公开(公告)号：US11156891B1

公开(公告)日：2021-10-26

申请号：US16161667

申请日：2018-10-16

Applicant: University of South Florida

Inventor： Manoj Kumar Ram

IPC: G02F1/163 ,  G02F1/1516

Abstract: In one embodiment, an electrochromic device includes a single unitary active layer including a dye having a nitrogen group and a conducting polymer having a nitrogen group, wherein the active layer has a first color in an oxidized state and a second color in a reduced state, and wherein the electrochromic device comprises no other active layer.

公开(公告)号：US11156613B2

公开(公告)日：2021-10-26

申请号：US16190475

申请日：2018-11-14

Applicant: UNIVERSITY OF SOUTH FLORIDA

Inventor： Patricia A. Kruk

IPC: G01N33/53 ,  G01N33/574 ,  C12Q1/6883

Abstract: The present invention relates to a method for the diagnosis, prognosis, and monitoring of cancer, such as early or late stage ovarian cancer, in a subject by detecting Bcl-2 in a biological sample from the subject, preferably a urine or blood sample. Bcl-2 may be measured using an agent that detects or binds to Bcl-2 protein or an agent that detects or binds to encoding nucleic acids, such as antibodies specifically reactive with Bcl-2 protein or a portion thereof. The invention further relates to kits for carrying out the methods of the invention. The invention further relates to a device for the rapid detection of Bcl-2 in a bodily fluid and methods for rapidly measuring Bcl-2 in a bodily fluid.

公开(公告)号：US11149065B2

公开(公告)日：2021-10-19

申请号：US16916517

申请日：2020-06-30

Applicant: University of South Florida

Inventor： Jianfeng Cai ,  Yan Shi

IPC: C07K7/54 ,  A61K38/12 ,  A61P35/00 ,  C40B40/10 ,  C40B50/16 ,  C07K1/04 ,  A61K38/00 ,  C07K7/06 ,  C07K17/14 ,  G01N33/566 ,  C40B30/04

Abstract: A one-bead-two-compound combinatorial synthesis technique provides libraries of macrocyclic peptidomimetic compounds and compositions with use as ligands for the Ephrin type-A receptor 2 (EphA2). The one-bead-two-compound technique and libraries of macrocyclic compounds are useful as research tools in drug discovery and/or to treat or prevent a range of diseases or disorders.

公开(公告)号：US20210315937A1

公开(公告)日：2021-10-14

申请号：US17224831

申请日：2021-04-07

Applicant: University of South Florida

Inventor： Subhra Mohapatra ,  Shyam S. Mohapatra ,  Mahasweta Das ,  Andrew McGill ,  Taylor Martinez ,  Karthick Mayilsamy

IPC: A61K35/28 ,  A61K31/4439 ,  A61K9/00

Abstract: The present application is related to methods of treating ARDS in a subject in need thereof, by administering (a) pioglitazone, or a pharmaceutically acceptable salt thereof, and (b) mesenchymal stromal cells to the subject. Also disclosed herein are methods of treating one or more symptoms of ARDS in a subject in need thereof.

公开(公告)号：US11138473B1

公开(公告)日：2021-10-05

申请号：US16511255

申请日：2019-07-15

Applicant: University of South Florida

Inventor： Balaji Padmanabhan ,  Utkarsh Shrivastava ,  Vivek Kumar Singh

IPC: G06K9/62 ,  G06N5/02 ,  G06N20/20

Abstract: Systems and methods for expert-assisted classification are described herein. An example method for evaluating an expert-assisted classifier can include providing a cascade classifier including a plurality of classifier stages; and providing a simulated expert stage between at least two of the classifier stages. The simulated expert stage can be configured to validate or contradict an output of one of the at least two classifier stages. The method can also include classifying each of a plurality of records into one of a plurality of categories using the cascade classifier combined with the simulated expert stage; and determining whether the simulated expert stage improves performance of the cascade classifier.

公开(公告)号：US20210253422A1

公开(公告)日：2021-08-19

申请号：US17057153

申请日：2019-05-21

Applicant: UNITED STATES GOVERNMENT AS REPRESENTED BY THE DEPARTMENT OF VETERANS AFFAIRS ,  University of South Florida

Inventor： Eleni Markoutsa ,  Subhra Mohapatra ,  Shyam Mohapatra

IPC: B82Y5/00 ,  C12N15/113 ,  A61K45/06 ,  A61K39/12 ,  A61K47/69 ,  A61K47/54

Abstract: This invention provides for a RSV-targeted nanoparticle PMN (RTPMN), combining HR2D anti-fusion peptide, and plasmid encoded siRNA against RSV-NS1 and/or RSV-P gene as a safe, effective and inexpensive anti-RSV prophylaxis and/or therapy.

公开(公告)号：US20210245395A1

公开(公告)日：2021-08-12

申请号：US17170103

申请日：2021-02-08

Applicant: University of South Florida

Inventor： Michael Cai Wang ,  YunJo Jeong

IPC: B28B11/08 ,  C01B32/19 ,  C04B35/14 ,  C04B41/45 ,  B28B11/10 ,  C04B41/50

Abstract: A method of forming a layered material including arranging a 2DLM on a base material comprising one or more Moiré interferences, and adding material or removing material at a location of the one or more Moiré interferences.

公开(公告)号：US11083373B1

公开(公告)日：2021-08-10

申请号：US16359343

申请日：2019-03-20

Applicant: UNIVERSITY OF SOUTH FLORIDA

Inventor： Kyle Brandon Reed ,  Theresa Ann Zesiewicz

IPC: A61B5/00

Abstract: In one embodiment, a system for neurologic vibratory sense evaluation includes a vibration article configured to attach to a body part of a patient under evaluation, the vibration article comprising a vibration element configured to vibrate against the body part, a control module configured to control an amplitude of vibrations generated by the vibration element, and a patient input device configured to enable a patient to start and stop an evaluation session, wherein starting the session in a first mode of operation causes the vibration element to initially vibrate at a relatively high amplitude that gradually decreases and wherein starting the session in a second mode of operation causes the vibration element to initially vibrate at a relatively low amplitude that gradually increases.

公开(公告)号：US20210230219A1

公开(公告)日：2021-07-29

申请号：US17063158

申请日：2020-10-05

Applicant: H. LEE MOFFITT CANCER CENTER AND RESEARCH INSTITUTE, INC. ,  THE ARIZONA BOARD OF REGENTS ON BEHALF OF THE UNIVERSITY OF ARIZONA ,  UNIVERSITY OF SOUTH FLORIDA

Inventor： David L. Morse ,  Josef Vagner ,  Mark McLaughlin ,  Robert Gillies ,  Amanda Huynh ,  Michael Doligalski

IPC: C07K5/083 ,  A61K49/00 ,  A61K51/04

Abstract: Disclosed are monoacylated Toll-like receptor 2 ligands which can be used in both the development of targeted agents for the imaging and treatment of pancreatic cancer as well as other cancers, and as an adjuvant for cancer immunotherapy. The monoacylated compounds disclosed herein have a higher binding affinity for TLR2 relative to a known potent diacylated agonists, but only −½ the bioactivity. Competition of the monoacylated compound with the diacylated compound for binding TLR2 was confirmed. Hence, the reported monoacylated compounds are inhibitors/antagonists of TLR2 activation.

公开(公告)号：US20210208142A1

公开(公告)日：2021-07-08

申请号：US17180189

申请日：2021-02-19

Applicant: University of South Florida

Inventor： Edwin John Weeber ,  Hayden Elyse Greene

IPC: G01N33/573

Abstract: A method and kit for diagnosing Angelman Syndrome by detecting and analyzing ubiquitination of the UBE3A protein in cerebrospinal fluid is presented. CSF is collected from a patient and incubated with a substrate, such as S5a, and ubiquitin. Ubiquitination of the substrate by UBE3A is measured and compared to a control sample for biochemical diagnosis of Angelman Syndrome. A method of determining the efficacy of a treatment is also presented in which CSF is collected from the patient both prior to and after treatment and incubated with a substrate and ubiquitin. Ubiquitination of the substrate by UBE3A is measured and an increase in ubiquitination in the sample obtained after treatment as compared to the reference sample collected prior to treatment indicates efficacy of the treatment.