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公开(公告)号：US11524162B2
公开(公告)日：2022-12-13
申请号：US16938438
申请日：2020-07-24
Inventor： Emil Toader , Hubert Cécile François Martens , Michel Marcel Jose Decré , Franciscus Paulus Maria Budzelaar , Pieter Gerrit Blanken , David James Anderson
Abstract: A method and system are provided for determining a relation between stimulation settings for a brain stimulation probe and a corresponding V-field. The brain stimulation probe comprises multiple stimulation electrodes. The V-field is an electrical field in brain tissue surrounding the stimulation electrodes. The method comprises sequentially applying a test current to n stimulation electrodes, n being a number between 2 and the number of stimulation electrodes of the brain stimulation probe, for each test current at one of the n stimulation electrodes, measuring a resulting excitation voltage at m stimulation electrodes, m being a number between 2 and the number of stimulation electrodes of the brain stimulation probe, from the stimulation settings and the measured excitation voltages, deriving a coupling matrix, an element in the coupling matrix reflecting an amount of electrical impedance between two of the stimulation electrodes, and using the coupling matrix for determining the relation between the stimulation settings and the corresponding V-field.
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公开(公告)号：US20190054293A1
公开(公告)日：2019-02-21
申请号：US16165348
申请日：2018-10-19
Applicant: NeuroNexus Technologies, Inc.
Inventor： David S. Pellinen , Bencharong Suwarato , Rio J. Vetter , Jamille Farraye Hetke , Daryl R. Kipke
Abstract: A neural probe system having a single guide tube that is inserted into neural tissue and from which a number of neural probes can be deployed is described. Each probe is deployable into tissue along a desired trajectory. This is done by supporting the electrode array on a spring tape-type carrier that maintains axial stiffness once the neural probe has deployed out a channel in the guide tube. That way, a target neural tissue is bounded by an increased number of neural probes while minimizing trauma to surrounding body tissue.
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公开(公告)号：US10052476B2
公开(公告)日：2018-08-21
申请号：US14941784
申请日：2015-11-16
Applicant: Neuronexus Technologies, Inc.
Inventor： John P. Seymour
CPC classification number: A61N1/04 , A61B5/04 , A61B5/04001 , A61B5/68 , A61B2562/0285 , A61B2562/125 , A61N1/05 , A61N1/0534 , A61N1/36
Abstract: Improved low-cost, highly reliable methods for increasing the electrochemical surface area of neural electrodes are described. A mono-layer of polymeric nanospheres is first deposited on a metallization supported on a dielectric substrate. The nanospheres self-assemble into generally repeating lattice forms with interstitial space between them. Then, the geometric surface area of the metallization material is increased by either selectively etching part-way into its depth at the interstitial space between adjacent nanospheres. Another technique is to deposit addition metallization material into the interstitial space. The result is undulation surface features provided on the exposed surface of the metallization. This helps improve the electrochemical surface area when the treated metallizations are fabricated into electrodes.
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公开(公告)号：US20170326382A1
公开(公告)日：2017-11-16
申请号：US15589471
申请日：2017-05-08
Applicant: NeuroNexus Technologies, Inc.
Inventor： John P. Seymour , Mayurachat Ning Gulari , Daryl R. Kipke , KC Kong
CPC classification number: A61N5/0622 , A61B5/0084 , A61B5/04001 , A61B5/4076 , A61B2562/0233 , A61B2562/046 , A61N2005/0626 , A61N2005/0643 , Y10T29/49016
Abstract: Waveguide neural interface devices and methods for fabricating such devices are provided herein. An exemplary interface device includes a neural device comprising an exterior neural device sidewall extending to a distal end portion of the neural device, an array of electrode sites supported by a first face of the neural device sidewall. The array includes a recording electrode site. The exemplary interface device further includes a waveguide extending along the neural device, the waveguide having a distal end to emit light to illuminate targeted tissue adjacent to the recording electrode site, and a light redirecting element disposed at the distal end of the waveguide. The light redirecting element redirects light traveling through the waveguide in a manner that avoids direct illumination of the recording electrode site on the first face of the neural device sidewall.
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公开(公告)号：US20170252553A1
公开(公告)日：2017-09-07
申请号：US15600877
申请日：2017-05-22
Applicant: NeuroNexus Technologies, Inc.
Inventor： David S. Pellinen , Mayurachat Ning Gulari , Jamille Farraye Hetke , David J. Anderson , Daryl R. Kipke , Rio J. Vetter
Abstract: An implantable electrode system of is disclosed that includes a conductive electrode layer, an interconnect coupled to the electrode layer, an insulator that insulates the interconnect, and an anchor that more securely fixes the electrode layer in place. This structure is particularly useful with the electrode layer being a neural interface that is configured to provide either a recording or stimulating function. A method for forming such an implantable electrode system includes forming an interconnect over a base layer, forming an anchoring structure over the base layer, depositing an insulating material layer over the interconnect structure and over the anchoring structure, exposing a portion of the interconnect structure, forming an electrode layer over the insulating layer, the electrode layer contacting the exposed portion of the interconnect structure.
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Patent Agency Ranking
公开(公告)号：US09636028B2
公开(公告)日：2017-05-02
申请号：US14536867
申请日：2014-11-10
Applicant: NeuroNexus Technologies, Inc.
Inventor： Rio J. Vetter , Jamille Farraye Hetke , David S. Pellinen , Bencharong Suwarato , Kc Kong
CPC classification number: A61N1/0529 , A61B5/04001 , A61B5/0478 , A61B5/6868 , A61B5/6882 , A61N1/0456 , A61N1/0472 , A61N1/0539 , H01R43/26 , Y10T29/49169
Abstract: A three-dimensional neural probe electrode array system is described. Planar probes are microfabricated and electrically connected to flexible micro-machined ribbon cables using a rivet bonding technique. The distal end of each cable is connected to a probe with the proximal end of the cable being customized for connection to a printed circuit board. Final assembly consists of combining multiple such assemblies into a single structure. Each of the two-dimensional neural probe arrays is positioned into a micro-machined platform that provides mechanical support and alignment for each array. Lastly, a micro-machined cap is placed on top of each neural electrode probe and cable assembly to protect them from damage during shipping and subsequent use. The cap provides a relatively planar surface for attachment of a computer controlled inserter for precise insertion into the tissue.
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17.发明授权Implantable electrode lead system with a three dimensional arrangement and method of making the same 有权具有三维布置的可植入电极引线系统及其制造方法公开(公告)号：US09289142B2
公开(公告)日：2016-03-22
申请号：US13750420
申请日：2013-01-25
Applicant: NeuroNexus Technologies, Inc.
Inventor： Kc Kong , Jamille Farraye Hetke , James A. Wiler , David S. Pellinen , Mayurachat Ning Gulari
CPC classification number: A61B5/04 , A61B5/04001 , A61B5/0492 , A61B5/685 , A61B2562/125 , A61B2562/166 , A61B2562/227 , A61M25/0147 , A61N1/05 , A61N1/0529 , A61N1/0534 , H05K1/00 , H05K1/147
Abstract: One embodiment of the invention includes an implantable electrode lead system that includes a series of shims stacked upon each other, a series of first components, and a series of second components connected to the series of first components through a series of connectors. One of the first components extends from one of the shims, and another of the first components extends from another one of the shims. The shims position the first components in a three dimensional arrangement.
Abstract translation: 本发明的一个实施例包括可植入电极引线系统，其包括彼此堆叠的一系列垫片，一系列第一部件和通过一系列连接器连接到该系列第一部件的一系列第二部件。 第一部件中的一个部件从其中一个垫片延伸，另一个部件从另一个垫片延伸。 垫片将第一部件置于三维布置中。
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18.发明申请公开(公告)号：US20150112360A1
公开(公告)日：2015-04-23
申请号：US14519346
申请日：2014-10-21
Applicant: NeuroNexus Technologies, Inc.
Inventor： David S. Pellinen , Bencharong Suwarato , Rio J. Vetter , Jamille Farraye Hetke , Daryl R. Kipke
CPC classification number: A61N1/0558 , A61B5/04001 , A61B5/0478 , A61M25/003 , A61M25/007 , A61M2025/0031 , A61N1/0534 , A61N1/36017 , G03F7/40
Abstract: A neural probe system having a single guide tube that is inserted into neural tissue and from which a number of neural probes can be deployed is described. Each probe is deployable into tissue along a desired trajectory. This is done by supporting the electrode array on a spring tape-type carrier that maintains axial stiffness once the neural probe has deployed out a channel in the guide tube. That way, a target neural tissue is bounded by an increased number of neural probes while minimizing trauma to surrounding body tissue.
Abstract translation: 描述了一种神经探针系统，其具有插入到神经组织中的单个引导管，并且可以从其中部署许多神经探针。 每个探针可以沿着所需的轨迹展开到组织中。 这是通过将电极阵列支撑在弹簧带型载体上来完成的，一旦神经探针已经在引导管中展开通道，则维持轴向刚度。 这样，目标神经组织被增加数量的神经探针所限制，同时使对周围的身体组织的创伤最小化。
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公开(公告)号：US20130158639A1
公开(公告)日：2013-06-20
申请号：US13713115
申请日：2012-12-13
Applicant: NEURONEXUS TECHNOLOGIES, INC.
Inventor： David S. Pellinen , Mayurachat Ning Gulari , Jamille Farraye Hetke , David J. Anderson , Daryl R. Kipke , Vetter Rio J.
IPC: A61N1/05
CPC classification number: A61N1/05 , A61B5/04001 , A61B2562/0209 , A61N1/0529 , A61N1/0551 , H05K1/0393 , H05K1/113 , H05K3/4644 , H05K2201/09781 , H05K2201/2072 , Y10T29/49117
Abstract: The implantable electrode system of the preferred embodiments includes a conductor, an interconnect coupled to the conductor, an insulator that insulates the interconnect, and an anchor that is connected to both the conductor and the insulating element. The anchor is mechanically interlocked with at least one of the conductor and the insulator.
Abstract translation: 优选实施例的可植入电极系统包括导体，耦合到导体的互连件，绝缘体互连件的绝缘体以及连接到导体和绝缘元件两者的锚固件。 锚固体与导体和绝缘体中的至少一个机械地互锁。
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公开(公告)号：US11602630B2
公开(公告)日：2023-03-14
申请号：US16002992
申请日：2018-06-07
Applicant: NeuroNexus Technologies, Inc.
Inventor： Rio J. Vetter , Peter Gerow , David S. Pellinen , Carlos Rackham , Daryl R. Kipke , Jamille F. Hetke
Abstract: A medical electrode array system comprising a thin-film substrate, a plurality of electrode contacts disposed on the thin-film substrate, and a plurality of traces. The plurality of electrode contacts is configured to provide electrical contact points. The plurality of traces is electrically connected to the plurality of electrode contacts. A electrode contact of the plurality of electrode contacts has a dedicated trace of the plurality of traces that provides electrical connectivity to the electrode contact. The thin-film substrate is configured to flex to maintain continuous contact with contours of patient anatomy. The plurality of traces includes flexible spring-like portions to add flexibility to the thin-film substrate.
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