Abstract:
A method for treatment of bacterial infections with rifalazil administered once-weekly, or twice-weekly. A method for treatment of tuberculosis caused by Mycobacterium tuberculosis, infections caused by Mycobacterium avium complex, infections caused by Chlamydia pneumoniae and infections caused by Helicobacter pylori by administering to a patient suffering from the bacterial infection 1-100 mg of rifalazil once or twice a week. In this dose regimen, the treatment is fast, efficacious and eliminates undesirable secondary symptoms observed with daily doses of 1-50 mg of rifalazil.
Abstract:
A process is disclosed for manufacturing a lubricant composition comprising combining a superabsorbent polymer with a material for decreasing friction between moving surfaces. The superabsorbent polymer absorbs from about 25 to greater than 100 times its weight in water and may comprise a polymer of acrylic acid, an acrylic ester, acrylonitrile or acrylamide, including co-polymers thereof or starch graft co-polymers thereof or mixtures thereof. A product produced by the process includes the material for decreasing friction comprising a petroleum lubricant containing an additive, water containing an additive, synthetic lubricant, grease, solid lubricant or metal working lubricant, wherein the synthetic lubricant, grease, solid lubricant or metal working lubricant optionally contain an additive. A process comprising controlling the delivery of a lubricant to at least one of two moving surfaces in order to decrease friction between said moving surfaces, is also disclosed. This process includes applying the lubricant composition to at least one of the surfaces. The lubricant composition in this instance comprises a superabsorbent polymer combined with a material for decreasing friction between moving surfaces, wherein the material for decreasing friction comprises a petroleum lubricant, water, synthetic lubricant, grease, solid lubricant or metal working lubricant, and optionally an additive.
Abstract:
A substrate is coated with an essentially water-free composition. The composition includes a superabsorbent polymer that absorbs from about 25 to greater than 100 times its weight in water and a material for lubricating the substrate. The superabsorbent polymer may be a polymer of acrylic acid, acrylamide or acrylate. Also included is a method for protecting a substrate from the effects of water or water migration.
Abstract:
A process is disclosed for manufacturing a lubricant composition comprising combining a superabsorbent polymer with a material for decreasing friction between moving surfaces. The superabsorbent polymer absorbs from about 25 to greater than 100 times its weight in water and may comprise a polymer of acrylic acid, an acrylic ester, acrylonitrile or acrylamide, including co-polymers thereof or starch graft co-polymers thereof or mixtures thereof. A product produced by the process includes the material for decreasing friction comprising a petroleum lubricant containing an additive, water containing an additive, synthetic lubricant, grease, solid lubricant or metal working lubricant, wherein the synthetic lubricant, grease, solid lubricant or metal working lubricant optionally contain an additive. A process comprising controlling the delivery of a lubricant to at least one of two moving surfaces in order to decrease friction between said moving surfaces, is also disclosed. This process includes applying the lubricant composition to at least one of the surfaces. The lubricant composition in this instance comprises a superabsorbent polymer combined with a material for decreasing friction between moving surfaces, wherein the material for decreasing friction comprises a petroleum lubricant, water, synthetic lubricant, grease, solid lubricant or metal working lubricant, and optionally an additive.
Abstract:
A slide bearing for internal combustion engines, comprising a slide layer including a lubricant outer layer in which a solid lubricant is contained, and wherein the lubricant outer layer contains an element which is contained in the solid lubricant, at a maximum concentration of not less than 5 mass % in the lubricant outer layer, and at least a solid lubricant gathered particle is formed on a surface of the lubricant outer layer, the solid lubricant gathered particle being a particle of the solid lubricant formed by gathering a plurality of primary particles, the solid lubricant gathered particle having a long side of not less than 20 μm but less than 100 μm in terms of surface visual field of the lubricant outer layer.
Abstract:
The production of solid lubricant agglomerates by combining solid lubricant powder, an inorganic binder, other fillers if optionally desired, and a liquid to form a mixture, and driving off the liquid to form dry agglomerates which are subsequently classified by size or milled and classified by size to yield agglomerates of a desired size range. These agglomerates are then treated to stabilize the binder, thereby strengthening the binder and rendering it nondispersible in the liquid. The treated agglomerates are then blended or clad with a metal, metal alloy or a metallic composition, to produce a composition suitable for thermal spray applications.
Abstract:
A tungsten disulfide powder comprised of macro-spherical particles of tungsten disulfide having an average particle diameter of from about 5 to about 50 micrometers is prepared by successively treating spray-dried powders of ammonium metatungstate with heat in air and sulfidizing the resultant tungsten trioxide in a carbon disulfide-containing atmosphere at about 750° C. The tungsten disulfide powder may also be formed to have a bimodal particle size distribution of the macro-spherical particles and smaller, dispersed micro- to submicron-sized fine particles.
Abstract:
The present invention relates to a method for screening and identifying test compounds that bind to a preselected target ribonucleic acid (nullRNAnull). Direct, non-competitive binding assays are advantageously used to screen libraries of compounds for those that selectively bind to a preselected target RNA. Binding of target RNA molecules to a particular test compound is detected using any physical method that measures the altered physical property of the target RNA bound to a test compound. The structure of the test compound attached to the labeled RNA is also determined. The methods used will depend, in part, on the nature of the library screened. The methods of the present invention provide a simple, sensitive assay for high-throughput screening of libraries of compounds to identify pharmaceutical leads.
Abstract:
A tungsten disulfide powder comprised of macro-spherical particles of tungsten disulfide having an average particle diameter of from about 5 to about 50 micrometers is prepared by successively treating spray-dried powders of ammonium metatungstate with heat in air and sulfidizing the resultant tungsten trioxide in a carbon disulfide-containing atmosphere at about 750null C. The tungsten disulfide powder may also be formed to have a bimodal particle size distribution of the macro-spherical particles and smaller, dispersed micro- to submicron-sized fine particles.
Abstract:
The present invention provides a new composite material comprising a porous matrix made of metal, metal alloy or semiconducting material and hollow fullerene-like nanoparticles of a metal chalcogenide compound or mixture of such compounds. The composite material is characterized by having a porosity between about 10% and about 40%. The amount of the hallow nanoparticles in the composite material is 1-20 wt. %.