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    Bellows Bulb Occlusion Valve
    161.
    发明申请
    Bellows Bulb Occlusion Valve 审中-公开
    波纹管灯泡闭塞阀

    公开(公告)号：US20140338667A1

    公开(公告)日：2014-11-20

    申请号：US14277827

    申请日：2014-05-15

    Applicant: Parker-Hannifin Corporation

    Inventor： Paul S. Baczkowski ,  Seth Wolf

    IPC: A61M16/20

    CPC classification number: A61M16/201 ,  A61M16/009 ,  A61M2205/075 ,  Y02C20/10

    Abstract: A flow control device for blocking the flow of analgesic gas to the mask of an analgesic system includes a bellows-bulb at the distal end of the breathing circuit. The device can be easily operated by hand. By depressing the bellows when the mask is removed, gaseous pollution, such as nitrous oxide or other gas pollution, can be controlled while the system is purged.

    Abstract translation: 用于阻止镇痛气体流向镇痛系统的面罩的流量控制装置包括在呼吸回路的远端处的波纹管灯泡。 该装置可以方便地手动操作。 当去除面罩时，通过按压波纹管，可以在系统清洗时控制气体污染，如一氧化二氮或其他气体污染。

    CONTINUOUS POSITIVE AIRWAY PRESSURE DEVICE
    163.
    发明申请
    CONTINUOUS POSITIVE AIRWAY PRESSURE DEVICE 有权
    连续正压空气压力装置

    公开(公告)号：US20140166013A1

    公开(公告)日：2014-06-19

    申请号：US13714913

    申请日：2012-12-14

    Applicant: B & B MEDICAL TECHNOLOGIES, INC.

    Inventor： Alex Stenzler ,  Steve Han

    IPC: A61M16/00

    CPC classification number: A61M16/0057 ,  A61M16/00 ,  A61M16/0006 ,  A61M16/201 ,  A61M2205/3348 ,  Y10T29/494

    Abstract: The present invention is directed to a Continuous Positive Airway Pressure Device as an apparatus configured to provide positive airway pressure in a respiratory circuit that comprises a container configured to be filled to a preselected level with liquids; a drop tube assembly comprising a hollow gas tube rotatably mounted in said container having an upper end extending a static distance outwardly of the container and connected to a respiratory circuit downstream of a user, and a hollow drop tube reciprocally movable upwardly and downwardly in the liquid in response to rotational movement of the gas tube. The container is provided with a gas vent and a liquid fill port.

    Abstract translation: 本发明涉及一种连续正气道压力装置，其被配置为在呼吸回路中提供正气道压力的装置，所述呼吸回路包括构造成用液体填充到预定位置的容器; 液滴管组件包括可旋转地安装在所述容器中的中空气管，所述中空气管具有在容器外部延伸静止距离的上端，并连接到使用者下游的呼吸回路，以及在液体中可向上和向下可往复运动的空心液滴管 响应于气体管的旋转运动。 容器设有气体排出口和液体填充口。

    SYNTHETIC APELIN MIMETICS FOR THE TREATMENT OF HEART FAILURE
    164.
    发明申请
    SYNTHETIC APELIN MIMETICS FOR THE TREATMENT OF HEART FAILURE 审中-公开
    用于治疗心脏衰竭的合成APELINMIMT

    公开(公告)号：US20140142022A1

    公开(公告)日：2014-05-22

    申请号：US14165680

    申请日：2014-01-28

    Applicant: Frederic ZECRI ,  Andrei GOLOSOV ,  Philipp GROSCHE ,  Kayo YASOSHIMA ,  Hongjuan ZHAO ,  Qi-Ying HU ,  Hidetomo IMASE ,  David Thomas PARKER

    Inventor： Frederic ZECRI ,  Andrei GOLOSOV ,  Philipp GROSCHE ,  Kayo YASOSHIMA ,  Hongjuan ZHAO ,  Qi-Ying HU ,  Hidetomo IMASE ,  David Thomas PARKER

    IPC: C07K7/08

    CPC classification number: A61M16/0816 ,  A61K38/00 ,  A61K38/10 ,  A61M16/0066 ,  A61M16/201 ,  A61M2016/0027 ,  A61M2016/003 ,  A61M2205/35 ,  A61M2205/502 ,  C07K7/08 ,  C07K7/56 ,  C07K7/60

    Abstract: The invention provides a synthetic polypeptide of Formula I′: or an amide, an ester or a salt thereof, wherein X1, X2, X3, X4, X5, X6, X7, X8, X9, X10, X11, X12 and X13 are defined herein. The polypeptides are agonist of the APJ receptor. The invention also relates to a method for manufacturing the polypeptides of the invention, and its therapeutic uses such as treatment or prevention of acute decompensated heart failure (ADHF), chronic heart failure, pulmonary hypertension, atrial fibrillation, Brugada syndrome, ventricular tachycardia, atherosclerosis, hypertension, restenosis, ischemic cardiovascular diseases, cardiomyopathy, cardiac fibrosis, arrhythmia, water retention, diabetes (including gestational diabetes), obesity, peripheral arterial disease, cerebrovascular accidents, transient ischemic attacks, traumatic brain injuries, amyotrophic lateral sclerosis, burn injuries (including sunburn) and preeclampsia. The present invention further provides a combination of pharmacologically active agents and a pharmaceutical composition.

    Abstract translation: 本发明提供式I'的合成多肽：或其酰胺，酯或其盐，其中X1，X2，X3，X4，X5，X6，X7，X8，X9，X10，X11，X12和X13被定义 这里。 多肽是APJ受体的激动剂。 本发明还涉及制备本发明多肽的方法及其治疗用途，例如治疗或预防急性失代偿性心力衰竭（ADHF），慢性心力衰竭，肺动脉高压，心房颤动，Brugada综合征，室性心动过速，动脉粥样硬化 ，高血压，再狭窄，缺血性心血管疾病，心肌病，心脏纤维化，心律失常，保水，糖尿病（包括妊娠糖尿病），肥胖，外周动脉疾病，脑血管意外，短暂性脑缺血发作，创伤性脑损伤，肌萎缩性侧索硬化，烧伤（ 包括晒伤）和先兆子痫。 本发明还提供药理活性剂和药物组合物的组合。

    VENTILATION INTERFACE FOR SLEEP APNEA THERAPY
    165.
    发明申请
    VENTILATION INTERFACE FOR SLEEP APNEA THERAPY 审中-公开
    休眠APNEA治疗通气接口

    公开(公告)号：US20140053846A1

    公开(公告)日：2014-02-27

    申请号：US14066665

    申请日：2013-10-29

    Applicant: InnoMed Technologies, Inc.

    Inventor： Thomas J. Wood

    IPC: A61M16/06 ,  A61M16/00 ,  A61M16/20

    CPC classification number: A61M16/0666 ,  A61M16/06 ,  A61M16/0616 ,  A61M16/0694 ,  A61M16/0816 ,  A61M16/0833 ,  A61M16/20 ,  A61M16/201 ,  A61M2206/20

    Abstract: The ventilation interface for sleep apnea therapy interfaces a ventilation device to the patient's airways. The ventilation interface includes a pair of nasal inserts made from flexible, resilient silicone which are oval shaped in cross-section and slightly tapered from a base proximal the ventilation supply to the distal tip end. A bead flange is disposed about the exterior of each insert at the distal end of the insert. A bleed port for release of exhaled air is defined through a conical vent projecting normally to the path of the incoming air flow, and continues through a nipple extending to the exterior of the air conduit. In one embodiment, a pair of nasal inserts are integral with a nasal cannula body, with bleed ports axially aligned with each insert. In another embodiment, each insert is independently connected to a separate, thin-walled, flexible supply line.

    Abstract translation: 用于睡眠呼吸暂停治疗的通气界面将通气装置接合到患者的气道。 通气界面包括一对由柔性弹性硅树脂制成的鼻插入件，其横截面为椭圆形，并且从靠近通气供应口的基部向远端尖端稍微渐缩。 胎圈凸缘设置在插入件的远端处的每个插入件的外部周围。 用于释放呼出空气的排放口通过一般通过入口气流路径的圆锥形通风口来限定，并且延伸通过延伸到空气管道外部的接头。 在一个实施例中，一对鼻插入件与鼻插管主体成一体，其中排出口与每个插入件轴向对准。 在另一个实施例中，每个插入件独立地连接到单独的薄壁柔性供应管线。

    Ventilation Mask with Integrated Piloted Exhalation Valve
    169.
    发明申请
    Ventilation Mask with Integrated Piloted Exhalation Valve 有权
    具有综合导向呼气阀的通气面罩

    公开(公告)号：US20130184602A1

    公开(公告)日：2013-07-18

    申请号：US13784561

    申请日：2013-03-04

    Applicant: Breathe Technologies, Inc.

    Inventor： Enrico Brambilla

    IPC: A61M16/06 ,  A61M16/00 ,  A61B5/03 ,  A61B5/00 ,  A61B5/097 ,  A61M16/20 ,  A61B5/087

    CPC classification number: A61M16/0666 ,  A61B5/03 ,  A61B5/087 ,  A61B5/097 ,  A61B5/4836 ,  A61M16/0066 ,  A61M16/0833 ,  A61M16/0858 ,  A61M16/0875 ,  A61M16/1045 ,  A61M16/20 ,  A61M16/201 ,  A61M16/207

    Abstract: In accordance with the present invention, there is provided a mask for achieving positive pressure mechanical ventilation (inclusive of CPAP, ventilator support, critical care ventilation, emergency applications), and a method for a operating a ventilation system including such mask. The mask of the present invention includes a piloted exhalation valve that is used to achieve the target pressures/flows to the patient. The pilot for the valve may be pneumatic and driven from the gas supply tubing from the ventilator. The pilot may also be a preset pressure derived in the mask, a separate pneumatic line from the ventilator, or an electro-mechanical control. The mask of the present invention may further include a heat and moisture exchanger (HME) which is integrated therein.

    Abstract translation: 根据本发明，提供了一种用于实现正压机械通气（包括CPAP，呼吸机支架，重要护理通气，紧急应用）的面罩，以及用于操作包括这种面罩的通风系统的方法。 本发明的掩模包括用于实现目标压力/流向患者的导向呼气阀。 阀门的先导阀可以是气动的，并且来自呼吸机的气体供应管道驱动。 驾驶员也可以是在面罩中产生的预设压力，来自呼吸机的独立气动管路或机电控制。 本发明的掩模还可以包括集成在其中的热和湿交换器（HME）。

    PROCESS FOR CHECKING THE FUNCTION OF A RESPIRATION SYSTEM
    170.
    发明申请
    PROCESS FOR CHECKING THE FUNCTION OF A RESPIRATION SYSTEM 有权
    检查呼吸系统功能的过程

    公开(公告)号：US20130112204A1

    公开(公告)日：2013-05-09

    申请号：US13457723

    申请日：2012-04-27

    Applicant: Ralf HEESCH ,  Till RAHLF

    Inventor： Ralf HEESCH ,  Till RAHLF

    IPC: A61M16/20 ,  A61M16/08

    CPC classification number: A61M16/00 ,  A61M16/0078 ,  A61M16/024 ,  A61M16/0891 ,  A61M16/201 ,  A61M16/202 ,  A61M16/208 ,  A61M16/22 ,  A61M2016/0027 ,  A61M2205/702

    Abstract: The function of a respiration system, with a patient port (1) with connected inspiration branch (3) and expiration branch, is checked. A rebreathing line (9) connects the inspiration branch to the expiration branch. A reservoir (25) is connected to a reservoir port (27) in the rebreathing line. An actuatable control valve (29) is provided in the rebreathing line between the expiration branch and the reservoir port. A pressure sensor (33) is connected to the rebreathing line. A control unit (39) is connected to the control valve and to pressure sensor. The process includes closing the control valve for a preset inspiration time and opening it for a preset expiration time. The value sent by the pressure sensor is detected with the control valve opened during the expiration time and compared with a preset first threshold valve. An error message is generated when the value sent exceeds the first threshold value.

    Abstract translation: 检查呼吸系统的功能，具有连接的灵感分支（3）和呼气支路的患者端口（1）。 重新呼吸线（9）将灵感分支连接到期满分支。 储存器（25）连接到再呼吸管线中的储存器端口（27）。 致动控制阀（29）设置在呼气支路和储液口之间的再呼吸管线中。 压力传感器（33）连接到再呼吸线路。 控制单元（39）连接到控制阀和压力传感器。 该过程包括关闭控制阀预设的吸气时间并打开预设的过期时间。 压力传感器发送的数值是在过期时间内打开的控制阀进行检测，并与预设的第一阈值阀进行比较。 当发送的值超过第一个阈值时，会生成错误消息。

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