公开(公告)号：US11360029B2

公开(公告)日：2022-06-14

申请号：US16840773

申请日：2020-04-06

Applicant: InSilixa, Inc.

Inventor： Arjang Hassibi ,  Arun Manickam ,  Rituraj Singh ,  Robert G. Kuimelis

IPC: G01N21/64 ,  H04N5/3745 ,  G01J3/44

Abstract: The present disclosure provides methods, apparatus and systems for time-gated fluorescent-based detection. Time-based fluorescence analysis can be used in certain biochemical assays by measuring the emitted photon flux from fluorophores after an individual excitation pulse.

公开(公告)号：US20220178750A1

公开(公告)日：2022-06-09

申请号：US17598211

申请日：2019-11-21

Applicant: WEIPENG (SUZHOU) MEDICAL DEVICES CO., LTD.

Inventor： Yan Xia ,  Bin Yang ,  Rui Li

IPC: G01J3/44 ,  G02B21/00 ,  G02B21/18 ,  G01J3/10 ,  G01N21/65 ,  G01J3/02

Abstract: A coherent anti-Stokes Raman scattering microscope imaging apparatus, comprising: a laser light source (21), a two-dimensional oscillating mirror assembly (22), a first light dichroic mirror plate (23), an objective lens (24), a sample translation platform (25), a collection device (26), and a data processing module; the laser light source (21) is used for producing a first laser beam and a second laser beam; the first laser beam and the second laser beam are coaxially emitted; the first laser beam and the second laser beam are incident on the two-dimensional oscillating mirror assembly (22), and the two-dimensional oscillating mirror assembly (22) adjusts the optical path of the first laser beam and the second laser beam; the first laser beam and the second laser beam leaving the two-dimensional oscillating mirror assembly pass in sequence through the first light dichroic mirror plate (23) and the objective lens (24); the objective lens (24) focuses the first laser beam and the second laser beam onto the sample translation platform; the signal light produced on the sample translation platform (25) passes through the objective lens (24), and the collection device (26) produces initial data on the basis of the signal light, and outputs the initial data to the data processing module; the need for beam splitting and wavelength adjustment of a single wavelength laser beam outputted by a laser is thereby avoided.

公开(公告)号：US11346715B2

公开(公告)日：2022-05-31

申请号：US16864786

申请日：2020-05-01

Applicant: Kaiser Optical Systems Inc.

Inventor： Timothy Norwood ,  Joseph B. Slater

IPC: G01J3/02 ,  G01J3/42 ,  G01J3/44

Abstract: A standard reference material interface for a Raman probe includes a locator including a housing having a first end and a second end, the first end including an attachment portion configured to mate with an attachment portion of the Raman probe. The locator defines a central axis that intersects the first end and the second end. The standard reference material interface also includes a hermetically sealed standard reference material enclosure positioned at the second end of the housing and enclosing a standard reference material. An optical port is positioned within the housing between the Raman probe and the standard reference material relative to the central axis. The optical port includes a window.

公开(公告)号：US11344201B2

公开(公告)日：2022-05-31

申请号：US16240215

申请日：2019-01-04

Applicant: Deneb Medical, S.L.

Inventor： Noé Ortega-Quijano ,  Nebai Bernal Simón ,  Iñigo Olcoz Basarte ,  Juan Arregui Altuna ,  Aritz Lazkoz Del Campo ,  José Antonio Aguilera Andoaga ,  Carlos Aragón Garbizu

IPC: A61B5/00 ,  A61B90/00 ,  G01J3/44 ,  G01J3/02 ,  A61B34/00 ,  G01N21/71 ,  G16C99/00 ,  A61B17/00

Abstract: The present invention relates to a device for the discrimination of biological tissues, such that it is capable of carrying out the discrimination of tissue under complicated operating conditions, for example due to the presence of contaminating elements given off by a cutting operation, due to the presence of moisture in the biological tissue, or due to the presence of a non-controlled atmosphere that interferes with the results of the readings. The invention allows building more complex devices, including cutting instruments, such that it is possible to carry out a surgical intervention in a safe manner by preventing cutting into tissues that are to be avoided during said cutting operation.

公开(公告)号：US11333597B2

公开(公告)日：2022-05-17

申请号：US15942430

申请日：2018-03-30

Applicant: CYTEK BIOSCIENCES, INC.

Inventor： Ming Yan ,  Yung-Chieh Hsieh ,  David Vrane ,  Eric Chase ,  Wenbin Jiang

IPC: G01N15/14 ,  G01J3/02 ,  G01J3/28 ,  G01J3/36 ,  G01N21/64 ,  G01J3/44 ,  G01J3/18 ,  G01J3/14 ,  G01N21/53 ,  G01J3/12 ,  G01N15/00 ,  G01N15/10

Abstract: A system, an apparatus, and a method are provided for a modular flow cytometer with a compact size. In one embodiment, the modular flow cytometry system includes the following: a laser system for emitting laser beams; a flow cell assembly positioned to receive the laser beams at an interrogation region of a fluidics stream where fluoresced cells scatter the laser beams into fluorescent light; a fiber assembly positioned to collect the fluorescent light; and a compact light detection module including a first image array having a transparent block, a plurality of micro-mirrors in a row coupled to a first side of the transparent block, and a plurality of filters in a row coupled to a second side of the transparent block opposite the first side.

公开(公告)号：US11326944B2

公开(公告)日：2022-05-10

申请号：US16510798

申请日：2019-07-12

Applicant: BioSpex, Inc.

Inventor： Wei Yang ,  Changqing Wang ,  Ming Chai ,  Shu Zhang

IPC: G01J3/02 ,  G06F1/16 ,  G01J3/10 ,  G01J3/44 ,  G01J3/28

Abstract: Systems for spectroscopy are provided. Exemplary systems include: an enclosure; a tunable laser disposed in the enclosure; an opening on a surface of the enclosure; a beam splitter disposed in the enclosure, the beam splitter being optically coupled to the tunable laser and the opening; a sensor, a sensing surface of the sensor having a filter disposed thereon; and electronics coupled to the tunable laser and the sensor, the electronics including a processor, memory, and a battery.

公开(公告)号：US11320369B2

公开(公告)日：2022-05-03

申请号：US16053514

申请日：2018-08-02

Applicant: Deere & Company

Inventor： Georg Kormann ,  Wolfram Haiges ,  Peter Schade ,  Nico Correns ,  Bernhard Fischer ,  Fred Grunert

IPC: G01J3/28 ,  G01N21/31 ,  G01N21/25 ,  G01N33/00 ,  A01B76/00 ,  A01C7/10 ,  G01N21/65 ,  G01J3/02 ,  G01J3/18 ,  G01J3/44 ,  A01C21/00 ,  G01N33/24 ,  A01B79/00

Abstract: In one embodiment, an agricultural sampling apparatus is provided. The apparatus comprising: a wave emitter; a wave transmitter configured to direct the waves from the wave emitter as a plurality of linewise waves to irradiate surface points of the agricultural sample; a dispersive element configured to receive waves arriving from the sample and deflect the arriving waves in at least two directions depending upon the wavelength of an arriving wave; and a detector configured with a plurality of detection elements disposed in at least two dimensions, the detector configured to convert the waves arriving from the dispersive element to a signal.

公开(公告)号：US20220128477A1

公开(公告)日：2022-04-28

申请号：US17513824

申请日：2021-10-28

Applicant: CytoVeris Inc.

Inventor： David Fournier ,  Rishikesh Pandey

IPC: G01N21/65 ,  G01J3/44 ,  G01N33/543 ,  A61B5/00

Abstract: A system and method for assaying high and low abundant biomolecules within a biological fluid sample is provided. The method includes: a) placing a biological fluid sample in contact with a first nanostructure surface; b) interrogating the sample with a light source, the sample in contact with the first nanostructure surface, the interrogation using a SERS technique; c) detecting an enhanced Raman scattering from at least one high abundant biomolecule type and producing first signals representative thereof; d) placing the sample in contact with a second nanostructure surface having a targeting agent that targets a low abundant biomolecule; e) interrogating the sample with the light source using the SERS technique; f) detecting the enhanced Raman scattering from the low abundant biomolecules and producing second signals representative thereof; and g) assaying the biological fluid sample using the first signals and the second signals.

公开(公告)号：US11313721B2

公开(公告)日：2022-04-26

申请号：US16437325

申请日：2019-06-11

Applicant: Oak Analytics

Inventor： Ruibo Wang ,  Pawel Adam Menzfeld

IPC: G01J3/10 ,  G01J3/02 ,  G01J3/06 ,  G01J3/28 ,  G01J3/36 ,  G01J3/44 ,  G01J3/18

Abstract: A compact spectrometer includes an excitation light source configured to generate excitation light and arranged to illuminate a spot on a sample. A dispersive element includes at least one movable component and spatially separates output light emanating from the sample in response to the excitation light into a plurality of different wavelength bands. A moveable component of the dispersive element causes the plurality of different wavelength bands of the output light to be scanned across a detector. The detector includes at least one light sensor that senses the wavelength bands of the output light and generates an output electrical signal in response to the sensed output light.

公开(公告)号：US11307090B2

公开(公告)日：2022-04-19

申请号：US16681192

申请日：2019-11-12

Applicant: MKS TECHNOLOGY

Inventor： Mark Watson ,  Shane Buller ,  Keith Carron

IPC: G01J3/02 ,  G01J3/06 ,  G01J3/44 ,  G01N21/65

Abstract: A spectrometer is provided. In one implementation, for example, a spectrometer comprises an excitation source, a focusing lens, a movable mirror, and an actuator assembly. The focusing lens is adapted to focus an incident beam from the excitation source. The actuator assembly is adapted to control the movable mirror to move a focused incident beam across a surface of the sample.