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    Process for producing microcapsules
    91.
    发明授权
    Process for producing microcapsules 失效
    微胶囊生产工艺

    公开(公告)号：US5470512A

    公开(公告)日：1995-11-28

    申请号：US120654

    申请日：1993-09-13

    Applicant: Minoru Noji ,  Akira Kunugise ,  Yumiko Imai

    Inventor： Minoru Noji ,  Akira Kunugise ,  Yumiko Imai

    IPC: B01J13/06 ,  B01J13/08 ,  B01J13/10 ,  A01N25/28 ,  A61K9/50

    CPC classification number: B01J13/06 ,  B01J13/08 ,  Y10S514/963 ,  Y10T428/2984 ,  Y10T428/2987 ,  Y10T428/2989

    Abstract: The present invention relates to a microcapsule having a core material encapsulated with a capsule wall obtained by coagulating the fine colloidal particles by using an electrolyte, and a process for producing such microcapsules. In the present invention, inorganic and/or organic colloidal particles are used as the wall material and such particles are coagulated by using an electrolyte to form the capsule wall, so that it is possible to produce the microcapsules under mild conditions and with simple operations, and in addition, even the physically and/or chemically instable core materials can be easily encapsulated.

    Abstract translation: 本发明涉及具有通过使用电解质凝固微胶体颗粒而获得的胶囊壁包封的芯材的微胶囊以及这种微胶囊的制造方法。 在本发明中，使用无机和/或有机胶体粒子作为壁材，通过使用电解质来形成胶囊壁，从而能够在温和的条件下进行微胶囊的制造和操作简便， 此外，即使物理和/或化学不稳定的芯材料也可以容易地包封。

    Process for the preparation of alginate capsules, apparatus for producing said capsules and cosmetic compositions containing said capsules
    92.
    发明授权
    Process for the preparation of alginate capsules, apparatus for producing said capsules and cosmetic compositions containing said capsules 失效
    制备藻酸盐胶囊的方法，用于制备所述胶囊的装置和含有所述胶囊的化妆品组合物

    公开(公告)号：US5204111A

    公开(公告)日：1993-04-20

    申请号：US826610

    申请日：1992-01-28

    Applicant: Rose-Marie Handjani ,  Myriam Kauffmann ,  Frederic Huguenin

    Inventor： Rose-Marie Handjani ,  Myriam Kauffmann ,  Frederic Huguenin

    IPC: A61K8/11 ,  A61K8/73 ,  A61K9/16 ,  A61K36/736 ,  A61Q19/00 ,  B01J13/08

    CPC classification number: A61K8/11 ,  A61K8/733 ,  A61K9/1652 ,  A61Q19/00 ,  B01J13/08 ,  A61K2800/412 ,  Y10S514/844 ,  Y10S514/962 ,  Y10T428/2982

    Abstract: A process for producing alginate capsules comprises slowly introducing an aqueous alginate solution into crosslinking solution of a polyvalent metal salt. The aqueous alginate solution has mannuronic units (M) and guluronic units (G) in a molar ratio between 0.4 and 1.9 and preferably an amount of (G) blocks greater than 50%. Preferably, the alginate is a sodium alginate having a viscosity, in a 0.5% solution in water at 25.degree. C., lower than 20 mPa.s measured with a TV Contraves viscosimeter having a No. 1 measurement body in the presence of a calcium chelate. The alginate concentration is between 0.2 and 2 weight percent. The polyvalent metal salt concentration in solution is from 3.4.times.10.sup.-3 to 6.8.times.10.sup.-2 M. The alginate capsules are employed in cosmetic compositions.

    Abstract translation: 生产藻酸盐胶囊的方法包括将藻酸水溶液缓慢引入多价金属盐的交联溶液中。 海藻酸水溶液具有摩尔比在0.4和1.9之间的甘露聚糖单元（M）和古罗勒糖单元（G），优选（G）嵌段的量大于50％。 优选地，藻酸盐是具有粘度的海藻酸钠，在25℃的水中的0.5％溶液中，低于20mPa.s，使用具有1号测量体的TV Contraves粘度计在钙的存在下测量 螯合。 藻酸盐浓度为0.2〜2重量％。 溶液中的多价金属盐浓度为3.4×10 -3至6.8×10 -2 M。 藻酸盐胶囊用于化妆品组合物中。

    Apparatus for gel-coating seeds
    93.
    发明授权
    Apparatus for gel-coating seeds 失效
    凝胶涂层装置

    公开(公告)号：US5107787A

    公开(公告)日：1992-04-28

    申请号：US608438

    申请日：1990-12-04

    Applicant: Yasushi Kouno

    Inventor： Yasushi Kouno

    IPC: A01C1/00 ,  A01C1/06 ,  B01J13/08 ,  B01J13/14

    CPC classification number: A01C1/06 ,  B01J13/08

    Abstract: Apparatus for generating seeds includes a seed supply portion having a rotating drum with a small aperture for attracting a seed by vacuum created inside the drum and which is broken at a predetermined rotational position, and a gel-coating portion having a cylindrical cutting plunger disposed inside of a nozzle body for opening and closing a gel flow channel and forming a gel-coating layer. A curing vessel having a curing agent flow channel and a spray nozzle for washing the coated seeds are also provided.

    Method of gel-coating seed and apparatus used therefor
    94.
    发明授权
    Method of gel-coating seed and apparatus used therefor 失效
    种子的凝胶涂覆方法及其使用的设备

    公开(公告)号：US5080925A

    公开(公告)日：1992-01-14

    申请号：US429597

    申请日：1989-10-31

    Applicant: Yasushi Kouno

    Inventor： Yasushi Kouno

    IPC: A01C1/00 ,  A01C1/06 ,  B01J13/08 ,  B01J13/14

    CPC classification number: A01C1/06 ,  B01J13/08

    Abstract: A method of gel-coating a seed comprises opening and closing a gel flow channel in a nozzle main body containing a gel therewithin by a cutting plunger, forming a gel-coating layer by opening a valve, supplying a seed contained in a seed storing vessel through the inside of said cutting plunger to the gel-coating layer thereby gel-coating the seed, and then falling the gel-coated seed into a curing vessel by closing the valve. A gel-coating apparatus included a seed supply portion comprising a rotational drum having a small aperture for attracting a speed by vacuum created inside which is broken at a predetermined rotational position by an aperture closing member and a gel-coating portion having a cylindrical cutting plunger disposed at the inside of a nozzle main body for opening and closing a gel flow channel and means for the supplying the gel into the gel flow channel.

    Abstract translation: 种子的凝胶涂覆方法包括：通过切割柱塞打开和关闭在其中含有凝胶的喷嘴主体中的凝胶流动通道，通过打开阀门形成凝胶涂层，供应包含在种子储存容器中的种子 通过所述切割柱塞的内部到凝胶涂层，从而使种子凝胶化，然后通过关闭阀将凝胶涂覆的种子落入固化容器中。 一种凝胶涂覆装置包括种子供应部分，该种子供应部分包括具有小孔径的旋转鼓，用于通过产生的内部真空吸引速度，所述旋转鼓通过孔闭合部件在预定旋转位置处被破坏，以及凝胶涂覆部分具有圆柱形切割柱塞 设置在用于打开和关闭凝胶流动通道的喷嘴主体的内部，以及用于将凝胶供应到凝胶流动通道中的装置。

    Method of producing microspheres
    95.
    发明授权
    Method of producing microspheres 失效
    微球的制备方法

    公开(公告)号：US4822534A

    公开(公告)日：1989-04-18

    申请号：US24554

    申请日：1987-03-11

    Applicant: Robert W. J. Lencki ,  Ronald J. Neufeld ,  Trevor Spinney

    Inventor： Robert W. J. Lencki ,  Ronald J. Neufeld ,  Trevor Spinney

    IPC: B01J13/08 ,  B01J13/02

    CPC classification number: B01J13/08

    Abstract: Providing a water slurry containing an immobilizing agent and an insoluble substance, such as calcium citrate, effective to cause gelation of the immobilizing agent. The water slurry is then contacted with a hydrophobic liquid, such as a vegetable oil under conditions leading to the formation of a dispersion of droplets of the water slurry in the hydrophobic liquid. The droplets gel to form microspheres by adding an oil-soluble organic acid, such as acetic acid to the dispersion containing the droplets. Possibility of producing microspheres which are very small and are constituted of nearly perfect spheres. If desired the method can be adapted to produce microspheres containing immobilized material.

    Abstract translation: 提供含有固定剂和不溶物质如柠檬酸钙的水浆，其有效地引起固定剂的凝胶化。 然后在导致在疏水液体中形成水浆液滴的分散体的条件下，水浆料与疏水性液体如植物油接触。 通过向包含液滴的分散体中加入油溶性有机酸如乙酸，将液滴凝胶形成微球。 生产微球的可能性非常小，由几乎完美的球体组成。 如果需要，该方法可以适于产生含有固定化材料的微球。

    Encapsulation of materials
    96.
    发明授权
    Encapsulation of materials 失效
    封装材料

    公开(公告)号：US4663286A

    公开(公告)日：1987-05-05

    申请号：US579494

    申请日：1984-02-13

    Applicant: Wen-Ghih Tsang ,  Ann W. Shyr

    Inventor： Wen-Ghih Tsang ,  Ann W. Shyr

    IPC: A61K9/16 ,  A61K9/50 ,  B01J13/08 ,  B01J13/14 ,  B01J13/20 ,  C12N5/00 ,  C12N5/02 ,  C12N5/16 ,  C12N11/04 ,  C12N11/10

    CPC classification number: A61K9/5031 ,  A61K9/1652 ,  A61K9/5073 ,  B01J13/08 ,  B01J13/20 ,  C12N5/0012 ,  C12N5/163 ,  C12N2533/74

    Abstract: A core material such as viable cells is encapsulated by gelling an alginate polymer with a polyvalent cation to form shape-retaining gelled masses containing the core material, expanding and hydrating the gelled masses by contacting the masses with an aqueous saline solution, and forming a membrane about the expanded gelled massed to form capsules by contacting the gelled masses with a polycationic polymer having a molecular weight greater than 3,000 daltons. Expanding before membrane formation, permits better control of permeability properties and uniformity of the membrane. The gelled masses within the membrane may be liquified by contacting the capsules with a chelating agent which is preferably ethylene glycol bis-(.beta.-amino ethyl ether)-N,N-tetra-acetic acid. A second membrane layer may be formed by contacting the capsules with a second polycationic polymer. The second membrane may be coated with a polyanionic polymer such as alginate.

    Abstract translation: 通过将藻酸盐聚合物与多价阳离子胶凝来形成核心材料，以形成包含芯材的形状保持凝胶状物质，通过使质量与盐水溶液接触来膨胀和水合凝胶体，并形成膜 通过使凝胶状物质与分子量大于3,000道尔顿的聚阳离子聚合物接触，使膨胀的凝胶团合形成胶囊。 在膜形成之前扩张可以更好地控制膜的渗透性能和均匀性。 通过使胶囊与优选乙二醇双 - （β-氨基乙基醚）-N，N-四乙酸的螯合剂接触来使膜内的胶凝物质液化。 可以通过使胶囊与第二聚阳离子聚合物接触来形成第二膜层。 可以用聚阴离子聚合物如藻酸盐涂覆第二膜。

    Process for preparation of microcapsules
    97.
    发明授权
    Process for preparation of microcapsules 失效
    微胶囊制备方法

    公开(公告)号：US4622244A

    公开(公告)日：1986-11-11

    申请号：US643547

    申请日：1984-08-23

    Applicant: Galen G. Lapka ,  Norbert S. Mason ,  Curt Thies

    Inventor： Galen G. Lapka ,  Norbert S. Mason ,  Curt Thies

    IPC: A61K9/16 ,  A61K9/50 ,  B01J13/08 ,  B01J13/02

    CPC classification number: B01J13/08 ,  A61K9/1647 ,  A61K9/1694 ,  A61K9/5031 ,  A61K9/5089 ,  Y10S514/811 ,  Y10S514/812 ,  Y10S514/963 ,  Y10T428/2989

    Abstract: Microcapsules particularly those less than 300 microns in size are provided which are adapted for injection by conventional means to afford controlled release of the encapsulated drug material, such as a narcotic antagonist, an antibiotic or the like, over a prolonged period. The microcapsules are characterized by a solid core material of a solid, injectable drug material and a wall material engulfing the core material and composed of a polymer material such as a bioabsorbable polymer material. The microcapsules are made by providing a system containing a mixture of particles of a solid, injectable drug material and a solution of a bioabsorbable polymer material in a solvent in which the drug material is substantially insoluble. The system is treated to induce phase separation of the bioabsorbable polymer material from the solution by the addition to the system of a phase separation agent at a temperature at least as low as -30.degree. C. Phase separation may also be carried out at room temperature, but in either event, isolation of the microcapsules formed during the phase separation should be carried out at a temperature at least as low as -30.degree. C. The system is maintained in an agitated condition until the walls of the microcapsules constituted by the bioabsorbable polymer are substantially solidified in order to avoid aggregation or agglomeration of the microcapsules into larger capsules. The microcapsules are ready for injection, for example by being suspended in an aqueous suspending medium, upon being isolated from the system.

    Abstract translation: 提供特别是尺寸小于300微米的微胶囊，其通过常规方法适于注射以长时间地提供包封的药物材料如麻醉拮抗剂，抗生素等的受控释放。 微胶囊的特征在于固体，可注射药物材料的固体芯材料和吞咽芯材料并由诸如生物可吸收聚合物材料的聚合物材料构成的壁材料。 通过提供一种包含固体，可注射药物材料的颗粒和生物可吸收聚合物材料的溶液在其中药物材料基本上不溶的溶剂中的混合物的体系来制备微胶囊。 处理该系统以通过在至少低至-30℃的温度下加入相分离剂体系来诱导生物可吸收聚合物材料与溶液的相分离。相分离也可以在室温下进行 ，但是在任一情况下，在相分离期间形成的微胶囊的分离应在至少低至-30℃的温度下进行。将体系保持在搅拌状态，直到微生物的壁由生物可吸收的 聚合物基本上被固化，以避免微胶囊聚集或聚集成更大的胶囊。 微胶囊可以注射，例如通过悬浮在水性悬浮介质中，与系统隔离。

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