公开(公告)号：US20080223794A1

公开(公告)日：2008-09-18

申请号：US11908146

申请日：2006-03-16

Applicant: Junta Yamamichi ,  Miki Ogawa ,  Kazuki Nakanishi

Inventor： Junta Yamamichi ,  Miki Ogawa ,  Kazuki Nakanishi

IPC: B01D61/00 ,  B01D71/02 ,  B01J19/00 ,  G01N21/01 ,  G01N21/76 ,  G01N21/64

CPC classification number: B01J20/28014 ,  B01J20/281 ,  B01J2220/54 ,  B01L3/502753 ,  B01L2300/0681 ,  B01L2300/0838 ,  B01L2300/0877 ,  B81B1/00 ,  B81B2201/0214 ,  G01N30/6069 ,  G01N2030/524

Abstract: A structure having an opening communicating with an inner space is adapted for separating or capturing a substance introduced from the opening into the inner space. The structure comprises a hollow member having the inner space with the opening and plural pillars positioned mutually separately in the inner space. The pillars are formed of a material containing an inorganic oxide and different in composition from the hollow member.

Abstract translation: 具有与内部空间连通的开口的结构适于将从开口引入的物质分离或捕获到内部空间中。 该结构包括具有开口的内部空间的中空构件和在内部空间中相互分开设置的多个支柱。 支柱由含有无机氧化物并且与中空构件的组成不同的材料形成。

公开(公告)号：US07410791B2

公开(公告)日：2008-08-12

申请号：US11331849

申请日：2006-01-13

Applicant: Rahul Singhvi ,  Amit Kumar ,  George M. Whitesides ,  Donald E. Ingber ,  Gabriel P. Lopez ,  Daniel I. C. Wang ,  Gregory Stephanopoulos

Inventor： Rahul Singhvi ,  Amit Kumar ,  George M. Whitesides ,  Donald E. Ingber ,  Gabriel P. Lopez ,  Daniel I. C. Wang ,  Gregory Stephanopoulos

IPC: C12N11/00 ,  C12N11/08 ,  C12N1/00

CPC classification number: C12N1/00 ,  B01J19/0046 ,  B01J2219/00382 ,  B01J2219/00385 ,  B01J2219/00585 ,  B01J2219/00596 ,  B01J2219/00605 ,  B01J2219/0061 ,  B01J2219/00612 ,  B01J2219/00617 ,  B01J2219/00619 ,  B01J2219/00621 ,  B01J2219/00626 ,  B01J2219/0063 ,  B01J2219/00637 ,  B01J2219/00659 ,  B01J2219/0072 ,  B81B2201/0214 ,  B81C1/00206 ,  B81C2201/034 ,  B82Y5/00 ,  B82Y30/00 ,  C12N5/0068 ,  C12N5/067 ,  C12N2535/10 ,  C12Q1/02 ,  C40B60/14

Abstract: The invention provides a device for adhering cells in a specific and predetermined position, and associated methods. The device includes a plate defining a surface and a plurality of cytophilic islands that adhere cells, isolated by cytophobic regions to which cells do not adhere, contiguous with the cytophilic islands. The islands or the regions or both may be formed of a self-assembled monolayer (SAM).

Abstract translation: 本发明提供一种用于将细胞粘附在特定和预定位置的装置以及相关方法。 该装置包括限定表面的板和多个细胞亲和岛，其附着细胞，由细胞不粘附的细胞渗透区隔离，与细胞色素岛邻接。 岛或区域或两者可以由自组装单层（SAM）形成。

公开(公告)号：US20080084363A1

公开(公告)日：2008-04-10

申请号：US11827175

申请日：2007-07-10

Applicant: John W. Hartzell ,  Pooran Chandra Joshi ,  Paul J. Schuele

Inventor： John W. Hartzell ,  Pooran Chandra Joshi ,  Paul J. Schuele

IPC: G09G3/20

CPC classification number: B81C1/00246 ,  B81B2201/0214 ,  B81C2203/075 ,  Y10S436/805

Abstract: A method of producing a precursor, active-matrix, fluid-assay micro-structure including the steps of (1) utilizing low-temperature TFT and Si technology, establishing preferably on a glass or plastic substrate a matrix array of non-functionalized pixels, and (2) preparing at least one of these pixels for individual, digitally-addressed (a) functionalization, and (b) reading out, ultimately, of completed assay results.

Abstract translation: 一种制备前体，活性基质，流体测定微结构的方法，包括以下步骤：（1）利用低温TFT和Si技术，优选在玻璃或塑料基材上建立非官能化像素的矩阵阵列， 和（2）准备用于个体，数字寻址（a）功能化的这些像素中的至少一个，以及（b）最终读出完成的测定结果。

公开(公告)号：US07319069B2

公开(公告)日：2008-01-15

申请号：US11354813

申请日：2006-02-16

Applicant: Tohru Den ,  Tatsuya Iwasaki

Inventor： Tohru Den ,  Tatsuya Iwasaki

IPC: H01L21/44

CPC classification number: B81C1/00031 ,  B81B1/002 ,  B81B2201/0214 ,  H01L43/12 ,  Y10S977/781 ,  Y10S977/893

Abstract: A minute structure is provided in which electroconductive paths are only formed in nanoholes, and a material is filled in the nanoholes, which are disposed in a specific area, by using the electroconductive paths. The minute structure comprising pores comprises a) a substrate, b) a plurality of electroconductive layers formed on a surface of the substrate, c) a layer primarily composed of aluminum oxide covering the plurality of electroconductive layers and a surface of the substrate where no electroconductive layer is formed, and d) a plurality of pores formed in the layer primarily composed of aluminum oxide, in which the pores are disposed above the electroconductive layers and the surface of the substrate where no electroconductive layers is formed, with a part of the layer primarily composed of aluminum oxide provided under the bottoms of the pores, and in which the layer primarily composed of aluminum oxide provided between the electroconductive layer and the bottoms of the pores disposed above the electroconductive layer comprises a material forming the electroconductive layer.

Abstract translation: 提供了一种微结构，其中导电路径仅形成在纳米孔中，并且通过使用导电路径将材料填充在设置在特定区域中的纳米孔中。 包括孔的微小结构包括a）基底，b）形成在基底表面上的多个导电层，c）主要由覆盖多个导电层的氧化铝组成的层和不具有导电性的基底的表面 层，以及d）主要由氧化铝构成的层中形成的多个孔，其中孔设置在导电层上方和不形成导电层的基板的表面上，其中一部分层 主要由设置在孔底部的氧化铝组成，其中主要由设置在导电层和设置在导电层上方的孔的底部之间的氧化铝组成的层包括形成导电层的材料。

公开(公告)号：US07282329B2

公开(公告)日：2007-10-16

申请号：US10669883

申请日：2003-09-23

Applicant: Scott Manalis ,  Thomas Burg

Inventor： Scott Manalis ,  Thomas Burg

IPC: C12Q1/68 ,  C12M1/36 ,  G01N15/06 ,  C07H21/04

CPC classification number: B01L3/502707 ,  B01L3/5027 ,  B01L2200/12 ,  B01L2300/0627 ,  B01L2400/0421 ,  B81B7/0061 ,  B81B7/007 ,  B81B2201/0214 ,  B81C1/00071 ,  B81C1/00206 ,  G01N33/54373 ,  H01L2224/48091 ,  H01L2224/48465 ,  H01L2924/00014 ,  H01L2924/00

Abstract: An apparatus for detecting an analyte in solution that has a suspended beam containing at least one microfluidic channel containing a capture ligand that bonds to or reacts with an analyte. The apparatus also includes at least one detector for measuring a change in the beam upon binding or reaction of the analyte. A method of making the suspended microfluidic channels is disclosed, as well as, a method of integrating the microfluidic device with conventional microfluidics having larger sample fluid channels.

Abstract translation: 一种用于检测溶液中分析物的装置，其具有包含至少一个含有与分析物结合或与分析物反应的捕获配体的至少一个微流体通道的悬浮梁。 该装置还包括至少一个检测器，用于在分析物的结合或反应时测量束的变化。 公开了一种制备悬浮微流体通道的方法，以及将微流体装置与具有较大样品流体通道的常规微流体整合的方法。

公开(公告)号：US20070202560A1

公开(公告)日：2007-08-30

申请号：US11360672

申请日：2006-02-24

Applicant: Yuji Kikuchi ,  Taiji Nishi ,  Motohiro Fukuda

Inventor： Yuji Kikuchi ,  Taiji Nishi ,  Motohiro Fukuda

IPC: C12Q1/54 ,  C12M3/00

CPC classification number: B01L3/502707 ,  B01L3/502746 ,  B01L2200/0668 ,  B01L2200/12 ,  B01L2300/0645 ,  B01L2300/0681 ,  B01L2300/0816 ,  B01L2400/086 ,  B81B2201/0214 ,  B81B2201/058 ,  B81C1/00071 ,  B81C99/009 ,  B81C2201/034

Abstract: A resin microchannel array includes a first substrate having a plurality of depressions, each depression having an inlet port at one end and an outlet port at another end, and walls sectioning the depressions, each wall having a micro groove connecting the depressions, and a second substrate having a flat surface bonded or pressure-contacted to a surface of the first substrate. Spaces created by the depressions and the grooves in a bonded or pressure contacted part between the first substrate and the second substrate serve as flow channels. Each of a width and a depth of the flow channel is within a range of 1 to 50 μm, and a ratio of the width and the depth of the flow channel is within a range of 1:10 to 10:1.

Abstract translation: 树脂微通道阵列包括具有多个凹陷的第一基底，每个凹陷部分在一端具有入口端口和另一端部的出口端口，以及分隔凹陷部分的壁，每个壁具有连接凹部的微凹槽， 衬底，其具有与第一衬底的表面结合或压力接触的平坦表面。 由第一基板和第二基板之间的结合或压力接触部分中的凹陷和凹槽产生的空间用作流动通道。 流路的宽度和深度各自在1〜50μm的范围内，流路的宽度和深度的比例在1:10〜10:1的范围内。

公开(公告)号：US07230315B2

公开(公告)日：2007-06-12

申请号：US10996593

申请日：2004-11-24

Applicant: Gabriele Barlocchi ,  Ubaldo Mastromatteo ,  Flavio Francesco Villa

Inventor： Gabriele Barlocchi ,  Ubaldo Mastromatteo ,  Flavio Francesco Villa

IPC: H01L29/00 ,  H01L31/06 ,  H01L31/00 ,  H01L29/06 ,  H01L29/40

CPC classification number: B81C1/00539 ,  B81B1/002 ,  B81B2201/0214 ,  B81B2201/051 ,  B81C1/00404

Abstract: The microreactor has a body of semiconductor material; a large area buried channel extending in the body and having walls; a coating layer of insulating material coating the walls of the channel; a diaphragm extending on top of the body and upwardly closing the channel. The diaphragm is formed by a semiconductor layer completely encircling mask portions of insulating material.

Abstract translation: 微反应器具有半导体材料体; 一个大面积的埋藏通道延伸到身体并具有墙壁; 覆盖通道壁的绝缘材料的涂层; 一个在主体顶部延伸并向上关闭通道的隔膜。 隔膜由完全环绕绝缘材料的掩模部分的半导体层形成。

公开(公告)号：US07178378B2

公开(公告)日：2007-02-20

申请号：US10651338

申请日：2003-08-28

Applicant: Ed Crawley ,  Mark Lundstrom ,  Brett Masters ,  Alok Srivastava ,  Martin Schmidt ,  Michael Miller

Inventor： Ed Crawley ,  Mark Lundstrom ,  Brett Masters ,  Alok Srivastava ,  Martin Schmidt ,  Michael Miller

IPC: G01N23/036

CPC classification number: G01N29/036 ,  B81B3/0089 ,  B81B2201/0214 ,  B82Y30/00 ,  B82Y35/00 ,  B82Y40/00 ,  G01L1/10 ,  G01N2291/0257 ,  G01N2291/0427

Abstract: The disclosed sensor chip includes a substrate and a moving member coupled to the substrate and disposed for movement relative to the substrate. The moving member moves relative to the substrate in a first direction and in a second direction in response to movement of the substrate. The first direction is different than the second direction. The moving member includes a plurality of receptors. The receptors are configured for selectively binding to a first measurand.

Abstract translation: 所公开的传感器芯片包括衬底和耦合到衬底并被设置为相对于衬底移动的移动构件。 移动构件响应于衬底的移动而在第一方向和第二方向上相对于衬底移动。 第一方向与第二方向不同。 移动构件包括多个受体。 受体被配置为选择性地结合第一被测量。

公开(公告)号：US20070007241A1

公开(公告)日：2007-01-11

申请号：US11407988

申请日：2006-04-20

Applicant: Lisa DeLouise

Inventor： Lisa DeLouise

IPC: B31D3/00 ,  C09K13/00 ,  B44C1/22 ,  H01L21/461

CPC classification number: G01N33/54373 ,  B81B2201/0214 ,  B81C1/00626 ,  B81C2201/0115 ,  Y10T428/24273

Abstract: Etchant solutions for making porous semiconductor materials. Also disclosed are methods of making porous semiconductor materials, post etch treatments, and porous semiconductor materials produced by these methods.

Abstract translation: 用于制造多孔半导体材料的蚀刻剂解决方案。 还公开了制造多孔半导体材料，后蚀刻处理和通过这些方法生产的多孔半导体材料的方法。

公开(公告)号：US20060210595A1

公开(公告)日：2006-09-21

申请号：US11331849

申请日：2006-01-13

Applicant: Rahul Singhvi ,  Amit Kumar ,  George Whitesides ,  Donald Ingber ,  Gabriel Lopez ,  Daniel Wang ,  Gregory Stephanopoulos

Inventor： Rahul Singhvi ,  Amit Kumar ,  George Whitesides ,  Donald Ingber ,  Gabriel Lopez ,  Daniel Wang ,  Gregory Stephanopoulos

IPC: A61F2/06 ,  A61F13/00

CPC classification number: C12N1/00 ,  B01J19/0046 ,  B01J2219/00382 ,  B01J2219/00385 ,  B01J2219/00585 ,  B01J2219/00596 ,  B01J2219/00605 ,  B01J2219/0061 ,  B01J2219/00612 ,  B01J2219/00617 ,  B01J2219/00619 ,  B01J2219/00621 ,  B01J2219/00626 ,  B01J2219/0063 ,  B01J2219/00637 ,  B01J2219/00659 ,  B01J2219/0072 ,  B81B2201/0214 ,  B81C1/00206 ,  B81C2201/034 ,  B82Y5/00 ,  B82Y30/00 ,  C12N5/0068 ,  C12N5/067 ,  C12N2535/10 ,  C12Q1/02 ,  C40B60/14

Abstract: The invention provides a device for adhering cells in a specific and predetermined position, and associated methods. The device includes a plate defining a surface and a plurality of cytophilic islands that adhere cells, isolated by cytophobic regions to which cells do not adhere, contiguous with the cytophilic islands. The islands or the regions or both may be formed of a self-assembled monolayer (SAM).