公开(公告)号：US20240404302A1

公开(公告)日：2024-12-05

申请号：US18613413

申请日：2024-03-22

Applicant: Beckman Coulter, Inc.

Inventor： Joanna JOHNSON ,  Taylor GREGORY ,  Amit SAWHNEY ,  Takayuki MIZUTANI

IPC: G06V20/69 ,  G01N15/075 ,  G06T7/00 ,  G06V10/25

Abstract: The present disclosure provides a method (400) of evaluating a fluidic substance (10) having particles (11). The method (400) comprises capturing a reference image (202) of at least a portion of a container (102) that is in an empty state; determining a reference grayscale value (V1) of at least a portion of the reference image (202); aspirating a volume of the fluidic substance (10) into the container (102); capturing a test image (252) of the container (102) containing the aspirated volume of the fluidic substance (10); determining a test grayscale value (V2) of at least a portion of the test image (252); calibrating a universal calibration curve (56) relating particle concentration and grayscale value based on the reference and test grayscale values (V1, V2); and determining a particle concentration (P1) in the fluidic substance (10) based on the test grayscale value (V2) and the calibrated universal calibration curve (60).

公开(公告)号：US12135291B2

公开(公告)日：2024-11-05

申请号：US18225594

申请日：2023-07-24

Applicant: Beckman Coulter, Inc.

Inventor： Brian Kozicki ,  Creigh Thompson ,  Richard Wolf ,  Laura Holmes ,  David Sorrentino

IPC: G01N21/27 ,  G01J1/44 ,  G01N21/76

Abstract: Assays (100) may be performed with a luminometer (400) having a chassis (405) that may include a reaction vessel chamber (610). The luminometer (400) may also include a light passage (640) that intersects the reaction vessel chamber (610). The luminometer (400) may also include a cap (415) that, when in a closed configuration, prevents light emitted by external sources from entering the reaction vessel chamber (610) and from entering the light passage (640). The cap (415) may provide access to the reaction vessel chamber (610) when in an open configuration. The luminometer (400) may also include a calibration light source (460) optically coupled to one end of the light passage (640) and a light detector (630) optically coupled to another end of the light passage (640). The light detector (630) may include a sensing element for receiving light from the light passage (640).

公开(公告)号：US20240361248A1

公开(公告)日：2024-10-31

申请号：US18661672

申请日：2024-05-12

Applicant: Beckman Coulter, Inc.

Inventor： Takayuki MIZUTANI ,  Amit SAWHNEY ,  Kevin Louis NOWAK ,  Laura Elizabeth Schilling HOLMES ,  Jessica Melissa Mattke TUBMAN

IPC: G01N21/65 ,  G01N35/00 ,  G01N35/10

CPC classification number: G01N21/658 ,  G01N35/00693 ,  G01N35/0092 ,  G01N35/1002 ,  G01N2035/00346 ,  G01N2201/06113

Abstract: The presently claimed and described technology provides systems and methods for determining concentration of an analyte of interest using Surface Enhanced Raman Spectroscopy (SERS). An automated SERS system can include a body for accepting a substrate, a fluid handling system, a light source, and a detector that collects and detects Raman scattered light.

公开(公告)号：US20240357232A1

公开(公告)日：2024-10-24

申请号：US18740301

申请日：2024-06-11

Applicant: Beckman Coulter, Inc.

Inventor： Jiuliu LU ,  Bian QIAN ,  John S. RILEY ,  Bart WANDERS ,  Ken GOOD

IPC: H04N23/67 ,  G01N15/01 ,  G01N15/1434 ,  G06T3/40 ,  G06T7/00

CPC classification number: H04N23/67 ,  G01N15/01 ,  G01N15/1436 ,  G06T3/40 ,  G06T7/0012 ,  G06T2207/10056 ,  G06T2207/10148 ,  G06T2207/20081 ,  G06T2207/20084 ,  G06T2207/30024

Abstract: A focusing distance (e.g., a distance between a focal plane of a camera used when n image was captured and the actual focal plane for an in-focus image) in a visual analysis system may be determined by subjecting one or more images captured by such a system to a multi-layer analysis. In such an analysis, an input may be subjected to one or more convolution filters, and the ultimate result of such convolution may be provided to a dense layer which can provide the focusing distance. This focusing distance may then be used to (re)focus a camera or for other purposes (e.g., generating an alert).

公开(公告)号：US12106588B2

公开(公告)日：2024-10-01

申请号：US18594423

申请日：2024-03-04

Applicant: Beckman Coulter, Inc.

Inventor： Takayuki Mizutani ,  Katsuhiro Seo ,  Shigeru Fujii ,  Kazuki Umebara ,  MArie Willette ,  Leila Nazemi

IPC: G06V20/69 ,  C12M1/34 ,  G06T7/62 ,  G06V10/50 ,  G06V20/50

CPC classification number: G06V20/69 ,  C12M41/46 ,  G06T7/62 ,  G06V10/50 ,  G06V20/50 ,  G06T2207/10024 ,  G06T2207/30072

Abstract: Automatic substance preparation and evaluation systems and methods are provided for preparing and evaluating a fluidic substance, such as e.g. a sample with bodily fluid, in a container and/or in a dispense tip. The systems and methods can detect volumes, evaluate integrities, and check particle concentrations in the container and/or the dispense tip.

公开(公告)号：US20240301131A1

公开(公告)日：2024-09-12

申请号：US18663716

申请日：2024-05-14

Applicant: Beckman Coulter, Inc.

Inventor： Arunkumar Easwaran ,  Sergei Gulnik ,  Massimiliano Tomasulo

IPC: C08G61/10 ,  C09B69/10 ,  G01N33/533 ,  G01N33/542 ,  G01N33/545 ,  G01N33/58

CPC classification number: C08G61/10 ,  C09B69/105 ,  G01N33/533 ,  G01N33/542 ,  G01N33/545 ,  G01N33/582 ,  C08G2261/11 ,  C08G2261/1424 ,  C08G2261/1432 ,  C08G2261/145 ,  C08G2261/1644 ,  C08G2261/18 ,  C08G2261/228 ,  C08G2261/314 ,  C08G2261/78 ,  C08G2261/94

Abstract: Water-soluble photoactive polymers, included polymer tandem dyes, as described as well as methods for their preparation and use. The photoactive polymers can be prepared by direct modification of core polymers (e.g., violet excitable polymers) with dyes or other functional groups. Methods of detecting analytes using the polymers are also described.

公开(公告)号：US20240296959A1

公开(公告)日：2024-09-05

申请号：US18661180

申请日：2024-05-10

Applicant: Beckman Coulter, Inc.

Inventor： Sean M. ROBERTS ,  Girish Simon

IPC: G16H50/30 ,  G16H10/60

CPC classification number: G16H50/30 ,  G16H10/60

Abstract: A computer-implemented method of determining a major adverse cardiovascular event, risk of MACE, in a patient, is provided. The method comprises receiving, with a computing device, subject value data for the patient, the subject value data including (i) at least one troponin value, (ii) at least one demographic value, and (iii) at least one of a value for prior history of cardiac disease, a value of prior history of renal disease, an erythrocyte mean corpuscular hemoglobin value and an electrolyte value. Further, the method comprises evaluating, with the computing device, the received subject value data of the patient based on a reference dataset indicative of reference subject values associated with one or more reference patients, wherein the reference dataset is indicative of reference subject values including (i) at least one troponin value, (ii) at least one demographic value, and (iii) a value for prior history of cardiac disease. Further, the risk of MACE is determined based on the evaluation.

公开(公告)号：US20240272189A1

公开(公告)日：2024-08-15

申请号：US18647869

申请日：2024-04-26

Applicant: Beckman Coulter, Inc.

Inventor： Noriyuki ITO ,  Noriyoshi OKADA ,  Takayuki MIZUTANI

IPC: G01N35/10

CPC classification number: G01N35/1002

Abstract: A system (100) is provided for an automated analyzer (10) having an analyzer arrangement (20) configured to consume liquid consumables (30L) when in an active mode (12). The liquid consumables (30L) are delivered to the automated analyzer (10) via consumables containers (30). The system (100) comprises a storage magazine (120) configured to removably hold at least one of the consumables containers (30), a tray (150) configured to manually receive one or more of the consumables containers (30) from an operator at least while the analyzer arrangement (20) is in the active mode (12), and a transfer system (250) configured to transfer one or more of the consumables containers (30) at least between the tray (150) and the storage magazine (120). The transfer system (250) transfers one or more of the consumables containers (30) to or from the storage magazine (120) at least while the tray (150) manually receives one or more of the consumables containers (30) from the operator.

公开(公告)号：US11994514B2

公开(公告)日：2024-05-28

申请号：US16390597

申请日：2019-04-22

Applicant: Beckman Coulter, Inc.

Inventor： Diana B. Careaga ,  Robert T. Magari ,  Liliana M. Tejidor ,  Nicole Carpio

IPC: G01N33/50 ,  A61B5/00 ,  G01N15/01 ,  G01N15/1031 ,  G01N15/14 ,  G01N33/487 ,  G01N33/49 ,  G01N33/569 ,  G16H10/40 ,  G01N15/06

CPC classification number: G01N33/5094 ,  A61B5/412 ,  G01N15/1031 ,  G01N33/48735 ,  G01N33/49 ,  G01N33/5091 ,  G01N33/56972 ,  G16H10/40 ,  G01N2015/016 ,  G01N15/0656 ,  G01N2015/1402 ,  G01N2800/26

Abstract: Embodiments of the present disclosure may allow for an efficient and accurate way or system to assess whether an individual has sepsis, including an individual who may exhibit symptoms or clinical criteria similar to inflammation. Embodiments include using a laboratory test that may be routinely ordered. Embodiments of the present invention may allow for the diagnosis of sepsis even when some cells show an abnormal size. Often, when white blood cells show a likelihood of an abnormal size, a “blast flag” in a system is triggered to warn a user that the sample may warrant further analysis. Unexpectedly, the diagnosis of sepsis status using standard deviation of monocyte volume may be more accurate when considering whether a blast flag has been triggered. Based on the sepsis status, treatment may be started quickly, thereby preventing complications, including organ failure and death, of not treating sepsis fast enough.

公开(公告)号：US11977088B2

公开(公告)日：2024-05-07

申请号：US16313704

申请日：2017-06-16

Applicant: Beckman Coulter, Inc.

Inventor： Wido Menhardt ,  Matthew Hanson ,  Anthony Camisa

IPC: G01N35/00 ,  B01L9/06 ,  G16H10/40

CPC classification number: G01N35/00613 ,  B01L9/06 ,  G01N35/00712 ,  G01N35/00871 ,  G16H10/40 ,  B01L2200/14 ,  B01L2200/146 ,  B01L2200/147 ,  B01L2200/185 ,  B01L2300/021 ,  B01L2300/023 ,  B01L2300/024 ,  B01L2300/0663 ,  G01N2035/00752 ,  G01N2035/00851

Abstract: A method of reducing quality problems associated with patient sample collection and delivery is provided. It is possible that the method can provide a chain of custody process to better track a sample from the initial point of sample collection to the final point of sample testing. Such a method can also include providing an alert to indicate a potential problem with the quality of the diagnostic test result when a measured parameter exceeds a threshold.