公开(公告)号：US20060263777A1

公开(公告)日：2006-11-23

申请号：US10540224

申请日：2004-01-27

Applicant: William Tong

Inventor： William Tong

IPC: C12Q1/68 ,  C12M1/34

CPC classification number: G01N21/636 ,  G01J3/42 ,  G01N21/253 ,  G01N30/74 ,  G01N2201/103 ,  G01N2201/12746

Abstract: Techniques and systems for using nonlinear four wave mixing to optically measure microarrays with sample cells of biological or chemical materials. Examples of suitable microarrays include but are not limited to DNA microchips and capillary electrophoresis microarrays.

Abstract translation: 使用非线性四波混合的光学测量微阵列与生物或化学材料样品池的技术和系统。 合适的微阵列的实例包括但不限于DNA微芯片和毛细管电泳微阵列。

公开(公告)号：US20050073686A1

公开(公告)日：2005-04-07

申请号：US10918647

申请日：2004-08-13

Applicant: Wayne Roth ,  Douglas Moore

Inventor： Wayne Roth ,  Douglas Moore

IPC: G01N15/14 ,  G01N21/00

CPC classification number: G01N15/1404 ,  G01N15/1012 ,  G01N21/645 ,  G01N2015/1415 ,  G01N2015/1477 ,  G01N2201/12746

Abstract: Various methods for controlling one or more parameters of a flow cytometer type measurement system are provided. One embodiment includes monitoring parameter(s) of the measurement system during measurements of sample microspheres. The method also includes altering the parameter(s) in real time based on the monitoring. Another method includes monitoring a temperature proximate to the measurement system. One such method includes altering a bias voltage of an avalanche photo diode in response to the temperature using empirically derived data. A different such method includes altering output signals of a photomultiplier tube in response to the temperature using a characteristic curve. Some methods include monitoring a temperature of a fluid, in which sample microspheres are disposed, that will flow through the flow cytometer type measurement system. This method also includes determining a velocity of the sample microspheres in the measurement system from a viscosity of the fluid at the temperature.

Abstract translation: 提供了用于控制流式细胞仪型测量系统的一个或多个参数的各种方法。 一个实施例包括在样品微球的测量期间监测测量系统的参数。 该方法还包括基于监视实时更改参数。 另一种方法包括监测靠近测量系统的温度。 一种这样的方法包括使用经验导出的数据来响应于温度来改变雪崩光电二极管的偏置电压。 不同的这种方法包括使用特性曲线响应于温度改变光电倍增管的输出信号。 一些方法包括监测将流过流式细胞仪类型测量系统的流体样品微球的设置温度。 该方法还包括从该温度下的流体的粘度确定测量系统中的样品微球的速度。