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    Flat-Field Imaging System and Methods of Use
    121.
    发明申请
    Flat-Field Imaging System and Methods of Use 有权

    公开(公告)号：US20220065767A1

    公开(公告)日：2022-03-03

    申请号：US17525477

    申请日：2021-11-12

    Applicant: LIFE TECHNOLOGIES CORPORATION

    Inventor： Mark ANDERSEN ,  Michael PALLAS ,  Haopeng Wang

    IPC: G01N15/04 ,  C12Q1/6816 ,  C12Q1/686

    Abstract: A method of aligning a plurality of targets is provided. The method includes generating a plurality of targets. A third phase includes the plurality of targets. The method further includes combining a first phase, a second phase, and the third phase in a volume. The first phase, the second phase, and the third phase are substantially immiscible, and the third phase is in fluid communication with the first phase and the second phase, and the first phase, the second phase, and the third phase are operable to be in a configuration of the third phase between the first phase and the second phase in the volume.

    SYSTEM AND METHOD INCORPORATING SOLID BUFFER
    122.
    发明申请
    SYSTEM AND METHOD INCORPORATING SOLID BUFFER 有权

    公开(公告)号：US20220057413A1

    公开(公告)日：2022-02-24

    申请号：US17465303

    申请日：2021-09-02

    Applicant: LIFE TECHNOLOGIES CORPORATION

    Inventor： James A. BALL ,  Jonathan SCHULTZ

    IPC: G01N33/84 ,  C12Q1/6869 ,  B01J19/00

    Abstract: A buffered suspension includes a surfactant and a solid buffer particulate having a point of zero charge at least 1.2 pH units different that the pH of the buffered suspension. The buffered suspension can be prepared by mixing a stock solution with the solid buffer particulate and titrating. A method of preforming a pH sensitive process includes drawing the buffered suspension from a reservoir, filtering the solid buffer particulate from the buffered suspension, and applying the filtered solution to a sensor.

    Fluid dispensing system with rotatable port assembly
    125.
    发明授权
    Fluid dispensing system with rotatable port assembly 有权

    公开(公告)号：US11242164B2

    公开(公告)日：2022-02-08

    申请号：US17145968

    申请日：2021-01-11

    Applicant: LIFE TECHNOLOGIES CORPORATION

    Inventor： Steven R. Kjar

    IPC: B65B3/00 ,  B65B3/28 ,  A61M39/22 ,  B65B3/36 ,  F16K11/085 ,  C12M1/00 ,  B65B39/00 ,  B65B3/30

    Abstract: A method of dispensing fluid includes dispensing a first quantity of fluid so that fluid flows through a manifold port assembly and into a first container, the manifold port assembly includes a housing having an inlet port and a plurality of outlet ports formed thereon; and a carousel bounding a plurality of fluid paths that each extend between a first end and an opposing second end, the carousel being rotatably disposed within the housing so that when the first end of each one of the plurality of fluid paths is aligned with the inlet port on the housing, the second end of the corresponding one of the plurality of fluid paths is aligned with one of the plurality of outlet ports. A motor is activated to rotate the carousel of the manifold port assembly to a second position. A second quantity of fluid is dispensed so that fluid flows through the manifold port assembly and into a second container.

    SCANNING SYSTEM AND METHOD FOR IMAGING AND SEQUENCING
    126.
    发明申请
    SCANNING SYSTEM AND METHOD FOR IMAGING AND SEQUENCING 有权

    公开(公告)号：US20220026365A1

    公开(公告)日：2022-01-27

    申请号：US17378479

    申请日：2021-07-16

    Applicant: LIFE TECHNOLOGIES CORPORATION

    Inventor： Mark F. Oldham ,  Eric S. Nordman ,  Hongye Sun ,  Steven Boege

    IPC: G01N21/64

    Abstract: A scanning detection system is provided wherein emissions from locations in a flow cell are detected. In some embodiments, the system can comprise an excitation source, a photocleavage source, and modulating optics configured to cause an excitation beam generated by the excitation source to irradiate a first group of the fixed locations and to cause a photocleavage beam generated by the photocleavage source to irradiate a second group of the fixed locations, which is separate and apart from the first group of fixed locations. Methods of detecting sequencing reactions using such a system are also provided.

    Systems and methods for genotyping by angle configuration search
    127.
    发明授权
    Systems and methods for genotyping by angle configuration search 有权

    公开(公告)号：US11227668B2

    公开(公告)日：2022-01-18

    申请号：US15889177

    申请日：2018-02-05

    Applicant: Life Technologies Corporation

    Inventor： Marcin Sikora

    IPC: G16B20/20 ,  G06F16/24 ,  G16B20/00 ,  G16B40/30 ,  G16B40/20 ,  G16B40/00 ,  G16B20/40

    Abstract: Methods and systems for the analysis of genotyping data are presented. According to various embodiments of methods and systems, an angle configuration search may be performed. In various embodiments, an exhaustive search over the entirety of an angle configuration space may be performed to provide a fit to a plurality of angles determined for a plurality of points in a data set generated from a plurality of biological samples. For various embodiments, the angle configuration space may be defined to ensure that a global fit may be determined. According to various methods and systems, a data base of possible angle configurations may be searched, in which each angle configuration may include three angles. According to various methods and systems, a data base of possible angle configurations may include for each angle configuration a probability that the angle configuration may occur.

    Fluid Manifold Systems and Methods of Manufacture
    128.
    发明申请
    Fluid Manifold Systems and Methods of Manufacture 有权

    公开(公告)号：US20220002007A1

    公开(公告)日：2022-01-06

    申请号：US17481605

    申请日：2021-09-22

    Applicant: LIFE TECHNOLOGIES CORPORATION

    Inventor： Michael E. Goodwin ,  Jeremy K. Larsen ,  Patrick L. Draper ,  Brandon M. Knudsen

    IPC: B65B1/04 ,  B65B3/00 ,  B65B3/02 ,  B65B3/04 ,  B65B51/02 ,  B65B51/22

    Abstract: A fluid manifold system includes a first manifold having portions of opposing flexible sheets welded together to form a fluid flow path therebetween, a fluid inlet communicating with the fluid flow path. The fluid flow path of the first manifold includes: a primary flow path communicating with the fluid inlet of the first manifold; and a plurality of spaced apart secondary flow paths that branch off of the primary flow path. Each secondary flow path has a first end communicating with the primary flow path and an opposing second end, each secondary flow path having a diameter that is smaller than a diameter of the primary flow path. The fluid manifold system also includes a plurality of tubular connectors with each tubular connector being secured to the first manifold at the second end of a corresponding one of the secondary flow paths.

    Thermal isolation of reaction sites on a substrate
    129.
    发明授权
    Thermal isolation of reaction sites on a substrate 有权

    公开(公告)号：US11207691B2

    公开(公告)日：2021-12-28

    申请号：US15757638

    申请日：2016-09-02

    Applicant: LIFE TECHNOLOGIES CORPORATION

    Inventor： Janusz Wojtowicz

    IPC: B01L7/00

    Abstract: A thermal block assembly is provided. The assembly can comprise a substrate comprising a first surface configured with a plurality of reaction sites each reaction site configured to contain a biological sample and a sample block comprising a plurality of pedestals configured to thermally modulate the plurality of biological samples wherein each pedestal is thermally coupled to one of the reaction sites. The assembly can further comprise cooling blocks, slots and insulating rings associated with reaction sites each capable of minimizing heat flow between reaction sites. A method for thermally isolating reaction sites is also provided. The method can comprise providing a substrate including a plurality of reaction sites, each reaction site configured to contain a biological sample, providing a sample block comprising pedestals, each pedestal having a dimension substantially equal to a dimension of the reaction site and thermally coupled to the reaction site, thermally isolating the reaction sites with a thermal isolating feature, modulating the temperature of the pedestals through a sequence of temperature and hold times and cooling the reaction sites with cooling blocks.

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