公开(公告)号：US20240302272A1

公开(公告)日：2024-09-12

申请号：US18178671

申请日：2023-03-06

Applicant: Colorado State University Research Foundation

Inventor： Ioannis Minas

IPC: G01N21/3563 ,  G01N21/3581

CPC classification number: G01N21/3563 ,  G01N21/3581 ,  G01N2201/0221

Abstract: The true impact of preharvest factors such as crop load, canopy position, cultivar and rootstock on peach internal quality can be determined using multivariate visible light radiation (Vis) and near infrared spectroscopy (NIRS) prediction models to non-destructively assess peach internal quality (dry matter content, DMC; soluble solids concentration, SSC) and maturity (index of absorbance difference, IAD). A novel crop load×fruit developmental stage protocol allowed accurate multivariate Vis-NIRS-based prediction models development for three major yellow fleshed peach typologies (fully red over-colored, early-ripening bi-colored and late-ripening bi-colored) to non-destructively assess peach internal quality (DMC and SSC) and maturity (IAD) with a single scan during fruit growth and development in the field. The impact of preharvest factors such as crop load and canopy position on peach quality and maturity can be evaluated across a variety of peach cultivars using this novel technology.

公开(公告)号：US20240293352A1

公开(公告)日：2024-09-05

申请号：US18288617

申请日：2022-05-06

Applicant: Ottawa Hospital Research Institute ,  Colorado State University Research Foundation

Inventor： Jean-Simon Diallo ,  Debbie C. Crans ,  Rozanne Arulanandam

IPC: A61K31/28 ,  A61K33/42 ,  A61K35/766 ,  A61K35/768 ,  A61P35/00

CPC classification number: A61K31/28 ,  A61K33/42 ,  A61K35/766 ,  A61K35/768 ,  A61P35/00

Abstract: The present application relates to vanadium compounds. More specifically, the present application relates to pharmaceutical compositions comprising vanadium salts, use thereof and methods using the same. The present application also includes compositions comprising vanadium compounds and a therapeutic or prophylactic virus providing for increased virus infection, spread, titer, activity, cytotoxicity and/or immunotherapeutic activity.

公开(公告)号：US20240278498A1

公开(公告)日：2024-08-22

申请号：US18643076

申请日：2024-04-23

Applicant: Colorado State University Research Foundation

Inventor： Mostafa Yourdkhani ,  Morteza Ziaee ,  Sean Smith ,  Carter Dojan

IPC: B29C64/295 ,  B29C64/165 ,  B29C64/209 ,  B29C64/218 ,  B29C64/268 ,  B29K63/00 ,  B29K75/00 ,  B29K105/08 ,  B29K105/12 ,  B29K105/16 ,  B33Y30/00 ,  B33Y70/10

CPC classification number: B29C64/295 ,  B29C64/165 ,  B29C64/209 ,  B29C64/218 ,  B29C64/268 ,  B29K2063/00 ,  B29K2075/00 ,  B29K2105/08 ,  B29K2105/12 ,  B29K2105/162 ,  B33Y30/00 ,  B33Y70/10

Abstract: Various implementations include a method of printing and curing of thermoset resin. The method includes outputting a thermoset resin from an outlet of a feeder and directing a stimulus from a stimulation source toward a portion of the output thermoset resin that is downstream from the outlet of the feeder. The stimulus is configured to heat the portion of the output thermoset resin to fully cure the portion of the output thermoset resin.

公开(公告)号：US12053164B2

公开(公告)日：2024-08-06

申请号：US17127520

申请日：2020-12-18

Applicant: Access Sensor Technologies LLC ,  Colorado State University Research Foundation

Inventor： David Leith ,  John Volckens ,  Christian L'Orange ,  Daniel D. Miller-Lionberg

IPC: A61B10/00 ,  G01N1/22 ,  G01N15/02

CPC classification number: A61B10/00 ,  G01N1/2208 ,  G01N1/2211 ,  G01N1/2273 ,  G01N15/0255 ,  A61B2010/0087 ,  G01N2015/0261

Abstract: A portable sampler, the sampler including a sampler assembly having a housing that includes a receiver defined therein for interchangeably receiving a number of removable inlet assemblies, the removable inlet assemblies including a respirable inlet assembly and a thoracic inlet assembly. The respirable inlet assembly includes a hybrid cyclone assembly, the hybrid cyclone assembly including an impaction stage and a cyclone in series. The thoracic inlet assembly includes an inlet slot configured to function as a size-selective inlet. Another thoracic inlet assembly includes a housing having a number of openings configured to receive a sample airflow; an inlet insert through which an inlet aperture is defined; a prequalification chamber defined between a lower surface of the housing and an upper surface of the inlet insert; and a protrusion extending downward from the lower surface of the housing into the inlet aperture of the inlet insert to from an inlet slot.

公开(公告)号：US11992411B2

公开(公告)日：2024-05-28

申请号：US17118756

申请日：2020-12-11

Applicant: Colorado State University Research Foundation

Inventor： Steve Simske ,  Adam Morrone

IPC: A61F2/44 ,  A61B17/04 ,  A61B17/68 ,  A61B17/80 ,  A61B17/86 ,  A61F2/08 ,  A61F2/30 ,  A61F2/36

CPC classification number: A61F2/3609 ,  A61F2/30771 ,  A61F2002/30354 ,  A61F2002/30878 ,  A61F2310/00023

Abstract: Various implementations include an anchoring device including a tubular body and at least one anchor. The at least one anchor extends along an opening between a first axial end and a second axial end of the opening. The at least one anchor includes a shape memory material. The at least one anchor is movable from a retracted position to an extended position by either increasing the temperature of the anchor above an austenite finishing temperature or decreasing the temperature of the anchor below a martensite finishing temperature. The anchor has a smaller radius of curvature in a plane that includes the longitudinal axis in the extended position than in the retracted position. When used as a coupler for medical implants, the device can be easily removed and reimplanted during re-surgery without damaging the bone of a patient by increasing or decreasing the temperature of the shape memory material anchors.

公开(公告)号：US20240158567A1

公开(公告)日：2024-05-16

申请号：US18492554

申请日：2023-10-23

Applicant: COLORADO STATE UNIVERSITY RESEARCH FOUNDATION

Inventor： Eugene CHEN ,  Ethan QUINN ,  Zhen ZHANG

IPC: C08G63/06 ,  C08L67/04 ,  C09J167/04

CPC classification number: C08G63/06 ,  C08L67/04 ,  C09J167/04 ,  C08L2205/025

Abstract: Syndio-rich P3HB (sr-P3HB), readily synthesized from the eight-membered meso-dimethyl diolide, has a unique set of stereomicrostructures comprising enriched syndiotactic [rr] and no isotactic [mm] triads but abundant stereo-defects randomly distributed along the chain. This sr-P3HB material is characterized by high toughness (UT=96 MJ/m3), as a result of its high elongation at break (>400%) and tensile strength (34 MPa), crystallinity (Tm=114° C.), and optical clarity (due to its sub-micron spherulites), and good barrier properties, while it still biodegrades in freshwater and soil. On the other hand, iso-rich P3HB (ir-P3HB) can be synthesized from the eight-membered rac-dimethyl diolide. While sr-P3HB exhibits excellent adhesion strength toward a variety of substrates, both sr-P3HB and ir-P3HB can substantially toughen brittle stereoperfect biological or synthetic P3HB. Both sr-P3HB and ir-P3HB can also be obtained from the four-membered rac-beta-butyrolactone with appropriate catalysts.

公开(公告)号：US20240131044A1

公开(公告)日：2024-04-25

申请号：US18483950

申请日：2023-10-10

Applicant: M.T.3, Inc. ,  Colorado State University Research Foundation

Inventor： Takamitsu Kato ,  Junko Maeda ,  Tomohiro Haga ,  Takaomi Fukuhara

IPC: A61K31/7028 ,  A61K31/407 ,  A61P35/00

CPC classification number: A61K31/7028 ,  A61K31/407 ,  A61P35/00

Abstract: There is provided with a method for treating cancer, comprising administering a pharmaceutical composition to a patient with cancer in combination with an anti-cancer agent, the pharmaceutical composition. A compound is represented by General Formula (I) or a pharmaceutically acceptable salt thereof:






where R1 is an acyl residue from a fatty acid.

公开(公告)号：US20240124501A1

公开(公告)日：2024-04-18

申请号：US18453027

申请日：2023-08-21

Applicant: COLORADO STATE UNIVERSITY RESEARCH FOUNDATION ,  THE UNIVERSITY OF SYDNEY

Inventor： Debbie C. CRANS ,  Peter A. LAY ,  Heide MURAKAMI ,  Aviva LEVINA ,  Kateryna KOSTENKOVA ,  Andrew BATES ,  John MANGANARO ,  Josef GRUNDY ,  Skyler MARKHAM ,  Kameron KLUGH

IPC: C07F9/00

CPC classification number: C07F9/005

Abstract: Disclosed are vanadium (V) compounds and pharmaceutical compositions comprising these vanadium compounds. Also disclosed are methods of making and using these vanadium compounds, for example, to treat cancer (e.g., including brain cancer).

公开(公告)号：US20240059709A1

公开(公告)日：2024-02-22

申请号：US18255969

申请日：2021-12-16

Applicant: COLORADO STATE UNIVERSITY RESEARCH FOUNDATION ,  CETYA THERAPEUTICS, INC.

Inventor： Robert M. WILLIAMS ,  Sivanagireddy KOTI ,  Subhadip DE ,  Anil M. SHELKE ,  Ryan E. CERBONE ,  Nobuyoshi YASUDA

IPC: C07D513/18

CPC classification number: C07D513/18

Abstract: Disclosed are various synthetic methods to prepare structural analogs of largazole and derivatives thereof. One structural analog is an amide isostere of largazole. Another structural analog replaces the thiazole ring of largazole with a pyridine moiety or an oxazole moiety. Also disclosed are various intermediate compounds obtained when preparing structural analogs of

公开(公告)号：US20240041802A1

公开(公告)日：2024-02-08

申请号：US18205603

申请日：2023-06-05

Applicant: Axlmmune, Inc. ,  Colorado State University Research Foundation

Inventor： Floyd TAUB ,  Amanda Guth

IPC: A61K31/16 ,  A61P35/00 ,  A61K9/00 ,  A61K38/17 ,  A61K38/20 ,  A61K39/395 ,  C12Q1/6886

CPC classification number: A61K31/16 ,  A61P35/00 ,  A61K9/0019 ,  A61K38/177 ,  A61K38/2013 ,  A61K39/3955 ,  C12Q1/6886 ,  C12Q2600/106 ,  C12Q2600/158

Abstract: The present disclosure provides methods, kits, and compositions comprising β-alethine and one or more immune modulators and methods to determine when they are advantageous. Particular applications include the use of β-alethine and one or more immune modulators in the treatment of cancer.