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    INCREASED MOLECULE CAPTURE RATE INTO A NANOPORE
    102.
    发明申请
    INCREASED MOLECULE CAPTURE RATE INTO A NANOPORE 失效
    增加的分子获取率纳入纳米比亚

    公开(公告)号：US20140027287A1

    公开(公告)日：2014-01-30

    申请号：US13570600

    申请日：2012-08-09

    Applicant: Hongbo Peng ,  Gustavo A. Stolovitzky ,  Deqiang Wang

    Inventor： Hongbo Peng ,  Gustavo A. Stolovitzky ,  Deqiang Wang

    IPC: B03C11/00 ,  B82Y30/00

    CPC classification number: B03C5/005 ,  B03C5/026 ,  B03C2201/26 ,  B82Y15/00

    Abstract: A mechanism for capturing molecules is provided. A nanopore through a membrane separates a first chamber from a second chamber, and the nanopore, the first chamber, and the second chamber are filled with ionic buffer. A narrowed neck is at a middle area of the first chamber, and the narrowed neck is aligned to an entrance of the nanopore. The narrowed neck has a high intensity electric field compared to other areas of the first chamber having low intensity electric fields. The narrowed neck having the high intensity electric field concentrates the molecules at the middle area aligned to the entrance of the nanopore. Voltage applied between the first chamber and the second chamber drives the molecules, concentrated at the entrance of the nanopore, through the nanopore.

    Abstract translation: 提供了捕获分子的机制。 通过膜的纳米孔将第一室与第二室分开，并且纳米孔，第一室和第二室用离子缓冲液填充。 狭窄的颈部位于第一腔室的中间区域，并且狭窄的颈部与纳米孔的入口对准。 与具有低强度电场的第一室的其他区域相比，变窄的颈部具有高强度电场。 具有高强度电场的狭窄颈部将分子集中在与纳米孔入口对准的中间区域。 施加在第一室和第二室之间的电压驱动分子，浓缩在纳米孔的入口处，通过纳米孔。

    METHOD AND MICROSYSTEM FOR DETECTING ANALYTES WHICH ARE PRESENT IN DROPS OF LIQUID
    103.
    发明申请
    METHOD AND MICROSYSTEM FOR DETECTING ANALYTES WHICH ARE PRESENT IN DROPS OF LIQUID 有权
    用于检测液体液体中分析物的方法和微结构

    公开(公告)号：US20140008224A1

    公开(公告)日：2014-01-09

    申请号：US13984964

    申请日：2011-02-11

    Applicant: Vincent Agache ,  Patrice Caillat ,  Pierre Puget

    Inventor： Vincent Agache ,  Patrice Caillat ,  Pierre Puget

    IPC: B03C5/00

    CPC classification number: B03C5/005 ,  B03C5/026 ,  B03C2201/26

    Abstract: A detection method of detecting analytes of interest which are present in a liquid. The detection method including the steps of forming drops of liquid on a first surface by capillary breaking of a finger of liquid, which is initially formed by liquid dielectrophoresis. The thus formed drops each come into contact with a different detection surface, which is arranged facing the first surface. Analytes of interest which are present in each of the drops are detected at the corresponding detection surface.

    Abstract translation: 检测存在于液体中的感兴趣的分析物的检测方法。 检测方法包括以下步骤：通过最初通过液体介电电泳形成的液体手指的毛细管断裂在第一表面上形成液滴。 这样形成的液滴各自与面对第一表面布置的不同检测表面接触。 每个液滴中存在的感兴趣的分析物在相应的检测表面被检测。

    FLUID CLEANSING DEVICES AND METHODS OF USE
    104.
    发明申请
    FLUID CLEANSING DEVICES AND METHODS OF USE 审中-公开
    流体清洁装置及其使用方法

    公开(公告)号：US20130334120A1

    公开(公告)日：2013-12-19

    申请号：US13918193

    申请日：2013-06-14

    Applicant: President And Fellows Of Harvard College

    Inventor： Donald E. Ingber ,  Joo Hun Kang ,  Richard C. Terry ,  Michael Super ,  Ryan M. Cooper ,  Karel Domansky ,  Chong Wing Yung

    IPC: B03C1/28

    CPC classification number: B03C1/28 ,  B03C1/01 ,  B03C1/288 ,  B03C2201/18 ,  B03C2201/26

    Abstract: A system and method for removing a target species from a fluid source is provided. The system includes a reciprocating fluid cleansing device, including a processing chamber with a port at a first end for fluid passage and a movable plunger at a second end, wherein the plunger in contact with a fluid includes a motorized mixing element for mixing the fluid with species-targeting magnetic particles. Motion of the plunger in a first direction transfers a first volume of the fluid from the fluid source into the processing chamber. Motion of the plunger in a second direction transfers the first volume of the fluid from the processing chamber to a fluid destination. At least one magnetic element provides a magnetic field gradient within the processing chamber. A connector connects the port of the first processing chamber to the fluid source and the fluid destination.

    Abstract translation: 提供了用于从流体源中去除目标物种的系统和方法。 该系统包括往复式流体清洁装置，其包括处理室，其具有用于流体通道的第一端的端口和在第二端处的可移动柱塞，其中与流体接触的柱塞包括用于将流体与 以物种为目标的磁性颗粒。 柱塞在第一方向上的运动将第一体积的流体从流体源传送到处理室。 柱塞在第二方向的运动将第一体积的流体从处理室传送到流体目的地。 至少一个磁性元件在处理室内提供磁场梯度。 连接器将第一处理室的端口连接到流体源和流体目的地。

    FLUID BASED ANALYTE DETECTOR
    107.
    发明申请
    FLUID BASED ANALYTE DETECTOR 审中-公开
    基于流体的分析仪检测器

    公开(公告)号：US20130199264A1

    公开(公告)日：2013-08-08

    申请号：US13879457

    申请日：2011-09-13

    Applicant: Aya Seike

    Inventor： Aya Seike

    IPC: G01N30/62

    CPC classification number: G01N30/62 ,  B03C3/017 ,  B03C3/38 ,  B03C3/41 ,  B03C3/45 ,  B03C2201/26 ,  G01N30/6095 ,  G01N2030/022

    Abstract: A gas chromatograph having a gas inlet port, a sealed fluid flow channel, a gas outlet port, a gas outlet port in fluid connection with a second end of the fluid flow channel, and a gas molecule detector in fluid connection with the gas outlet port, is disclosed. The first end of the sealed fluid flow channel is in fluid connection with the gas inlet port. The sealed fluid flow channel contains one or more pairs of electrodes running lengthwise along the inner surface of the fluid flow channel.

    Abstract translation: 具有气体入口，密封流体流动通道，气体出口，与流体流动通道的第二端流体连接的气体出口以及与气体出口端口流体连通的气体分子检测器的气相色谱仪 ，被披露。 密封流体流动通道的第一端与气体入口端口流体连通。 密封的流体流动通道包含沿流体流动通道的内表面纵向延伸的一对或多对电极。

    Microscale sorting cytometer
    109.
    发明授权
    Microscale sorting cytometer 有权
    微尺度分选细胞仪

    公开(公告)号：US08454813B2

    公开(公告)日：2013-06-04

    申请号：US12081995

    申请日：2008-04-24

    Applicant: Joel Voldman ,  Brian Michael Taff

    Inventor： Joel Voldman ,  Brian Michael Taff

    IPC: G01N27/453

    CPC classification number: B03C5/005 ,  B03C5/026 ,  B03C2201/26 ,  G01N15/1475 ,  G01N2015/0038 ,  G01N2015/1006 ,  G01N2015/1081 ,  G01N2015/149

    Abstract: The present invention provides a device and methods of use thereof in microscale cell sorting. This invention provides sorting cytometers, which trap individual cells within vessels following exposure to dielectrophoresis, allow for the assaying of trapped cells, such that a population is identified whose isolation is desired, and their isolation.

    Abstract translation: 本发明提供了一种在微细胞分选中的装置及其使用方法。 本发明提供了分选细胞计数器，其在暴露于介电电泳之后捕获容器内的单个细胞，允许捕获的细胞的测定，使得鉴定其需要分离的群体及其分离。

    STIRRING APPARATUS
    110.
    发明申请
    STIRRING APPARATUS 审中-公开
    搅拌装置

    公开(公告)号：US20130126436A1

    公开(公告)日：2013-05-23

    申请号：US13307742

    申请日：2011-11-30

    Applicant: Ji-tae OK ,  Seong-kook KIM

    Inventor： Ji-tae OK ,  Seong-kook KIM

    IPC: B03C1/30 ,  B01F13/08

    CPC classification number: B01F7/005 ,  B01F7/161 ,  B01F9/002 ,  B01F9/0021 ,  B01F9/0023 ,  B01F11/0022 ,  B01F15/00454 ,  B01F15/00681 ,  B03C1/032 ,  B03C1/286 ,  B03C1/30 ,  B03C2201/26 ,  G01N35/0098

    Abstract: A stirring apparatus and a method of separating magnetic beads from a sample including the magnetic beads are provided. The stirring apparatus includes at least one rotational body having a hollow formed therein; a driving unit which moves upward and downward and rotates the at least one rotational body; a cap which is combined with the rotational body, extends in a vertical direction, and has an internal space connected to the hollow of the rotational body; and a magnetic force application unit which moves upward and downward to be inserted into or taken out of the internal space of the cap via the hollow of the rotational body.

    Abstract translation: 提供了一种从包括磁珠的样品中分离磁珠的搅拌装置和方法。 所述搅拌装置包括至少一个具有形成在其中的中空的旋转体; 驱动单元，其向上和向下移动并旋转所述至少一个旋转体; 与旋转体组合的盖在垂直方向上延伸，并且具有连接到旋转体的中空部的内部空间; 以及磁力施加单元，其经由旋转体的中空部向上下移动以插入或取出盖的内部空间。

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