公开(公告)号：US06572564B2

公开(公告)日：2003-06-03

申请号：US09836151

申请日：2001-04-17

Applicant: Narushi Ito ,  Akio Ohashi

Inventor： Narushi Ito ,  Akio Ohashi

IPC: A61B500

CPC classification number: A61B5/201 ,  A61B5/0002 ,  A61B5/14507 ,  A61B5/20 ,  A61B10/007 ,  G06F19/00 ,  Y10S128/92

Abstract: A system for providing a home health care service includes a health care center, a service recipient device, and the Internet that connects these components. The health care center: is constructed on the Internet; includes a database for registering personal data that are necessary for the health care of registered at-home patients as basic health care data and storing measurement data that are provided from at-home patients over the course of time; and has the functions of inferring the health conditions of at-home patients based on the measurement data as well as the basic health care data and offering services necessary for health care or services appropriate for inferred health conditions, to at-home patients. The service recipient device includes a biosensor and a signal processor. The biosensor detects chemical components contained in a substance that is discharged from the human body and converts detected values to electrical signals at the point of discharge. The signal processor performs processing of the output of the biosensor to automatically generate measurement data and transmits the measurement data to the health care center by way of the Internet. Chosen Drawing: FIG. 5

Abstract translation: 用于提供家庭保健服务的系统包括保健中心，服务接收设备和连接这些组件的因特网。 保健中心：在互联网上建成; 包括用于登记登记的在家患者的医疗保健所需的个人数据的数据库作为基本卫生保健数据，并存储在家庭病人随时间提供的测量数据; 并具有根据测量数据以及基本医疗保健数据推荐家庭病人健康状况的功能，并为家庭病人提供适合推断健康状况的医疗保健或服务所需的服务。 服务接收装置包括生物传感器和信号处理器。 生物传感器检测从人体排出的物质中含有的化学成分，并将检测值转换为放电点的电信号。 信号处理器执行生物传感器的输出处理，以自动生成测量数据，并通过因特网将测量数据发送到保健中心。 选择图： 5

公开(公告)号：US20010034483A1

公开(公告)日：2001-10-25

申请号：US09828429

申请日：2001-04-07

Inventor： Martin R. Prince

IPC: A61B005/055

CPC classification number: A61K49/18 ,  A61B5/201 ,  A61B5/411 ,  A61B5/416 ,  A61M5/007 ,  A61M5/1456 ,  A61M5/16827 ,  G01R33/281 ,  G01R33/5601 ,  G01R33/5619 ,  G01R33/563 ,  G01R33/56308 ,  G01R33/5635

Abstract: The present invention is a technique and apparatus for providing preferential enhancement of an artery of interest relative to adjacent veins and background tissue by correlating the collection of a predetermined portion of data of a magnetic resonance contrast image during the arterial phase of the magnetic resonance contrast enhancement. The arterial phase of the contrast enhancement may be described as a period of a maximum, substantially elevated, or elevated contrast concentration in the artery of interest relative to adjacent veins. The present invention includes a detection system for monitoring and detecting the arrival of the contrast agent in the artery and tissues of interest. When the concentration of contrast agent in the artery of the region of interest is maximum, substantially elevated or elevated (e.g., about 20-50% greater than the response of the region of interest to a series of magnetic resonance pulses before administration of a magnetic resonance contrast agent), a predetermined portion of the magnetic resonance image data (e.g., data which is representative of the center of k-space) may be acquired. Thus, the present invention facilitates synchronization between collecting the central portion of k-space image data with the arterial phase of contrast enhancement. The center of k-space corresponds to the lowest spatial frequency data which dominates image contrast.

Abstract translation: 本发明是一种通过将磁共振对比度增强的动脉期期间的磁共振对比度图像的预定部分数据的收集相关联来提供相对于相邻静脉和背景组织的感兴趣的动脉的优先增强的技术和装置 。 对比度增强的动脉期可以描述为相对于相邻静脉的感兴趣动脉中的最大，基本升高或升高的对比浓度的周期。 本发明包括用于监测和检测造影剂到动脉和感兴趣组织的检测系统。 当感兴趣区域的动脉中的造影剂的浓度最大时，基本升高或升高（例如，在给予磁性之前一系列磁共振脉冲的感兴趣区域的响应大约20-50％ 共振造影剂），可以获取磁共振图像数据的预定部分（例如，表示k空间的中心的数据）。 因此，本发明有助于将k空间图像数据的中心部分与对比度增强的动脉相位之间的同步。 k空间的中心对应于支配图像对比度的最低空间频率数据。

公开(公告)号：US06243600B1

公开(公告)日：2001-06-05

申请号：US09061102

申请日：1998-04-16

Applicant: Martin R. Prince

Inventor： Martin R. Prince

IPC: A61B5055

CPC classification number: A61B5/416 ,  A61B5/201 ,  A61B5/411 ,  A61B5/7285 ,  A61K49/18 ,  G01R33/281 ,  G01R33/5601 ,  G01R33/5619 ,  G01R33/563 ,  G01R33/56308

Abstract: The present invention is a method and apparatus for providing preferential enhancement of an artery of interest relative to adjacent veins and background tissue. The method and apparatus adapts the timing of a maximum or substantially elevated rate of infusion to correlate with the collection of image data corresponding to the center of k-space. The technique and apparatus temporally correlates the timing of a maximum or substantially elevated rate of infusion and the mapping of k-space according to the location of the artery of interest, the size of the artery of interest, the physical condition of the patient, the time delay due to the configuration of the contrast agent delivery system, and/or the type of pulse sequence employed by the imaging apparatus. Adapting the timing of a maximum or substantially elevated rate of infusion to correlate with the collection of image data corresponding to the center of k-space provides a period of a maximum or substantially elevated contrast concentration in the artery of interest relative to adjacent veins during collection of at least a portion of the image data corresponding to the center of k-space.

Abstract translation: 本发明是一种用于相对于相邻静脉和背景组织提供感兴趣的动脉的优先增强的方法和装置。 所述方法和装置使最大或基本上提高的输注速率的时间适应与对应于k空间中心的图像数据的收集相关。 技术和设备根据感兴趣的动脉的位置，感兴趣的动脉的大小，患者的身体状况，时间上相关联的最大或基本上升高的输注速率的时间和k空间的映射 由于造影剂传送系统的配置引起的时间延迟和/或成像装置采用的脉冲序列的类型。 适应最大或基本上提高的输注速率的时间与对应于k空间中心的图像数据的收集相关联，提供在收集期间相对于相邻静脉的感兴趣动脉中的最大或基本上升高的对比浓度的周期 的图像数据的至少一部分对应于k空间的中心。

公开(公告)号：US5846517A

公开(公告)日：1998-12-08

申请号：US790550

申请日：1997-01-30

Applicant: Evan C. Unger

Inventor： Evan C. Unger

IPC: A61K49/22 ,  A61K49/04

CPC classification number: A61B5/411 ,  A61K49/223 ,  A61K49/227 ,  A61B5/201

Abstract: A method for providing an image of an internal region of a patient has been developed. The method reduces imaging artifacts by providing enhanced contrast between tissue and blood during imaging. The method comprises administering to a patient a contrast agent in combination with a renal vasodilator and performing ultrasound imaging of the region. Renal disease, including renal arterial stenosis, may be diagnosed using the method.

Abstract translation: 已经开发了用于提供患者的内部区域的图像的方法。 该方法通过在成像期间通过提供组织和血液之间的增强的对比来减少成像伪像。 该方法包括向患者施用与肾血管扩张剂组合的造影剂并对该区域进行超声成像。 可以使用该方法诊断肾脏疾病，包括肾动脉狭窄。

公开(公告)号：US5799649A

公开(公告)日：1998-09-01

申请号：US715736

申请日：1996-09-19

Applicant: Martin R. Prince

Inventor： Martin R. Prince

IPC: A61K49/18 ,  G01R33/28 ,  G01R33/561 ,  G01R33/563 ,  A61B5/055

CPC classification number: A61K49/18 ,  A61B5/02007 ,  A61B5/055 ,  G01R33/563 ,  A61B5/201 ,  A61B5/416 ,  A61B5/7285 ,  G01R33/281 ,  G01R33/5619 ,  G01R33/56308

Abstract: The present invention is a technique and apparatus for acquiring anatomic information used in diagnosing and characterizing abdominal aortic aneurismal disease and the like. This technique provides anatomic information, in the form of images, using a combination of a plurality of magnetic resonance angiography sequences, including a spin-echo and four contrast enhanced (e.g., gadolinium) magnetic resonance angiography sequences. The anatomic images may be used in, for example, pre-operative, operative and post-operative evaluation of aortic pathology, including aneurysms, atherosclerosis, and occlusive disease of branch vessels such as the renal arteries. The gadolinium-enhanced magnetic resonance angiography provides sufficient anatomic detail to detect aneurysms and all relevant major branch vessel abnormalities seen at angiography operation. This technique and apparatus allows for imaging the aorta at a fraction of the cost of conventional aortography and without the risks of arterial catheterization or iodinated contrast.

公开(公告)号：US5746208A

公开(公告)日：1998-05-05

申请号：US689270

申请日：1996-08-06

Applicant: Martin R. Prince

Inventor： Martin R. Prince

IPC: A61K49/18 ,  G01R33/28 ,  G01R33/561 ,  G01R33/563 ,  A61B5/055

CPC classification number: A61B5/416 ,  A61B5/411 ,  A61K49/18 ,  G01R33/5601 ,  G01R33/563 ,  A61B5/201 ,  A61B5/7285 ,  G01R33/281 ,  G01R33/5619 ,  G01R33/56308

Abstract: The present invention is a method and apparatus for providing preferential enhancement of an artery of interest relative to adjacent veins and background tissue. The method and apparatus adapts the timing of a maximum or substantially elevated rate of infusion to correlate with the collection of image data corresponding to the center of k-space. The technique and apparatus temporally correlates the timing of a maximum or substantially elevated rate of infusion and the mapping of k-space according to the location of the artery of interest, the size of the artery of interest, the physical condition of the patient, the time delay due to the configuration of the contrast agent delivery system, and/or the type of pulse sequence employed by the imaging apparatus. Adapting the timing of a maximum or substantially elevated rate of infusion to correlate with the collection of image data corresponding to the center of k-space provides a period of a maximum or substantially elevated contrast concentration in the artery of interest relative to adjacent veins during collection of at least a portion of the image data corresponding to the center of k-space.

公开(公告)号：US4284073A

公开(公告)日：1981-08-18

申请号：US037766

申请日：1979-05-10

Applicant: Horst E. Krause ,  Edwin L. Stanley

Inventor： Horst E. Krause ,  Edwin L. Stanley

IPC: A61B5/0456 ,  A61F2/958 ,  A61M1/10 ,  A61M1/03

CPC classification number: A61M1/1086 ,  A61B5/0456 ,  A61B5/201 ,  A61M25/10 ,  A61M1/1037 ,  A61M1/1072

Abstract: A dynamically augmenting pump system incorporates a sealed liquid-filled catheter which is inserted into a vessel such as an artery, and the pump system is operated in timed relation with the heart to aid the heart during episodes of impairment or failure of cardiac function by producing higher frequency pulsation or pressure waves within the blood during diastole and during the isometric contraction period of the heart. This frequency of pulsation is adjusted to the dynamic transmission characteristics of a selected circulatory subsystem, such as the coronary vascular system, to assure the transmission of a maximum of pulsatile energy into the subsystem. The catheter provides energy to maintain adequate blood flow through the healthy part of the myocardium and has a passage for injecting successive quantities of medication into the coronary arteries. The pump system also functions to penetrate the ischemic myocardial tissue with arterial blood and medication. The pump system may also be used to provide enhanced perfusion for other parts of the systemic circulatory system, for example, to prevent such detrimental effects as renal failure. Any one or combination of the functions may be used depending on the special medical conditions of the patient.

Abstract translation: 动态增压泵系统结合了一个密封的充满液体的导管，该导管插入血管如动脉，并且泵系统以心脏的时间关系运作，以通过产生心脏功能障碍或失败的心脏来帮助心脏 在舒张期和心脏的等长收缩期间血液内的高频脉动或压力波。 这种脉动频率被调整到所选择的循环系统（例如冠状动脉血管系统）的动态传输特性，以确保将最大的脉冲能量传输到子系统中。 导管提供能量以维持足够的血液流过心肌的健康部分，并具有将连续量的药物注入冠状动脉的通道。 泵系统还用于通过动脉血和药物渗透缺血心肌组织。 泵系统还可以用于为系统循环系统的其它部分提供增强的灌注，例如以防止诸如肾衰竭的这种不利影响。 可以根据患者的特殊医疗条件使用任何一种或其组合的功能。

公开(公告)号：US4154227A

公开(公告)日：1979-05-15

申请号：US841017

申请日：1977-10-11

Applicant: Horst E. Krause ,  Edwin L. Stanley

Inventor： Horst E. Krause ,  Edwin L. Stanley

IPC: A61B5/0456 ,  A61F2/958 ,  A61M1/10 ,  A61M25/14 ,  A61B19/00

CPC classification number: A61M1/1086 ,  A61B5/0456 ,  A61B5/201 ,  A61M25/10 ,  A61M1/1037 ,  A61M1/1072

Abstract: A dynamically augmenting pump system incorporates a sealed liquid-filled catheter which is inserted into a vessel such as an artery, and the pump system is operated in timed relation with the heart to aid the heart during episodes of impairment or failure of cardiac function by producing higher frequency pulsation or pressure waves within the blood during diastole and during the isometric contraction period of the heart. This frequency of pulsation is adjusted to the dynamic transmission characteristics of a selected circulatory subsystem, such as the coronary vascular system, to assure the transmission of a maximum of pulsatile energy into the subsystem. The catheter provides energy to maintain adequate blood flow through the healthy part of the myocardium and has a passage for injecting successive quantities of medication into the coronary arteries. The pump system also functions to penetrate the ischemic myocardial tissue with arterial blood and medication. The pump system may also be used to provide enhanced perfusion for other parts of the systemic circulatory system, for example, to prevent such detrimental effects as renal failure. Any one or combination of the functions may be used depending on the special medical conditions of the patient.

Abstract translation: 动态增压泵系统结合了一个密封的充满液体的导管，该导管插入血管如动脉，并且泵系统以心脏的时间关系运作，以通过产生心脏功能障碍或失败的心脏来帮助心脏 在舒张期和心脏的等长收缩期间血液内的高频脉动或压力波。 这种脉动频率被调整到所选择的循环系统（例如冠状动脉血管系统）的动态传输特性，以确保将最大的脉冲能量传输到子系统中。 导管提供能量以维持足够的血液流过心肌的健康部分，并具有将连续量的药物注入冠状动脉的通道。 泵系统还用于通过动脉血和药物渗透缺血心肌组织。 泵系统还可以用于为系统循环系统的其它部分提供增强的灌注，例如以防止诸如肾衰竭的这种不利影响。 可以根据患者的特殊医疗条件使用任何一种或其组合的功能。

公开(公告)号：US4073292A

公开(公告)日：1978-02-14

申请号：US736996

申请日：1976-10-29

Applicant: William Edelman

Inventor： William Edelman

IPC: A61B5/20 ,  A61M5/142 ,  A61M5/172 ,  A61M5/00

CPC classification number: A61B5/201 ,  A61B5/14507 ,  A61M5/1723 ,  A61M5/14276 ,  Y10S128/13

Abstract: The control apparatus of the invention comprises a feedback system to maintain the level of glucose in a diabetic within predetermined limits. Surgically implanted in the body are a means for sensing glucose levels and a means for dispensing insulin in an amount determined by the sensing mechanism. The sensing mechanism employs a chemical solution, which, like the insulin, is stored within a reservoir forming part of the surgical implant. Means are additionally provided to couple these reservoirs to the surface of the skin so as to permit their rechargings at regular time intervals. Integrated circuit technology is employed to translate an indication of an unacceptable glucose level into an automatic injection of insulin, with the electronics being of the type capable of being powered by batteries of the kind employed in pacemaker technology.

Abstract translation: 本发明的控制装置包括将糖尿病患者的葡萄糖水平维持在预定限度内的反馈系统。 手术植入体内是用于检测葡萄糖水平的装置和用于由感测机构确定的量分配胰岛素的装置。 感测机构使用化学溶液，其像胰岛素一样储存在形成手术植入物的一部分的储液器中。 另外提供了将这些储存器联接到皮肤表面的装置，以便允许它们以规则的时间间隔进行充电。 采用集成电路技术将不可接受的葡萄糖水平的指示转化为胰岛素的自动注射，其中电子装置的类型能够由起搏器技术中采用的电池供电。

公开(公告)号：US2626385A

公开(公告)日：1953-01-20

申请号：US17339050

申请日：1950-07-12

Applicant: THOMAS SCHUMANN ROBERT

Inventor： THOMAS SCHUMANN ROBERT

IPC: A61B5/20

CPC classification number: A61B5/201 ,  A61B5/208 ,  Y10T137/7287 ,  Y10T137/86389