公开(公告)号：US20090126402A1

公开(公告)日：2009-05-21

申请号：US12325120

申请日：2008-11-28

Applicant: George Maltezos ,  Axel Scherer

Inventor： George Maltezos ,  Axel Scherer

IPC: A44C17/00

CPC classification number: A44C17/001

Abstract: Methods of fabricating improved gemstones and gemstones thus obtained are described. Roughness is introduced on facets of a gemstone through application of nanometer and/or micrometer sized features, to provide the facets with a hazy white-colored appearance. Alternatively, millimeter-sized reflective features can be applied on the facets, to form a gemstone with improved scintillation or play of light.

Abstract translation: 描述了如此获得的改进的宝石和宝石的制造方法。 通过应用纳米和/或微米尺寸的特征，在宝石的小面上引入粗糙度，以使面具有朦胧的白色外观。 或者，可以在刻面上应用毫米尺寸的反射特征，以形成具有改善的闪烁或光照的宝石。

公开(公告)号：US07494555B2

公开(公告)日：2009-02-24

申请号：US10945737

申请日：2004-09-20

Applicant: Marc A. Unger ,  Hou-Pu Chou ,  Todd A. Thorsen ,  Axel Scherer ,  Stephen R. Quake

Inventor： Marc A. Unger ,  Hou-Pu Chou ,  Todd A. Thorsen ,  Axel Scherer ,  Stephen R. Quake

IPC: B32B37/00

CPC classification number: B29C51/00 ,  B01L3/502707 ,  B01L3/50273 ,  B01L3/502738 ,  B01L2300/0861 ,  B01L2300/0887 ,  B01L2300/123 ,  B01L2400/046 ,  B01L2400/0481 ,  B01L2400/0655 ,  B33Y80/00 ,  B81B5/00 ,  B81B2201/036 ,  B81B2201/054 ,  B81C1/00119 ,  B81C2201/019 ,  B81C2201/034 ,  C12Q1/6874 ,  F04B43/043 ,  F15C1/06 ,  F15C5/00 ,  F16K11/20 ,  F16K13/00 ,  F16K31/126 ,  F16K99/0001 ,  F16K99/0015 ,  F16K99/0046 ,  F16K99/0048 ,  F16K99/0051 ,  F16K99/0059 ,  F16K2099/0074 ,  F16K2099/0076 ,  F16K2099/0078 ,  F16K2099/008 ,  F16K2099/0094 ,  Y10T137/0491 ,  Y10T137/0497 ,  Y10T137/2224 ,  Y10T137/87249 ,  Y10T156/10 ,  Y10T428/24479 ,  Y10T428/24744 ,  C12Q2535/125

Abstract: A method of fabricating an elastomeric structure, comprising: forming a first elastomeric layer on top of a first micromachined mold, the first micromachined mold having a first raised protrusion which forms a first recess extending along a bottom surface of the first elastomeric layer; forming a second elastomeric layer on top of a second micromachined mold, the second micromachined mold having a second raised protrusion which forms a second recess extending along a bottom surface of the second elastomeric layer; bonding the bottom surface of the second elastomeric layer onto a top surface of the first elastomeric layer such that a control channel forms in the second recess between the first and second elastomeric layers; and positioning the first elastomeric layer on top of a planar substrate such that a flow channel forms in the first recess between the first elastomeric layer and the planar substrate.

公开(公告)号：US07466409B2

公开(公告)日：2008-12-16

申请号：US11448343

申请日：2006-06-06

Applicant: Axel Scherer ,  Mark Adams

Inventor： Axel Scherer ,  Mark Adams

IPC: G01J3/28

CPC classification number: G01J3/26 ,  G01J3/02 ,  G01J3/0256 ,  G01N21/0303 ,  G01N21/031 ,  G01N21/05 ,  G01N21/645 ,  G01N2021/0346 ,  G01N2021/058 ,  G01N2021/6417 ,  G01N2021/6482

Abstract: A miniaturized fluidic spectrometer comprises a light source, a fluidic circuit having a plurality of flow channels through which an analyte flows, and a proximity detector array for detecting light from the light source transmitted through the fluidic circuit. Where the light source is broadband, a variable filter is disposed between the detector array and the fluidic circuit so that each position of the detector array is provided with a different wavelength response. The fluidic circuit is disposed in an optimized Fabry-Perot etalon. The fluidic circuit is defined in an elastomeric material and includes means for tuning the Fabry-Perot etalon by pressurization of flow channels in the elastomeric material.

Abstract translation: 微型流体光谱仪包括光源，具有分析物流过的多个流动通道的流体回路和用于检测透过流体回路的光源的光的接近检测器阵列。 在光源是宽带的情况下，在检测器阵列和流体回路之间设置可变滤波器，使得检测器阵列的每个位置具有不同的波长响应。 流体回路设置在优化的法布里 - 珀罗标准具中。 流体回路被限定在弹性体材料中，并且包括用于通过对弹性体材料中的流动通道加压来调节法布里 - 珀罗标准具的装置。

公开(公告)号：US20080289710A1

公开(公告)日：2008-11-27

申请号：US11932552

申请日：2007-10-31

Applicant: Marc A. Unger ,  Hou-Pu Chou ,  Todd A. Thorsen ,  Axel Scherer ,  Stephen R. Quake ,  Markus M. Enzeiberger ,  Mark L. Adams ,  Carl L. Hansen

Inventor： Marc A. Unger ,  Hou-Pu Chou ,  Todd A. Thorsen ,  Axel Scherer ,  Stephen R. Quake ,  Markus M. Enzeiberger ,  Mark L. Adams ,  Carl L. Hansen

IPC: B81B3/00 ,  F16K11/10 ,  B26D1/00 ,  B81C1/00 ,  F15C3/00

CPC classification number: F15C3/00 ,  B01J2219/00355 ,  B01J2219/00378 ,  B01J2219/00396 ,  B01J2219/00398 ,  B01J2219/00439 ,  B01J2219/005 ,  B01J2219/00527 ,  B01J2219/00605 ,  B01J2219/00659 ,  B01J2219/00707 ,  B01J2219/00722 ,  B01J2219/00725 ,  B01L3/502707 ,  B01L3/50273 ,  B01L3/502738 ,  B01L7/54 ,  B01L9/527 ,  B01L2200/025 ,  B01L2200/027 ,  B01L2200/0605 ,  B01L2200/10 ,  B01L2300/0681 ,  B01L2300/0861 ,  B01L2300/0887 ,  B01L2300/123 ,  B01L2300/14 ,  B01L2300/18 ,  B01L2400/0481 ,  B01L2400/0655 ,  B01L2400/0688 ,  B32B2037/1081 ,  F04B19/006 ,  F04B43/043 ,  F16K99/0001 ,  F16K99/0026 ,  F16K99/0059 ,  F16K2099/0074 ,  F16K2099/0076 ,  F16K2099/0078 ,  F16K2099/008 ,  F16K2099/0084 ,  Y10T137/2202 ,  Y10T137/2224 ,  Y10T137/87885

Abstract: A method of fabricating an elastomeric structure, comprising: forming a first elastomeric layer on top of a first micromachined mold, the first micromachined mold having a first raised protrusion which forms a first recess extending along a bottom surface of the first elastomeric layer; forming a second elastomeric layer on top of a second micromachined mold, the second micromachined mold having a second raised protrusion which forms a second recess extending along a bottom surface of the second elastomeric layer; bonding the bottom surface of the second elastomeric layer onto a top surface of the first elastomeric layer such that a control channel forms in the second recess between the first and second elastomeric layers; and positioning the first elastomeric layer on top of a planar substrate such that a flow channel forms in the first recess between the first elastomeric layer and the planar substrate.

公开(公告)号：US07454095B2

公开(公告)日：2008-11-18

申请号：US11116110

申请日：2005-04-26

Applicant: Tom Baehr-Jones ,  Michael J. Hochberg ,  Axel Scherer

Inventor： Tom Baehr-Jones ,  Michael J. Hochberg ,  Axel Scherer

IPC: G02B6/12 ,  G02B6/26

CPC classification number: G02B6/1226 ,  B82Y20/00

Abstract: A metal waveguide is coupled to a dielectric waveguide to obtain transmission of light in a plasmon mode along an edge of the metal waveguide. Efficient, broadband light transmission is obtained, achieving a low insertion loss, using standard processing tools. An efficient integrated optical circuit is obtained.

Abstract translation: 金属波导耦合到电介质波导，以沿着金属波导的边缘获得等离子体激发光的透射。 使用标准的处理工具，实现了高效的宽带光传输，实现了低插入损耗。 获得了高效的集成光电路。

公开(公告)号：US20080210322A1

公开(公告)日：2008-09-04

申请号：US11934235

申请日：2007-11-02

Applicant: Marc A. Unger ,  Hou-Pu Chou ,  Todd A. Thorsen ,  Axel Scherer ,  Stephen R. Quake

Inventor： Marc A. Unger ,  Hou-Pu Chou ,  Todd A. Thorsen ,  Axel Scherer ,  Stephen R. Quake

IPC: F15C1/06

CPC classification number: F15C1/06 ,  B01L3/502707 ,  B01L3/50273 ,  B01L3/502738 ,  B01L2300/0861 ,  B01L2300/0887 ,  B01L2400/046 ,  B01L2400/0481 ,  B01L2400/0655 ,  C12Q1/6874 ,  F04B43/043 ,  F16K1/20 ,  F16K99/0001 ,  F16K99/0015 ,  F16K99/0046 ,  F16K99/0048 ,  F16K99/0051 ,  F16K99/0059 ,  F16K2099/0074 ,  F16K2099/0078 ,  F16K2099/008 ,  F16K2099/0094 ,  Y10T137/2224 ,  Y10T137/87981 ,  C12Q2535/125

Abstract: A method of fabricating an elastomeric structure, comprising: forming a first elastomeric layer on top of a first micromachined mold, the first micromachined mold having a first raised protrusion which forms a first recess extending along a bottom surface of the first elastomeric layer; forming a second elastomeric layer on top of a second micromachined mold, the second micromachined mold having a second raised protrusion which forms a second recess extending along a bottom surface of the second elastomeric layer; bonding the bottom surface of the second elastomeric layer onto a top surface of the first elastomeric layer such that a control channel forms in the second recess between the first and second elastomeric layers; and positioning the first elastomeric layer on top of a planar substrate such that a flow channel forms in the first recess between the first elastomeric layer and the planar substrate.

公开(公告)号：US20080173833A1

公开(公告)日：2008-07-24

申请号：US11853531

申请日：2007-09-11

Applicant: Saurabh Vyawahare ,  Suresh Sitaula ,  Dvin Adalian ,  Axel Scherer

Inventor： Saurabh Vyawahare ,  Suresh Sitaula ,  Dvin Adalian ,  Axel Scherer

IPC: F16K31/00

CPC classification number: F16K99/0001 ,  C08L2201/12 ,  F16K99/0015 ,  F16K99/0034 ,  F16K99/0038 ,  F16K99/004 ,  F16K99/0044 ,  F16K99/0059 ,  F16K2099/0078 ,  F16K2099/0084

Abstract: Microfluidic valves constructed from elastomeric materials as the valve body components and employing shape memory alloy in wire form as the valve actuator. Various configurations of individual valves having both normally open and normally closed states are described. Apparatus using such valves and providing logic functionality with fluidic logic outputs are discussed. Apparatus that can be used for materials processing at the nano- or micro-scale are presented. Various forms of logical control of valve arrays are explained.

Abstract translation: 由弹性体材料构成的微流体阀作为阀体部件，并采用线形式的形状记忆合金作为阀致动器。 描述具有常开和常闭状态的各个阀的各种构造。 讨论了使用这种阀并提供具有流体逻辑输出的逻辑功能的装置。 介绍了可用于纳米级或微尺度材料加工的设备。 说明阀阵列的各种形式的逻辑控制。

公开(公告)号：US20080159351A1

公开(公告)日：2008-07-03

申请号：US11836578

申请日：2007-08-09

Applicant: Zhenyu Li ,  Demetri Psaltis ,  Axel Scherer ,  Zhaoyu Zhang

Inventor： Zhenyu Li ,  Demetri Psaltis ,  Axel Scherer ,  Zhaoyu Zhang

IPC: H01S3/20 ,  H01S3/10

CPC classification number: H01S3/022 ,  H01S3/08036 ,  H01S3/1053 ,  H01S3/1055 ,  H01S3/213

Abstract: The invention relates to a microfluidic dye laser including a pump light source configured to provide light having a pump light wavelength. The microfluidic dye laser also includes an elastomer substantially optically transparent at the pump light wavelength and at a microfluidic dye laser wavelength. A microfluidic channel configured to accept a fluidic dye is defined in the elastomer. An optical grating is formed in a single mode 3D waveguide in the microfluidic channel in order to provide a single mode microfluidic dye laser light as output in response to illumination with light from the pump light source. In another aspect, the invention features a method of tuning a wavelength of a microfluidic dye laser light by mechanically deforming the elastomeric laser chip to change the grating period in the optical cavity.

Abstract translation: 本发明涉及一种微流体染料激光器，其包括被配置为提供具有泵浦光波长的光的泵浦光源。 微流体染料激光器还包括在泵浦光波长处和微流体染料激光波长基本上光学透明的弹性体。 在弹性体中限定了构造成接受流体染料的微流体通道。 在微流体通道中的单模3D波导中形成光栅，以便响应于来自泵浦光源的光的照明，提供单模微流体染料激光作为输出。 在另一方面，本发明的特征在于通过机械地使弹性体激光芯片变形以改变光腔中的光栅周期来调谐微流体染料激光的波长的方法。

公开(公告)号：US20080151249A1

公开(公告)日：2008-06-26

申请号：US11876211

申请日：2007-10-22

Applicant: Christopher I. Walker ,  Axel Scherer

Inventor： Christopher I. Walker ,  Axel Scherer

IPC: G01N21/55

CPC classification number: G01N21/0303 ,  G01N21/645 ,  G01N2021/6482

Abstract: The invention provides a high efficiency coupling structure for extracting illumination such as fluorescent radiation from a chemical reaction vessel such as a cuvette. The cuvette is provided with a mirrored surface. An end cap for the cuvette includes a probe portion that exhibits total internal reflection. Lenses are provided in various embodiments that improve the light collection and directing properties of the end cap. A fast optical system for free space coupling of optical radiation emanating from a chemical processing cuvette that uses the end cap as an element is also described.

Abstract translation: 本发明提供了一种高效率耦合结构，用于提取诸如比色皿等化学反应容器的荧光辐射照明。 比色杯配有镜面。 用于比色杯的端盖包括具有全内反射的探针部分。 在改善端盖的光收集和引导性能的各种实施例中提供了透镜。 还描述了用于使用端盖作为元件的化学处理试管发出的光辐射的自由空间耦合的快速光学系统。

公开(公告)号：US07378280B2

公开(公告)日：2008-05-27

申请号：US10416418

申请日：2001-11-16

Applicant: Stephen R. Quake ,  Marc A. Unger ,  Hou-Pu Chou ,  Todd A. Thorsen ,  Axel Scherer

Inventor： Stephen R. Quake ,  Marc A. Unger ,  Hou-Pu Chou ,  Todd A. Thorsen ,  Axel Scherer

IPC: G01N33/00 ,  G01N15/06 ,  G01N1/10 ,  G01N33/48 ,  G01N35/00

CPC classification number: G01N33/00 ,  B01D57/02 ,  B01D61/18 ,  B01D61/28 ,  B01D63/081 ,  B01D63/088 ,  B01D2313/08 ,  B01D2313/90 ,  B01F5/0646 ,  B01F5/0647 ,  B01F7/00 ,  B01F11/0071 ,  B01F13/0059 ,  B01F13/1013 ,  B01F13/1022 ,  B01L3/502707 ,  B01L3/502715 ,  B01L3/50273 ,  B01L3/502738 ,  B01L3/502746 ,  B01L3/502761 ,  B01L2200/0631 ,  B01L2200/10 ,  B01L2300/0627 ,  B01L2300/0645 ,  B01L2300/0681 ,  B01L2300/0816 ,  B01L2300/0864 ,  B01L2300/0867 ,  B01L2300/0877 ,  B01L2300/0887 ,  B01L2300/123 ,  B01L2300/1822 ,  B01L2300/1827 ,  B01L2400/0415 ,  B01L2400/0481 ,  B01L2400/0487 ,  B01L2400/0633 ,  B01L2400/0655 ,  B01L2400/082 ,  C12M23/16 ,  C12M41/46 ,  F04B43/043 ,  F16K99/0001 ,  F16K99/0009 ,  F16K99/0015 ,  F16K99/0046 ,  F16K99/0048 ,  F16K99/0051 ,  F16K99/0059 ,  F16K2099/0074 ,  F16K2099/008 ,  F16K2099/0084 ,  G01N15/06 ,  G01N27/44743 ,  G01N27/44791 ,  G01N33/5005 ,  G01N33/5008 ,  G01N33/56966 ,  Y10T436/11 ,  Y10T436/117497 ,  Y10T436/25 ,  Y10T436/25375 ,  Y10T436/2575

Abstract: The present invention provides microfluidic devices and methods for using the same. In particular, microfluidic devices of the present invention are useful in conducting a variety of assays and high throughput screening. Microfluidic devices of the present invention include elastomeric components and comprise a main flow channel; a plurality of branch flow channels; a plurality of control channels; and a plurality of valves. Preferably, each of the valves comprises one of the control channels and an elastomeric segment that is deflectable into or retractable from the main or branch flow channel upon which the valve operates in response to an actuation force applied to the control channel.

Abstract translation: 本发明提供微流体装置及其使用方法。 特别地，本发明的微流体装置可用于进行各种测定和高通量筛选。 本发明的微流体装置包括弹性体部件并且包括主流动通道; 多个分支流动通道; 多个控制信道; 和多个阀。 优选地，每个阀包括控制通道中的一个和可响应于施加到控制通道的致动力而从阀或液流通道偏转进入或从其中缩回的弹性体段。