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    Method for making a porous polymeric material
    1.
    发明授权
    Method for making a porous polymeric material 有权
    制造多孔聚合材料的方法

    公开(公告)号：US08697108B2

    公开(公告)日：2014-04-15

    申请号：US10948486

    申请日：2004-09-23

    Applicant: Timothy A. Ringeisen ,  Scott M. Goldman

    Inventor： Timothy A. Ringeisen ,  Scott M. Goldman

    IPC: A61F2/00

    CPC classification number: C08J9/0033 ,  A61L27/34 ,  A61L27/54 ,  B29C41/12 ,  B29C41/14 ,  B29C45/0001 ,  C08J9/0014 ,  C08J9/0023 ,  C08J9/0028 ,  C08J9/28 ,  C08J2201/054

    Abstract: Porous polymers having a plurality of openings or chambers that are highly convoluted, with each chamber being defined by multiple, thin, flat partitions are produced by a new gel enhanced phase separation technique. In a preferred embodiment, a second liquid is added to a polymer solution, the second liquid causing the solution to increase in viscosity. With sufficient polymer and second liquid present, the increase in viscosity can be up to that of a gel. The gel can then be shaped as needed. Subsequent solvent extraction leaves the porous polymeric body of defined shape. The porous polymers have utility as medical prostheses, the porosity permitting ingrowth of neighboring tissue. A second material may be incorporated into the chambers, thereby creating a microstructure filling the voids of the macrostructure. A porous polymeric body manufactured by this process may incorporate biologically active agents, and which agents may be delivered in a time-staged delivery manner, where differing drugs may be delivered over differing periods.

    Abstract translation: 通过新的凝胶增强相分离技术产生多孔聚合物，其具有高度卷曲的多个开口或室，每个室由多个薄的平坦隔板限定。 在优选的实施方案中，将第二液体加入到聚合物溶液中，使第二液体溶液增加粘度。 当存在足够的聚合物和第二液体时，粘度的增加可以达到凝胶的增加。 然后可以根据需要成型凝胶。 随后的溶剂萃取离开具有限定形状的多孔聚合物体。 多孔聚合物可用作医用假体，孔隙度允许相邻组织向内生长。 可以将第二材料并入室中，从而产生填充宏观结构的空隙的微结构。 通过该方法制造的多孔聚合体可以并入生物活性剂，并且哪些试剂可以按时间递送方式递送，其中不同的药物可以在不同的时期内递送。

    FORMED ARTICLE AND PROCESS FOR THE PRODUCTION THEREOF
    2.
    发明申请
    FORMED ARTICLE AND PROCESS FOR THE PRODUCTION THEREOF 有权
    形成的物品及其生产方法

    公开(公告)号：US20130029398A1

    公开(公告)日：2013-01-31

    申请号：US13644408

    申请日：2012-10-04

    Applicant: Teijin Engineering Ltd.

    Inventor： Ryohichi NAGASHIMA ,  Haruko HIROSE

    IPC: B01J20/30 ,  C12N11/08

    CPC classification number: C08J9/28 ,  C08J9/0004 ,  C08J2201/054 ,  C08J2205/05

    Abstract: This invention is made to provide a formed article which ensures, for example, that an active substance included therein and a substance outside capsules can effectively come in contact with each other without suffering influences such as a pressure loss. This invention is a formed article having a plurality of cells formed in a polymer (A), (1) each cell including an active substance, (2) the polymer (A) having pores, each pore communicating with other pores and having a diameter in the range of 1 nm to 1 μm, and (3) the internal wall of each cell and the active substance being substantially not in contact with each other.

    Abstract translation: 本发明提供一种成形制品，其确保例如其中包含的活性物质和胶囊外的物质可以有效地彼此接触而不会受到诸如压力损失的影响。 本发明是一种具有在聚合物（A）中形成的多个电池的成形体，（1）包含活性物质的每个电池，（2）具有孔的聚合物（A），每个孔与其它孔连通并具有直径 在1nm至1μm的范围内，和（3）每个电池的内壁和活性物质基本上不彼此接触。

    Method for making a porous polymeric material
    3.
    发明申请
    Method for making a porous polymeric material 审中-公开
    制造多孔聚合材料的方法

    公开(公告)号：US20040267354A1

    公开(公告)日：2004-12-30

    申请号：US10864143

    申请日：2004-06-09

    Inventor： Timothy A. Ringeisen ,  Scott M. Goldman

    IPC: A61F002/06

    CPC classification number: C08J9/28 ,  A61L27/18 ,  A61L27/48 ,  A61L27/52 ,  A61L27/54 ,  A61L27/56 ,  A61L2300/114 ,  A61L2300/236 ,  A61L2300/252 ,  A61L2300/406 ,  A61L2300/42 ,  A61L2300/43 ,  A61L2300/64 ,  A61L2300/802 ,  C08J2201/054 ,  Y10T428/1386 ,  Y10T428/139 ,  C08L75/04

    Abstract: Porous polymers having a plurality of openings or chambers that are highly convoluted, with each chamber being defined by multiple, thin, flat partitions are produced by a new gel enhanced phase separation technique. In a preferred embodiment, a second solvent is added to a polymer solution, the second solvent causing the solution to gel. The gel can then be shaped as needed. Subsequent solvent extraction leaves the porous polymeric body of defined shape. The porous polymers have utility as medical prostheses, the porosity permitting ingrowth of neighboring tissue. A second polymer material may be incorporated into the chambers, thereby creating a microstructure filling the voids of the macrostructure. A porous polymeric body manufactured by this process may serve to deliver biologically active agents in a time-staged delivery manner, where differing drugs may be delivered over differing periods.

    Abstract translation: 通过新的凝胶增强相分离技术产生具有多个高度卷积的多个开口或室的多孔聚合物，其中每个室由多个薄的平坦隔板限定。 在优选的实施方案中，将第二溶剂加入到聚合物溶液中，第二溶剂使溶液凝胶化。 然后可以根据需要成型凝胶。 随后的溶剂萃取离开具有限定形状的多孔聚合物体。 多孔聚合物可用作医用假体，孔隙度允许相邻组织向内生长。 可以将第二聚合物材料结合到室中，从而产生填充宏观结构的空隙的微结构。 通过该方法制造的多孔聚合物体可用于以时间递送的方式递送生物活性剂，其中不同的药物可以在不同的时期内递送。

    METHOD FOR PRODUCING A RESIN COMPOSITION HAVING A POROUS STRUCTURE WITH INDEPENDENT POROSITIES
    6.
    发明申请
    METHOD FOR PRODUCING A RESIN COMPOSITION HAVING A POROUS STRUCTURE WITH INDEPENDENT POROSITIES 审中-公开
    生产具有独立多孔性的多孔结构的树脂组合物的方法

    公开(公告)号：US20150197616A1

    公开(公告)日：2015-07-16

    申请号：US14666924

    申请日：2015-03-24

    Applicant: CANON KABUSHIKI KAISHA

    Inventor： Yohei Miyauchi ,  Naotake Sato ,  Yuichi Hashimoto ,  Toshihiro Kikuchi

    IPC: C08J9/28

    CPC classification number: C08J9/286 ,  C08G73/10 ,  C08G73/1046 ,  C08G73/14 ,  C08G2101/00 ,  C08J9/28 ,  C08J2201/054 ,  C08J2205/044 ,  C08J2205/052 ,  C08L77/00 ,  C08L79/08 ,  G03G15/162 ,  G03G15/2057 ,  G03G2215/1676

    Abstract: An object of the present invention is to provide a porous material (resin composition) having high heat insulation properties, mechanical properties, and electrical properties by controlling function of a porous film by setting a porosity size, distribution of the porosity size, and a porosity ratio of the porous film in predetermined ranges. The resin composition according to the present invention is comprised of an engineering plastic having porous structure in which not less than 80% of a total porosity is comprised of independent porosities, a mean porosity size is not less than 0.01 μm and not more than 0.9 μm, and not less than 80% of the total porosity has a porosity size within ±30% of the mean porosity size.

    Abstract translation: 本发明的目的是提供一种通过设定孔隙率尺寸，孔隙度尺寸的分布和孔隙率来控制多孔膜的功能而具有高绝热性，机械性能和电性能的多孔材料（树脂组合物） 多孔膜的比例在预定范围内。 根据本发明的树脂组合物由具有多孔结构的工程塑料组成，其中不少于80％的总孔隙率由独立的孔隙度组成，平均孔隙度不小于0.01μm且不大于0.9μm ，并且不小于总孔隙率的80％具有在平均孔隙度尺寸的±30％内的孔隙率。

    FORMED ARTICLE AND PROCESS FOR THE PRODUCTION THEREOF
    7.
    发明申请
    FORMED ARTICLE AND PROCESS FOR THE PRODUCTION THEREOF 审中-公开
    形成的物品及其生产方法

    公开(公告)号：US20100130347A1

    公开(公告)日：2010-05-27

    申请号：US12089282

    申请日：2006-10-04

    Applicant: Ryohichi Nagashima ,  Haruko Hirose

    Inventor： Ryohichi Nagashima ,  Haruko Hirose

    IPC: B01J31/06

    CPC classification number: C08J9/28 ,  C08J9/0004 ,  C08J2201/054 ,  C08J2205/05

    Abstract: This invention is made to provide a formed article which ensures that an active substance included therein and a substance outside capsules can effectively come in contact with each other without suffering influences such as a pressure loss, that the surface area thereof can be utilized to the utmost without having the surface of an active substance coated with a polymer, that the active substance does not easily come off or separate even when external friction or the like is exerted and that an active substance does not directly come in contact with a human body or is not sucked into a human body.This invention is a formed article having a plurality of cells formed in a polymer (Z), (1) each cell including an active substance, (2) the polymer (A) having pores, each pore communicating with other pores in the polymer (A) and having a diameter in the range of 1 nm to 1 μm, and (3) the internal wall of each cell and the active substance being substantially not in contact with each other, and process for production thereof.

    Abstract translation: 本发明是为了提供一种成形体，其能够确保其中包含的活性物质和胶囊外的物质能够有效地彼此接触，而不会受到诸如压力损失的影响，可以最大程度地利用其表面积 没有涂覆有聚合物的活性物质的表面，即使发生外部摩擦等，活性物质也不容易脱落或分离，并且活性物质不直接与人体接触或者是 没有吸入人体。 本发明是一种具有在聚合物（Z）中形成的多个电池的成形体，（1）包含活性物质的每个电池，（2）具有孔的聚合物（A），每个孔与聚合物中的其它孔连通 A），直径在1nm〜1μm的范围内，（3）各电池的内壁和活性物质基本上不接触，其制造方法。

    Biofoam II
    9.
    发明授权
    Biofoam II 失效
    生物泡沫II

    公开(公告)号：US5360828A

    公开(公告)日：1994-11-01

    申请号：US215159

    申请日：1994-03-21

    Applicant: Robert L. Morrison

    Inventor： Robert L. Morrison

    IPC: C08J9/00 ,  C08J9/28 ,  C08J9/26

    CPC classification number: C08J9/0085 ,  C08J9/28 ,  C08J2201/048 ,  C08J2201/054 ,  C08J2305/00 ,  C08J2389/00

    Abstract: Biofoam is a rigid, microcellular organic foam made from organic materials derived from natural products and biological organisms. Starting materials include agar, agarose, gelatin, algin, alginates, gellan gum, and microcrystalline cellulose. The organic material is dissolved in a polar solvent, typically water, and the mixture is gelled. The water in the gel pores is replaced at least once with another solvent to reduce the pore size of the final biofoam. The solvent in the gel pores may be replaced several times. After the final replacement of solvent, the gel is frozen and freeze-dried to form a biofoam. Translucent biofoams are formed by selecting a final solvent that forms very small crystals. A variety of crystalline, fibrous, amorphous, or metallic additives may be incorporated into the foam structure to produce lightweight composite materials with enhanced strength and insulating properties.

    Abstract translation: 生物泡沫塑料是由天然产物和生物有机体衍生的有机材料制成的刚性微孔有机泡沫。 原料包括琼脂，琼脂糖，明胶，藻酸盐，藻酸盐，结冷胶和微晶纤维素。 将有机材料溶解在极性溶剂中，通常为水，混合物凝胶化。 凝胶孔中的水用另一种溶剂至少更换一次以减少最终生物泡沫的孔径。 凝胶孔中的溶剂可以被多次更换。 最后更换溶剂后，将凝胶冷冻并冷冻干燥以形成生物泡沫。 通过选择形成非常小的晶体的最终溶剂形成半透明生物泡沫。 可以将多种结晶，纤维，无定形或金属添加剂掺入泡沫结构中，以制备具有增强的强度和绝缘性能的轻质复合材料。

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