公开(公告)号：US11300448B2

公开(公告)日：2022-04-12

申请号：US17130295

申请日：2020-12-22

Applicant: Pendar Technologies, LLC

Inventor： Daryoosh Vakhshoori ,  Romain Blanchard ,  Peili Chen ,  Masud Azimi ,  Tobias Mansuripur ,  Kalyani Krishnamurthy ,  Arran M. Bibby ,  Fred R. Huettig, III ,  Gokhan Ulu ,  Greg Vander Rhodes

IPC: G01J3/44 ,  G01J3/02 ,  G01J3/28 ,  G01J3/06 ,  H01S3/00 ,  G01K11/3213 ,  H01S3/094 ,  H01S3/108 ,  H01S3/30 ,  G01K11/324

Abstract: A compact, portable Raman spectrometer makes fast, sensitive standoff measurements at little to no risk of eye injury or igniting the materials being probed. This spectrometer uses differential Raman spectroscopy and ambient light measurements to measure point-and-shoot Raman signatures of dark or highly fluorescent materials at distances of 1 cm to 10 m or more. It scans the Raman pump beam(s) across the sample to reduce the risk of unduly heating or igniting the sample. Beam scanning also transforms the spectrometer into an instrument with a lower effective safety classification, reducing the risk of eye injury. The spectrometer's long standoff range automatic focusing make it easier to identify chemicals through clear and translucent obstacles, such as flow tubes, windows, and containers. And the spectrometer's components are light and small enough to be packaged in a handheld housing or housing suitable for a small robot to carry.

公开(公告)号：US11280740B2

公开(公告)日：2022-03-22

申请号：US16968330

申请日：2018-04-06

Applicant: Hewlett-Packard Development Company, L.P.

Inventor： Steven Barcelo ,  Anita Rogacs ,  Raghuvir N. Sengupta

IPC: G01N21/65 ,  G01J3/44 ,  G01N21/64 ,  G01N21/552 ,  B82Y15/00

Abstract: A luminescence-enhancement system can include a luminescence-enhancement sensor having a substrate and a group of nanofingers with individual nanofingers that can be flexible and include a support end attached to the substrate, a distal tip positioned distally with respect to the substrate, and a middle portion between the support end and the distal tip. A coating of a metal or metal alloy can be applied to the substrate and the distal tip that is conductively continuous. The middle portion can be devoid of the coating or the coating at the middle portion is conductively discontinuous. A liquid ejector can be present and can include a jetting nozzle to eject a liquid droplet having a volume of 2 pL to 10 μL. The group of nanofingers and the jetting nozzle can be positionable relative to one another for the droplet to be deposited on the group of nanofingers.

公开(公告)号：US11268978B2

公开(公告)日：2022-03-08

申请号：US16583269

申请日：2019-09-26

Applicant: National Institute of Metrology, China

Inventor： Zhen-Dong Zhu ,  Si-Tian Gao ,  Wei Li ,  Shi Li ,  Jing-Tao Xu

IPC: G01J3/02 ,  G01Q70/10 ,  G01J3/10 ,  G01J3/14 ,  G01J3/28 ,  G01J3/44 ,  G01J3/12

Abstract: The present disclosure provides a tip-enhanced Raman spectroscope system. The system includes a laser emitting unit, a laser excitation unit, a first dichroic beam splitter, a first Raman spectrometer, and a confocal detecting unit. The laser excitation unit includes a sample stage and a first scanning probe. The sample stage is configured to have a sample disposed thereon such that a first incident laser beam emitted from the laser emitting unit is transmitted to the sample to excite first scattered light. The first dichroic beam splitter is configured to split a first Raman scattered light from the first Rayleigh scattered light. The first Raman spectrometer is disposed on a first Raman optical path of the first Raman scattered light. The confocal detecting unit is disposed on a first Rayleigh optical path of the first Rayleigh scattered light to image the sample.

公开(公告)号：US11262309B2

公开(公告)日：2022-03-01

申请号：US16509372

申请日：2019-07-11

Applicant: Advanced Cytometry Instrumentation Systems, LLC ,  The Research Foundation for The State University of New York

Inventor： Andrey N. Kuzmin ,  Artem Pliss ,  Paras N. Prasad

IPC: G01N21/65 ,  G01N33/50 ,  G01J3/44 ,  G01N33/92

Abstract: Methods for determining lipid composition. The lipid(s) in a composition may include phospholipids. A method may be carried out on an individual cell. A method may compare the Raman spectrum of the portion of a cell with a model Raman spectrum, which does not include the lipid component, where the difference between the Raman spectrum of the portion of the cell and the model Raman spectrum correlates to the lipid composition in the portion of the cell in the portion of the cell). A method may be used to diagnose a disease such as, for example, cancers, including breast cancer, prostate cancer, and via the presence and/or absence of abnormal or damaged cells in an individual.

公开(公告)号：US11262302B2

公开(公告)日：2022-03-01

申请号：US16890950

申请日：2020-06-02

Applicant: The Boeing Company

Inventor： Keith D. Humfeld ,  Morteza Safai

IPC: G01N21/64 ,  G01J3/44 ,  G01J3/02 ,  H01S5/10 ,  G01J3/06 ,  G01J3/28

Abstract: An example system for inspecting a surface includes a laser, an optical system, a gated camera, and a control system. The laser is configured to emit pulses of light, with respective wavelengths of the pulses of light varying over time. The optical system includes at least one optical element, and is configured to direct light emitted by the laser to points along a scan line one point at a time. The gated camera is configured to record a fluorescent response of the surface from light having each wavelength of a plurality of wavelengths at each point along the scan line. The control system is configured to control the gated camera such that an aperture of the gated camera is open during fluorescence of the surface but closed during exposure of the surface to light emitted by the laser.

公开(公告)号：US20220057265A1

公开(公告)日：2022-02-24

申请号：US17517743

申请日：2021-11-03

Applicant: Ariel Scientific Innovations Ltd.

Inventor： Shmuel STERNKLAR ,  Ziv GLASSER

IPC: G01J3/44

Abstract: A method of spectroscopy, comprises: transmitting output radiation to a sample; collecting from the sample input radiation being indicative of interaction between the output radiation and the sample; modulating at least one of the output radiation and the input radiation, wherein at least one of the output radiation and the modulation is characterized by a scanned parameter; combining the input radiation, following the modulation, with a reference signal to provide a combined signal; processing the combined signal to construct a vector describing a dependence of a radiation property of the input radiation on the parameter; and at least partially identifying the sample or a change in comprises sample based on at least the vector.

公开(公告)号：US20220054004A1

公开(公告)日：2022-02-24

申请号：US17201961

申请日：2021-03-15

Applicant: The General Hospital Corporation ,  Intelon Optics, Inc.

Inventor： Jang Lawrence Hyun Yoo ,  Dominik Jean Michel Beck ,  Giuliano Scarcelli ,  Niaz Karim ,  Seok-Hyun Yun

IPC: A61B3/103 ,  A61B3/10 ,  A61B5/00 ,  G01J3/44

Abstract: A procedure is performed on at least one section of an ocular component. At least one first electro-magnetic radiation is provided to the section so as to interact with at least one acoustic wave in the ocular component. At least one second electro-magnetic radiation is produced based on the interaction. Multiple portions of the second electromagnetic radiation are received. Each portion was emitted from a different corresponding segment of the section. A visco-elastic modulus of the section is monitored based on the multiple portions during the procedure. Feedback is applied to the procedure based at least in part on the monitored visco-elastic modulus, including at least one of: (1) guiding a trajectory of an incision based on different respective monitored values of visco-elastic modulus for the segments, or (2) determining a number of incisions to be made based on different respective monitored values of visco-elastic modulus for the segments.

公开(公告)号：US11255837B2

公开(公告)日：2022-02-22

申请号：US16421831

申请日：2019-05-24

Applicant: University of Vienna

Inventor： Alipasha Vaziri ,  Robert Prevedel

IPC: G01N33/48 ,  G01N33/483 ,  G01J3/44 ,  G01N21/63 ,  G01N21/64 ,  G02B21/02 ,  G02B21/16 ,  A61B5/00

Abstract: Devices and methods for recording dynamics of cellular and/or biochemical processes, including a device including one or more dispersive elements configured to receive a pulsed laser beam with a spectrum of different wavelengths and disperse the spectrum of the pulsed laser beam; and one or more first elements configured to receive the dispersed spectrum of the pulsed laser beam, and generate a multiphoton excitation area in a biological sample by re-overlapping in time and space the dispersed spectrum of the pulsed laser beam on an area in the biological sample, wherein the device is configured to record at high speed changes of cellular and biochemical processes of a population of cells of the biological sample based on generation of the multiphoton excitation area in the biological sample.

公开(公告)号：US20220034715A1

公开(公告)日：2022-02-03

申请号：US17335299

申请日：2021-06-01

Applicant: Rajeev J. RAM ,  Amir H. Atabaki ,  Nili Persits ,  Jaehwan Kim

Inventor： Rajeev J. RAM ,  Amir H. Atabaki ,  Nili Persits ,  Jaehwan Kim

IPC: G01J3/02 ,  G01N21/65 ,  G01J3/44

Abstract: Swept-source Raman spectroscopy uses a tunable laser and a fixed-wavelength detector instead of a spectrometer or interferometer to perform Raman spectroscopy with the throughput advantage of Fourier transform Raman spectroscopy without bulky optics or moving mirrors. Although the tunable laser can be larger and more costly than a fixed wavelength diode laser used in other Raman systems, it is possible to split and switch the laser light to multiple ports simultaneously and/or sequentially. Each site can be monitored by its own fixed-wavelength detector. This architecture can be scaled by cascading fiber switches and/or couplers between the tunable laser and measurement sites. By multiplexing measurements at different sites, it is possible to monitor many sites at once. Moreover, each site can be meters to kilometers from the tunable laser. This makes it possible to perform swept-source Raman spectroscopy at many points across a continuous flow manufacturing environment with a single laser.

公开(公告)号：US11236379B2

公开(公告)日：2022-02-01

申请号：US16284050

申请日：2019-02-25

Applicant: Seraph Biosciences, Inc. ,  Wayne State University

Inventor： Gregory William Auner ,  Charles Shanley ,  Michelle Brusatori ,  Tara Twomey ,  David Sant

IPC: C12Q1/04 ,  G01J3/44 ,  G01J3/02 ,  G01N21/65 ,  A61B5/00 ,  C12Q1/14

Abstract: A Raman spectroscopy based system and method for examination and interrogation provides a method for rapid and cost effective screening of various protein-based compounds such as bacteria, virus, drugs, and tissue abnormalities. A hand-held spectroscope includes a laser and optical train for generating a Raman-shifting sample signal, signal processing and identification algorithms for signal conditioning and target detection with combinations of ultra-high resolution micro-filters and an imaging detector array to provide specific analysis of target spectral peaks within discrete spectral bands associated with a target pathogen.