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    Ultrasound Device and Method Using Same
    4.
    发明申请
    Ultrasound Device and Method Using Same 审中-公开
    超声波装置及其使用方法

    公开(公告)号：US20080194954A1

    公开(公告)日：2008-08-14

    申请号：US11570227

    申请日：2005-06-10

    Applicant: Evan C. Unger ,  Terry O. Matsunaga ,  Reena Zutshi

    Inventor： Evan C. Unger ,  Terry O. Matsunaga ,  Reena Zutshi

    IPC: A61B8/13 ,  A61N7/00

    CPC classification number: A61B17/22012 ,  A61N7/02 ,  A61N2007/0078

    Abstract: An ultrasound energy emitting apparatus is disclosed. The ultrasound energy emitting apparatus comprises a hand-held enclosure and a plurality of ultrasound transducers disposed on that enclosure, or disposed within and extending outwardly from the enclosure. The plurality of ultrasound transducers can be operated simultaneously, or in a programmed fashion whereunder one or more of, but fewer than all, of the transducers emit ultrasound energy at one time.

    Abstract translation: 公开了一种超声能量发射装置。 超声能量发射装置包括手持外壳和设置在该外壳上的多个超声波换能器，或设置在外壳内并从外壳向外延伸。 多个超声换能器可以同时操作或以编程方式操作，其中一个或多个，但少于全部的换能器一次发射超声能量。

    Composition comprising low density microspheres
    5.
    发明授权
    Composition comprising low density microspheres 失效
    组合物包含低密度微球

    公开(公告)号：US07344705B2

    公开(公告)日：2008-03-18

    申请号：US11252659

    申请日：2005-10-18

    Applicant: Evan C. Unger

    Inventor： Evan C. Unger

    IPC: A61K49/00 ,  A61K9/14

    CPC classification number: A61K49/0419 ,  Y10T428/2982 ,  Y10T428/31862

    Abstract: Low density microspheres, methods for preparing same, and use of same as contrast agents are described. The microspheres have a void which contains a gas or the vapor of a volatile liquid selected from the group consisting of aliphatic hydrocarbons, chlorofluorocarbons, tetraalkyl silanes and perfluorocarbons.

    Abstract translation: 描述低密度微球，其制备方法及其作为造影剂的用途。 微球体具有空隙，其含有选自脂族烃，氯氟烃，四烷基硅烷和全氟化碳的挥发性液体的气体或蒸汽。

    Ultrasound imaging and treatment
    6.
    发明授权
    Ultrasound imaging and treatment 失效
    超声成像和治疗

    公开(公告)号：US07078015B2

    公开(公告)日：2006-07-18

    申请号：US10983406

    申请日：2004-11-08

    Applicant: Evan C. Unger

    Inventor： Evan C. Unger

    IPC: A61B8/00

    CPC classification number: A61K9/1278 ,  A61B2017/00716 ,  A61B2017/22088 ,  A61K9/127 ,  A61K9/1277 ,  A61K41/0028 ,  A61K41/0052 ,  A61K47/6911 ,  A61K47/6925 ,  A61K49/1815 ,  A61K49/22 ,  A61K49/223 ,  A61K49/227 ,  A61M5/3145 ,  A61M2202/0476 ,  A61N7/02 ,  A61N2007/025

    Abstract: Methods of and apparatus for preparing temperature activated gaseous precursor-filled liposomes are described. Gaseous precursor-filled liposomes prepared by these methods are particularly usefull for example, in ultrasonic imaging applications and in therapeutic drug delivery systems.Gas, gaseous precursors and perfluorocarbons are presented as novel potentiators for ultrasonic hyper-thermia. The gas, gaseous precursors and perfluorocarbons which may be administered into the vasculature, interstitially or into any body cavity are designed to accumulate in cancerous and diseased tissues. When therapeutic ultrasonic energy is applied to the diseased region heating is increased because of the greater effectiveness of sound energy absorption caused by these agents.

    Abstract translation: 描述了制备温度活化气态前体填充脂质体的方法和装置。 通过这些方法制备的气态前体填充脂质体在超声成像应用和治疗药物递送系统中特别有用。 气体，气体前体和全氟化碳被提出作为超声超热的新型增效剂。 可以施用到脉管系统，间质或任何体腔内的气体，气体前体和全氟化碳被设计成积累在癌和组织中。 当将治疗性超声能量应用于患病区域时，由于这些药剂引起的声能吸收的效力更高，因此加热是增加的。

    Methods and systems for applying multi-mode energy to biological samples
    8.
    发明授权
    Methods and systems for applying multi-mode energy to biological samples 失效
    将多模式能量应用于生物样品的方法和系统

    公开(公告)号：US06627421B1

    公开(公告)日：2003-09-30

    申请号：US09827583

    申请日：2001-04-05

    Applicant: Evan C. Unger ,  Yunqiu Wu ,  Thomas McCreery

    Inventor： Evan C. Unger ,  Yunqiu Wu ,  Thomas McCreery

    IPC: C12N1300

    CPC classification number: C12M35/04 ,  C12M35/02 ,  C12N15/87

    Abstract: A system for applying energy to cells so as to elicit the formation of pores, to enhance transfection, and/or cell transformation, includes a computer, a plurality of acoustic probes for controllably applying acoustic energy to batches of cells, and a robot operatively for effecting relative movement between the probes and the batches of cells. Preferably, the acoustic energy comprises ultrasonic energy, which is applied in combination with optical or electrical energy to enhance the formation of pores in surface membranes of the cells.

    Abstract translation: 用于向细胞施加能量以引起孔的形成，增强转染和/或细胞转化的系统包括计算机，用于可控地将声能施加到批次的细胞的多个声探针，以及用于 影响探针和批次的细胞之间的相对运动。 优选地，声能包括超声能量，其与光学或电能结合使用以增强细胞表面膜中孔隙的形成。

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