公开(公告)号：US20210393860A1

公开(公告)日：2021-12-23

申请号：US17336321

申请日：2021-06-02

Applicant: KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY

Inventor： Joonseok LEE ,  Eunyoung JEON

IPC: A61L31/08 ,  A61L31/16

Abstract: Provided are a method of manufacturing a stent for drug release that may be coated with a drug by forming a 3D nanostructured film on the surface of a stent and a stent for drug release manufactured thereby, more particularly, a method of manufacturing a stent for drug release including: (a) preparing a stent, (b) forming a 3D nanostructured film on a surface of the stent; and (c) surface-treating the 3D nanostructured film, and a stent for drug release manufactured thereby.

公开(公告)号：US20210371742A1

公开(公告)日：2021-12-02

申请号：US17319095

申请日：2021-05-13

Applicant: KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY

Inventor： Seung Hee HAN ,  Sung Ju HAN ,  Min SEO ,  Min Gyeong CHO

IPC: C09K11/65 ,  C23C14/48 ,  C23C14/06 ,  C23C14/58 ,  C01B32/28 ,  C01B32/26

Abstract: The present invention relates to a fluorescent nanodiamond preparing method including a first operation of preparing nanodiamonds having an average particle diameter of 10 nm or less, a second operation of implanting plasma ions into the nanodiamonds, a third operation of heat-treating the nanodiamonds implanted with the plasma ions under a vacuum or inert gas atmosphere, a fourth operation of oxygen treatment of the heat-treated nanodiamonds under a gas atmosphere including oxygen to oxidize the surfaces of the nanodiamonds, a fifth operation of acid-treating the oxygen-treated nanodiamonds, a sixth operation of centrifuging and cleaning the acid-treated nanodiamonds, and a seventh operation of drying the cleaned nanodiamonds, wherein, in the second operation, the plasma ions are implanted at an incident ion dose of 1013 ions/cm2 or more and 1020 ions/cm2 or less.

公开(公告)号：US20210371515A1

公开(公告)日：2021-12-02

申请号：US16771918

申请日：2020-03-10

Applicant: KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY ,  THE ASAN FOUNDATION ,  UNIVERSITY OF ULSAN FOUNDATION FOR INDUSTRY COOPERATION

Inventor： Mihue JANG ,  Eunsung JUN ,  Anna JU

IPC: C07K16/28 ,  C12N5/0783 ,  C07K14/705 ,  C07K14/725 ,  A61P35/00 ,  C12N15/86 ,  A61K35/17

Abstract: Provided are a genetically modified immunocyte expressing a chimeric antigen receptor (CAR) comprising an antigen binding domain specifically binding to cancer cells and/or expressing TRAIL, a composition for preventing or treating cancer, the composition comprising the immunocytes, a cell therapeutic agent, a method of providing information for cancer diagnosis, and a method of preparing the genetically modified immunocyte.

公开(公告)号：US20210370393A1

公开(公告)日：2021-12-02

申请号：US16921254

申请日：2020-07-06

Applicant: KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY

Inventor： Ji Won LEE ,  Soo Yeol PHYO ,  Sun CHOI ,  Sung CHOI

IPC: B22F3/24 ,  C09D183/04 ,  B22F3/105 ,  B33Y10/00 ,  B33Y40/20 ,  C22C14/00

Abstract: Embodiments of the present disclosure provide a method of manufacturing a metal column using 3D printing technology. The method of manufacturing a metal column includes steps of: creasing a 3D-CAD design for printing the metal column; printing the metal column; pretreating the inner surface of a channel inside the metal column at low temperature; and coating the inner surface of the channel with a stationary phase so that the metal column is capable of separating a gas mixture into components.

公开(公告)号：US11186776B2

公开(公告)日：2021-11-30

申请号：US16538831

申请日：2019-08-13

Applicant: KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY

Inventor： Hong Jin Lim ,  Nam Ho You ,  Seokhoon Ahn ,  Munju Goh ,  Se Gyu Jang ,  Myung Jong Kim

IPC: C09K19/38 ,  C08K3/013 ,  C08K3/14 ,  C08K3/22 ,  C08K3/28 ,  C08L63/00

Abstract: The present disclosure relates to a high thermal conductive polymer composite, comprising: a liquid crystalline resin comprising a mesogen and at least one linear polymerization reactive group, wherein the liquid crystalline resin is cured with a linear polymerization initiator and includes a molecular structure aligned in at least one direction.

公开(公告)号：US11173481B2

公开(公告)日：2021-11-16

申请号：US16534216

申请日：2019-08-07

Applicant: KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY ,  GLOBAL FRONTIER CENTER FOR MULTISCALE ENERGY SYSTEMS

Inventor： Sung Jong Yoo ,  Injoon Jang ,  Hee-Young Park ,  So Young Lee ,  Hyun Seo Park ,  Jin Young Kim ,  Jong Hyun Jang ,  Hyoung-Juhn Kim

IPC: B01J37/34 ,  B01J23/50 ,  B01J23/52 ,  B01J37/02 ,  H01M4/90 ,  H01M4/88

Abstract: Disclosed are a metal single-atom catalyst and a method for preparing the same. The method uses a minimal amount of chemicals and is thus environmentally friendly compared to conventional chemical and/or physical methods. In addition, the method enables the preparation of a single-atom catalyst in a simple and economical manner without the need for further treatment such as acid treatment or heat treatment. Furthermore, the method is universally applicable to the preparation of single-atom catalysts irrespective of the kinds of metals and supports, unlike conventional methods that suffer from very limited choices of metal materials and supports. Therefore, the method can be widely utilized to prepare various types of metal single-atom catalysts. All metal atoms in the metal single-atom catalyst can participate in catalytic reactions. This optimal atom utilization achieves maximum reactivity per unit mass and can minimize the amount of the metal used, which is very economical.

公开(公告)号：US20210340240A1

公开(公告)日：2021-11-04

申请号：US17283607

申请日：2019-10-17

Applicant: INSERM (Institut National de la Santé et de la Recherche Médicale ,  Centre National de la Recherche Scientifique (CNRS) ,  Université Claude Bernard - Lyon 1 ,  Centre Leon Berard ,  KIST (Korea Institute of Science and Technology)

Inventor： Ana HENNINO

IPC: C07K16/22 ,  C07K16/28 ,  A61P35/04

Abstract: To study the mechanism of βig-h3 modulation of the anti-tumoral immune response in pancreatic cancer, Inventors took advantage of engineered mouse models of spontaneous pancreatic neoplasia and cancer to evaluate the effect of depleting βig-h3 on the modulation of anti-tumor immunity and its subsequent impact on tumour growth alone and in combination with an immune checkpoint inhibitor. This association proved to be effective in vivo in this model showing a synergic effect of the therapeutic combination. Accordingly, the present invention relates to a combination of (i) an immune checkpoint inhibitor, and (ii) a βig-h3 antagonist, for simultaneous or sequential use in the treatment of a patient suffering from solid tumor, e.g. a pancreatic cancer. The present invention also provides a βig-h3 antagonist, for use in a method for enhancing sensitivity of a patient suffering from a solid tumor to an immune checkpoint inhibitor.

公开(公告)号：US20210338759A1

公开(公告)日：2021-11-04

申请号：US17059595

申请日：2019-05-28

Applicant: KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY ,  SEOUL NATIONAL UNIVERSITY R&DB FOUNDATION ,  UNIVERSITY-INDUSTRY COOPERATION GROUP OF KYUNG HEE UNIVERSITY ,  KOREA ADVANCED INSTITUTE OF SCIENCE AND TECHNOLOGY ,  BIO-SYNERGY RESEARCH CENTER

Inventor： Hyun Ok YANG ,  Keon Wook KANG ,  Sung Won KWON ,  Jeong Hill PARK ,  Hocheol KIM ,  Myung Sook OH ,  Dae Sik JANG ,  Doheon LEE ,  Hak Cheol KWON ,  Byung Hwa JUNG

IPC: A61K36/54 ,  A61K36/268 ,  A61K36/346

Abstract: The present invention relates to a pharmaceutical composition for prevention or treatment of an allergic disease comprising a mixed extract of two or more selected from the group consisting of Asiasarum root, Platycodon root, and Cinnamomi ramulus as an active ingredient; a method for prevention or treatment of an allergic disease using the pharmaceutical composition; and a health functional food and a feed composition for improvement of an allergic disease.
The composition provided in the present invention comprising a mixed extract of two or more selected from the group consisting of Asiasarum root, Platycodon root, and Cinnamomi ramulus as an active ingredient can specifically inhibit the differentiation of Th2 cells and thus can be effectively used as a composition for prevention or treatment of an allergic disease.

公开(公告)号：US11154849B2

公开(公告)日：2021-10-26

申请号：US16255662

申请日：2019-01-23

Applicant: KOREA INSTITUTE OF SCIENCE AND TECHNOLOGY

Inventor： Ji Young Byun ,  Sang Hoon Kim ,  Jong Sik Kim

IPC: B01J35/04 ,  B01J23/86 ,  B01J37/08 ,  B01J37/02 ,  B01J21/02 ,  B01J35/00 ,  F01N3/00

Abstract: A method of manufacturing a honeycomb metal structure includes providing a substrate comprising iron (Fe) and a container containing water; coating at least a part of the substrate with a viscid material whose viscidity is increased by moisture; attaching metal powder onto the viscid material; adhering the metal powder to the substrate due to an increase in viscidity of the viscid material by evaporating a portion of the water in the container and supplying moisture to the viscid material; and generating an uneven structure made of the metal powder bonded to the substrate by performing a heat treatment on the substrate to which the metal powder is adhered. The heat treatment may include performing a first heat treatment on the substrate to generate an intermetallic layer at an interface between the substrate and the metal powder; and performing a second heat treatment to dissolve the intermetallic compound layer.

公开(公告)号：US20210328229A1

公开(公告)日：2021-10-21

申请号：US17197893

申请日：2021-03-10

Applicant: Korea Institute of Science and Technology

Inventor： Hyung Suk OH ,  Woong Hee LEE ,  Byoung Koun MIN ,  Yun Jeong HWANG ,  Ung LEE ,  Dong Ki LEE ,  Da Hye WON ,  Jai Hyun KOH

IPC: H01M4/90 ,  C25B11/089 ,  B22F1/00

Abstract: Proposed is an iridium alloy catalyst having reversible catalytic activity for an oxygen evolution reaction (OER), a hydrogen evolution reaction (HER), and a hydrogen oxidation reaction (HOR) by including an iridium alloy including iridium (Ir) and nickel (Ni). The iridium alloy catalyst according to the present disclosure is rapidly converted to an iridium alloy catalyst in an oxide form and an iridium alloy catalyst in a metallic form according to applied voltage by controlling its crystallinity. Thus, even in case an oxide layer is formed after the OER, the oxidation layer disappears during the HER and HOR and the properties of an iridium metal catalyst remain, thereby maintaining HER/HOR performance.