公开(公告)号：US20100267162A1

公开(公告)日：2010-10-21

申请号：US12761299

申请日：2010-04-15

Applicant: Emil P. KARTALOV ,  Axel Scherer ,  Clive R. Taylor

Inventor： Emil P. KARTALOV ,  Axel Scherer ,  Clive R. Taylor

IPC: G01N27/22 ,  G01N27/00

CPC classification number: B01L3/502753 ,  B01L2200/0647 ,  B01L2300/0645 ,  B01L2300/0816 ,  B01L2300/0864

Abstract: Described herein are methods for quantitative target detection in a sample through use of microbeads and related devices and systems.

Abstract translation: 本文描述了通过使用微珠和相关装置和系统在样品中进行定量目标检测的方法。

公开(公告)号：US20100267064A1

公开(公告)日：2010-10-21

申请号：US12717402

申请日：2010-03-04

Applicant: Emil P. Kartalov ,  Axel Scherer ,  Clive Taylor

Inventor： Emil P. Kartalov ,  Axel Scherer ,  Clive Taylor

IPC: G01N33/53 ,  G01N33/00 ,  C12M1/34 ,  G01N30/96

CPC classification number: G01N33/5306 ,  B01L3/502738 ,  B01L2300/0816 ,  B01L2300/0864 ,  B01L2300/088 ,  B01L2300/0883 ,  B01L2400/0475

Abstract: Described herein is a method for detection of a target in a sample and related devices and systems.

Abstract translation: 这里描述了用于检测样品中的目标物和相关装置和系统的方法。

公开(公告)号：US07777877B2

公开(公告)日：2010-08-17

申请号：US11876211

申请日：2007-10-22

Applicant: Christopher I. Walker ,  Axel Scherer

Inventor： Christopher I. Walker ,  Axel Scherer

IPC: G01N1/10 ,  G01N21/01

CPC classification number: G01N21/0303 ,  G01N21/645 ,  G01N2021/6482

Abstract: The invention provides a high efficiency coupling structure for extracting illumination such as fluorescent radiation from a chemical reaction vessel such as a cuvette. The cuvette is provided with a mirrored surface. An end cap for the cuvette includes a probe portion that exhibits total internal reflection. Lenses are provided in various embodiments that improve the light collection and directing properties of the end cap. A fast optical system for free space coupling of optical radiation emanating from a chemical processing cuvette that uses the end cap as an element is also described.

Abstract translation: 本发明提供了一种高效率耦合结构，用于提取诸如比色皿等化学反应容器的荧光辐射照明。 比色杯配有镜面。 用于比色杯的端盖包括具有全内反射的探针部分。 在改善端盖的光收集和引导性能的各种实施例中提供了透镜。 还描述了用于使用端盖作为元件的化学处理试管发出的光辐射的自由空间耦合的快速光学系统。

公开(公告)号：US20100187105A1

公开(公告)日：2010-07-29

申请号：US12556373

申请日：2009-09-09

Applicant: Marc A. Unger ,  Hou-Pu Chou ,  Todd A. Thorsen ,  Axel Scherer ,  Stephen R. Quake

Inventor： Marc A. Unger ,  Hou-Pu Chou ,  Todd A. Thorsen ,  Axel Scherer ,  Stephen R. Quake

IPC: G01N27/26 ,  B32B3/10 ,  B05D3/00 ,  B05D5/06 ,  B05D5/12 ,  B32B37/00 ,  F25B21/02 ,  H05B3/00

CPC classification number: B32B3/00 ,  B01J2219/00355 ,  B01J2219/00378 ,  B01J2219/00396 ,  B01J2219/00398 ,  B01J2219/00439 ,  B01J2219/005 ,  B01J2219/00527 ,  B01J2219/00605 ,  B01J2219/00612 ,  B01J2219/00659 ,  B01J2219/00707 ,  B01J2219/00722 ,  B01J2219/00725 ,  B01L3/502707 ,  B01L3/50273 ,  B01L3/502738 ,  B01L7/54 ,  B01L9/527 ,  B01L2200/025 ,  B01L2200/027 ,  B01L2200/0605 ,  B01L2200/10 ,  B01L2300/0681 ,  B01L2300/0861 ,  B01L2300/0887 ,  B01L2300/123 ,  B01L2300/14 ,  B01L2300/18 ,  B01L2400/046 ,  B01L2400/0481 ,  B01L2400/0655 ,  B01L2400/0688 ,  B32B2037/1081 ,  B81B3/0032 ,  B81B3/0051 ,  B81B2201/036 ,  B81B2201/054 ,  B81C1/00119 ,  B81C2201/019 ,  C12Q1/6874 ,  F04B43/043 ,  F15C5/00 ,  F16K99/0001 ,  F16K99/0015 ,  F16K99/0046 ,  F16K99/0051 ,  F16K99/0059 ,  F16K2099/0074 ,  F16K2099/0076 ,  F16K2099/0078 ,  F16K2099/008 ,  F16K2099/0094 ,  Y10T137/0491 ,  Y10T137/2224 ,  Y10T137/87716 ,  Y10T137/87804 ,  Y10T137/87812 ,  Y10T137/87893 ,  Y10T156/10 ,  Y10T156/1002 ,  Y10T156/1064 ,  Y10T428/24479 ,  Y10T428/2457 ,  Y10T428/24612 ,  Y10T428/24744 ,  C12Q2535/125

Abstract: A method of fabricating an elastomeric structure, comprising: forming a first elastomeric layer on top of a first micromachined mold, the first micromachined mold having a first raised protrusion which forms a first recess extending along a bottom surface of the first elastomeric layer; forming a second elastomeric layer on top of a second micromachined mold, the second micromachined mold having a second raised protrusion which forms a second recess extending along a bottom surface of the second elastomeric layer; bonding the bottom surface of the second elastomeric layer onto a top surface of the first elastomeric layer such that a control channel forms in the second recess between the first and second elastomeric layers; and positioning the first elastomeric layer on top of a planar substrate such that a flow channel forms in the first recess between the first elastomeric layer and the planar substrate.

公开(公告)号：US20100084371A1

公开(公告)日：2010-04-08

申请号：US12572211

申请日：2009-10-01

Applicant: Christopher I. WALKER ,  Aditya Rajagopal ,  Axel Scherer

Inventor： Christopher I. WALKER ,  Aditya Rajagopal ,  Axel Scherer

IPC: B44C1/22

CPC classification number: B01L3/502707 ,  B01L2200/12 ,  B01L2300/0645 ,  B01L2300/0816 ,  B01L2300/16 ,  H05K1/0272 ,  H05K3/06 ,  H05K3/068 ,  H05K2203/0285

Abstract: Methods for fabrication of microfluidic systems on printed circuit boards (PCB) are described. The PCB contains layers of insulating material and a layer or layers of metal buried within layers of insulating material. The metal layers are etched away, leaving fully enclosed microfluidic channels buried within the layers of insulating material.

Abstract translation: 描述了在印刷电路板（PCB）上制造微流体系统的方法。 PCB包含绝缘材料层和埋在绝缘材料层内的一层或多层金属。 金属层被蚀刻掉，留下完全封闭的微流体通道掩埋在绝缘材料层内。

公开(公告)号：US20100068781A1

公开(公告)日：2010-03-18

申请号：US12554817

申请日：2009-09-04

Applicant: Aditya Rajagopal ,  Axel Scherer ,  Mladen Barbic

Inventor： Aditya Rajagopal ,  Axel Scherer ,  Mladen Barbic

IPC: C12N13/00 ,  C12M1/42

CPC classification number: C12N13/00 ,  C12M47/06 ,  C12N1/066

Abstract: Methods and arrangements to lyse a biological sample are described. The arrangements comprise a lysis tube containing the sample, one or more electromagnets generating a magnetic field, and one or more permanent magnets inside the lysis tube. The permanent magnets move and lyse the sample when a magnetic field is generated by the electromagnets.

Abstract translation: 描述了裂解生物样品的方法和布置。 该装置包括含有样品的裂解管，产生磁场的一个或多个电磁体和裂解管内的一个或多个永磁体。 当电磁铁产生磁场时，永久磁铁移动并裂开样品。

公开(公告)号：US20090275014A1

公开(公告)日：2009-11-05

申请号：US12335413

申请日：2008-12-15

Applicant: George MALTEZOS ,  Matthew Johnston ,  David Goodwin ,  Axel Scherer ,  Christopher I. Walker

Inventor： George MALTEZOS ,  Matthew Johnston ,  David Goodwin ,  Axel Scherer ,  Christopher I. Walker

IPC: C12Q1/70 ,  C12Q1/68 ,  C12P19/34

CPC classification number: G01N21/645 ,  B01L3/50851 ,  B01L3/50853 ,  B01L7/52 ,  B01L7/54 ,  B01L2200/147 ,  B01L2300/0829 ,  B01L2300/0838 ,  B01L2300/12 ,  B01L2300/168 ,  B01L2300/1822 ,  B01L2300/1827 ,  B01L2300/185 ,  B01L2300/1861

Abstract: This invention provides a method for carrying out nucleic acid amplification reactions involving heating and cooling of samples in sample vessels utilizing a heat block comprising a liquid. The method can be used to perform multiple nucleic acid amplification reactions simultaneously in which each of the reactions is performed so as to have temperature profiles. The apparatus can be used for performing PCR, and real time PCR in particular, with control and uniformity.

Abstract translation: 本发明提供了一种用于进行核酸扩增反应的方法，其涉及使用包含液体的热块加热和冷却样品容器中的样品。 该方法可以同时进行多个核酸扩增反应，其中进行每个反应以具有温度分布。 该装置可用于进行PCR，特别是具有控制和均匀性的实时PCR。

公开(公告)号：US20090052830A1

公开(公告)日：2009-02-26

申请号：US12110153

申请日：2008-04-25

Applicant: Michael J. Hochberg ,  Tom Baehr-Jones ,  Axel Scherer

Inventor： Michael J. Hochberg ,  Tom Baehr-Jones ,  Axel Scherer

IPC: G02B6/00

CPC classification number: G02B6/0229 ,  H01L31/035272

Abstract: A photodetector device, comprises an optical input, a nanoscale silicon waveguide and an electrical output. The waveguide is a high-contrast waveguide, with a refractive index contrast with the outside environment of more that 10%. The optical mode distribution across the waveguide has a peak intensity in correspondence of surface states of the nanoscale silicon waveguide. A related method is also disclosed.

Abstract translation: 一种光检测器件，包括光输入，纳米级硅波导和电输出。 波导是高对比度波导，其折射率与外部环境的对比度高达10％。 波导上的光学模式分布具有与纳米级硅波导的表面状态对应的峰值强度。 还公开了相关方法。

公开(公告)号：US20080277005A1

公开(公告)日：2008-11-13

申请号：US11685654

申请日：2007-03-13

Applicant: Marc A. Unger ,  Hou-Pu Chou ,  Todd A. Thorsen ,  Axel Scherer ,  Stephen R. Quake ,  Markus M. Enzelberger ,  Mark L. Adams ,  Carl L. Hansen

Inventor： Marc A. Unger ,  Hou-Pu Chou ,  Todd A. Thorsen ,  Axel Scherer ,  Stephen R. Quake ,  Markus M. Enzelberger ,  Mark L. Adams ,  Carl L. Hansen

IPC: F15C3/00

CPC classification number: B05D3/04 ,  B01J2219/00355 ,  B01J2219/00378 ,  B01J2219/00396 ,  B01J2219/00398 ,  B01J2219/00439 ,  B01J2219/005 ,  B01J2219/00527 ,  B01J2219/00605 ,  B01J2219/00612 ,  B01J2219/00621 ,  B01J2219/00659 ,  B01J2219/00707 ,  B01J2219/00722 ,  B01J2219/00725 ,  B01L3/502707 ,  B01L3/50273 ,  B01L3/502738 ,  B01L7/54 ,  B01L9/527 ,  B01L2200/025 ,  B01L2200/027 ,  B01L2200/0605 ,  B01L2200/10 ,  B01L2300/0681 ,  B01L2300/0861 ,  B01L2300/0887 ,  B01L2300/123 ,  B01L2300/14 ,  B01L2300/18 ,  B01L2400/046 ,  B01L2400/0481 ,  B01L2400/06 ,  B01L2400/0655 ,  B01L2400/0688 ,  B32B2037/1081 ,  B65B31/00 ,  B81B2201/036 ,  B81B2201/054 ,  B81C1/00119 ,  B81C2201/019 ,  C12Q1/6832 ,  C12Q1/6874 ,  C30B29/54 ,  F04B43/043 ,  F15C1/06 ,  F15C3/00 ,  F15C5/00 ,  F16K99/0001 ,  F16K99/0015 ,  F16K99/0046 ,  F16K99/0051 ,  F16K99/0059 ,  F16K2099/0074 ,  F16K2099/0076 ,  F16K2099/0078 ,  F16K2099/008 ,  F16K2099/0084 ,  F16K2099/0094 ,  Y10T137/0324 ,  Y10T137/0379 ,  Y10T137/0424 ,  Y10T137/206 ,  Y10T137/2082 ,  Y10T137/2164 ,  Y10T137/2169 ,  Y10T137/2174 ,  Y10T137/2202 ,  Y10T137/2224 ,  Y10T137/3084 ,  Y10T137/7837 ,  Y10T137/86027 ,  Y10T156/10 ,  Y10T428/24479 ,  Y10T428/24612 ,  C12Q2535/125

Abstract: A method of fabricating an elastomeric structure, comprising: forming a first elastomeric layer on top of a first micromachined mold, the first micromachined mold having a first raised protrusion which forms a first recess extending along a bottom surface of the first elastomeric layer; forming a second elastomeric layer on top of a second micromachined mold, the second micromachined mold having a second raised protrusion which forms a second recess extending along a bottom surface of the second elastomeric layer; bonding the bottom surface of the second elastomeric layer onto a top surface of the first elastomeric layer such that a control channel forms in the second recess between the first and second elastomeric layers; and positioning the first elastomeric layer on top of a planar substrate such that a flow channel forms in the first recess between the first elastomeric layer and the planar substrate.

公开(公告)号：US07443902B2

公开(公告)日：2008-10-28

申请号：US10967080

申请日：2004-10-15

Applicant: Axel Scherer

Inventor： Axel Scherer

IPC: H01S3/082

CPC classification number: B82Y20/00 ,  B82Y10/00 ,  G02F3/00 ,  H01S5/041 ,  H01S5/105 ,  H01S5/3412 ,  H01S5/5072

Abstract: Optical switches and logic devices comprising microstructure-doped nanocavity lasers are described. These switches and logic devices have gain and thus can be cascaded and integrated in a network or system such as for example on a chip. Exemplary switching elements switch the intensity, wavelength, or direction of the output. Exemplary logic devices include AND, OR, NAND, NOR, NOT, and XOR gates as well as flip-flops. Microfluidic sorting and delivery as well as optical tweezing and trapping may be employed to select and position a light emitter in a nanooptical cavity to form the nanolaser.

Abstract translation: 描述了包括微结构掺杂的纳米腔激光器的光开关和逻辑器件。 这些开关和逻辑器件具有增益，因此可以级联并集成在网络或系统中，例如在芯片上。 示例性的开关元件切换输出的强度，波长或方向。 示例性逻辑器件包括AND，OR，NAND，NOR，NOT和XOR门以及触发器。 可以使用微流控分选和输送以及光学镊子和捕获来选择和定位纳米光腔中的发光体以形成纳米激光。