公开(公告)号：US20220002336A1

公开(公告)日：2022-01-06

申请号：US17292963

申请日：2019-11-11

Applicant: MITSUBISHI TANABE PHARMA CORPORATION ,  OSAKA UNIVERSITY

Inventor： Hiroaki SAWAMOTO ,  Shinji KUMAGAI ,  Hiroyuki FURUKAWA ,  Tomo ARAKI ,  Masayuki UTSUGI ,  Satoshi OBIKA

IPC: C07H19/20 ,  C07H19/10 ,  C07H21/04

Abstract: The present invention provides a novel bridged artificial nucleic acid and an oligomer containing the same as a monomer. The present invention provides specifically a compound represented by general formula (I) (wherein each symbol is the same as defined in the specification) or salts thereof; as well as an oligonucleotide compound represented by general formula (I′) (wherein each symbol is the same as defined in the specification) or salts thereof.

公开(公告)号：US20210403395A1

公开(公告)日：2021-12-30

申请号：US17253438

申请日：2019-06-18

Applicant: OSAKA UNIVERSITY

Inventor： Kei OHKUBO

IPC: C07B33/00 ,  C07C29/48 ,  C07C51/29 ,  C07C45/30

Abstract: The present invention is intended to provide a method that can produce an oxidation reaction product of a hydrocarbon or a derivative thereof in an aqueous phase using a hydrocarbon or a derivative thereof as a raw material. In order to achieve the above object, the method for producing an oxidation reaction product of a hydrocarbon or a derivative thereof of the present invention includes the step of: irradiating a reaction system with light in a presence of a raw material and a halogen oxide radical to react, wherein the raw material is a hydrocarbon or a derivative thereof, the reaction system is a reaction system containing an aqueous phase, the aqueous phase contains the raw material and the halogen oxide radical, and in the reaction step, the raw material is oxidized to produce an oxidation reaction product of the raw material.

公开(公告)号：US11209320B2

公开(公告)日：2021-12-28

申请号：US16508497

申请日：2019-07-11

Applicant: Murata Manufacturing Co., Ltd. ,  OSAKA UNIVERSITY

Inventor： Yasunori Hioki ,  Tsuyoshi Sekitani ,  Takafumi Uemura ,  Tomoaki Onoue

IPC: G01K7/22 ,  H01C7/04 ,  G01K1/024 ,  G01K1/02 ,  H01C17/065

Abstract: A temperature sensor that includes an organic-inorganic composite negative temperature coefficient thermistor and a transistor. The organic-inorganic composite negative temperature coefficient thermistor includes a thermistor layer which includes spinel-type semiconductor ceramic composition powder containing Mn, Ni and Fe and an organic polymer component, and a pair of electrode layers. The semiconductor ceramic composition powder has a molar ratio of Mn to Ni of 85/15≥Mn/Ni≥65/35 and a Fe content of 30 parts by mole or less when a total molar amount of Mn and Ni is regarded as 100 parts by mole, and has a peak with a local maximum value of around 29° to 31° in its X-ray diffraction pattern, a half width of which peak is 0.15 or more. The transistor is electrically connected with either one of the pair of electrode layers.

公开(公告)号：US11203803B2

公开(公告)日：2021-12-21

申请号：US15757968

申请日：2016-09-16

Applicant: OSAKA UNIVERSITY ,  KOMATSU LTD.

Inventor： Yoritoshi Minamino ,  Takemori Takayama ,  Koji Yamamoto ,  Yusuke Hiratsuka

IPC: C22C38/18 ,  C22C38/06 ,  C22C38/34 ,  C22C38/44 ,  C22C38/46 ,  C22C38/58 ,  C22C38/38 ,  C21D6/00 ,  C21D1/613

Abstract: A steel with high hardness and excellent toughness contains, in mass %, 0.55-1.10% C, 0.10-2.00% Si, 0.10-2.00% Mn, 0.030% or less P, 0.030% or less S, 1.10-2.50% Cr, and 0.010-0.10% Al, with the balance consisting of Fe and unavoidable impurities. The structure of the steel after quenching is a dual phase structure of martensitic structure and spheroidized carbide. Spheroidized cementite particles with an aspect ratio of 1.5 or less constitute at least 90% of all cementite particles. The proportion of the number of spheroidized cementite particles on the prior austenite grain boundaries to a total number of cementite particles is 20% or less.

公开(公告)号：US11189392B2

公开(公告)日：2021-11-30

申请号：US15759922

申请日：2016-09-23

Applicant: OSAKA UNIVERSITY

Inventor： Satoshi Matsuyama ,  Jumpei Yamada

IPC: G21K7/00 ,  G21K1/06

Abstract: An X-ray microscope includes at least one of an X-ray source, a sample holding part, a concave Kirkpatrick-Baez mirror, a convex Kirkpatrick-Baez mirror, and a light receiving part located at a position in an imaging relation to a position of the sample holding part in this order along an optical axis.

公开(公告)号：US11187984B2

公开(公告)日：2021-11-30

申请号：US15779013

申请日：2016-11-25

Applicant: OSAKA UNIVERSITY

Inventor： Seiichi Tagawa

IPC: G03F7/20 ,  G03F7/40 ,  G03F7/38 ,  G03F7/004 ,  G03F7/038 ,  G03F7/039 ,  G03F7/11 ,  G03F7/075 ,  G03F7/09

Abstract: A resist patterning method includes a resist layer forming step, a patterned exposure step, a flood exposure step, and a developing step. In the resist layer forming step, a resist layer is formed on a substrate. In the patterned exposure step, a sensitizer is produced from a sensitizer precursor in the resist layer. In the flood exposure step, flood exposure is performed on the resist layer in which the sensitizer has been produced to produce an acid from a strong acid generator. In the developing step, the resist layer is developed. The patterned exposure step includes: producing a strong acid from the strong acid generator; producing the sensitizer through a reaction between the strong acid and the sensitizer precursor; producing a weak acid through a reaction between the strong acid and a base; and producing the sensitizer through a reaction between the weak acid and the sensitizer precursor.

公开(公告)号：US20210347953A1

公开(公告)日：2021-11-11

申请号：US17259859

申请日：2019-07-12

Applicant: OSAKA UNIVERSITY ,  DAIKIN INDUSTRIES, LTD.

Inventor： Akihiro OSHIMA ,  Takayuki TANAKA ,  Hideki NAKAYA ,  Kazuyuki SATOH ,  Ryosuke SENBA

IPC: C08J3/28 ,  C08F8/50 ,  C08F114/26

Abstract: Provided is a method for producing low-molecular-weight polytetrafluoroethylene which is less likely to generate C6-C14 perfluorocarboxylic acids and salts thereof. The disclosure relates to a method for producing low-molecular-weight polytetrafluoroethylene having a melt viscosity at 380° C. of 1.0×102 to 7.0×105 Pa·s. The method includes (1) irradiating high-molecular-weight polytetrafluoroethylene with radiation in a substantially oxygen-free state and decomposing the high-molecular-weight polytetrafluoroethylene into a low-molecular-weight component and (2) deactivating, in a substantially oxygen-free state, at least part of main-chain radicals and end radicals generated by the irradiation and providing the low-molecular-weight polytetrafluoroethylene.

公开(公告)号：US20210338770A1

公开(公告)日：2021-11-04

申请号：US17282560

申请日：2019-10-11

Applicant: Osaka University

Inventor： Takahisa Furukawa ,  Taro Chaya

IPC: A61K38/13 ,  A61K31/436 ,  A61P27/02 ,  C12Q1/44 ,  G01N33/50 ,  C12Q1/48

Abstract: The present invention provides a medicament for improving or preventing a symptom relating to a retina and/or light reception, the medicament comprising, as an active ingredient, a substance capable of maintaining or enhancing the phosphorylation state of Unc119; a method for screening for a substance capable of improving or preventing a symptom relating to a retina and/or light reception, the method comprising the step of selecting a substance capable of inhibiting calcineurin, or selecting a substance capable of activating casein kinase 2; and an agent for inhibiting retinal degeneration and an agent for protecting a retina, the agents each comprising, as an active ingredient, a substance capable of maintaining or enhancing the phosphorylation state of Unc119.

公开(公告)号：US11151903B2

公开(公告)日：2021-10-19

申请号：US16929825

申请日：2020-07-15

Applicant: OSAKA UNIVERSITY ,  JMC CORPORATION

Inventor： Keita Okayama ,  Shinsuke Nanto ,  Yasushi Sakata ,  Daichi Watanabe ,  Makoto Inada ,  Munekuni Sato

IPC: G09B23/30 ,  G09B23/28 ,  G09B9/00 ,  G06T7/00 ,  G09B23/32

Abstract: An imaging method for a catheter having a heart model, the heart model being installed in a container in a state of having the container filled with a liquid, and being provided with coronary arteries and an aorta. The imaging method includes causing a chemical reaction between an injection agent injected into the coronary arteries through a catheter, and the liquid in the container, and changing the color of the injection agent to the same color as that of the liquid.

公开(公告)号：US20210317233A1

公开(公告)日：2021-10-14

申请号：US17264496

申请日：2019-07-31

Applicant: The University of Tokyo ,  Osaka University

Inventor： Hiroaki Suga ,  Junichi Takagi

IPC: C07K16/46 ,  C07K16/28

Abstract: The purpose of the present invention is to provide an efficient and versatile method for granting an additional binding activity to an antibody by inserting a peptide sequence into the antibody. The present invention provides a method of granting a binding ability to a second target molecule to an antibody, comprising inserting an internal peptide sequence of a cyclic peptide into an Fc region of the antibody, wherein the cyclic peptide has the binding ability to the second target molecule different from a first target molecule to be recognized by the antibody.