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    Distinguishing protein aggregation mechanisms
    1.
    发明授权
    Distinguishing protein aggregation mechanisms 有权

    公开(公告)号：US11532381B2

    公开(公告)日：2022-12-20

    申请号：US16070117

    申请日：2017-01-12

    Applicant: ADVANCED POLYMER MONITORING TECHNOLOGIES, INC. ,  THE ADMINISTRATORS OF THE TULANE EDUCATION FUND

    Inventor： Wayne Frederick Reed ,  Daniel J. Rees

    IPC: G16C20/20 ,  G01N15/00

    Abstract: Method, device, and system for identifying a model-based time dependent light scattering signature that includes receiving an experimental time dependent light scattering signature comprising experimental data descriptive of an average molecular weight of protein components in a solution over time. The method further includes identifying an Ansatz for evaluating the experimental time dependent light scattering signature, the Ansatz being an initial model-based time dependent light scattering signature, the initial model-based time dependent light scattering signature identifying at least one key variable. The method also includes adjusting the at least one key variable in the initial model-based time dependent light scattering signature until a final model-based time dependent light scattering signature is identified. In some instances, the final model-based time dependent light scattering signature identifies at least one protein aggregation mechanism.

    MU OPIOID RECEPTOR AGONIST ANALOGS OF THE ENDOMORPHINS
    2.
    发明申请
    MU OPIOID RECEPTOR AGONIST ANALOGS OF THE ENDOMORPHINS 审中-公开
    内啡肽的阿片受体激动剂类似物

    公开(公告)号：US20130178427A1

    公开(公告)日：2013-07-11

    申请号：US13790505

    申请日：2013-03-08

    Applicant: The Administrators of the Tulane Education Fund

    Inventor： James E. ZADINA ,  Laszlo HACKLER

    IPC: C07K7/64

    CPC classification number: C07K7/64 ,  A61K38/00 ,  C07K5/1016 ,  C07K5/126 ,  C07K7/56 ,  C07K14/665 ,  G01N33/566 ,  G01N33/9486 ,  G01N2333/70571 ,  G01N2500/04

    Abstract: The invention relates to cyclic peptide agonists that bind to the mu (morphine) opioid receptor and their use in the treatment of acute and/or chronic pain. Embodiments of the invention are directed to cyclic pentapeptide and hexapeptide analogs of endomorphin that have (i) a carboxy-terminal extension with an amidated hydrophilic amino acid and (ii) a substitution in amino acid position 2, and a 2′,6′-dimethyltyrosine (Dmt) residue in place of the N-terminal tyrosine residue a position 1. These peptide analogs exhibit increased solubility compared to similar tetrapeptide analogs while maintaining favorable or improved therapeutic ratios of analgesia to side effects.

    Abstract translation: 本发明涉及结合mu（吗啡）阿片受体的环肽激动剂及其在治疗急性和/或慢性疼痛中的用途。 本发明的实施方案涉及内啡肽的环状五肽和六肽类似物，其具有（i）具有酰胺化的亲水氨基酸的羧基末端延伸和（ii）氨基酸位置2的取代和2'，6'- 二甲基酪氨酸（Dmt）残基代替N-末端酪氨酸残基位置1.与类似的四肽类似物相比，这些肽类似物表现出增加的溶解度，同时保持镇痛与副作用的有利或改善的治疗比。

    DISTINGUISHING PROTEIN AGGREGATION MECHANISMS
    3.
    发明申请
    DISTINGUISHING PROTEIN AGGREGATION MECHANISMS 审中-公开

    公开(公告)号：US20190025178A1

    公开(公告)日：2019-01-24

    申请号：US16070117

    申请日：2017-01-12

    Applicant: ADVANCED POLYMER MONITORING TECHNOLOGIES, INC. ,  THE ADMINISTRATORS OF THE TULANE EDUCATION FUND

    Inventor： Wayne Frederick Reed ,  Daniel J. Rees

    IPC: G01N15/02 ,  G06F19/00

    Abstract: Method, device, and system for identifying a model-based time dependent light scattering signature that includes receiving an experimental time dependent light scattering signature comprising experimental data descriptive of an average molecular weight of protein components in a solution over time. The method further includes identifying an Ansatz for evaluating the experimental time dependent light scattering signature, the Ansatz being an initial model-based time dependent light scattering signature, the initial model-based time dependent light scattering signature identifying at least one key variable. The method also includes adjusting the at least one key variable in the initial model-based time dependent light scattering signature until a final model-based time dependent light scattering signature is identified. In some instances, the final model-based time dependent light scattering signature identifies at least one protein aggregation mechanism.

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