公开(公告)号：US4958529A

公开(公告)日：1990-09-25

申请号：US440230

申请日：1989-11-22

Applicant: Marvin L. Vestal

Inventor： Marvin L. Vestal

IPC: G01N30/28 ,  G01N30/30 ,  G01N30/60 ,  G01N30/72 ,  G01N30/84 ,  H01J49/04

CPC classification number: G01N30/84 ,  G01N30/7273 ,  H01J49/044 ,  G01N2030/3038 ,  G01N2030/6013 ,  G01N2030/8423 ,  G01N2030/8447 ,  G01N30/72 ,  G01N30/7293 ,  G01N30/74

Abstract: An improved interface is provided for receiving effluent from a chromatographic device and outputting sample particles of interest to a detector for analysis. The interface includes a gas diffusion cell having a membrane therein separating the cell into an aerosol flow chamber and a sweep gas flow chamber. The effluent is sprayed as an aerosol into the aerosol flow chamber, and vaporized solvent diffuses through the gas membrane into the sweep gas flow chamber while particles of interest are output to the detector. Sweep gas is passed through the sweep gas flow chamber for removing the solvent vapor, and the flow rate of sweep gas is controlled to achieve little or no net flow of gas across the membrane. Efficient solvent removal may be achieved at room temperature for certain LC flow rates, and high detector resolution is possible by maintaining laminar flow of the carrier gas through the aerosol flow chamber.

Abstract translation: 提供了一种改进的界面，用于接收色谱装置的流出物，并将感兴趣的样品颗粒输出到检测器进行分析。 该界面包括一个气体扩散池，该气体扩散池具有一个隔膜，将该隔室分离成一个气溶胶流动室和一个吹扫气流室。 将流出物作为气溶胶喷射到气溶胶流动室中，并且蒸发的溶剂通过气体膜扩散到吹扫气体流动室中，同时将感兴趣的颗粒输出到检测器。 扫气通过吹扫气流室以除去溶剂蒸气，并且控制吹扫气体的流速以实现很少的或没有净流过膜的气体。 在室温下可以在某些LC流速下实现有效的溶剂去除，并且可以通过保持载气的层流通过气溶胶流动室来实现高检测器分辨率。