公开(公告)号：US20160238625A1

公开(公告)日：2016-08-18

申请号：US15042968

申请日：2016-02-12

Applicant: Abbott Laboratories

Inventor： Razvan Raicu ,  Robert P. Luoma, II

IPC: G01N35/02 ,  B65G1/06

CPC classification number: G01N35/026 ,  B01L9/06 ,  B65G1/06 ,  G01N15/1459 ,  G01N35/0099 ,  G01N35/025 ,  G01N35/1011 ,  G01N35/1081 ,  G01N2035/00435 ,  G01N2035/00445 ,  G01N2035/0405 ,  G01N2035/0412 ,  G01N2035/0462 ,  G01N2035/0465

Abstract: Example automated storage modules for analyzer liquids are described herein. An example apparatus includes a refrigerated storage module having a plurality of shelves (to store a plurality of carriers) and a loading bay having an array of slots to receive one or more of the carriers. The loading bay is accessible by a user for manual loading or unloading of the carriers. The example apparatus includes a first carrier transporter coupled to the storage module to transfer the carriers between the shelves and a first transfer location and a second carrier transporter movable along a track connecting the storage module to an automated diagnostic analyzer. The second carrier transporter is to transfer a first carrier between the first transfer location and a slot in the loading bay and a second carrier between the first transfer location and a second transfer location accessible by the automated diagnostic analyzer.

Abstract translation: 本文描述了用于分析器液体的示例性自动存储模块。 示例性装置包括具有多个搁架（以存储多个载体）的冷藏存储模块和具有用于接收一个或多个载体的槽阵列的装载室。 装载舱可由用户进行手动装载或卸载。 示例性装置包括耦合到存储模块的第一载体传送器，用于将载体转移到架子和第一传送位置之间，并且第二载体传送器沿着将存储模块连接到自动诊断分析仪的轨道移动。 第二运输运输工具是在第一转运位置和装载箱中的槽之间传送第一载体，以及在第一转运位置和由自动诊断分析仪可接近的第二转运位置之间的第二载体。

公开(公告)号：US20160237504A1

公开(公告)日：2016-08-18

申请号：US15019829

申请日：2016-02-09

Applicant: Abbott Laboratories

Inventor： Dimitri Semizarov ,  Xin Lu ,  Ke Zhang ,  Rick R. Lesniewski ,  John S. Coon

IPC: C12Q1/68

CPC classification number: C12Q1/6886 ,  C12Q2600/106 ,  C12Q2600/112 ,  C12Q2600/118 ,  C12Q2600/156 ,  C12Q2600/178 ,  G01N33/57423 ,  G01N2800/52 ,  G01N2800/54 ,  G01N2800/56 ,  G01N2800/60

Abstract: The present disclosure provides methods for identifying early stage non-small-cell lung cancer (NSCLC) patients who will have an unfavorable prognosis for the recurrence of lung cancer after surgical resection. The methods are based in part on the discovery of chromosomal copy number abnormalities that can be used for prognostic classification. The methods preferably use fluorescence in situ hybridization with fluorescently labeled nucleic acid probes to hybridize to patient samples to quantify the chromosomal copy number of these genetic loci.

Abstract translation: 本公开提供了用于鉴定在手术切除后对肺癌复发有不利预后的早期非小细胞肺癌（NSCLC）患者的方法。 这些方法部分基于可用于预后分类的染色体拷贝数异常的发现。 方法优选使用与荧光标记的核酸探针的荧光原位杂交与患者样品杂交以定量这些遗传基因座的染色体拷贝数。

公开(公告)号：US09398947B2

公开(公告)日：2016-07-26

申请号：US13942215

申请日：2013-07-15

Applicant: Abbott Laboratories Vascular Enterprises Limited

Inventor： Milisav Obradovic ,  Rainer Bregulla

IPC: A61F2/06 ,  A61F2/07 ,  A61F2/91 ,  A61F2/915 ,  A61F2/852 ,  A61F2/89

CPC classification number: A61F2/07 ,  A61F2/852 ,  A61F2/89 ,  A61F2/91 ,  A61F2/915 ,  A61F2002/072 ,  A61F2002/91575 ,  A61F2220/0058 ,  A61F2250/0063

Abstract: A stent-graft including an inner stent having a wall structure including juxtaposed strut-patterns with interconnected struts and connectors connecting the strut-patterns is described. The wall structure of the inner stent has a predetermined length. An outer stent is coaxially arranged around the inner stent and has a wall structure including juxtaposed strut-patterns with interconnected struts and connectors connecting the strut-patterns. The wall structure of the outer stent has a predetermined length and a flexible stretchable material layer arranged between the inner stent and the outer stent. The wall structure of the inner stent has a design differing from the design of the wall structure of the outer stent and the length of the inner stent is equal to the length of the outer stent.

公开(公告)号：US09388455B2

公开(公告)日：2016-07-12

申请号：US14036527

申请日：2013-09-25

Applicant: Abbott Laboratories

Inventor： Klara X. Abravaya ,  John R. Hackett ,  Shihai X. Huang ,  Ka-Cheung X. Luk ,  John A. Salituro ,  Larry E. Morrison

IPC: C12Q1/68 ,  C12Q1/70

CPC classification number: C12Q1/6818 ,  C12Q1/6832 ,  C12Q1/6851 ,  C12Q2561/113 ,  C12Q2537/137 ,  C12Q2525/107 ,  C12Q2565/101 ,  C12Q2565/525

Abstract: A double-stranded nucleic acid hybridization probe and methods of using the same are described. The probe described is particularly suited for real-time RT-PCR reactions and has high tolerance to mismatches.

Abstract translation: 描述双链核酸杂交探针及其使用方法。 所述的探针特别适用于实时RT-PCR反应，并且具有高的错配耐受性。

公开(公告)号：US20160192913A1

公开(公告)日：2016-07-07

申请号：US15069230

申请日：2016-03-14

Applicant: Abbott Laboratories

Inventor： Arkady Kokish

IPC: A61B17/00 ,  A61B17/08 ,  A61B17/34 ,  A61B17/10

CPC classification number: A61B17/08 ,  A61B17/00234 ,  A61B17/0057 ,  A61B17/083 ,  A61B17/10 ,  A61B17/3423 ,  A61B2017/00004 ,  A61B2017/00584 ,  A61B2017/00663 ,  A61B2017/00672

Abstract: An engaging element for engaging tissue that includes a first member and a second member. The first member includes at least one tissue engaging portion at a first free end. The first tissue engaging member is movable between an open position and a closed position and has a second free end. The first tissue engaging member is restrained in movement at an intermediate position between the first free end and the second free end. A lock portion is operatively associated with the first member with the lock portion maintaining a spacing between the first member and the second member and inhibiting movement of the first member to the open position. The lock portion is operatively associated with a portion of the first tissue engaging member proximal the intermediate position.

Abstract translation: 一种用于接合组织的接合元件，包括第一构件和第二构件。 第一构件包括在第一自由端处的至少一个组织接合部分。 第一组织接合构件可在打开位置和关闭位置之间移动并具有第二自由端。 第一组织接合构件在第一自由端和第二自由端之间的中间位置被约束运动。 锁定部分与第一构件可操作地相关联，其中锁定部分保持第一构件和第二构件之间的间隔并且阻止第一构件移动到打开位置。 锁定部分可操作地与第一组织接合构件的靠近中间位置的部分相关联。

公开(公告)号：US09381327B2

公开(公告)日：2016-07-05

申请号：US13784820

申请日：2013-03-04

Applicant: Abbott Laboratories

Inventor： Boris Warnack

IPC: A61M25/10 ,  A61M25/01

CPC classification number: A61M25/1011 ,  A61M25/10 ,  A61M2025/0183 ,  A61M2025/1013 ,  A61M2025/1075

Abstract: A balloon catheter comprises a shaft having a proximal end and a distal end. An inflatable member is disposed adjacent the distal end of the shaft. The inflatable member has an inner inflatable member and an outer inflatable member disposed around the inner inflatable member. The inflatable members have different compliant properties.

Abstract translation: 球囊导管包括具有近端和远端的轴。 可膨胀构件邻近轴的远端设置。 可膨胀构件具有内部可膨胀构件和设置在内部可膨胀构件周围的外部可膨胀构件。 可膨胀构件具有不同的柔性特性。

公开(公告)号：US20160185496A1

公开(公告)日：2016-06-30

申请号：US14653902

申请日：2013-12-11

Applicant: ABBOTT LABORATORIES

Inventor： CHRISTOPHER COX ,  JAMES PERRY

IPC: B65D55/08 ,  B65D41/04

CPC classification number: B65D55/0818 ,  B65D1/023 ,  B65D1/0253 ,  B65D41/0435 ,  B65D41/045 ,  B65D41/0485 ,  B65D55/0854 ,  B65D2203/00

Abstract: An apparatus includes a bottle, a cap, and a tamper evident film. The bottle forms an opening having a lip that extends circumferentially around the opening. The cap is able to cover and seal the opening. The cap has a top with an outer surface, an inner surface, and a side wall. The outer surface and the side wall define a recessed region of the cap. The tamper evident film includes a perforated tear strip. The perforated tear strip is positioned to overlap a portion of the recessed region. The cap may also include a combination of micro knurls and/or micro knurls along the side wall of the cap. The lip may have a beveled profile able to interface with a gasket on the underside of the cap.

Abstract translation: 一种装置包括瓶，盖和防篡改膜。 瓶形成具有围绕开口周向延伸的唇缘的开口。 盖子能够覆盖和密封开口。 盖具有顶部，其具有外表面，内表面和侧壁。 外表面和侧壁限定盖的凹陷区域。 防篡改膜包括穿孔撕裂带。 多孔撕裂条定位成与凹陷区域的一部分重叠。 盖子还可以包括沿着盖子的侧壁的微型滚花和/或微型滚花的组合。 唇缘可以具有能够与盖的下侧上的垫圈相接合的斜面轮廓。

公开(公告)号：US20160184823A1

公开(公告)日：2016-06-30

申请号：US14976684

申请日：2015-12-21

Applicant: Abbott Laboratories

Inventor： Andrew Fischer

IPC: B01L3/00

CPC classification number: B01L3/502707 ,  B01L3/502792 ,  B01L2300/0645 ,  B01L2300/0861 ,  B01L2300/089 ,  B01L2400/0427

Abstract: Example methods, apparatus, systems for diluting samples are disclosed. An example method includes depositing a first fluid droplet on a first electrode of a plurality of electrodes. The first electrode has a first area. The first fluid droplet has a first volume associated with the first area. The example method includes depositing a second fluid droplet on a second electrode of the plurality of electrodes. The second electrode has a second area. The second fluid droplet has a second volume associated with the second area. The second volume is different than the first volume. The example method includes forming a combined droplet by selectively activating at least one of the first electrode or the second electrode to cause one of the first fluid droplet or the second fluid droplet to merge with the other of the first fluid droplet or the second fluid droplet.

Abstract translation: 公开了用于稀释样品的示例性方法，装置，系统。 一个示例性方法包括将第一流体液滴沉积在多个电极的第一电极上。 第一电极具有第一区域。 第一流体液滴具有与第一区域相关联的第一体积。 该示例性方法包括将第二流体液滴沉积在多个电极的第二电极上。 第二电极具有第二区域。 第二流体液滴具有与第二区域相关联的第二体积。 第二卷与第一卷不同。 该示例性方法包括通过选择性地激活第一电极或第二电极中的至少一个来形成组合的液滴，以使第一流体液滴或第二流体液滴中的一个与第一流体液滴或第二流体液滴 。

公开(公告)号：US20160175130A1

公开(公告)日：2016-06-23

申请号：US15058407

申请日：2016-03-02

Applicant: ABBOTT LABORATORIES VASCULAR ENTERPRISES LIMITED

Inventor： Michael Schwager ,  Martin Frei ,  Suk-Woo Ha

IPC: A61F2/958 ,  A61F2/915

CPC classification number: A61F2/958 ,  A61F2/91 ,  A61F2/915 ,  A61F2002/91533 ,  A61F2002/91558 ,  A61F2002/9522 ,  A61F2002/9583 ,  A61F2310/00011 ,  A61M2025/1004 ,  Y10T29/49927

Abstract: Stent delivery system having a contracted delivery configuration and an expanded deployed configuration is provided. The stent delivery system includes a stent having a plurality of expandable elements and a plurality of interstices disposed between adjacent expandable elements, and a delivery catheter having an inflatable balloon including creases extending non-uniformly within the interstices of the stent in the contracted delivery configuration. Each crease defines a maximum radial height within a corresponding interstice, and the maximum radial heights of the creases vary. A method for stenting at a target site within a patient's vessel including providing a stent delivery system is also provided.

Abstract translation: 提供具有合同传送配置和扩展部署配置的支架传送系统。 支架输送系统包括具有多个可扩张元件的支架和设置在相邻的可膨胀元件之间的多个间隙，以及具有可膨胀气囊的输送导管，其包括在收缩递送构型中在支架的空隙内不均匀延伸的折痕。 每个折痕限定相应空隙内的最大径向高度，并且折痕的最大径向高度变化。 还提供了一种用于在患者容器内的靶部位进行支架置入的方法，包括提供支架输送系统。

公开(公告)号：US09358096B2

公开(公告)日：2016-06-07

申请号：US13908854

申请日：2013-06-03

Applicant: Abbott Laboratories

Inventor： Kent C. B. Stalker ,  Winnette S. McIntosh ,  Dudley S. Jayasinghe ,  Gregory C. Orr ,  John E. Papp ,  Lewis B. Schwartz

IPC: A61F2/06 ,  A61L31/02 ,  A61L31/10 ,  A61L31/16

CPC classification number: A61F2/915 ,  A61F2/06 ,  A61F2002/91541 ,  A61F2002/91583 ,  A61F2250/0067 ,  A61L31/022 ,  A61L31/10 ,  A61L31/16 ,  A61L2300/416 ,  A61L2420/08

Abstract: A drug eluting stent can include a stent body having a polymeric coating with a lipophilic and/or hydrophilic element. A drug that has a bioactivity that inhibits cell proliferation can be disposed in the polymeric coating. The drug can be present in the polymer at an amount greater than or equal to about 150 μg/cm2. The polymeric coating and drug are configured to cooperate so as to form a diffusion pathway with tissue when the stent is disposed in a body lumen such that the drug preferentially diffuses into the tissue over a body fluid passing through the body lumen such that a maximum systemic blood concentration of the drug is less than about 40 ng/ml.

Abstract translation: 药物洗脱支架可以包括具有亲脂和/或亲水元件的聚合物涂层的支架体。 具有抑制细胞增殖的生物活性的药物可以设置在聚合物涂层中。 药物可以以大于或等于约150μg/ cm 2的量存在于聚合物中。 聚合物涂层和药物被配置为配合以便当支架设置在体腔中时与组织形成扩散路径，使得药物优先地通过穿过体腔的体液扩散到组织中，使得最大系统 药物的血液浓度小于约40ng / ml。