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    PROCESS FOR THE PRODUCTION OF BIPHENYLS
    92.
    发明申请
    PROCESS FOR THE PRODUCTION OF BIPHENYLS 审中-公开
    生产BIPHENYLS的工艺

    公开(公告)号：US20090030233A1

    公开(公告)日：2009-01-29

    申请号：US12092324

    申请日：2006-11-13

    Applicant: Josef Ehrenfreund ,  Harald Walter ,  Hans Tobler ,  Camilla Corsi

    Inventor： Josef Ehrenfreund ,  Harald Walter ,  Hans Tobler ,  Camilla Corsi

    IPC: C07C211/45 ,  C07C205/06

    CPC classification number: C07C201/12 ,  C07C2601/02 ,  C07C205/06 ,  C07C205/11 ,  C07C205/19 ,  C07C205/34 ,  C07C205/42 ,  C07C205/56

    Abstract: The present invention relates to a novel process for the preparation of a compound of formula (I): which comprises reacting a compound of formula (II): with a compound of general formula (III): wherein R1 and R2 are H or C1-4 alkyl or R1 and R2 join together to form a C2-3 alkylene group, which is optionally substituted by from 1 to 4 methyl or ethyl groups, or an anhydride of the compound (III), in the presence of a base and of a palladium catalyst which is (a) a palladium (0)- or palladium (II)-triarylphosphine complex optionally in the presence of additional amounts of a triarylphoshine ligand, or (b) a palladium (II) salt in the presence of a triarylphosphine ligand, or (c) metallic palladium, optionally deposited on a support, in the presence of triarylphosphine; there being used from 0.9 to 2 moles of compound (III) for each mole of compound (II).

    Abstract translation: 本发明涉及制备式（I）化合物的新方法：其包括使式（II）化合物与通式（III）的化合物反应：其中R1和R2是H或C1- 4烷基或R 1和R 2连接在一起形成C2-3亚烷基，其任选被1至4个甲基或乙基取代，或化合物（III）的酸酐，在碱存在下， 钯催化剂，其是（a）钯（0）​​ - 或钯（II） - 三芳基膦配合物，任选在另外量的三芳基膦酸配体存在下，或（b）钯（II）盐，在三芳基膦配体 ，或（c）金属钯，任选地沉积在载体上，在三芳基膦存在下; 对于每摩尔化合物（II），使用0.9至2摩尔的化合物（III）。

    Process for the Preparation of Phenolic Hydroxy-Substituted Compounds
    97.
    发明申请
    Process for the Preparation of Phenolic Hydroxy-Substituted Compounds 有权
    酚羟基取代的化合物的制备方法

    公开(公告)号：US20080039643A1

    公开(公告)日：2008-02-14

    申请号：US11577434

    申请日：2005-12-07

    Applicant: Andras Vass ,  Jozsef Dudas ,  Laszlo Borbely ,  Ferenc Haasz ,  Peter Jekkel

    Inventor： Andras Vass ,  Jozsef Dudas ,  Laszlo Borbely ,  Ferenc Haasz ,  Peter Jekkel

    IPC: C07C39/00 ,  C07J1/00

    CPC classification number: C07C37/055 ,  C07C45/673 ,  C07C49/755 ,  C07C49/84 ,  C07C51/367 ,  C07C201/12 ,  C07C2602/10 ,  C07J1/0059 ,  C07J1/0074 ,  C07C65/03 ,  C07C65/10 ,  C07C39/04 ,  C07C39/14 ,  C07C39/07 ,  C07C39/28 ,  C07C39/27 ,  C07C39/08 ,  C07C39/17 ,  C07C205/22

    Abstract: The invention relates to a process for the preparation of a phenolic hydroxy-substituted compound of the general formula (I) by desalkylation of an alkyl aryl ether of the general formula (II) by treatment with a thiourea/aluminum chloride reagent pair, in said general formulae R1 stands for straight chain or branched C1-6 alkyl group; R2, R3, R4, R5, and R6 have the same or different meanings and stand for hydrogen or halogen atom, hydroxy, carboxy, nitro, oxo, C1-6 alkylcarbonyl, straight chain or branched alkyl or -alkoxy, or aryl group, or R2 and R3 together stand for a 5-7 membered ring or fused ring system; said 5-7 membered ring may be a partially saturated ring optionally substituted with an oxo group or can be an unsaturated ring; or said fused ring system may constitute with the first ring a steroid, preferably an estratriene derivative optionally substituted with an oxo or C1-6 alkylcarbonyloxy group in the 17 position.

    Abstract translation: 本发明涉及一种制备通式（I）的酚羟基取代的化合物的方法，该方法通过在所述的硫脲/氯化铝试剂对中用硫脲/氯化铝试剂对进行脱烷基处理来制备通式（Ⅱ）的烷基芳基醚 通式R 1代表直链或支链C 1-6烷基; R 2，R 3，R 4，R 5和R 6， 具有相同或不同的含义，代表氢或卤原子，羟基，羧基，硝基，氧代，C 1-6烷基羰基，直链或支链烷基或 - 烷氧基或芳基，或R 一起代表5-7元环或稠环系统; 所述5-7元环可以是任选被氧代基取代的部分饱和的环，或者可以是不饱和环; 或所述稠环体系可以与第一环一起构成甾族化合物，优选在17位任选被氧代或C 1-6烷基羰基氧基取代的雌三烯衍生物。

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