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    Method and apparatus for verifying proper operation of a photometric device, such as a cell density probe
    141.
    发明申请
    Method and apparatus for verifying proper operation of a photometric device, such as a cell density probe 有权
    用于验证诸如细胞密度探针的测光装置的正确操作的方法和装置

    公开(公告)号：US20050264816A1

    公开(公告)日：2005-12-01

    申请号：US10856885

    申请日：2004-05-27

    Applicant: Paul Williams

    Inventor： Paul Williams

    IPC: C12M1/34 ,  G01J1/32 ,  G01N21/27 ,  G01N21/53 ,  G01N21/85 ,  G01B9/02

    CPC classification number: G01N21/534 ,  G01N21/274 ,  G01N21/4785 ,  G01N21/8507 ,  G01N2021/8535 ,  G01N2201/0218 ,  G01N2201/024 ,  G01N2201/1242 ,  G01N2201/12746

    Abstract: An in-situ technique is provided for automatically verifying proper operation of a photometric device, such as a cell density probe (CDP). The CDP has a first detector and a second detector. The first detector senses light that is transmitted from a light source of the CDP. The second detector senses light that has passed through an optical gap at a tip of the CDP, wherein the sensed light has been reduced in intensity due to light absorption. Electrical current provided to the light source is reduced, and the resultant values of a light characteristic (such as intensity) at the first and second detectors are sensed. These values from the detectors are compared against one or more predicted values. If the CDP is operating properly, the values from the detectors will be consistent with the predicted values. If there is a malfunction in the CDP, then the values from the detectors will be inconsistent with the predicted values.

    Abstract translation: 提供了用于自动验证诸如细胞密度探针（CDP）的光度测量装置的正确操作的原位技术。 CDP具有第一检测器和第二检测器。 第一检测器感测从CDP的光源传输的光。 第二检测器感测已经通过CDP顶端的光学间隙的光，其中感测的光由于光吸收而被强度降低。 提供给光源的电流减小，并且感测在第一和第二检测器处的​​光特性（例如强度）的合成值。 来自检测器的这些值与一个或多个预测值进行比较。 如果CDP正常工作，检测器的值将与预测值一致。 如果CDP出现故障，则检测器的值将与预测值不一致。

    Universal optical imaging and processing system
    142.
    发明申请
    Universal optical imaging and processing system 有权
    通用光学成像和处理系统

    公开(公告)号：US20050201898A1

    公开(公告)日：2005-09-15

    申请号：US11127717

    申请日：2005-05-12

    Applicant: Damon Borich ,  Steve Savoy ,  Michael McAleer ,  Andrew Milder ,  Daniel Mitchell

    Inventor： Damon Borich ,  Steve Savoy ,  Michael McAleer ,  Andrew Milder ,  Daniel Mitchell

    IPC: G01N21/00

    CPC classification number: G01N21/78 ,  G01N21/81 ,  G01N2201/0221 ,  G01N2201/024

    Abstract: The disclosure is directed to a test media reader module including a housing, a membrane, and an optical imager. The housing is configured to receive a test media adapter and has a barrier wall configured to separate the test media adapter from an interior of the housing. The barrier wall includes a window having an interior side and an exterior side. The membrane is transparent to a wavelength useful for imaging test media in the test media adapter. The membrane has a reactive region and overlies at least a portion of the exterior side of the window. The optical imager is located interior to the housing and is configured to image the test media located on the exterior side of the window along an optical path extending through the window and the membrane.

    Abstract translation: 本公开涉及包括壳体，膜和光学成像器的测试介质读取器模块。 壳体被配置为接收测试介质适配器并且具有被配置为将测试介质适配器与壳体的内部分离的阻挡壁。 阻挡壁包括具有内侧和外侧的窗。 该膜对于用于在测试介质适配器中成像测试介质的波长是透明的。 膜具有反应性区域并且覆盖在窗口的外侧的至少一部分上。 光学成像器位于壳体的内部，并被配置成沿着沿窗口和膜延伸的光路对位于窗口外侧的测试介质进行成像。

    Fluorometer
    143.
    发明申请
    Fluorometer 审中-公开
    荧光计

    公开(公告)号：US20050105080A1

    公开(公告)日：2005-05-19

    申请号：US10491730

    申请日：2002-05-23

    Applicant: Richard Landlinger

    Inventor： Richard Landlinger

    IPC: G01N21/25 ,  G01N21/64 ,  G01N21/00

    CPC classification number: G01N21/6452 ,  G01N21/6445 ,  G01N2021/6463 ,  G01N2021/6471 ,  G01N2021/6484 ,  G01N2201/024

    Abstract: A fluorometer with at least one light source, a measuring station with a holder for at least one specimen, a measuring head, and an evaluation station with a detector for evaluating emission signals emitted by a specimen. The measuring head is formed by three optical blocks (A, B, C) assembled in a modular manner. A different measurement method is able to be carried out with each optical block (A, B, C). All the optical blocks (A, B, C) operate the same detector.

    Abstract translation: 具有至少一个光源的荧光计，具有用于至少一个样本的保持器的测量站，测量头和具有用于评估由样本发射的发射信号的检测器的评估站。 测量头由以组合方式组装的三个光学块（A，B，C）形成。 可以用每个光学块（A，B，C）进行不同的测量方法。 所有光学块（A，B，C）操作相同的检测器。

    Instrumentation for optical measurement of samples
    145.
    发明申请
    Instrumentation for optical measurement of samples 审中-公开
    样品光学测量仪器

    公开(公告)号：US20040057870A1

    公开(公告)日：2004-03-25

    申请号：US10247632

    申请日：2002-09-20

    Inventor： Christer Isaksson ,  Markku Ojala ,  Janne Salonen

    IPC: G01N021/76

    CPC classification number: G01N21/6452 ,  G01N21/253 ,  G01N21/76 ,  G01N2201/024

    Abstract: The present invention relates generally to the field of biochemical laboratory. More particularly the invention relates to the improved and more accurate instrumental features of equipment used as e.g. fluorometers, photometers and luminometers. The object of the invention is achieved by providing an optical measurement instrument for photoluminescence and chemiluminescence measurements wherein there is chemiluminescence detector in such a proximity to the sample that the emission radiation from the sample may reach the detector via a direct path. This way it is possible to achieve an essentially improved accuracy of the chemiluminescence measurement as well as an improved overall efficiency of the optical measurements.

    Abstract translation: 本发明一般涉及生化实验室领域。 更具体地，本发明涉及用于例如设备的改进和更精确的设备的功能。 荧光计，光度计和光度计。 本发明的目的是通过提供用于光致发光和化学发光测量的光学测量仪器来实现，其中在样品附近存在化学发光检测器，使得来自样品的发射辐射可以经由直接路径到达检测器。 以这种方式，可以实现化学发光测量的基本上提高的准确度以及改进的光学测量的总体效率。

    Imaging system with a cylindrical lens array
    147.
    发明授权
    Imaging system with a cylindrical lens array 失效
    具有柱面透镜阵列的成像系统

    公开(公告)号：US06473239B2

    公开(公告)日：2002-10-29

    申请号：US09835172

    申请日：2001-04-12

    Applicant: Martin Völcker ,  Christof Fattinger

    Inventor： Martin Völcker ,  Christof Fattinger

    IPC: G02B2710

    CPC classification number: G01N21/6452 ,  G01N21/253 ,  G01N2201/024 ,  G02B3/005 ,  G02B3/0068 ,  G02B5/045

    Abstract: The invention relates to an imaging system for optical automatic analysers, especially fluorescence readers. On the sample side, the imaging system contains a cylindrical lens array and a prism array, which is arranged upstream of the cylindrical lens array. The prismatic effect of the prisms of the prism array lies in the direction of the cylinder axes of the cylindrical lenses. Together with a telescopic imaging system, the inventive imaging system creates a number of parallel cylindrical focussing volumes between the cylindrical lens array and a detector array, these focussing volumes being slanted towards the optical axis of the telescopic system in relation to the vertical. The arrangement enables the detection of fluorescence with a large aperture in one direction, and at the same time enables depth selective analysis of the fluorescence signal, especially the discrimination of the fluorescent radiation originating from the solution above.

    Abstract translation: 本发明涉及一种用于光学自动分析仪，特别是荧光读取器的成像系统。 在样本侧，成像系统包括柱面透镜阵列和棱镜阵列，其布置在柱面透镜阵列的上游。 棱镜阵列的棱镜的棱镜效应位于柱面透镜的圆柱轴线的方向上。 与可伸缩成像系统一起，本发明的成像系统在柱面透镜阵列和检测器阵列之间产生多个平行的圆柱形聚焦体积，这些聚焦体积相对于垂直方向朝伸缩系统的光轴倾斜。 该装置能够在一个方向上检测具有大孔径的荧光，并且同时能够对荧光信号进行深度选择性分析，特别是鉴别源于上述溶液的荧光辐射。

    Microscope for use in modular FTIR spectrometer system
    148.
    发明授权
    Microscope for use in modular FTIR spectrometer system 失效
    显微镜用于模块化FTIR光谱仪系统

    公开(公告)号：US4852955A

    公开(公告)日：1989-08-01

    申请号：US907993

    申请日：1986-09-16

    Applicant: Walter M. Doyle ,  Norman S. Hughes

    Inventor： Walter M. Doyle ,  Norman S. Hughes

    IPC: G01N21/35 ,  G02B21/18

    CPC classification number: G01N21/35 ,  G02B21/18 ,  G01N2021/1738 ,  G01N2021/3595 ,  G01N21/359 ,  G01N21/474 ,  G01N2201/024

    Abstract: A microscopic unit for a multi-station modular FTIR spectrometer system is disclosed. The microscope unit, which has a Cassegrain objective, not only provides the usual optical path for radiation during visual observation, and for infrared radiation in the transmission mode, but also provides a separate optical path for infrared radiation in the reflectance mode and in a macroscopic transmission mode. An optical switching wheel is in the path of entering radiation, which may enter through any of three ports; and the wheel is movable into a plurality of alternative positions, including a position in which radiation entering through one port passes through the wheel toward the objective, a position in which radiation entering through the same port is reflected by a wheel-carried mirror along the separate optical path, a position in which a wheel-carried mirror causes radiation to bypass the microscope, and positions in which other wheel-carried mirrors reflect into the microscope radiation entering through other ports.

    Abstract translation: 公开了一种用于多工位模块化FTIR光谱仪系统的微观单元。 具有卡塞格林目标的显微镜单元不仅在视觉观察期间提供通常的辐射光路，而且在透射模式下提供用于红外辐射的通常光路，而且还提供用于反射模式和宏观上的红外辐射的单独光路 传输模式。 光学切换轮处于进入辐射的路径，其可以通过三个端口中的任一个进入; 并且车轮可移动到多个替代位置，包括通过一个端口进入的辐射通过车轮朝向物镜的位置，其中通过相同端口进入的辐射被沿着沿着车轮的镜子反射的位置 单独的光路，轮式镜面引起辐射绕过显微镜的位置，以及其他车轮镜反射到通过其他端口进入的显微镜辐射的位置。

    Combination teaching aid and modular instrumental analysis system and components therefor
    149.
    发明授权
    Combination teaching aid and modular instrumental analysis system and components therefor 失效
    组合教学辅助和模块化仪器分析系统及其组件

    公开(公告)号：US3554648A

    公开(公告)日：1971-01-12

    申请号：US3554648D

    申请日：1967-12-29

    Applicant: SARGENT WELCH SCIENTIFIC CO

    Inventor： BOOSTROM ROY E ,  MANDELL ARMAN ,  MALTER LEWIS

    IPC: G01J3/02 ,  G01N21/25 ,  G09B23/22 ,  G01J3/42 ,  G01J3/48 ,  G09B23/24

    CPC classification number: G01J3/02 ,  G01J3/021 ,  G01J3/0291 ,  G01N21/253 ,  G01N2201/024 ,  G09B23/22

    Abstract: A COMBINATION TEACHING AID AND MODULAR INSTRUMENTAL ANALYSIS SYSTEM IN WHICH A PLURALITY OF MODULES ARE PROVIDED, EACH HAVING A SEPARATE FUNCTION, AND IN WHICH THE DIFFERENT MODULES ARE ADAPTED TO BE PLACE TOGETHER IN DIFFERENT COMBINATION TO PROVIDE DIFFERENT OPTICAL ANALYSIS INSTRUMENTS. THE MODULES INCLUDE A LIGHT SOURCE FOR PROVIDING LIGHT, A DETECTOR MODULE FOR RECEIVING LIGHT WHICH HAS BEEN EXPOSED TO A SAMPLE COMPARTMENT MODULE WHICH RECEIVES ONE OR MORE SAMPLES TO BE ANALYZED, AND MAY INCLUDE DISPLAY MEANS IN THE FORM OF A METER OR THE LIKE FOR READING THE OUTPUT OF THE DETECTOR MODULE. THE COMBINATION MAY ALSO INCLUDE A MONOCHROMATOR UNIT FOR PROVIDING SUBSTANTIALLY MONOCHROMATIC LIGHT, AND A FILTER MODULE WHICH IS ADAPTED TO CONTAIN ONE OR MORE FILTERS THROUGH WHICH A LIGHT BEAM MAY BE PASSED FOR OBTAINING A BEAM OF DESIRED FREQUENCY. DIFFERENT ARRANEMENTS OF THE VARIOUS MODULES WILL PRODUCE A SPECTROPHOTOMETER, A FILTER PHOTOMETER, OR A NEPHELOMETER. THE DESCRIBED MODULE UNITS ARE ARRANGED SO THAT AT LEAST SOME OF THEM MAY BE DISPOSED ON A BASE AND OPTICALLY ALIGNED BY MEANS OF COMBINATION ADJUSTING AND CLAMPING MEANS, SO THAT THE UNITS MAY BE THERE AFTER MOVED, OR REPLACED AS DESIRED WITHOUT AFFECTING THE ALINGMENT THEREOF. THE DESCRIBED UNITS ARE CONSTRUCTED AND ARRANGED SO THAT ALL THE SIGNIFICANT OPERATIONAL AND FUNCTIONAL PROPERTIES OF EACH MODULE MAY BE DIRECTLY OBSERVED BY THE STUDENT. THEREFORE, EACH MODULE IS ADAPTED TO PERFORM A MINIMUM NUMBER OF FUNCTIONS, AND THE MODULAR CONCEPT AND THE CONSTRUCTION FEATURES ARE USED AS A TEACHING AID USED TO EMPHASIZE THE RELATION BETWEEN VARIOUS SYSTEMS OF OPTICAL INSTRUMENTAL ANAYLSIS. THE FILTER COMPARTMENT MODULE AND THE SAMPLE COMPARTMENT MODULE INCLUDE HOLDER MEANS FOR HOLDING LIGHT FILTERS OR SAMPLE UNITS, AND THE HOLDER UNIT IS CONSTRUCTED SO AS TO FACILITATE INTERCHANGE OF SAMPLE HOLDERS AND FILTER UNITS, AND TO BE ADAPTED FOR USE WITHOUT CHANGE TO PERFORM DIFFERENT FUNCTIONS IN DIFFERENT INSTRUMENATAL COMBINATIONS.

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