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公开(公告)号：US20120149725A1
公开(公告)日：2012-06-14
申请号：US13386550
申请日：2010-08-06
Applicant: Vinayak Govind Gore , Bindu Manojkumar , Dattatraya Shinde , Dattatrey Kokane
Inventor： Vinayak Govind Gore , Bindu Manojkumar , Dattatraya Shinde , Dattatrey Kokane
IPC: A61K31/437 , A61P11/00 , A61P11/06 , C07D491/18
CPC classification number: C07D491/18 , C07D451/10
Abstract: Novel Anhydrate The present invention relates to a novel form of anhydrous tiotropium bromide, processes for the preparation of anhydrous tiotropium bromide, pharmaceutical compositions comprising anhydrous tiotropium bromide and uses of the compositions.
Abstract translation: 新型无水物技术领域本发明涉及一种新型无水噻托溴铵，制备无水噻托溴铵的方法，含有无水噻托溴铵的药物组合物和组合物的用途。
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公开(公告)号：US20100234468A1
公开(公告)日：2010-09-16
申请号：US12602939
申请日：2008-05-30
Applicant: Abhay Gaitonde , Bindu Manojkumar , Sandeep Mekde , Dattatrey Kokane
Inventor： Abhay Gaitonde , Bindu Manojkumar , Sandeep Mekde , Dattatrey Kokane
IPC: A61K31/165 , C07C233/11 , A61P25/00
CPC classification number: C07C315/02 , C07B2200/07 , C07B2200/13 , C07C315/06 , C07C317/44
Abstract: The present invention relates to a process for the preparation of polymorphic forms of the R- and S-enantiomers of modafinil, R-(−)-2-benzhydrylsulfinylacetamide and S-(+)-2-benzhydrylsulfinylacetamide respectively.
Abstract translation: 本发明涉及分别制备莫多非尼，R - （ - ） - 2-二苯甲基亚磺酰基乙酰胺和S-（+） - 2-二苯甲基亚磺酰基乙酰胺的R-和S-对映异构体的多晶形式的方法。
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公开(公告)号：US20110039871A1
公开(公告)日：2011-02-17
申请号：US12866373
申请日：2009-02-06
Applicant: Abhay Gaitonde , Bindu Manojkumar , Sandeep Mekde , Vikas Padalkar , Hemant Mande
Inventor： Abhay Gaitonde , Bindu Manojkumar , Sandeep Mekde , Vikas Padalkar , Hemant Mande
IPC: A61K31/506 , C07D403/04 , A61P9/00 , A61P9/10 , A61P9/12 , A61P9/14
CPC classification number: C07D239/52 , C07D239/69
Abstract: The present invention relates to a novel intermediate useful in the preparation of bosentan and to processes for the preparation of said intermediate and bosentan. The invention further relates to compositions comprising bosentan prepared according to the processes of the invention and their use in the treatment of endothelin-receptor mediated disorders.
Abstract translation: 本发明涉及一种可用于制备波生坦的新型中间体和用于制备所述中间体和波生坦的方法。 本发明还涉及包含根据本发明的方法制备的波生坦及其在治疗内皮素受体介导的病症中的用途的组合物。
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公开(公告)号：US20100324139A1
公开(公告)日：2010-12-23
申请号：US12810244
申请日：2008-12-19
Applicant: Abhay Gaitonde , Debashish Datta , Bindu Manojkumar , Sunanda Phadtare
Inventor： Abhay Gaitonde , Debashish Datta , Bindu Manojkumar , Sunanda Phadtare
IPC: C07C227/04 , C07C201/10 , C07C227/34 , C07C69/716 , C07C69/675 , C07C69/63 , C07C229/08 , A61K31/197 , A61P29/00 , A61P9/10 , A61P25/24 , A61P25/22 , A61P25/08 , A61P25/18
CPC classification number: C07C227/32 , C07B2200/07 , C07C67/307 , C07C67/31 , C07C67/343 , C07C201/12 , C07C227/04 , C07C229/08 , C07C309/65 , C12P7/42 , C12P41/002 , C07C69/63 , C07C69/675 , C07C69/716 , C07C205/51
Abstract: The present invention relates to a novel method for the preparation of racemic pregabalin (1) or a single enantiomer thereof, (S)-(+)-3-(aminomethyl)-5-methyl-hexanoic acid (2).
Abstract translation: 本发明涉及一种制备外消旋普瑞巴林（1）或其单一对映异构体（S） - （+） - 3-（氨基甲基）-5-甲基 - 己酸（2）的新方法。
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公开(公告)号：US20100234590A1
公开(公告)日：2010-09-16
申请号：US12600009
申请日：2008-05-14
Applicant: Abhay Gaitonde , Bindu Manojkumar , Rahul Bhalerao , Dattatraya Shinde
Inventor： Abhay Gaitonde , Bindu Manojkumar , Rahul Bhalerao , Dattatraya Shinde
IPC: C07D243/10 , H01J49/26 , G01N30/00
CPC classification number: C07D495/04
Abstract: The present invention relates to a novel process for the preparation of pharmaceutically pure olanzapine. The invention is also related to impurities obtained during the preparation of pharmaceutically pure olanzapine and methods for the detection of the impurities.
Abstract translation: 本发明涉及制备药学上纯的奥氮平的新方法。 本发明还涉及在制备药学上的奥氮平期间获得的杂质和用于检测杂质的方法。
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Patent Agency Ranking
公开(公告)号：US08785461B2
公开(公告)日：2014-07-22
申请号：US12866373
申请日：2009-02-06
Applicant: Abhay Gaitonde , Bindu Manojkumar , Sandeep Mekde , Vikas Padalkar , Hemant Mande
Inventor： Abhay Gaitonde , Bindu Manojkumar , Sandeep Mekde , Vikas Padalkar , Hemant Mande
IPC: A01N43/54 , A61K31/505
CPC classification number: C07D239/52 , C07D239/69
Abstract: The present invention relates to a novel intermediate useful in the preparation of bosentan and to processes for the preparation of said intermediate and bosentan. The invention further relates to compositions comprising bosentan prepared according to the processes of the invention and their use in the treatment of endothelin-receptor mediated disorders.
Abstract translation: 本发明涉及一种可用于制备波生坦的新型中间体和用于制备所述中间体和波生坦的方法。 本发明还涉及包含根据本发明的方法制备的波生坦及其在治疗内皮素受体介导的病症中的用途的组合物。
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公开(公告)号：US20110251254A1
公开(公告)日：2011-10-13
申请号：US12864063
申请日：2008-11-27
Applicant: Abhay Gaitonde , Bindu Manojkumar , Rahul Bhalerao , Sinderpal Tank
Inventor： Abhay Gaitonde , Bindu Manojkumar , Rahul Bhalerao , Sinderpal Tank
IPC: A61K31/4045 , A61P1/04 , A61P1/08 , C07D209/14
CPC classification number: C07D209/14
Abstract: The present invention relates to a novel salt of tegaserod, namely tegaserod suberate, and to processes for the preparation thereof. The invention also relates to crystalline forms of the novel salt and to pharmaceutical compositions comprising the novel salt. Further, the invention relates to uses of said compositions in treating patients suffering from gastrointestinal disorders.
Abstract translation: 本发明涉及替加色罗的新型盐，即辛伐他替康，以及其制备方法。 本发明还涉及新型盐的结晶形式和包含该新型盐的药物组合物。 此外，本发明涉及所述组合物在治疗患有胃肠道疾病的患者中的用途。
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公开(公告)号：US20110028508A1
公开(公告)日：2011-02-03
申请号：US12810231
申请日：2009-01-09
Applicant: Abhay Gaitonde , Bindu Manojkumar , Dattatraya Shinde , Sinderpal Tank
Inventor： Abhay Gaitonde , Bindu Manojkumar , Dattatraya Shinde , Sinderpal Tank
IPC: A61K31/437 , C07D491/08 , A61P11/00 , A61P11/06 , A61P11/08
CPC classification number: C07D451/10
Abstract: The present invention relates to novel processes for the preparation of scopine esters and their quaternary salts. In particular, the present invention relates to a process for the preparation of tiotropium bromide, pharmaceutical compositions comprising tiotropium bromide and the use of such compositions in the treatment of respiratory disorders.
Abstract translation: 本发明涉及制备莨菪碱及其季盐的新方法。 特别地，本发明涉及一种制备噻托溴铵的方法，包括噻托溴铵的药物组合物和这些组合物在治疗呼吸系统疾病中的用途。
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9.发明申请公开(公告)号：US20100249162A1
公开(公告)日：2010-09-30
申请号：US12665997
申请日：2008-06-27
Applicant: Abhay Gaitonde , Bindu Manojkumar , Sandeep Sonawane , Dattatrey Kokane , Sandeep Mekde , Dattatraya Shinde , Prakash Bansode
Inventor： Abhay Gaitonde , Bindu Manojkumar , Sandeep Sonawane , Dattatrey Kokane , Sandeep Mekde , Dattatraya Shinde , Prakash Bansode
IPC: A61K31/513 , C07D403/04 , A61P11/00
CPC classification number: C07D239/69
Abstract: The present invention relates to an improved process for the preparation of bosentan. In particular it relates to a process for preparing bosentan substantially free from the dimer impurity of formula (II) and the 6-hydroxy impurity of formula (III). The invention also relates to a pharmaceutical composition comprising bosentan and its use in the treatment of endothelin-receptor mediated disorders.
Abstract translation: 本发明涉及一种制备波生坦的改进方法。 特别涉及制备基本上不含式（II）的二聚物杂质和式（III）的6-羟基杂质的波生坦的方法。 本发明还涉及包含波生坦的药物组合物及其在治疗内皮素受体介导的病症中的用途。
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公开(公告)号：US08946414B2
公开(公告)日：2015-02-03
申请号：US13700845
申请日：2011-05-31
Applicant: Dattatrey Kokane , Bindu Manojkumar , Vinayak Govind Gore
Inventor： Dattatrey Kokane , Bindu Manojkumar , Vinayak Govind Gore
IPC: C07D487/00 , C07D491/00 , C07D487/04
CPC classification number: A61K31/519 , C07D487/04
Abstract: The present invention relates to the active pharmaceutical ingredient dipyridamole. In particular, it relates to efficient processes for the preparation of dipyridamole which are amenable to large scale commercial production and provide the required product with improved yield and purity. The present invention also relates to a novel crystallization method for the purification of dipyridamole.
Abstract translation: 本发明涉及活性药物成分双嘧达莫。 特别涉及制备适于大规模商业生产的双嘧达莫的有效方法，并提供具有改善的产率和纯度的所需产物。 本发明还涉及一种用于纯化双嘧达莫的新型结晶方法。
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