公开(公告)号：US20240326053A1

公开(公告)日：2024-10-03

申请号：US18740966

申请日：2024-06-12

Applicant: ROCHE MOLECULAR SYSTEMS, INC.

Inventor： Stephan Korner ,  Emad Sarofim ,  Goran Savatic ,  Marko Simic

IPC: B01L3/00 ,  B03C1/28

CPC classification number: B01L3/502761 ,  B01L3/5085 ,  B03C1/28 ,  B01L2200/0668 ,  B01L2300/0829 ,  B03C2201/18 ,  B03C2201/26

Abstract: The present disclosure relates to a method for isolating a biological target material from a liquid sample in a multiwell plate using magnetic particles, wherein high efficiency and low elution volumes are achieved by specific movements of the multiwell plate and a magnetic separation plate in relation to each other. Also disclosed is a pre-analytical system suitable for carrying out the method.

公开(公告)号：US20240294897A1

公开(公告)日：2024-09-05

申请号：US18657335

申请日：2024-05-07

Applicant: BIOMAGNETIC SOLUTIONS LLC

Inventor： Paul A. LIBERTI ,  Todor R. KHRISTOV ,  Dustin W. RITTER

IPC: C12N13/00 ,  A61M1/36 ,  B01D15/38 ,  B01F31/23 ,  B01F33/452 ,  B03C1/01 ,  B03C1/033 ,  B03C1/034 ,  B03C1/28 ,  G01N33/543

CPC classification number: C12N13/00 ,  A61M1/3618 ,  B01D15/3885 ,  B01F31/23 ,  B01F33/452 ,  B03C1/01 ,  B03C1/0332 ,  B03C1/034 ,  B03C1/288 ,  G01N33/54326 ,  B03C2201/18 ,  B03C2201/22 ,  B03C2201/26

Abstract: An apparatus and methods are provided for the magnetic separation of target bioentities. The apparatus includes a fluid chamber and a magnetic clement for drawing target bioentities toward a collection surface of the fluid chamber. The apparatus may include a positioning assembly operable to variable change the position and orientation of the fluid chamber relative to the magnetic element.

公开(公告)号：US12076719B2

公开(公告)日：2024-09-03

申请号：US16980362

申请日：2019-03-12

Applicant: Virginia Tech Intellectual Properties, Inc.

Inventor： Temple Douglas ,  Philip Melvin Graybill ,  Rafael Davalos

IPC: B01L3/00 ,  B03C5/00 ,  B03C5/02 ,  G01N33/50

CPC classification number: B01L3/502715 ,  B01L3/50273 ,  B01L3/502761 ,  B03C5/005 ,  B03C5/026 ,  G01N33/5008 ,  B01L2300/0645 ,  B01L2300/069 ,  B01L2300/0829 ,  B01L2300/0883 ,  B01L2400/0424 ,  B03C2201/26

Abstract: Described herein are aspects of a microfluidic separation and assay system that can include a microfluidic contactless dielectrophoretic (cDEP) device, a microfluidic concentrator, and a microfluidic assay chamber. In some aspects, microfluidic separation and assay system can be included on a single microfluidic chip. Also described herein are methods of using the microfluidic separation and assay system described herein.

公开(公告)号：US12059586B2

公开(公告)日：2024-08-13

申请号：US17458649

申请日：2021-08-27

Applicant: City University of Hong Kong

Inventor： Steven Wang ,  Ruquan Ye ,  Wei Deng

IPC: A62B7/10 ,  A62B18/00 ,  A62B18/02 ,  A62B18/08 ,  B01D53/00 ,  B01D53/86 ,  B03C3/155 ,  B03C3/32 ,  B03C3/41 ,  B03C3/47 ,  B03C3/70 ,  H02J50/10

CPC classification number: A62B7/10 ,  A62B18/006 ,  A62B18/025 ,  A62B18/084 ,  B01D53/007 ,  B01D53/86 ,  B03C3/155 ,  B03C3/32 ,  B03C3/41 ,  B03C3/47 ,  B03C3/70 ,  H02J50/10 ,  B01D2255/104 ,  B01D2255/20707 ,  B01D2255/20723 ,  B01D2255/20761 ,  B01D2255/2096 ,  B01D2255/802 ,  B01D2259/804 ,  B03C2201/26

Abstract: The present invention provides a wireless rechargeable and portable anti-microbial respirator. The respirator includes a face-piece with an air inlet and an air outlet; a first belt and a second belt, the first belt is connected to ends of the face-piece, and the second belt is configured to wrap around the waist of a user; a flexible outlet tube, where the first end of the flexible outlet tube is connected to the air outlet of the face-piece; a flexible intake tube, where the first end of the flexible intake tube is connected to the air inlet of the face-piece; and a filtration system fixed onto the second belt. The key features of the respirator in the present invention include highly antibacterial and antiviral, long duration, reusable, self-cleaning and self-disinfecting, lightweight and portable, wireless power transfer, and great airflow and comfortable breathing.

公开(公告)号：US20240238802A1

公开(公告)日：2024-07-18

申请号：US18365318

申请日：2023-08-04

Applicant: The Trustees of the University of Pennsylvania

Inventor： David Issadore ,  Venkata Yelleswarapu ,  Jina Ko

IPC: B03C1/28 ,  B03C1/01 ,  B03C1/032 ,  B03C1/034 ,  G01N33/543 ,  G01N33/574

CPC classification number: B03C1/288 ,  B03C1/01 ,  B03C1/032 ,  B03C1/034 ,  G01N33/54333 ,  G01N33/5434 ,  G01N33/574 ,  B01L2300/0681 ,  B03C2201/18 ,  B03C2201/26

Abstract: A magnetic separation filter has an unsupported magnetically soft material layer having a plurality of pores, and, optionally, a passivation layer disposed on the magnetically soft material layer. The magnetic separation filter may be part of a microfluidic device having a lateral flow channel and a vertical flow magnetic separation filter. The magnetic separation device may be used to separate magnetically tagged particles, such as cells.

公开(公告)号：US12038370B2

公开(公告)日：2024-07-16

申请号：US17621979

申请日：2020-07-02

Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA

Inventor： Aydogan Ozcan ,  Aniruddha Ray ,  Yibo Zhang ,  Dino Di Carlo

IPC: G01N15/1433 ,  B03C1/01 ,  B03C1/02 ,  G01N15/1434 ,  G03H1/00 ,  G06V10/147 ,  G06V10/82 ,  G06V20/69 ,  G01N15/01 ,  G01N15/10

CPC classification number: G01N15/1433 ,  B03C1/01 ,  B03C1/02 ,  G01N15/1434 ,  G03H1/0005 ,  G06V10/147 ,  G06V10/82 ,  G06V20/693 ,  G06V20/698 ,  B03C2201/18 ,  B03C2201/26 ,  G01N15/01 ,  G01N2015/1006 ,  G03H2001/005 ,  G03H2222/12

Abstract: A computational cytometer operates using magnetically modulated lensless speckle imaging, which introduces oscillatory motion to magnetic bead-conjugated rare cells of interest through a periodic magnetic force and uses lensless time-resolved holographic speckle imaging to rapidly detect the target cells in three-dimensions (3D). Detection specificity is further enhanced through a deep learning-based classifier that is based on a densely connected pseudo-3D convolutional neural network (P3D CNN), which automatically detects rare cells of interest based on their spatio-temporal features under a controlled magnetic force. This compact, cost-effective and high-throughput computational cytometer can be used for rare cell detection and quantification in bodily fluids for a variety of biomedical applications.

公开(公告)号：US20240139757A1

公开(公告)日：2024-05-02

申请号：US18407757

申请日：2024-01-09

Applicant: MANTA BIOFUEL

Inventor： Ryan Joseph POWELL ,  John William STURGIS, IV ,  Maximilian Davis MARSHALL ,  Scott Joseph WITTE

IPC: B03C1/01 ,  B03C1/033 ,  B03C1/28 ,  C12N1/02 ,  C12N1/12

CPC classification number: B03C1/01 ,  B03C1/0332 ,  B03C1/286 ,  C12N1/02 ,  C12N1/12 ,  B03C2201/18 ,  B03C2201/26

Abstract: Systems and methods for harvesting algae is described herein. The system can include an algae pool containing at least one algae organism; a magnetic particle storage unit adapted or configured to introduce at least one magnetic particle into the algae pool, wherein the at least one magnetic particle binds to the at least one algae organism to form at least one algae conjugate; and an algae harvester, including: at least one magnetic disc adapted or configured to attach, via a surface of the at least one magnetic disc, to the at least one algae conjugate when the at least one algae conjugate comes in contact with the at least one magnetic disc; and at least one scraper adapted or configured to: remove the at least one algae conjugate from the surface of the at least one magnetic disc; and transport the at least one algae conjugate from the algae harvester.

公开(公告)号：US11946038B1

公开(公告)日：2024-04-02

申请号：US17332371

申请日：2021-05-27

Applicant: 10X Genomics, Inc.

Inventor： Alireza Salmanzadeh ,  Dagmar Walter

IPC: C12N15/10 ,  B03C1/28

CPC classification number: C12N15/1013 ,  B03C1/28 ,  B03C2201/18 ,  B03C2201/26

Abstract: Systems, and their methods of use, for sorting or separating magnetic particles are provided. A system having a magnetic module with features that mate with voids in a flow module exerts a magnetic field on magnetic particles to separate particles.

公开(公告)号：US11883820B2

公开(公告)日：2024-01-30

申请号：US15911184

申请日：2018-03-05

Applicant: Yuchen Zhou

Inventor： Yuchen Zhou

IPC: B01D21/02 ,  B03C1/033 ,  B03C1/28 ,  B03C1/30 ,  B01L3/00 ,  G01N1/40 ,  G01N33/49 ,  B01D21/28 ,  G01N33/543 ,  G01N35/00 ,  A61K38/27 ,  C12Q1/6806 ,  B03C1/005 ,  B01D35/06 ,  G01N27/74 ,  B03C1/23 ,  G01N15/00 ,  B01F31/86

CPC classification number: B01L3/502753 ,  A61K38/27 ,  B01D21/283 ,  B01D35/06 ,  B01F31/86 ,  B01L3/50273 ,  B01L3/502715 ,  B01L3/502761 ,  B03C1/005 ,  B03C1/0332 ,  B03C1/23 ,  B03C1/288 ,  B03C1/30 ,  C12Q1/6806 ,  G01N1/4077 ,  G01N15/00 ,  G01N27/745 ,  G01N33/491 ,  G01N33/54326 ,  G01N33/54333 ,  G01N35/0098 ,  B01L2200/027 ,  B01L2200/0647 ,  B01L2200/0652 ,  B01L2200/0668 ,  B01L2300/021 ,  B01L2300/0861 ,  B01L2300/0864 ,  B01L2400/043 ,  B01L2400/0436 ,  B01L2400/0439 ,  B01L2400/0457 ,  B01L2400/0487 ,  B01L2400/0496 ,  B03C2201/18 ,  B03C2201/20 ,  B03C2201/26 ,  G01N2035/00554

Abstract: The current invention relates to the device and method to separate biological entities from a sample fluid by a microfluidic device. The claimed methods separate biological entities by differentiating the sizes of the biological entities with ultrasound modes. The claimed methods further utilize a multi-staged design that removes smaller size entities at earlier and wider sections and concentrates larger entities at later and narrower sections of a microfluidic channel.

公开(公告)号：US20230417702A1

公开(公告)日：2023-12-28

申请号：US18339511

申请日：2023-06-22

Applicant: Exokeryx, Inc.

Inventor： Bryan Joseph Rice ,  Richard Louis Young ,  Amber Noelle Murray ,  Tyler Lee Harris ,  Jordan Alexandra Saalfeld ,  Daniel Philip Heineck

IPC: G01N27/447 ,  G01N33/58 ,  B01L3/00 ,  B03C5/00 ,  B03C5/02

CPC classification number: G01N27/44791 ,  G01N33/58 ,  B01L3/502761 ,  B03C5/005 ,  B03C5/022 ,  B01L2400/0424 ,  B01L2300/0645 ,  B01L2300/0681 ,  B01L2300/027 ,  B01L2300/087 ,  B01L2200/0652 ,  B03C2201/26

Abstract: In one embodiment, a method for isolating and detection one or more biomarkers of interest on a dielectrophoresis device includes receiving a first biological sample containing one or more biomarkers of interest onto a dielectrophoresis (DEP) electrode array, applying a DEP force through particular electrodes of the DEP electrode array, wherein a strength, direction, and period of time of the DEP force is specific to the one or more biomarkers of interest of the first biological sample, and determining, via a digital sensor, a quantity of the one or more biomarkers of interest of the first biological sample.