公开(公告)号：US20190025178A1

公开(公告)日：2019-01-24

申请号：US16070117

申请日：2017-01-12

Applicant: ADVANCED POLYMER MONITORING TECHNOLOGIES, INC. ,  THE ADMINISTRATORS OF THE TULANE EDUCATION FUND

Inventor： Wayne Frederick Reed ,  Daniel J. Rees

IPC: G01N15/02 ,  G06F19/00

Abstract: Method, device, and system for identifying a model-based time dependent light scattering signature that includes receiving an experimental time dependent light scattering signature comprising experimental data descriptive of an average molecular weight of protein components in a solution over time. The method further includes identifying an Ansatz for evaluating the experimental time dependent light scattering signature, the Ansatz being an initial model-based time dependent light scattering signature, the initial model-based time dependent light scattering signature identifying at least one key variable. The method also includes adjusting the at least one key variable in the initial model-based time dependent light scattering signature until a final model-based time dependent light scattering signature is identified. In some instances, the final model-based time dependent light scattering signature identifies at least one protein aggregation mechanism.

公开(公告)号：US20180224473A1

公开(公告)日：2018-08-09

申请号：US15746268

申请日：2016-07-21

Applicant: ADVANCED POLYMER MONITORING TECHNOLOGIES, INC.

Inventor： Wayne Frederick Reed

IPC: G01N35/00 ,  G01N35/10 ,  G01N21/53

CPC classification number: G01N35/0092 ,  G01N21/253 ,  G01N21/53 ,  G01N35/10 ,  G01N2021/4711 ,  G01N2021/4726 ,  G01N2035/1062

Abstract: A device, method, and system for scheduling the analytical testing and throughput of macromolecular solutions based on light scattering measurements of one or more time dependent macromolecular solution characteristics. A device that includes a plurality of monitoring reservoirs, each configured to receive a macromolecular solution sample, coupled to a light scattering detection instrument configured to monitor light scattering from the plurality of macromolecular solution samples. The device further includes a computing device configured to measure a predetermined time dependent solution characteristic based on the monitored light scattering data and further configured to determine a time for performing an operation on one or more of the macromolecular solution samples based on the predetermined time dependent characteristic measurement.

公开(公告)号：US11474044B2

公开(公告)日：2022-10-18

申请号：US16094542

申请日：2017-04-21

Applicant: ADVANCED POLYMER MONITORING TECHNOLOGIES, INC. ,  THE ADMINISTRATORS OF THE TULANE EDUCATIONAL FUND

Inventor： Wayne Frederick Reed ,  Rick D. Montgomery ,  Michael Felix Drenski ,  Aide Wu

IPC: G01N21/75 ,  B01J19/00 ,  C08F20/56

Abstract: Devices and methods for determining the cumulative distribution of a polymer property in a reactor without physical separation of reaction subcomponents. The device includes a means of measuring an instantaneous property of the polymers being produced in a reaction vessel a plurality of times during a polymerization reaction as well as a means of determining the corresponding change in polymer concentration in the reaction vessel between measurements of the instantaneous polymer property The device also includes a means of computing a statistical distribution appropriate to the polymer characteristic and applying the statistical distribution to a recently measured instantaneous value of the polymer property so as to have an instantaneous distribution of the polymer property and a means of adding together the instantaneous distributions of the polymer property in order to obtain the cumulative distribution of the polymer property in the reactor.

公开(公告)号：US20170212054A1

公开(公告)日：2017-07-27

申请号：US15515119

申请日：2015-09-30

Applicant: ADVANCED POLYMER MONITORING TECHNOLOGIES, INC. ,  THE ADMINISTRATORS OF THE TULANE EDUCATIONAL FUND

Inventor： Wayne Frederick Reed ,  Michael Felix Drenski

IPC: G01N21/75 ,  B01J8/18 ,  G05B13/04 ,  G01N15/06 ,  G01N11/02

CPC classification number: G01N21/75 ,  B01J8/1809 ,  G01N11/02 ,  G01N15/06 ,  G01N2015/0693 ,  G05B13/04

Abstract: Manual and automatic methods and devices using a ACOMP system for active control of polymerization reaction processes. An ideal desired trajectory of one or more reaction and polymer characteristics can be established to produce a desired fmal polymer product with specified characteristics from a polymerization reaction process. A current reaction trajectory of a polymerization reaction process can be driven to an ideal or desired reaction trajectory. In a manual embodiment an operator can use ACOMP data to adjust process variables in order to drive the current reaction trajectory toward the ideal or desired reaction trajectory. In an automated mode a control program can use ACOMP data to make adjustments to process variables to drive the polymerization reaction process toward the desired trajectory as closely as possible either empirically or by solving the governing equations for the polymerization reaction process.