公开(公告)号：US08530488B2

公开(公告)日：2013-09-10

申请号：US12739303

申请日：2008-10-24

Applicant: Abhay Gaitonde ,  Bindu Manojkumar ,  Sandeep Mekde ,  Prakash Bansode ,  Dattatraya Shinde ,  Sunanda Phadtare

Inventor： Abhay Gaitonde ,  Bindu Manojkumar ,  Sandeep Mekde ,  Prakash Bansode ,  Dattatraya Shinde ,  Sunanda Phadtare

IPC: A01N43/54 ,  A61K31/505

CPC classification number: C07D239/69

Abstract: The present invention relates to novel crystalline forms of bosentan and processes for their preparation. Further, the invention relates to pharmaceutical compositions comprising said crystalline forms and use of said compositions in the treatment of patients suffering from endothelin receptor mediated disorders, for example, cardiovascular disorders such as hypertension, pulmonary hypertension, ischemia, vasospasm and angina pectoris.

Abstract translation: 本发明涉及新生的波生坦结晶形式及其制备方法。 此外，本发明涉及包含所述结晶形式的药物组合物和所述组合物用于治疗患有内皮素受体介导的病症的患者，例如心血管疾病如高血压，肺动脉高压，局部缺血，血管痉挛和心绞痛。

公开(公告)号：US20100261742A1

公开(公告)日：2010-10-14

申请号：US12599108

申请日：2008-05-08

Applicant: Abhay Gaitonde ,  Bindu Manojkumar ,  Sandeep Mekde ,  Dattatraya Shinde ,  Prakash Bansode

Inventor： Abhay Gaitonde ,  Bindu Manojkumar ,  Sandeep Mekde ,  Dattatraya Shinde ,  Prakash Bansode

IPC: A61K31/506 ,  C07D403/04 ,  A61P9/12 ,  A61P9/10

CPC classification number: C07D403/04

Abstract: Novel polymorphic forms of bosentan and processes for their preparation are disclosed. Further, pharmaceutical compositions comprising said polymorphic forms and the use of said compositions in the treatment of patients suffering from endothelin receptor mediated disorders, for example, cardiovascular disorders such as hypertension, pulmonary hypertension, ischemia, vasospasm and angina pectoris are disclosed.

Abstract translation: 公开了波形坦的新型多晶型物及其制备方法。 此外，公开了包含所述多形态形式的药物组合物和所述组合物在治疗患有内皮素受体介导的病症的患者中的用途，例如心血管疾病如高血压，肺动脉高压，局部缺血，血管痉挛和心绞痛。