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公开(公告)号：US11278521B2
公开(公告)日：2022-03-22
申请号：US16063077
申请日：2016-12-15
Applicant: UNIVERSITY OF SOUTH FLORIDA , The United States Government as Represented by The Department of Veterans Affairs
Inventor： Niketa A. Patel , Jianfeng Cai
IPC: A61K31/396 , A61K31/395 , A61K45/06 , C07D285/00
Abstract: Provided herein are compounds that can bind GAS5 long non-coding RNA, compositions thereof, and uses thereof.
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公开(公告)号：US11278011B1
公开(公告)日：2022-03-22
申请号：US16781633
申请日：2020-02-04
Applicant: University of South Florida
Inventor： Norma A. Alcantar , Daniela Miranda de Lima Stebbins , Kevan Main
IPC: A01K63/04 , C02F1/72 , C02F1/32 , C02F103/20 , C02F101/32
Abstract: A reacting canister utilizing transparent optical fiber technology coated with a photo-catalyst and a plasmonic layer, including yttrium aluminum garnet nanoparticles, disposed between the optical fiber and the photo-catalyst to degrade off-flavor compounds in aquacultured aquatic life. The degradation of off-flavored compounds—including 2-methylisoborneol—can be significantly enhanced by increasing the surface area of the catalyst. Coating individual transparent optical fibers and aligning those fibers in a canister configuration allows the treatment of large volumes of water in portable and scalable reactors. Once the fluid is treated, the fluid is returned to the reservoir containing the aquacultured aquatic life.
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公开(公告)号：US20220026773A1
公开(公告)日：2022-01-27
申请号：US17496429
申请日：2021-10-07
Applicant: University of South Florida
Inventor： Manoj Kumar Ram
IPC: G02F1/1516 , G02F1/163
Abstract: An electrochromic device including a single unitary active layer with a dye having a nitrogen group and a conducting polymer having a nitrogen group. The active layer has a first color in an oxidized state and a second color in a reduced state; the electrochromic device has no other active layer.
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公开(公告)号：US11214595B2
公开(公告)日：2022-01-04
申请号：US16222534
申请日：2018-12-17
Inventor： Luisa Lynn Scott , Joseph Paul Walton
Abstract: The present invention concerns peptides and nucleic acids encoding the peptides, and their use for modulating large conductance Ca2+ activated K+ (BK) channel activity in cells; for treating conditions such as presbycusis (age-related hearing loss), audiogenic seizures, alcohol addiction, cancer, and neurodegenerative disease; and for delivering a cargo moiety to the brain of a subject through the blood-brain barrier.
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105.发明授权公开(公告)号：US11202604B2
公开(公告)日：2021-12-21
申请号：US16389513
申请日：2019-04-19
Applicant: University of South Florida
Inventor： Ghadh Alzamzmi , Chih-Yun Pai , Dmitry Goldgof , Rangachar Kasturi , Terri Ashmeade , Yu Sun
Abstract: A system and method of automatically assessing pediatric and neonatal pain using facial expressions along with crying sounds, body movement, and vital signs change to improve the diagnosis and treatment of pain in the pediatric patient population.
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Patent Agency Ranking
公开(公告)号：US11198842B1
公开(公告)日：2021-12-14
申请号：US16799428
申请日：2020-02-24
Applicant: University of South Florida
Inventor： Subhra Mohapatra , Shyam S. Mohapatra , Tao Wang , Taylor Martinez
Abstract: An in vitro microfluidic device includes a device configured to model a blood-brain barrier. The device includes a center well in fluidic communication with each of an inlet and an outlet. Each of the center well, inlet, and outlet includes a porous membrane that separates a “blood” portion (a fluid flow portion) from a “brain” portion (a fluid containing portion). The porous membrane is seeded with endothelial cells such as the human venule endothelial cells (HUVECs) on the blood side, and with astrocytes on the brain side, to accurately model the blood-brain barrier. Fluid flows between the inlet, the center well, and the outlet to test the permeability of the porous membrane, thereby providing an accurate in vitro model of a blood-brain barrier.
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公开(公告)号：US20210369863A1
公开(公告)日：2021-12-02
申请号：US17395683
申请日：2021-08-06
Applicant: University of South Florida
Inventor： Shyam S. Mohapatra , Subhra Mohapatra , Eleni Markousta
IPC: A61K47/69 , A61K47/60 , A61P27/02 , A61K9/00 , C12N15/113 , A61K31/7088 , A61K31/4439 , A61K47/61 , A61K47/62 , A61K47/54
Abstract: A multifunctional dendrimer nanoparticle and method of treating diseases of the posterior segment of the eye is presented. The functionalized polyamidoamine (PAMAM) dendrimer effectively delivers drugs and/or genes to the posterior eye, thereby providing for the effective, non-invasive, and topical treatment of diseased in the posterior eye. The multifunctional dendrimer nanoparticle has shRNA-encoding DNA and small molecule drug encapsulated cyclodextrin complexed to the outer surface of the dendrimer for delivery to the posterior segment of the eye.
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公开(公告)号：US20210369157A1
公开(公告)日：2021-12-02
申请号：US17335276
申请日：2021-06-01
Applicant: University of South Florida
Inventor： Kavyashree Puttananjegowda , Sylvia Thomas , Arash Takshi
IPC: A61B5/1486 , A61B5/145
Abstract: The present disclosure presents glucose monitoring systems and methods. One such system comprises a glucose monitoring sensor having at least a counter electrode, a reference electrode, and a working electrode; and a silicon-carbide-silicon-carbide-nanoparticles-electrospun-nanofibrous-membrane contacting the working electrode. The system further includes a glucose oxidase enzyme solution contacting the silicon-carbide-silicon-carbide-nanoparticles-electrospun-nanofibrous-membrane, wherein a conductive polymer membrane assists in binding the glucose oxidase enzyme composition with the silicon-carbide-silicon-carbide-nanoparticles-electrospun-nanofibrous-membrane. Other systems and methods are also provided.
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公开(公告)号：US11181482B1
公开(公告)日：2021-11-23
申请号：US16121932
申请日：2018-09-05
Applicant: University of South Florida
Inventor： Anna Pyayt , Arsenii Zhdanov , Jordan Keefe , Luis Franco-Waite
IPC: G01N21/78 , G01N21/25 , G01N21/64 , G01N21/27 , G01N33/543 , G01N21/03 , G01N21/29 , G01N33/569 , G01N33/574
Abstract: A mobile phone-based system for ELISA (MELISA). The MELISA system can perform all steps of ELISA procedure and output hormone concentration values. The system includes a heater that keeps the temperature required for sample incubation, illumination system for sample image capturing, and a digital camera system. All components are enclosed in a dark box to create optimal light conditions for image capturing. After sample images are captured, they are digitally processed, and hormone concentration values are reported based on colorimetric data from the samples. The system can be used to complete all steps of the assay, including incubation and reading. It is lightweight, can be fabricated at low cost, is portable, and can transfer test results via mobile phone. MELISA can be calibrated for accurate measurements of progesterone and has demonstrated successful measurements with the calibrated system.
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110.发明授权公开(公告)号：US11169256B2
公开(公告)日：2021-11-09
申请号：US16567595
申请日：2019-09-11
Applicant: University of South Florida
Inventor： Sajad Jazayeri , Sarah Kruse
Abstract: A new system and method for FWI of common-offset GPR data, particularly targeting the dimensions and infilling material of buried objects. The method is useful in situations where clear isolated diffraction hyperbolas indicate the presence of an underground object, but the object's dimensions and filling may be unknown. The present invention acquires GPR data and applies advanced numerical methods to get the depth and size of the underground object in a very accurate manner. An embodiment of the invention includes five main steps: GPR data processing, ray-based analysis to set a good initial model, 3D to 2D transformation of data, effective SW estimation, and FWI.
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