公开(公告)号：US08808649B2

公开(公告)日：2014-08-19

申请号：US12682402

申请日：2008-10-10

Applicant: Gal Ingber ,  William G. Atterbury ,  Russell H. Barnes ,  Douglas E. Boyd ,  Joseph D. Dennis ,  Jonathan Gurfinkel ,  Dave Holley ,  Steven E. Huckaby ,  Thomas A. Klausing ,  John S. Laudo ,  Kevin Sadeski ,  Jason A. Schaefer ,  K. Bryan Scott ,  Carol Stillman ,  Sherwood Talbert ,  John Tallarico

Inventor： Gal Ingber ,  William G. Atterbury ,  Russell H. Barnes ,  Douglas E. Boyd ,  Joseph D. Dennis ,  Jonathan Gurfinkel ,  Dave Holley ,  Steven E. Huckaby ,  Thomas A. Klausing ,  John S. Laudo ,  Kevin Sadeski ,  Jason A. Schaefer ,  K. Bryan Scott ,  Carol Stillman ,  Sherwood Talbert ,  John Tallarico

IPC: B01L3/00 ,  G01N31/16 ,  G01N21/00 ,  G01N21/64 ,  G01N21/66 ,  A61J1/06

CPC classification number: G01N33/493 ,  C12Q1/04 ,  G01N21/0303 ,  G01N35/025 ,  G01N35/04 ,  G01N2021/6482 ,  G01N2035/0436 ,  G01N2035/0444 ,  G01N2035/0448 ,  G01N2035/0458 ,  G01N2201/0415

Abstract: A system for conducting the identification and quantification of micro-organisms, e.g., bacteria in urine samples which includes: 1) several disposable cartridges for holding four disposable components including a centrifuge tube, a pipette tip having a 1 ml volume, a second pipette tip having a 0.5 ml volume, and an optical cup or cuvette; 2) a sample processor for receiving the disposable cartridges and processing the urine samples including transferring the processed urine sample to the optical cups; and 3) an optical analyzer for receiving the disposable cartridges and configured to analyze the type and quantity of micro-organisms in the urine sample. The disposable cartridges with their components including the optical cups or cuvettes are used in the sample processor, and the optical cups or cuvettes containing the processed urine samples are used in the optical analyzer for identifying and quantifying the type of micro-organism existing in the processed urine samples.

Abstract translation: 用于进行微生物识别和定量的系统，例如尿样中的细菌，其包括：1）几个用于容纳四个一次性组件的一次性盒，包括离心管，具有1ml体积的移液管尖端，第二移液管尖 具有0.5ml体积，以及光学杯或比色皿; 2）用于接收一次性盒并且处理尿液样品的样品处理器，包括将经处理的尿样转移到光学杯; 以及3）用于接收一次性盒并用于分析尿样中的微生物的类型和数量的光学分析仪。 在样品处理器中使用具有包括光学杯或比色皿的组件的一次性盒，并且在光学分析仪中使用含有经处理的尿液样品的光学杯或比色杯，用于鉴定和定量存在于加工过程中的微生物的类型 尿样。

公开(公告)号：US20130102772A1

公开(公告)日：2013-04-25

申请号：US13550425

申请日：2012-07-16

Applicant: Dennis ESHIMA ,  Mehmet Husnu ,  Jim Stone ,  Derrick Alcaide ,  Henry Padgett ,  Joseph E. Zambanini ,  Thomas A. Klausing ,  Chad E. Bouton ,  Brian C. Kelley ,  Scott N. Danhof ,  David A. Holley ,  Jeffrey T. Stroup ,  James B. Gleeson ,  Eric Hassenpflug ,  James A. Prescott ,  Herman Benecke ,  Daniel B. Garbark

Inventor： Dennis ESHIMA ,  Mehmet Husnu ,  Jim Stone ,  Derrick Alcaide ,  Henry Padgett ,  Joseph E. Zambanini ,  Thomas A. Klausing ,  Chad E. Bouton ,  Brian C. Kelley ,  Scott N. Danhof ,  David A. Holley ,  Jeffrey T. Stroup ,  James B. Gleeson ,  Eric Hassenpflug ,  James A. Prescott ,  Herman Benecke ,  Daniel B. Garbark

IPC: B01J19/00 ,  B65B1/00

CPC classification number: B01J19/0006 ,  A61J3/002 ,  A61K51/0491 ,  B01J19/004 ,  B01J19/0046 ,  B01J2219/00049 ,  B01J2219/00351 ,  B01J2219/00355 ,  B01J2219/00585 ,  B01J2219/00693 ,  B01J2219/00702 ,  B01J2219/0072 ,  B01J2219/00722 ,  B01J2219/00759 ,  B65B1/00 ,  B65B3/003 ,  G21G1/10 ,  G21G2001/0015

Abstract: Systems, methods, and devices for generating radionuclides for use in production of radiopharmaceuticals; synthesizing the radionuclides generated and removing any unwanted products; measuring the quantity and activity level of the synthesized radionuclides; distributively delivering the radionuclides in appropriate quantities to modular cassette synthesis units in a modular cassette subsystem for contemporaneous/parallel production of radiopharmaceutical output and that allow reuse and/or quick, safe, and disposable replacement of portions of the subsystem; delivering non-radionuclide components to the modular cassette synthesis units as part of production of radiopharmaceutical output; measuring the quantity and activity level of each stream of radiopharmaceutical output; purifying the radiopharmaceutical output; dispensing individual doses in sterile vial(s); automatically producing labeling and dose related information; performing automated quality control on extracted samples of produced radiopharmaceutical output; and providing software and hardware controls for overall and sub-portion operation for optional remote data collection, communication, and/or control.

Abstract translation: 用于产生用于放射性药物生产的放射性核素的系统，方法和装置; 合成生成的放射性核素并除去任何不需要的产物; 测量合成放射性核素的数量和活度水平; 将放射性核素分配递送到模块化盒式系统中的模块化盒式合成单元，用于同时/并行生产放射性药物输出，并允许重复使用和/或快速，安全和一次性更换子系统的一部分; 将非放射性核素组分作为放射性药物输出生产的一部分提供给模块化盒式合成单元; 测量每个放射性药物输出流量的数量和活动水平; 净化放射性药物输出; 在无菌小瓶中分配单个剂量; 自动生成标签和剂量相关信息; 对提取的放射性药物输出样品进行自动化质量控制; 并为可选的远程数据收集，通信和/或控制提供用于整体和子部分操作的软件和硬件控制。

公开(公告)号：US20130020727A1

公开(公告)日：2013-01-24

申请号：US13550026

申请日：2012-07-16

Applicant: Thomas A. KLAUSING ,  Jeffrey T. STROUP ,  Brian C. KELLEY ,  Joseph E. ZAMBANINI ,  David A. HOLLEY

Inventor： Thomas A. KLAUSING ,  Jeffrey T. STROUP ,  Brian C. KELLEY ,  Joseph E. ZAMBANINI ,  David A. HOLLEY

IPC: B01J19/00 ,  C07B47/00

CPC classification number: B01J19/004 ,  B01J19/0093 ,  B01J2219/00006 ,  B01J2219/0002 ,  G05B15/02

Abstract: Compact modular cassette systems and methods for the synthesis of radiopharmaceutical products are provided, the compact modular cassette system including a modular unit having valve plates, a reaction cassette, a reagent pack, and other seal and connector plates to ensure that reagents can be mixed together inside one or more chambers of the reaction cassette in a timely and efficient manner. When a new chamber for each new reaction or process should be used, a valveless modular system having removable reaction cassettes and the reagent packs may be used. In such a system, the reagent container, the reaction cassette, or both, can be removed from the modular cassette system and discarded after a desired reaction or process has taken place.

Abstract translation: 提供了紧凑的模块化盒式系统和用于合成放射性药物产品的方法，紧凑的模块化盒式系统包括具有阀板的模块化单元，反应盒，试剂包和其它密封件和连接器板，以确保将试剂混合在一起 以及时和有效的方式在反应盒的一个或多个室内。 当需要使用每个新的反应或过程的新室时，可以使用具有可移除的反应盒和试剂包的无阀模块系统。 在这种系统中，试剂容器，反应盒或两者可以从模块化盒式系统中移出，并在所需的反应或过程发生之后丢弃。

公开(公告)号：USD655016S1

公开(公告)日：2012-02-28

申请号：US29331946

申请日：2009-02-05

Applicant: John S Laudo ,  Gal Ingber ,  William G Atterbury ,  Thomas A Klausing ,  Dave Holley ,  John Tallarico

Designer： John S Laudo ,  Gal Ingber ,  William G Atterbury ,  Thomas A Klausing ,  Dave Holley ,  John Tallarico

公开(公告)号：US20110093207A1

公开(公告)日：2011-04-21

申请号：US12885993

申请日：2010-09-20

Applicant: Gal Ingber ,  William G. Atterbury ,  Dave Holley ,  Thomas A. Klausing ,  John S. Laudo ,  Jason A. Schaefer ,  Sherwood Talbert ,  John Tallarico

Inventor： Gal Ingber ,  William G. Atterbury ,  Dave Holley ,  Thomas A. Klausing ,  John S. Laudo ,  Jason A. Schaefer ,  Sherwood Talbert ,  John Tallarico

IPC: G06F19/00 ,  G01N1/10 ,  G01N21/55 ,  B01L3/00 ,  B65D83/00 ,  A47B96/00

CPC classification number: G01N35/025 ,  B04B9/14 ,  G01N2035/00504 ,  G01N2035/0434 ,  G01N2035/0458

Abstract: The present invention relates to a system for conducting the identification and quantification of micro-organisms, e.g., bacteria in biological samples. More particularly, the invention relates to a system comprising a cooling, heating and fan arrangement for maintaining a predetermined optimum temperature of the samples during testing; a visual, circumferential and axial alignment system for aligning the samples within the carousel; a transfer system for transferring the samples from the carousel to the centrifuge; a balancing system of minimizing the rotational vibrations of the centrifuge; a safety system and anti-tipping design for the sample containing system; liquid dispensing arms for dispensing the buffered saline solution; and discharge ports for discharging and disposing of the liquid removed from the samples to a location external of the system.

Abstract translation: 本发明涉及用于进行微生物（例如生物样品中的细菌）的鉴定和定量的系统。 更具体地，本发明涉及一种包括用于在测试期间保持样品的预定最适温度的冷却，加热和风扇装置的系统; 用于使转盘内的样品对准的视觉，圆周和轴向对准系统; 将样品从转盘转移到离心机的转移系统; 使离心机的旋转振动最小化的平衡系统; 采样系统的安全系统和防倾翻设计; 用于分配缓冲盐溶液的液体分配臂; 以及用于将从样品去除的液体排放和处置到系统外部的位置的排出口。

公开(公告)号：USD610698S1

公开(公告)日：2010-02-23

申请号：US29326051

申请日：2008-10-10

Applicant: John S. Laudo ,  Gal Ingber ,  William G. Atterbury ,  Thomas A. Klausing ,  Dave Holley ,  John Tallarico

Designer： John S. Laudo ,  Gal Ingber ,  William G. Atterbury ,  Thomas A. Klausing ,  Dave Holley ,  John Tallarico