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公开(公告)号：US11441949B2
公开(公告)日：2022-09-13
申请号：US17222858
申请日：2021-04-05
Applicant: CytoVeris Inc.
Inventor： Gary Root , David Fournier , Rishikesh Pandey
Abstract: A method and system for identifying a Raman spectrum component of an observed spectrum is provided. The observed spectrum is produced by interrogating a material such as a tissue sample with light at the one or more predetermined wavelengths, and the observed spectrum includes a background fluorescence component representative of fluorescent emissions resulting from the light interrogation and a Raman spectrum component representative of a Raman scattering resulting from the light interrogation. The method includes a) creating a reconstructed fluorescence spectrum representative of the background fluorescence component of the observed spectrum using one or more empirically determined fluorescent spectral profiles; and b) identifying the Raman spectrum of the observed spectrum using the reconstructed fluorescence spectrum.
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公开(公告)号：US11441948B2
公开(公告)日：2022-09-13
申请号：US17054157
申请日：2020-03-25
Applicant: MKS TECHNOLOGY, INC.
Inventor： Quaid Vohra , Celestin Zemtsop , Mark Watson
Abstract: A multi-dispersive spectrometer is provided in which the spectrometer comprises an optical system configured to direct an excitation signal from an excitation light source toward a sample, receive a spectroscopy signal from the sample, and direct the spectroscopy signal toward the detector. The optical system comprises a movable optical component adapted to move the spectroscopy signal relative to at least one sensor of the detector and the detector is adapted to detect a plurality of discrete shifted spectroscopy signals. A method of obtaining a Raman spectrum from a sample is also provided. The method comprises directing an excitation signal from an excitation light source toward a sample; receiving a spectroscopy signal from the sample; and directing the spectroscopy signal toward a detector, wherein the spectroscopy signal is moved relative to at least one sensor of the detector to provide a plurality of discrete shifted spectroscopy signals.
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公开(公告)号：US11428638B2
公开(公告)日：2022-08-30
申请号：US16961675
申请日：2019-01-11
Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
Inventor： Ya-Hong Xie , Owen Liang
IPC: G01N33/574 , G01N21/65 , G01J3/02 , G01J3/44 , G01N33/569 , G01N33/68 , G01N21/35
Abstract: Systems and methods for characterizing biological specimens, which may involve identifying a cell type or state corresponding to a disease or health condition of a subject. A biological specimen is subjected to electromagnetic radiation for spectroscopic analysis such as Surface Enhanced Raman Spectroscopy (SERS) to determine the relative abundance of proteins or amino acids in the cells, which is used in a comparison to previously stored relative abundance data of a database to automatically identifies at least one of cell type and/or cell state of the cells (or the disease/health state of the subject with the disease state including the possibility of virus infection, or drug susceptibility of a subject to bacteria or fungus). The method may also be employed with biological entities or cellular structures such as exosomes and even protein or nucleic acid fragments to determine disease states or health states of the subject.
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公开(公告)号：US11419590B2
公开(公告)日：2022-08-23
申请号：US16994327
申请日：2020-08-14
Inventor： Daniel Orringer , Christian Freudiger , Jay Trautman , Andrew Kelly
Abstract: Devices and systems for analyzing biological samples are provided. Devices include a hollow body extending from a first end to a second end. The body defines a sample collecting portion. A first opening at the first end of the body is operable to receive a source of negative pressure and a second opening at the second end of the body is operable to receive a biological sample. The body also includes an optically transparent region disposed in a region corresponding to the sample collecting portion, the optically transparent region being configured to transmit electromagnetic radiation therethrough from an imaging device capable of imaging the biological sample when disposed in the sample collecting portion.
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公开(公告)号：US11408770B2
公开(公告)日：2022-08-09
申请号：US16760055
申请日：2018-10-30
Applicant: University of Maryland, College Park
Inventor： Giuliano Scarcelli , Jitao Zhang , Milos Nikolic
IPC: G01J3/44 , G01J3/02 , G01J3/26 , G01N21/359 , G01N21/64 , G01N21/65 , G02B21/00 , G02B21/08 , G01N21/35
Abstract: A Brillouin modality can be supplemented by an auxiliary modality, such as an optical imaging modality or a spectroscopy modality. In some embodiments, the auxiliary modality can be used to guide the Brillouin measurement to a desired region of interest, so that acquisition times for the Brillouin measurement can be reduced as compared to interrogating the entire sample. The auxiliary modality may have an acquisition speed faster than that of the Brillouin modality. In some embodiment, the auxiliary modality determines a composition of materials within a voxel in the sample interrogated by the Brillouin modality. Using the information provided by the auxiliary modality, the Brillouin signatures corresponding to the materials within the voxel can be unmixed, thereby providing a more accurate measurement of the sample.
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Patent Agency Ranking
公开(公告)号：US20220246427A1
公开(公告)日：2022-08-04
申请号：US17650402
申请日：2022-02-09
Applicant: NGK INSULATORS, LTD.
Inventor： Jun YOSHIKAWA , Morimichi WATANABE , Hiroshi FUKUI
Abstract: Provided is an α-Ga2O3 based semiconductor film having a crystal having a corundum-type crystal structure composed of α-Ga2O3 or an α-Ga2O3 solid solution as a main phase. This semiconductor film has a size in which the diameter of the largest circle inscribed in the outer circumference thereof is 5.08 cm (2 inches) or more, and at the center point X and each of four outer circumferential points A, B, C, and D of the largest circle on the surface of the semiconductor film, the full width at half maximum of the peak in the vicinity of 216 cm−1 in Raman spectrum of the semiconductor film, as measured by laser Raman spectroscopy, is 6.0 cm−1 or less.
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公开(公告)号：US20220222497A1
公开(公告)日：2022-07-14
申请号：US17574837
申请日：2022-01-13
Applicant: Qinghai Normal University
Inventor： Xin JIN , Yanxiang JIN , Dengxing YANG , Di FU
Abstract: A method for identifying a dry salt flat based on the sentinel-1 data is provided. The method includes: carrying out field survey and acquiring data; processing sentinel-1 data; determining backscattering values, spectrum characteristics and colors of different polarization; and determining a classification criterion and carrying out threshold classification.
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公开(公告)号：US11385216B2
公开(公告)日：2022-07-12
申请号：US17306269
申请日：2021-05-03
Applicant: PHILLIPS 66 COMPANY
Inventor： Paul Rady , Marisa Purificato , Franklin Uba , Ayuba Fasasi
Abstract: In one embodiment, a pipeline interchange flows a product through an upstream pipeline. An automated analyzer is connected to the upstream pipeline to analyze different physical and/or chemically properties in the product and generate data from the product without extracting a sample from the upstream pipeline. An automatic splitter is placed downstream of the automated analyzer, capable of receiving and interpreting the data from the automated analyzer and directing the refined petroleum product into at least three different downstream pipelines, wherein at least one of the downstream pipelines is a transmix pipeline.
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公开(公告)号：US11378567B2
公开(公告)日：2022-07-05
申请号：US17306522
申请日：2021-05-03
Applicant: PHILLIPS 66 COMPANY
Inventor： Paul Rady , Marisa Purificato , Franklin Uba , Ayuba Fasasi
Abstract: In one embodiment, a process is taught where the process begins by flowing a first product through a first pipeline and flowing a second product through a second pipeline. In this embodiment, the first product in the first pipeline is analyzed with a first product automated analyzer that is capable of physical and/or chemically analyzing the first product in the first pipeline and generating a first product data. Additionally, in this embodiment, the second product in the second pipeline is analyzed with a second product automated analyzer that is capable of physical and/or chemically analyzing the second product in the second pipeline and generating a second product data. The process then produces a blended product by mixing both the first product and the second product within a pipeline interchange which is connected downstream to both the first pipeline and the second pipeline. The blended product then flows from the pipeline interchange to a third pipeline that is connected downstream of pipeline interchange. The first product data and the second product data is then interpreted in a data analyzer by comparing the physical and/or chemical characteristics of the physical and/or chemical characteristics of the first data to an optimal first data and the physical and/or chemical characteristics of the second data to an optimal second data. The data analyzer then determines the adjustments in the flow of the first product and the flow of the second product to achieve optimal blended data from the blended product. The adjustments are then communicated to adjust the flow of the first product in the first pipeline and the flow of the second product in the second pipeline.
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公开(公告)号：US11366013B2
公开(公告)日：2022-06-21
申请号：US17009175
申请日：2020-09-01
Applicant: HITACHI HIGH-TECH SCIENCE CORPORATION , Inter-University Research Institute Corporation Research Organization of information and Systems
Inventor： Jun Horigome , Hiroki Okawa , Takahiro Tamashima , Imari Sato , Yinqiang Zheng
IPC: G01N21/64 , G01J3/44 , G06F3/14 , H04N5/225 , G06V10/143
Abstract: A method of obtaining a quantum efficiency distribution in a predetermined sample surface, including: irradiating a reference material with excitation light belonging to a first wavelength range; obtaining the reference material's image, which includes a first channel for the first wavelength range and a second channel for a second wavelength range, the first and the second channel's irradiation luminance value in each pixel; irradiating the predetermined sample surface with the excitation light; obtaining the first and the second channel's measurement luminance value in each pixel of the image of the predetermined surface; calculating an absorption luminance value from a difference between the first channel's irradiation luminance value and measurement luminance value; calculating a fluorescence luminance value from difference between the second channel's irradiation luminance value and measurement luminance value; calculating quantum efficiency of each pixel based on the values; and obtaining quantum efficiency distribution.
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