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    Medical devices and applications of polyhydroxyalkanoate polymers
    121.
    发明申请
    Medical devices and applications of polyhydroxyalkanoate polymers 有权
    聚羟基链烷酸酯聚合物的医疗装置和应用

    公开(公告)号：US20020156150A1

    公开(公告)日：2002-10-24

    申请号：US10082954

    申请日：2002-02-26

    Applicant: Metabolix, Inc.

    Inventor： Simon F. Williams ,  David P. Martin ,  Frank A. Skraly

    IPC: A61F002/00

    CPC classification number: A61L27/58 ,  A61F2/07 ,  A61F2210/0004 ,  A61K31/715 ,  A61L17/12 ,  A61L27/18 ,  A61L31/06 ,  A61L31/148 ,  A61L31/16 ,  A61L2300/00 ,  C08G63/06 ,  C08J9/26 ,  C08J2201/0444 ,  C08J2201/0482 ,  C08J2367/04 ,  C08K5/0033 ,  C08L67/04 ,  C12P7/625 ,  Y10S606/911

    Abstract: Devices formed of or including biocompatible polyhydroxyalkanoates are provided with controlled degradation rates, preferably less than one year under physiological conditions. Preferred devices include sutures, suture fasteners, meniscus repair devices, rivets, tacks, staples, screws (including interference screws), bone plates and bone plating systems, surgical mesh, repair patches, slings, cardiovascular patches, orthopedic pins (including bone filling augmentation material), adhesion barriers, stents, guided tissue repair/regeneration devices, articular cartilage repair devices, nerve guides, tendon repair devices, atrial septal defect repair devices, pericardial patches, bulking and filling agents, vein valves, bone marrow scaffolds, meniscus regeneration devices, ligament and tendon grafts, ocular cell implants, spinal fusion cages, skin substitutes, dural substitutes, bone graft substitutes, bone dowels, wound dressings, and hemostats. The polyhydroxyalkanoates can contain additives, be formed of mixtures of monomers or include pendant groups or modifications in their backbones, or can be chemically modified, all to alter the degradation rates. The polyhydroxyalkanoate compositions also provide favorable mechanical properties, biocompatibility, and degradation times within desirable time frames under physiological conditions.

    Abstract translation: 由生物相容性聚羟基链烷酸酯形成或包括生物相容性聚羟基链烷酸酯的设备具有受控的降解速率，优选在生理条件下小于一年。 优选的装置包括缝线，缝线紧固件，弯液面修复装置，铆钉，钉，钉，螺钉（包括干涉螺钉），骨板和骨电镀系统，外科手术网，修复贴片，吊索，心血管贴片，矫形针 材料），粘附屏障，支架，引导组织修复/再生装置，关节软骨修复装置，神经导管，肌腱修复装置，房间隔缺损修复装置，心包块，填充剂和填充剂，静脉瓣，骨髓支架，半月板再生 装置，韧带和腱移植物，眼细胞植入物，脊髓融合笼，皮肤替代物，硬脑膜替代物，骨移植物替代物，骨榫，伤口敷料和止血剂。 聚羟基链烷酸酯可以含有由单体的混合物形成的添加剂，或者在其主链中包括侧基或修饰，或者可以化学改性，以改变降解速率。 聚羟基链烷酸酯组合物还在生理条件下的期望时间范围内提供有利的机械性能，生物相容性和降解时间。

    Process for producing porous polymer materials
    122.
    发明授权
    Process for producing porous polymer materials 有权
    生产多孔聚合物材料的方法

    公开(公告)号：US06436426B1

    公开(公告)日：2002-08-20

    申请号：US09870370

    申请日：2001-05-30

    Applicant: Chun-Jen Liao ,  Chin-Fu Chen ,  Jui-Hsiang Chen ,  Ken-Yuan Chang ,  Yure-Ru Lin ,  Shu-Fang Chiang

    Inventor： Chun-Jen Liao ,  Chin-Fu Chen ,  Jui-Hsiang Chen ,  Ken-Yuan Chang ,  Yure-Ru Lin ,  Shu-Fang Chiang

    IPC: A61F200

    CPC classification number: C08J9/26 ,  C08J2201/0444 ,  C08J2201/046 ,  C08J2201/0542

    Abstract: The present invention provides a process for producing porous polymer materials. In the present invention, a polymer material and a soluble material are mixed in their solid states. The surface of the polymer material is partially dissolved and fused by introducing a solvent. The present invention makes use of a pressure difference while introducing a non-solvent into the polymer material to solidify and resolve the solved polymer material. Then, a substantial amount of water is used to wash the inside soluble material out. Therefore, the porous polymer materials with high porosity and interconnecting pores inside the materials are produced massively and rapidly.

    Abstract translation: 本发明提供一种生产多孔聚合物材料的方法。 在本发明中，将聚合物材料和可溶性材料以其固态混合。 通过引入溶剂将聚合物材料的表面部分溶解并熔融。 本发明利用压力差，同时将非溶剂引入聚合物材料中以固化和分解溶解的聚合物材料。 然后，大量的水被用来洗涤内部的可溶性材料。 因此，材料内部具有高孔隙率和互连孔的多孔聚合物材料大量且快速地产生。

    Process for the production of microporous polybenzimidazole articles
    124.
    发明授权
    Process for the production of microporous polybenzimidazole articles 失效
    生产微孔聚苯并咪唑制品的方法

    公开(公告)号：US4828699A

    公开(公告)日：1989-05-09

    申请号：US87548

    申请日：1987-08-20

    Applicant: John W. Soehngen

    Inventor： John W. Soehngen

    IPC: C08J9/26 ,  C08J9/28

    CPC classification number: B01D71/62 ,  B01D67/003 ,  C08J9/26 ,  C08J9/28 ,  C08J2201/0444 ,  C08J2201/0502 ,  C08J2379/04

    Abstract: Disclosed herein are microporous polybenzimidazole articles prepared by the addition of a leachable additive to a polybenzimidazole polymer solution or dope and the subsequent leaching of the additive from the polybenzimidazole article. The microporous polybenzimidazole article may be formed into filaments or films. The micropores of the microporous polybenzimidazole article may be filled with an absorbent resin which will act to absorb chemicals or other harmful products. The microporous polybenzimidazole article with absorbent material may be formed into clothing which is highly resistant to both chemicals and heat.

    Abstract translation: 本文公开了通过向聚苯并咪唑聚合物溶液或涂料中加入可浸出添加剂并随后从聚苯并咪唑制品中浸出添加剂而制备的微孔聚苯并咪唑制品。 微孔聚苯并咪唑制品可以形成长丝或薄膜。 微孔聚苯并咪唑制品的微孔可以填充吸收树脂，其吸收化学物质或其它有害物质。 具有吸收材料的微孔聚苯并咪唑制品可以形成为对化学品和热均具有高度抗性的衣服。

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