公开(公告)号：US09259545B2

公开(公告)日：2016-02-16

申请号：US13457723

申请日：2012-04-27

Applicant: Ralf Heesch ,  Till Rahlf

Inventor： Ralf Heesch ,  Till Rahlf

IPC: A61M16/00 ,  A62B7/00 ,  F16K31/02 ,  A61M16/08 ,  A61M16/20 ,  A61M16/22

CPC classification number: A61M16/00 ,  A61M16/0078 ,  A61M16/024 ,  A61M16/0891 ,  A61M16/201 ,  A61M16/202 ,  A61M16/208 ,  A61M16/22 ,  A61M2016/0027 ,  A61M2205/702

Abstract: The function of a respiration system, with a patient port (1) with connected inspiration branch (3) and expiration branch, is checked. A rebreathing line (9) connects the inspiration branch to the expiration branch. A reservoir (25) is connected to a reservoir port (27) in the rebreathing line. An actuatable control valve (29) is provided in the rebreathing line between the expiration branch and the reservoir port. A pressure sensor (33) is connected to the rebreathing line. A control unit (39) is connected to the control valve and to pressure sensor. The process includes closing the control valve for a preset inspiration time and opening it for a preset expiration time. The value sent by the pressure sensor is detected with the control valve opened during the expiration time and compared with a preset first threshold valve. An error message is generated when the value sent exceeds the first threshold value.

Abstract translation: 检查呼吸系统的功能，具有连接的灵感分支（3）和呼气支路的患者端口（1）。 重新呼吸线（9）将灵感分支连接到期满分支。 储存器（25）连接到再呼吸管线中的储存器端口（27）。 致动控制阀（29）设置在呼气支路和储液口之间的再呼吸管线中。 压力传感器（33）连接到再呼吸线路。 控制单元（39）连接到控制阀和压力传感器。 该过程包括关闭控制阀预设的吸气时间并打开预设的过期时间。 压力传感器发送的数值是在过期时间内打开的控制阀进行检测，并与预设的第一阈值阀进行比较。 当发送的值超过第一个阈值时，会生成错误消息。

公开(公告)号：US20160001025A1

公开(公告)日：2016-01-07

申请号：US14851292

申请日：2015-09-11

Applicant: Osborne Williams

Inventor： Osborne Williams

IPC: A61M16/00 ,  A61M16/08 ,  A61M16/10 ,  A61M16/20

CPC classification number: A61M16/0078 ,  A61M16/0003 ,  A61M16/0051 ,  A61M16/0081 ,  A61M16/0084 ,  A61M16/021 ,  A61M16/04 ,  A61M16/06 ,  A61M16/08 ,  A61M16/0875 ,  A61M16/0883 ,  A61M16/0891 ,  A61M16/1005 ,  A61M16/104 ,  A61M16/20 ,  A61M16/201 ,  A61M16/208 ,  A61M16/22 ,  A61M2016/0027 ,  A61M2016/0033 ,  A61M2016/103 ,  A61M2202/0225 ,  A61M2205/18 ,  A61M2205/3327 ,  A61M2205/3331 ,  A61M2205/35 ,  A61M2205/502 ,  A61M2205/8206 ,  A61M2230/432

Abstract: A portable, compact closed circuit ventilation device for manual ventilation of a patient undergoing a surgical or medical procedure that requires sedation as well as emergency management of respiratory failure. One example embodiment includes a closed breathing circuit having a manually squeezable bag, a carbon dioxide absorption canister, a plurality of valves, a gas port and a plurality of sensors for measuring Tidal Volume (TV), Peak Airway Pressure (PAP) and End Tidal CO2 (ETCO2). Another example embodiment includes an open breathing circuit having a bag, valves and sensors. A monitor displays the sensor measurements during the respiratory phases. In a spontaneously breathing patient the device may be used to assess the adequacy of patient's respiratory efforts. During manual or assisted ventilation, the monitor assures safe and efficacious ventilation by the closed breathing circuit.

公开(公告)号：US20150359982A1

公开(公告)日：2015-12-17

申请号：US14655778

申请日：2014-01-08

Applicant: KONINKLIJKE PHILIPS N.V.

Inventor： Smita GARDE ,  Samir AHMAD ,  Michael Edward MADISON

IPC: A61M16/00 ,  A61M16/06 ,  A61M16/08

CPC classification number: A61M16/0006 ,  A61B5/087 ,  A61B5/091 ,  A61M16/0051 ,  A61M16/0063 ,  A61M16/0069 ,  A61M16/0072 ,  A61M16/0075 ,  A61M16/0096 ,  A61M16/024 ,  A61M16/06 ,  A61M16/0875 ,  A61M16/161 ,  A61M16/201 ,  A61M16/204 ,  A61M2016/0024 ,  A61M2016/0027 ,  A61M2016/003 ,  A61M2016/0033 ,  A61M2205/18 ,  A61M2205/3317 ,  A61M2205/332 ,  A61M2205/3334 ,  A61M2205/3365 ,  A61M2205/3368 ,  A61M2205/3584 ,  A61M2205/505 ,  A61M2205/52

Abstract: The present disclosure pertains to a ventilation therapy system configured to control a pressure or flow generator to apply an intra-pulmonary percussive ventilation therapy regime to a pressurized flow of breathable gas during baseline ventilation therapy. The ventilation therapy system is configured to automatically control the pressurized flow of breathable gas. The system may automatically control an extent of hyperinflation during IPPV in a subject. The system is configured such that therapy set points, alarm settings, and/or other factors are automatically adjusted during the application of IPPV relative to the set points and alarm settings during baseline ventilation therapy. In some embodiments, the system comprises one or more of a pressure or flow generator, a subject interface, one or more sensors, one or more processors, a user interface, electronic storage, and/or other components.

Abstract translation: 本公开涉及一种通气治疗系统，其构造成在基线通气治疗期间控制压力或流量发生器以将肺内打击式通气治疗方案应用于加压的可呼吸气体流。 通气治疗系统被配置为自动控制可呼吸气体的加压流。 该系统可以在受试者的IPPV期间自动控制恶性通气的程度。 系统被配置为使得在基线通气治疗期间，在IPPV相对于设定点和报警设置的应用期间，治疗设定点，报警设置和/或其他因素被自动调整。 在一些实施例中，系统包括压力或流量发生器，对象接口，一个或多个传感器，一个或多个处理器，用户界面，电子存储器和/或其他组件中的一个或多个。

公开(公告)号：US20150352302A1

公开(公告)日：2015-12-10

申请号：US14741848

申请日：2015-06-17

Applicant: Gilbert Jacobus Kuypers ,  Richard Anthony McCulloch

Inventor： Gilbert Jacobus Kuypers ,  Richard Anthony McCulloch

IPC: A61M16/00 ,  A61M16/04 ,  A61M16/20 ,  A61M16/06

CPC classification number: A61M16/0069 ,  A61M16/0003 ,  A61M16/0048 ,  A61M16/0072 ,  A61M16/04 ,  A61M16/06 ,  A61M16/0666 ,  A61M16/0875 ,  A61M16/12 ,  A61M16/20 ,  A61M16/201 ,  A61M16/205 ,  A61M16/208 ,  A61M16/209 ,  A61M2016/0015 ,  A61M2016/0027 ,  A61M2016/003 ,  A61M2016/0036 ,  A61M2202/0208 ,  A61M2205/073 ,  A61M2205/106 ,  A61M2205/3334 ,  A61M2205/3341 ,  A61M2205/3368 ,  A61M2205/502 ,  A61M2230/06 ,  A61M2230/42 ,  A61M2230/432

Abstract: The present invention relates to an electrically operable resuscitation device comprising a pump including a rigid cylinder including at least one gas inlet and at least one gas outlet, a piston to travel in said cylinder, and at least one valve, the or each valve configured to allow gas to be displaced into said cylinder through said at least one gas inlet during at least one of a first stroke direction and second stroke direction of said piston in said cylinder, and for allowing gas to displaced through said at least one gas outlet during an opposite of said at least one of the first stroke direction and second stroke direction of said piston in said cylinder; a motor, selected from one of a stepper motor and feedback motor and stepper motor with feedback and linear motor, operatively connected to said piston to move said piston in said cylinder; a patient interface in ducted fluid connection with said pump to receive gas via said at least one gas outlet and to deliver said gas to said patient.

Abstract translation: 本发明涉及一种电动操作的复苏装置，其包括一泵，该泵包括刚性圆柱体，该刚性圆柱体包括至少一个气体入口和至少一个气体出口，在所述气缸中行进的活塞，以及至少一个阀， 在所述气缸中的所述活塞的第一行程方向和第二行程方向中的至少一个中允许气体通过所述至少一个气体入口移动到所述气缸中，并且用于在气缸内在气体出口处移动通过所述至少一个气体出口 与所述气缸中的所述活塞的第一行程方向和第二冲程方向中的至少一个相对; 选自步进电动机和反馈电动机中的一个和具有反馈和线性电动机的步进电动机的电动机，可操作地连接到所述活塞以使所述活塞在所述气缸中移动; 与所述泵的管道流体连接的患者接口，以经由所述至少一个气体出口接收气体并将所述气体输送到所述患者。

公开(公告)号：US09149598B2

公开(公告)日：2015-10-06

申请号：US13359773

申请日：2012-01-27

Applicant: Greg J. Dugan ,  Andre M. Rustad ,  Brian W. Pierro

Inventor： Greg J. Dugan ,  Andre M. Rustad ,  Brian W. Pierro

IPC: A61M16/20

CPC classification number: A61M16/201 ,  A61M16/0003 ,  A61M16/0057 ,  A61M16/0666 ,  A61M16/0875 ,  A61M16/208 ,  A61M16/209 ,  A61M2205/3331 ,  A61M2205/42

Abstract: A pressure relief device comprising a valve configured to resiliently deform in response to a predetermined pressure; and a sound dampener configured to dampen a sound generated by the valve when the valve resiliently deforms in response to said predetermined pressure.

Abstract translation: 一种减压装置，包括构造成响应于预定压力弹性变形的阀; 以及声阻尼器，其构造成当阀响应于所述预定压力弹性变形时抑制由阀产生的声音。

公开(公告)号：US20150252076A1

公开(公告)日：2015-09-10

申请号：US14714914

申请日：2015-05-18

Applicant: Frederic ZECRI ,  Andrei GOLOSOV ,  Philipp GROSCHE ,  Hongjuan ZHAO ,  Qi-Ying HU ,  Hidetomo IMASE

Inventor： Frederic ZECRI ,  Andrei GOLOSOV ,  Philipp GROSCHE ,  Hongjuan ZHAO ,  Qi-Ying HU ,  Hidetomo IMASE

IPC: C07K7/08 ,  A61K38/10

CPC classification number: A61M16/0816 ,  A61K38/00 ,  A61K38/10 ,  A61M16/0066 ,  A61M16/201 ,  A61M2016/0027 ,  A61M2016/003 ,  A61M2205/35 ,  A61M2205/502 ,  C07K7/08 ,  C07K7/56 ,  C07K7/60

Abstract: The invention provides a synthetic polypeptide of Formula I′: or an amide, an ester or a salt thereof, wherein X1, X2, X3, X4, X5, X6, X7, X8, X9, X10, X11, X12 and X13 are defined herein. The polypeptides are agonist of the APJ receptor. The invention also relates to a method for manufacturing the polypeptides of the invention, and its therapeutic uses such as treatment or prevention of acute decompensated heart failure (ADHF), chronic heart failure, pulmonary hypertension, atrial fibrillation, Brugada syndrome, ventricular tachycardia, atherosclerosis, hypertension, restenosis, ischemic cardiovascular diseases, cardiomyopathy, cardiac fibrosis, arrhythmia, water retention, diabetes (including gestational diabetes), obesity, peripheral arterial disease, cerebrovascular accidents, transient ischemic attacks, traumatic brain injuries, amyotrophic lateral sclerosis, burn injuries (including sunburn) and preeclampsia. The present invention further provides a combination of pharmacologically active agents and a pharmaceutical composition.

Abstract translation: 本发明提供式I'的合成多肽：或其酰胺，酯或其盐，其中X1，X2，X3，X4，X5，X6，X7，X8，X9，X10，X11，X12和X13被定义 这里。 多肽是APJ受体的激动剂。 本发明还涉及制备本发明多肽的方法及其治疗用途，例如治疗或预防急性失代偿性心力衰竭（ADHF），慢性心力衰竭，肺动脉高压，心房颤动，Brugada综合征，室性心动过速，动脉粥样硬化 ，高血压，再狭窄，缺血性心血管疾病，心肌病，心脏纤维化，心律失常，保水，糖尿病（包括妊娠糖尿病），肥胖，外周动脉疾病，脑血管意外，短暂性脑缺血发作，创伤性脑损伤，肌萎缩性侧索硬化，烧伤（ 包括晒伤）和先兆子痫。 本发明还提供药理活性剂和药物组合物的组合。

公开(公告)号：US20150209529A1

公开(公告)日：2015-07-30

申请号：US14330359

申请日：2014-07-14

Applicant: Dualams, LLC

Inventor： John S. Houston

IPC: A61M11/00 ,  A61M37/00 ,  A61M5/00

CPC classification number: A61M11/005 ,  A61M5/00 ,  A61M11/042 ,  A61M16/0816 ,  A61M16/104 ,  A61M16/109 ,  A61M16/18 ,  A61M16/201 ,  A61M2202/0241 ,  A61M2202/048 ,  A61M2205/50 ,  A61M2210/1028 ,  A61M2210/1032

Abstract: A medication delivery apparatus and system for the application of a local anesthetic to a treatment site, such as an airway, and method for use of same are disclosed. In one embodiment of the medication delivery apparatus and system, a reservoir supplies a local anesthetic to a lower chamber of a housing wherein an ultrasonic transducer applies ultrasonic energy thereto, thereby nebulizing the local anesthetic. A control valve is interposed between a source of positive pressure air and an upper chamber of the housing to selectively apply positive air pressure to the upper chamber. Upon the application of positive air pressure, the airflow delivers the nebulized anesthetic to a patient's airway by way of a laryngoscope side port coupling, laryngoscope vacuum port coupling, or catheter coupling, for example. The application of local anesthetic, itself, in this nebulized manner mitigates gaging, chocking, aspirating, bucking and laryngospasms.

Abstract translation: 公开了一种用于将局部麻醉剂施用于诸如气道的治疗部位的药物输送装置和系统及其使用方法。 在药物输送装置和系统的一个实施例中，储存器将局部麻醉剂提供给壳体的下腔室，其中超声换能器向其施加超声能量，从而使局部麻醉剂雾化。 控制阀介于正压空气源和壳体的上腔之间，以选择性地向上腔室施加正空气压力。 在施加正空气压力时，气流例如通过喉镜侧端口联接，喉镜真空端口联接或导管联接将雾化的麻醉剂递送到患者的气道。 局部麻醉剂本身以这种雾化方式的应用减轻了测量，阻塞，吸气，降压和喉部扩张。

公开(公告)号：US20150165137A1

公开(公告)日：2015-06-18

申请号：US14519466

申请日：2014-10-21

Applicant: Vectura GmbH

Inventor： Bernhard Mullinger ,  Tobias Kolb ,  Martin Huber ,  Tobias Hoffmann

IPC: A61M15/00 ,  A61M16/20 ,  A61M16/00

CPC classification number: A61M15/009 ,  A61M11/005 ,  A61M11/042 ,  A61M15/00 ,  A61M15/002 ,  A61M15/0021 ,  A61M15/0071 ,  A61M15/0085 ,  A61M15/0091 ,  A61M15/025 ,  A61M16/0003 ,  A61M16/201 ,  A61M2016/0027 ,  A61M2016/003 ,  A61M2016/0033 ,  A61M2205/27 ,  A61M2205/276 ,  A61M2205/3334 ,  A61M2205/3584 ,  A61M2205/52 ,  A61M2205/583 ,  A61M2205/584 ,  A61M2205/6045 ,  A61M2205/8206

Abstract: An inhalation device having a base unit, a mouthpiece, and an aerosol head is provided. The base unit has an air inlet, an air outlet opening, a groove for receiving the mouthpiece, and key lock member(s). The mouthpiece has two segments: a first segment which is insertable into the groove of the base unit and has an air inlet opening and a lateral opening for receiving an aerosol generator and a second segment with an aerosol outlet. The aerosol head has an aerosol generator, a liquid reservoir, and key lock member(s) complementary to those of the base unit. The base unit, mouthpiece and aerosol head are connectable with one another such that when engaging the members of the key lock with the complementary members, the aerosol generator is inserted into the lateral opening of the mouthpiece.

Abstract translation: 提供了具有基座单元，接口管和气溶胶头的吸入装置。 基座单元具有空气入口，出气口，用于容纳接口的槽和钥匙锁定构件。 接口具有两个部分：第一部分，其可插入基部单元的凹槽中，并且具有空气入口开口和用于接收气溶胶发生器的侧向开口和具有气溶胶出口的第二部分。 气溶胶头具有气溶胶发生器，液体储存器和与基座单元互补的键锁构件。 基座单元，接口管和气溶胶头可彼此连接，使得当将键锁的构件与互补构件接合时，气溶胶发生器插入到接口管的侧向开口中。

公开(公告)号：US20150068525A1

公开(公告)日：2015-03-12

申请号：US14479128

申请日：2014-09-05

Applicant: Qool Therapeutics, Inc.

Inventor： Amir Belson

IPC: A61M19/00 ,  A61M16/20 ,  A61M16/06 ,  A61M16/10 ,  A61M16/00 ,  A61M16/04

CPC classification number: A61M19/00 ,  A61F7/12 ,  A61M5/44 ,  A61M16/0051 ,  A61M16/0069 ,  A61M16/026 ,  A61M16/04 ,  A61M16/0486 ,  A61M16/06 ,  A61M16/1075 ,  A61M16/201 ,  A61M2205/18 ,  A61M2205/3368 ,  A61M2205/3606 ,  A61M2205/3646 ,  A61M2230/50

Abstract: A treatment system includes a delivery device which delivers a combination of a breathing gas and frozen ice or other particles to a patient in order to induce hypothermia. The treatment system also includes a temperature system for measuring the temperature of exhaled gases and a controller which can adjust the duration or rate at which the ice particles are delivered in order to control the patient's core temperature based on the measured exhalation gas temperature.

Abstract translation: 治疗系统包括输送装置，其将呼吸气体和冰冻冰或其它颗粒的组合递送给患者以诱发低体温。 处理系统还包括用于测量呼出气体的温度的温度系统和控制器，该控制器可以调节冰颗粒输送的持续时间或速率，以便根据所测得的呼气温度来控制患者的核心温度。

公开(公告)号：US20150040898A1

公开(公告)日：2015-02-12

申请号：US14384104

申请日：2013-03-08

Applicant: INTERSURGICAL AG

Inventor： Laura Elizabeth Breckon

IPC: A61M16/08 ,  A61M16/20 ,  A61M16/06 ,  A61M16/00

CPC classification number: A61M16/0816 ,  A61M16/0078 ,  A61M16/0084 ,  A61M16/009 ,  A61M16/06 ,  A61M16/0825 ,  A61M16/0833 ,  A61M16/0875 ,  A61M16/0883 ,  A61M16/201 ,  A61M16/208 ,  A61M16/209 ,  A61M39/10 ,  A61M39/1011 ,  A61M39/1055 ,  A61M2039/1072 ,  A61M2202/0208 ,  A61M2202/0283 ,  F16L27/0816 ,  F16L37/098 ,  F16L37/53

Abstract: The invention concerns a connector for connecting respiratory ducts together such that they are placed in fluid communication. The connector comprises a first conduit having a female connector end and a second conduit having a male connector end adapted to be received within the female connector end of the first conduit such that the male and female connector ends form a common conduit having an inner surface formed at least in part by the male connector end. The male connector has a retaining formation which is adapted to abut a corresponding formation of the female connector so as to resist separation of the first and second conduits whilst permitting relative rotation there-between when connected. The inner surface of the male connector may comprise a gas washed surface in use. The engagement formation is preferably a recessed area of the female connector, which may be generally annular in shape. In one embodiment, the member(s) may comprise a valve seat. The invention also concerns a breathing circuit comprising the connector.

Abstract translation: 本发明涉及用于将呼吸管连接在一起的连接器，使得它们被放置成流体连通。 连接器包括具有阴连接器端的第一导管和具有适于容纳在第一导管的阴连接器端内的阳连接器端的第二导管，使得阳连接器端和阴连接器端形成具有形成的内表面的公共导管 至少部分地由阳连接器端部。 阳连接器具有保持结构，该保持结构适于邻接阴连接器的相应形式，以便在连接时允许第一和第二导管间隔开，同时允许相对旋转。 阳连接器的内表面可以包括在使用中的气体洗涤表面。 接合形式优选地是阴连接器的凹陷区域，其可以是大致环形的形状。 在一个实施例中，构件可以包括阀座。 本发明还涉及包括连接器的呼吸回路。