S. Kende ,  Barbara H. Iglewski ,  Roger Smith ,  Richard P. Phipps ,  James P. Pearson

IPC: A61K3940

CPC classification number: C07D207/273 ,  A61K39/385 ,  A61K2039/505 ,  A61K2039/6081 ,  C07D263/26 ,  C07D307/33 ,  C07D333/36 ,  C07K16/1203 ,  C07K16/1214 ,  G01N33/56911 ,  Y10S435/975 ,  Y10S436/80 ,  Y10S436/804 ,  Y10S530/806 ,  Y10S530/808

Abstract: The present invention relates to an immunogenic conjugate comprising a carrier molecule coupled to an autoinducer of a Gram negative bacteria. The immunogenic conjugate, when combined with a pharmaceutically acceptable carrier, forms a suitable vaccine for mammals to prevent infection by the Gram negative bacteria. The immunogenic conjugate is also used to raise and subsequently isolate antibodies or binding portions thereof which are capable of recognizing and binding to the autoinducer. The antibodies or binding portions thereof are utilized in a method of treating infections, a method of inhibiting autoinducer activity, and in diagnostic assays which detect the presence of autoinducers or autoinducer antagonists in fluid or tissue samples.

Abstract translation: 本发明涉及包含与革兰氏阴性细菌的自动诱导剂偶联的载体分子的免疫原性缀合物。 当与药学上可接受的载体组合时，免疫原性缀合物形成用于哺乳动物的合适的疫苗，以防止革兰氏阴性菌感染。 免疫原性缀合物也用于引发和随后分离能够识别和结合自动诱导剂的抗体或其结合部分。 抗体或其结合部分用于治疗感染的方法，抑制自身诱导剂活性的方法，以及用于检测流体或组织样品中自身诱导剂或自身诱导剂拮抗剂的存在的诊断测定。

公开(公告)号：US06058405A

公开(公告)日：2000-05-02

申请号：US965686

申请日：1997-11-06

Applicant: Priyadarshan Kolte ,  Roger Smith

Inventor： Priyadarshan Kolte ,  Roger Smith

IPC: G06T5/20 ,  G06F17/10

CPC classification number: G06T5/20 ,  Y10S707/99937

Abstract: One way of filtering graphics images to remove pixel dropout and shot noise while preserving overall image quality is to use non-linear filters based on rank order of an M.times.N grid of pixel values surrounding a pixel to be filtered. This rank order filter method for M.times.N grids first sorts columns, then sorts rows, and finally sorts diagonals to obtain either just a median filter value, a rank-based filter value, or a complete sorted order of the M.times.N grid. All of the sort operations are control-flow-free allowing implementation on SIMD processors processing multiple overlapping M.times.N grids in parallel. Advantage is taken of columns and rows that are shared among the horizontally and vertically overlapping M.times.N grids in the digital image to reduce the total number of sort operations for the image.

Abstract translation: 过滤图形图像以消除像素丢失和拍摄噪声同时保持整体图像质量的一种方法是使用基于要滤波的像素周围的像素值的M×N网格的秩顺序的非线性滤波器。 MxN网格的这种排序过滤器方法首先对列进行排序，然后对行进行排序，最后对对角线进行排序，以获得MxN网格的中值过滤器值，基于排序的过滤器值或完整排序顺序。 所有的排序操作都是无流控制的，允许在SIMD处理器上实现并行处理多个重叠的MxN网格。 优点在数字图像中的水平和垂直重叠的MxN网格之间共享的列和行，以减少图像的排序操作的总数。

公开(公告)号：US5799143A

公开(公告)日：1998-08-25

申请号：US703261

申请日：1996-08-26

Applicant: Farooq Butt ,  Roger Smith ,  Katherine E. Stewart

Inventor： Farooq Butt ,  Roger Smith ,  Katherine E. Stewart

IPC: G06F11/36 ,  G06F11/00

CPC classification number: G06F11/3612 ,  G06F11/3636 ,  G06F11/3644

Abstract: A method for multiple context analysis of software applications in a multiprocessing (22, 23), multithreaded computer environment utilizes instrumentation code inserted (54, 55) into the applications. For each execution (67) of the application (60), a context set is selected (62). Execution of the instrumented code (67) provides information for analysis in an instrumentation buffer (82) addressed by a reserved register (80) or buffer pointer. The operating system is responsible for providing in the reserved register (80) the address of the instrumentation buffer (82) appropriate for each instrumented context executed. When the application (60) is done with an instrumentation buffer (82), the buffer may be processed by filter software (68). The combination of using a reserved register (80) and allowing the operating system to keep track of relevant context switches allows applications to be instrumented (54, 55) for various context sets without the necessity of modifying (53) or recompiling (52) the application software (60).

公开(公告)号：USD297153S

公开(公告)日：1988-08-09

申请号：US806213

申请日：1985-11-25

Applicant: Roger Smith

Designer： Roger Smith

公开(公告)号：US12031421B2

公开(公告)日：2024-07-09

申请号：US17687089

申请日：2022-03-04

Applicant: Max Maxwell ,  Major Patterson ,  Roger Smith

Inventor： Max Maxwell ,  Major Patterson ,  Roger Smith

IPC: E21B43/28 ,  E21B43/14 ,  E21B43/30

CPC classification number: E21B43/281 ,  E21B43/14 ,  E21B43/305

Abstract: A modular solution mining method may include the steps of: providing an injection wellbore, the injection wellbore including a horizontal injection portion, in which the horizontal injection portion includes a toe end and heel end; providing a production wellbore, in which the production wellbore includes a horizontal production portion that is proximate to the toe end; injecting a solvent into the horizontal injection portion; generating a turbulent solvent flow proximate to the toe end to generate a mineral solution and an initial cavern proximate to the horizontal production portion; and motivating the mineral solution from the initial cavern, into the horizontal production portion, and to a surface location. Optionally, the method may include the step of repositioning the turbulent solvent flow to be closer to heel ends to generate mineral solution and subsequent caverns further from horizontal production wellbore.

公开(公告)号：US10466288B2

公开(公告)日：2019-11-05

申请号：US15428892

申请日：2017-02-09

Applicant: Roger Smith

Inventor： Roger Smith

IPC: G01R29/08 ,  G01R33/032

Abstract: This disclosure is directed to fiber optic pulsed polarimeters based on either streak camera or photodiode detection using a backscatter tailored optical fiber and the polarization optical time domain reflectometry technique for conducting remote diagnostic measurements of inducing fields along the fiber. The backscatter tailored optical fiber comprises a single mode fiber with an array of fiber Bragg gratings written to produce a predetermined distribution of backscatter signal in intensity and spectral content in response to a pulse propagating along the array. The fiber optic pulsed polarimeter includes a directional coupler that diverts the backscatter from the backscatter-tailored optical fiber to a polarization detection system for determining the polarization state of the backscatter as the polarized light pulse transits the backscatter-tailored optical fiber.

公开(公告)号：US09268538B2

公开(公告)日：2016-02-23

申请号：US12062511

申请日：2008-04-04

Applicant: Jacob Taylor ,  Majed Itani ,  Roger Smith

Inventor： Jacob Taylor ,  Majed Itani ,  Roger Smith

IPC: G06F9/44 ,  G06F13/00

CPC classification number: G06F8/38 ,  G06F8/30

Abstract: A metadata driven user interface system and method are provided. In an exemplary embodiment, a software-based customer relationship management system and method may include the metadata driven user interface system.

Abstract translation: 提供了元数据驱动的用户界面系统和方法。 在示例性实施例中，基于软件的客户关系管理系统和方法可以包括元数据驱动的用户界面系统。

公开(公告)号：US08207172B2

公开(公告)日：2012-06-26

申请号：US11662416

申请日：2005-08-19

Applicant: Chengzhi Zhang ,  Jacques Dumas ,  Qingming Zhu ,  Roger Smith ,  Qingjie Liu ,  Sharad Verma ,  Jason Duquette ,  Qian Zhao ,  Dongping Fan ,  Georgiy Bondar ,  Philip Coish

Inventor： Chengzhi Zhang ,  Jacques Dumas ,  Qingming Zhu ,  Roger Smith ,  Qingjie Liu ,  Sharad Verma ,  Jason Duquette ,  Qian Zhao ,  Dongping Fan ,  Georgiy Bondar ,  Philip Coish

IPC: C07D471/04

CPC classification number: C07D495/04 ,  C07D495/14

Abstract: The invention relates to novel heterocycles of formula (I) processes for their preparation and their use for preparing medicaments for the treatment or prophylaxis of disorders, especially of hyperproliferative disorders.

Abstract translation: 本发明涉及式（I）的新型杂环，其制备方法及其用于制备用于治疗或预防病症，特别是过度增殖性疾病的药物的用途。

公开(公告)号：US20090215780A1

公开(公告)日：2009-08-27

申请号：US11918836

申请日：2006-04-18

Applicant: Roger Smith ,  Derek Lowe ,  Philip Coish ,  Ann-Marie Campbell ,  Gan Wang ,  Manoj Patel ,  Gerogiy Bondar

Inventor： Roger Smith ,  Derek Lowe ,  Philip Coish ,  Ann-Marie Campbell ,  Gan Wang ,  Manoj Patel ,  Gerogiy Bondar

IPC: A61K31/5375 ,  C07C229/40 ,  A61K31/192 ,  A61K31/4418 ,  C07D213/75 ,  C07D295/195 ,  A61P3/04

CPC classification number: C07D209/24 ,  C07C233/54 ,  C07C233/55 ,  C07C233/63 ,  C07C233/81 ,  C07C235/40 ,  C07C235/56 ,  C07C275/42 ,  C07C311/08 ,  C07C311/13 ,  C07C311/21 ,  C07C311/29 ,  C07C311/51 ,  C07C2601/02 ,  C07C2601/04 ,  C07C2601/08 ,  C07C2601/14 ,  C07C2602/08 ,  C07D207/06 ,  C07D209/08 ,  C07D209/42 ,  C07D209/44 ,  C07D211/16 ,  C07D213/56 ,  C07D213/75 ,  C07D215/08 ,  C07D235/06 ,  C07D239/16 ,  C07D261/10 ,  C07D265/30 ,  C07D295/205 ,  C07D307/14 ,  C07D307/30 ,  C07D307/52 ,  C07D307/85 ,  C07D309/04 ,  C07D309/08 ,  C07D333/24 ,  C07D333/62 ,  C07D333/68 ,  C07D335/02 ,  C07D401/04 ,  C07D405/12

Abstract: This invention relates to certain aryl alkyl acid compounds, compositions, and methods for treating or preventing obesity and related diseases.

Abstract translation: 本发明涉及某些芳基烷基酸化合物，组合物和治疗或预防肥胖症和相关疾病的方法。

公开(公告)号：US20090073442A1

公开(公告)日：2009-03-19

申请号：US11900948

申请日：2007-09-14

Applicant: Roger Smith

Inventor： Roger Smith

IPC: G01J4/00

CPC classification number: G01J4/04 ,  G01N21/21 ,  G01N2021/1793

Abstract: Embodiments of the present invention are directed to pulsed polarimeters for conducting remote, non-perturbative diagnostic measurements of inducing fields of a medium demonstrating induced optical activity. In one aspect, a pulse polarimeter includes a light source emitting a polarized light pulse having sufficiently narrow spatial extent at a prescribed wavelength and a light gathering optical system including a light gathering optic having an optic axis directed toward the medium and positioned to collect and collimate a predetermined solid angle of an emission from the medium into a collimated emission beam, while preserving the polarization state of the emission. The pulse polarimeter includes a directional coupler that makes coincident the propagation direction of the polarized light pulse with the optic axis and a polarization detection system for measuring the intensity and determining the polarization state of the collimated emission beam continuously in time as the polarized light pulse transits the medium.

Abstract translation: 本发明的实施例涉及用于进行远程的非扰动诊断测量的脉冲偏振计，用于诱导介导的光学活动的介质的场。 在一个方面，脉冲偏振计包括发射具有在规定波长下具有足够狭窄的空间范围的偏振光脉冲的光源，以及包括具有朝向介质的光轴的聚光光学系统的聚光光学系统，并被定位以收集和准直 从介质到准直发射光束的发射的预定立体角，同时保持发射的偏振状态。 脉冲偏振计包括使偏振光脉冲与光轴的传播方向一致的定向耦合器和用于测量强度的偏振检测系统，并且随着偏振光脉冲的转移，及时确定准直发射光束的偏振状态 介质。