公开(公告)号：US20190242918A1

公开(公告)日：2019-08-08

申请号：US16319282

申请日：2017-07-19

Applicant: Siemens Healthcare Diagnostics Inc.

Inventor： Joson K. Joseph ,  Bestin Abraham

IPC: G01N35/00 ,  G01N21/13 ,  G01N35/02 ,  G01N35/04 ,  B01L3/00

CPC classification number: G01N35/00712 ,  A61B5/14557 ,  B01L3/5085 ,  B01L9/06 ,  B01L2200/028 ,  B01L2300/0803 ,  G01N21/13 ,  G01N21/253 ,  G01N35/00663 ,  G01N35/025 ,  G01N35/04 ,  G01N2035/0444 ,  G01N2201/025 ,  G01N2201/0415

Abstract: A computer-implemented method for performing photometric cuvette mapping includes detecting edges associated with a plurality of gaps between a plurality of vessels in a reaction ring during a complete rotation of a reaction ring. Each gap is determined according to an edge detection process which includes identifying: a vessel interior in response to detection of a first predetermined number of photometer device control manager (DCM) measurements below a threshold value; a rising edge in response to detection of a second predetermined number of photometer DCM measurements above the threshold value; and identifying a falling edge in response to detection of a third predetermined number of photometer DCM measurements below the threshold value. The edge detection process further includes recording the rising edge and the falling edge as being indicative of one of the plurality of gaps.

公开(公告)号：US09933358B2

公开(公告)日：2018-04-03

申请号：US13401047

申请日：2012-02-21

Applicant: Kanako Iwamura ,  Shoichi Kanayama

Inventor： Kanako Iwamura ,  Shoichi Kanayama

IPC: G01N21/59 ,  G01N21/25 ,  G01N35/02 ,  G01N35/04

CPC classification number: G01N21/253 ,  G01N35/025 ,  G01N35/04 ,  G01N2035/0455 ,  G01N2201/0415 ,  G01N2201/124 ,  G01N2201/1245 ,  G01N2201/127

Abstract: According to one embodiment, an automatic analyzer comprises a light source, a spectroscope, a photo detection unit, a storage unit, a selection unit, and a calculation unit. The storage unit stores photo detector identifiers related to photo detectors and wavelength band identifiers in association with each other. The selection unit selects a specific photo detector from photo detectors. The specific photo detector corresponds to a specific photo detector identifier associated with a wavelength band identifier of a wavelength band according to a measurement item of a sample. The calculation unit calculates an absorbance related to the measurement item based on a signal from the selected specific photo detector.

公开(公告)号：US20170191933A1

公开(公告)日：2017-07-06

申请号：US15389897

申请日：2016-12-23

Applicant: Gen-Probe Incorporated

Inventor： David OPALSKY ,  Srajan RAGHUWANSHI ,  James BUI

IPC: G01N21/64

CPC classification number: G01N21/645 ,  G01N21/0332 ,  G01N21/276 ,  G01N21/75 ,  G01N35/00732 ,  G01N35/025 ,  G01N2021/6441 ,  G01N2035/00356 ,  G01N2035/0455 ,  G01N2035/0475 ,  G01N2035/0484 ,  G01N2201/0407 ,  G01N2201/0415 ,  G01N2201/12723

Abstract: A system for measuring optical signal detector performance includes an optical signal detector comprising a first detection channel having a first light source and a first sensor. The first detection channel is configured to emit and focus light generated by the first light source at a first detection zone, and to receive and focus light on the first sensor. The system also includes a controller operatively coupled to the optical signal detector and configured to determine an operational performance status of the optical signal detector based on at least one of (i) a first measured characteristic of light focused on the sensor while a first non-fluorescent surface portion is in the first detection zone and (ii) a second measured characteristic of light focused on the sensor while a void is in the first detection zone. The optical signal detector can be a fluorometer.

公开(公告)号：US09194793B2

公开(公告)日：2015-11-24

申请号：US13002664

申请日：2009-07-30

Applicant: Sakuichiro Adachi ,  Kunio Harada ,  Isao Yamazaki ,  Masaharu Kiyama ,  Takeshi Fujita

Inventor： Sakuichiro Adachi ,  Kunio Harada ,  Isao Yamazaki ,  Masaharu Kiyama ,  Takeshi Fujita

IPC: G01N21/59 ,  G01N21/25 ,  G01N35/02 ,  G01N21/03 ,  G01N35/00 ,  G01N35/04

CPC classification number: G01N21/253 ,  G01N21/0332 ,  G01N21/255 ,  G01N35/025 ,  G01N2035/00386 ,  G01N2035/0455 ,  G01N2201/0231 ,  G01N2201/0415 ,  G01N2201/0453 ,  G01N2201/0624 ,  G01N2201/0627

Abstract: Using an LED element as a light source, a photometric unit including the light source, a light receiving element and other components therebetween is reduced in size. A holder 30 detachable from the device as a unit holds a light emission unit 15 formed of an LED and a light receiving element 21, and the holder is placed inside a thermostatic chamber 18 which holds a constant temperature fluid 17. Thus, the photometric unit is reduced in size.

Abstract translation: 使用LED元件作为光源，包括光源，光接收元件和其间的其它部件的光度单元的尺寸减小。 从装置作为一个单元可拆卸的保持器30保持由LED和光接收元件21形成的发光单元15，并且保持器放置在保持恒温流体17的恒温室18内部。因此，测光单元 尺寸减小。

公开(公告)号：US20150033831A1

公开(公告)日：2015-02-05

申请号：US14379356

申请日：2013-02-12

Applicant: HITACHI HIGH-TECHNOLOGIES CORPORATION

Inventor： Kotaro Yamashita ,  Masahiko Iijima

IPC: G01N21/55 ,  G01N33/493 ,  G01N33/49 ,  G01N35/00 ,  G01N33/48

CPC classification number: G01N21/55 ,  G01N21/253 ,  G01N21/274 ,  G01N21/51 ,  G01N21/78 ,  G01N21/82 ,  G01N33/48 ,  G01N33/49 ,  G01N33/493 ,  G01N35/00 ,  G01N35/00623 ,  G01N2021/0325 ,  G01N2021/0389 ,  G01N2021/3129 ,  G01N2021/513 ,  G01N2021/825 ,  G01N2035/009 ,  G01N2201/0415

Abstract: An automatic analyzer has a multi-wavelength light source that irradiates a reaction cuvette containing a liquid mixture of a sample to be analyzed and a reagent. A transmitted-light quantity detector detects the amount of light transmitted through the reaction cuvette and internal contents of the reaction cuvette. A single-wavelength light source irradiates the reaction cuvette with single-wavelength light; and a transmitted-light quantity detector detects the amount of single-wavelength light scattered from the reaction cuvette. A memory stores the results of the transmitted-light quantity detection and the scattered-light quantity detection; and the deterioration states of the single-wavelength light source, multi-wavelength light source, and reaction cuvette are determined in accordance with measurement results of cell blank measurements conducted on the reaction cuvette where a predetermined reference solution is stored to detect the amount of light transmitted through and the amount of light scattered from.

Abstract translation: 自动分析仪具有多波长光源，其照射含有待分析样品和试剂的液体混合物的反应池。 透射光量检测器检测透射通过反应池的光量和反应池的内部物质。 单波长光源用单波长光照射反应池; 并且透射光量检测器检测从反应容器散射的单波长光的量。 存储器存储透射光量检测和散射光量检测的结果; 并且根据在存储预定参考溶液的反应池中进行的细胞空白测量的测量结果来确定单波长光源，多波长光源和反应池的劣化状态，以检测光量 透过光散射的光量。

公开(公告)号：US20150010993A1

公开(公告)日：2015-01-08

申请号：US14330450

申请日：2014-07-14

Applicant: POCARED Diagnostics LTD.

Inventor： Gal Ingber ,  William G. Atterbury ,  Russell H. Barnes ,  Douglas E. Boyd ,  Joseph D. Dennis ,  Jonathan Gurfinkel ,  Dave Holley ,  Steven E. Huckaby ,  Thomas A. Klausing ,  Kevin Sadeski ,  Jason A. Schaefer ,  K. Bryan Scott ,  Carol Stillman ,  Sherwood Talbert ,  John Tallarico ,  John S. Laudo

IPC: G01N33/493 ,  G01N35/02 ,  G01N21/03

CPC classification number: G01N33/493 ,  C12Q1/04 ,  G01N21/0303 ,  G01N35/025 ,  G01N35/04 ,  G01N2021/6482 ,  G01N2035/0436 ,  G01N2035/0444 ,  G01N2035/0448 ,  G01N2035/0458 ,  G01N2201/0415

Abstract: A system for conducting the identification and quantification of micro-organisms, e.g., bacteria in urine samples which includes: 1) several disposable cartridges for holding four disposable components including a centrifuge tube, a pipette tip having a 1 ml volume, a second pipette tip having a 0.5 ml volume, and an optical cup or cuvette; 2) a sample processor for receiving the disposable cartridges and processing the urine samples including transferring the processed urine sample to the optical cups; and 3) an optical analyzer for receiving the disposable cartridges and configured to analyze the type and quantity of micro-organisms in the urine sample. The disposable cartridges with their components including the optical cups or cuvettes are used in the sample processor, and the optical cups or cuvettes containing the processed urine samples are used in the optical analyzer for identifying and quantifying the type of micro-organism existing in the processed urine samples.

Abstract translation: 用于进行微生物识别和定量的系统，例如尿样中的细菌，其包括：1）几个用于保持四个一次性组件的一次性盒，包括离心管，具有1ml体积的移液管尖端，第二移液管尖 具有0.5ml体积，以及光学杯或比色皿; 2）用于接收一次性盒并且处理尿液样品的样品处理器，包括将经处理的尿样转移到光学杯; 以及3）用于接收一次性盒并用于分析尿样中的微生物的类型和数量的光学分析仪。 在样品处理器中使用具有包括光学杯或比色皿的组件的一次性盒，并且在光学分析仪中使用含有经处理的尿液样品的光学杯或比色杯，用于鉴定和定量存在于加工过程中的微生物的类型 尿样。

公开(公告)号：US08248586B2

公开(公告)日：2012-08-21

申请号：US12427280

申请日：2009-04-21

Applicant: Mamoru Tomita

Inventor： Mamoru Tomita

IPC: G01N33/48 ,  G01N21/00 ,  G01B11/00 ,  G01B11/14

CPC classification number: G01N21/07 ,  G01N21/59 ,  G01N35/00584 ,  G01N35/025 ,  G01N2035/00148 ,  G01N2201/0415 ,  G01N2201/0446 ,  G01N2201/1247

Abstract: A blood analysis apparatus is provided. The blood analysis apparatus includes: a chip holding portion having an aperture which allows light to pass therethrough and holding a μ-TAS chip for holding a measurement liquid; a rotary body on which the chip holding portion is mounted; a light source; and a light-receiving unit. A measurement position of the rotary body at which the measurement liquid is to be measured with the light from the light source is set by: rotating the rotary body to obtain a light value of light which is emitted from the light source and received by the light-receiving unit through the aperture; and setting a rotational position of the rotary body where the light value is a threshold value or more, as the measurement position.

Abstract translation: 提供血液分析装置。 血液分析装置包括：芯片保持部，具有允许光通过的孔，并保持用于保持测量液体的μ-TAS芯片; 旋转体，其上安装有芯片保持部; 光源; 和光接收单元。 利用来自光源的光来测量测量液体的旋转体的测量位置是通过旋转旋转体来获得从光源发射并被光接收的光的光值 - 接收单元通过孔径; 并且将光值为阈值以上的旋转体的旋转位置设定为测量位置。

公开(公告)号：US08008066B2

公开(公告)日：2011-08-30

申请号：US11372221

申请日：2006-03-10

Applicant: Gary D. Lair ,  Thanh N. Nguyen ,  Haitao Li ,  Florence F. Li ,  Byron J. Knight ,  Robert E. Heinz ,  Jerzy A. Macioszek ,  Christopher B. Davis ,  Robert F. Scalese

Inventor： Gary D. Lair ,  Thanh N. Nguyen ,  Haitao Li ,  Florence F. Li ,  Byron J. Knight ,  Robert E. Heinz ,  Jerzy A. Macioszek ,  Christopher B. Davis ,  Robert F. Scalese

IPC: C12M1/34 ,  C12M3/00 ,  C12M1/00

CPC classification number: G01N21/6428 ,  B01L7/52 ,  C12Q1/6813 ,  C12Q1/6851 ,  G01N21/6454 ,  G01N21/76 ,  G01N35/00693 ,  G01N35/0092 ,  G01N35/0098 ,  G01N35/0099 ,  G01N35/025 ,  G01N35/026 ,  G01N35/028 ,  G01N35/04 ,  G01N35/1002 ,  G01N2021/6419 ,  G01N2021/6421 ,  G01N2021/6432 ,  G01N2021/6439 ,  G01N2021/6441 ,  G01N2035/00346 ,  G01N2035/00356 ,  G01N2035/00524 ,  G01N2035/0097 ,  G01N2035/0441 ,  G01N2035/0443 ,  G01N2035/0444 ,  G01N2035/0455 ,  G01N2035/0491 ,  G01N2035/103 ,  G01N2201/0415 ,  Y10S435/808 ,  Y10S435/809 ,  Y10T436/113332 ,  Y10T436/25 ,  C12Q2537/165

Abstract: An automated analyzer for performing multiple diagnostic assays simultaneously includes multiple stations in which discrete aspects of the assay are performed on fluid samples contained in sample vessels. The analyzer includes stations for automatically preparing a sample, incubating the sample, preforming an analyte isolation procedure, ascertaining the presence of a target analyte, and analyzing the amount of a target analyte. An automated receptacle transporting system moves the sample vessels from one station to the next. A method for performing an automated diagnostic assay includes an automated process for isolating and amplifying a target analyte, and, in one embodiment, a method for real-time monitoring of the amplification process.

Abstract translation: 用于同时执行多个诊断测定的自动分析器包括多个站，其中在样品容器中包含的流体样品上执行测定的离散方面。 分析仪包括用于自动准备样品，孵育样品，预先分析分析程序，确定目标分析物的存在以及分析目标分析物的量的站。 自动化容器输送系统将样品容器从一个站移动到另一个站。 执行自动诊断测定的方法包括用于分离和扩增靶分析物的自动化过程，并且在一个实施方案中，用于实时监测扩增过程的方法。

公开(公告)号：US07978325B2

公开(公告)日：2011-07-12

申请号：US12121120

申请日：2008-05-15

Applicant: Sakuichiro Adachi

Inventor： Sakuichiro Adachi

IPC: G01J3/04 ,  G01J3/28

CPC classification number: G01N21/253 ,  G01J3/02 ,  G01J3/0218 ,  G01J3/0229 ,  G01J3/0262 ,  G01J3/04 ,  G01J3/36 ,  G01J3/42 ,  G01N21/13 ,  G01N21/255 ,  G01N2021/0325 ,  G01N2021/115 ,  G01N2021/3155 ,  G01N2201/0415 ,  G01N2201/0446 ,  G01N2201/0453 ,  G01N2201/0618

Abstract: A light amount is increased and an analyzing accuracy can be kept in accordance with an enlargement of a load angle, however, a scattered light tends to be loaded in an analysis accompanying the scattered light and a dynamic range of a concentration which can be measured becomes narrow. A light is dispersed by a light dispersing portion, a load angle of the received light is changed per wavelength, the load angle is made larger in the light of a wavelength having a small light amount, and the load angle is made smaller in the light a wavelength having a large light amount and used for an analysis accompanying a scattered light. Accordingly, it is possible to gain a dynamic range of a concentration which can be measured in the analysis accompanying the scattered light, while increasing the light amount and maintaining the analyzing accuracy.

Abstract translation: 光量增加，并且可以根据负载角的放大来保持分析精度，然而，伴随散射光的分析倾向于加载散射光，并且可测量的浓度的动态范围变为 狭窄。 通过光分散部分散射光，每波长改变接收光的负载角度，在具有小光量的波长的光中使负载角变大，并且使光的负载角变小 具有大光量的波长并用于伴随散射光的分析。 因此，在增加光量并保持分析精度的同时，可以获得在伴随散射光的分析中可以测量的浓度的动态范围。

公开(公告)号：US20110147610A1

公开(公告)日：2011-06-23

申请号：US13031889

申请日：2011-02-22

Applicant: Jerzy A. MACIOSZEK ,  Christopher B. DAVIS ,  Gary D. LAIR ,  Thanh N. NGUYEN ,  Haitao LI ,  Florence F. LI ,  Byron J. KNIGHT ,  Robert F. SCALESE ,  Robert E. HEINZ

Inventor： Jerzy A. MACIOSZEK ,  Christopher B. DAVIS ,  Gary D. LAIR ,  Thanh N. NGUYEN ,  Haitao LI ,  Florence F. LI ,  Byron J. KNIGHT ,  Robert F. SCALESE ,  Robert E. HEINZ

IPC: G01N21/01 ,  G01N23/10

CPC classification number: G01N21/6428 ,  B01L7/52 ,  C12Q1/6813 ,  C12Q1/6851 ,  G01N21/6454 ,  G01N21/76 ,  G01N35/00693 ,  G01N35/0092 ,  G01N35/0098 ,  G01N35/0099 ,  G01N35/025 ,  G01N35/026 ,  G01N35/028 ,  G01N35/04 ,  G01N35/1002 ,  G01N2021/6419 ,  G01N2021/6421 ,  G01N2021/6432 ,  G01N2021/6439 ,  G01N2021/6441 ,  G01N2035/00346 ,  G01N2035/00356 ,  G01N2035/00524 ,  G01N2035/0097 ,  G01N2035/0441 ,  G01N2035/0443 ,  G01N2035/0444 ,  G01N2035/0455 ,  G01N2035/0491 ,  G01N2035/103 ,  G01N2201/0415 ,  Y10S435/808 ,  Y10S435/809 ,  Y10T436/113332 ,  Y10T436/25 ,  C12Q2537/165

Abstract: An automated analyzer for performing multiple diagnostic assays simultaneously includes multiple stations in which discrete aspects of the assay are performed on fluid samples contained in sample vessels. The analyzer includes stations for automatically preparing a sample, incubating the sample, preforming an analyte isolation procedure, ascertaining the presence of a target analyte, and analyzing the amount of a target analyte. An automated receptacle transporting system moves the sample vessels from one station to the next. A method for performing an automated diagnostic assay includes an automated process for isolating and amplifying a target analyte, and, in one embodiment, a method for real-time monitoring of the amplification process.

Abstract translation: 用于同时执行多个诊断测定的自动分析器包括多个站，其中在样品容器中包含的流体样品上执行测定的离散方面。 分析仪包括用于自动准备样品，孵育样品，预先分析分析程序，确定目标分析物的存在以及分析目标分析物的量的站。 自动化容器输送系统将样品容器从一个站移动到另一个站。 执行自动诊断测定的方法包括用于分离和扩增靶分析物的自动化过程，并且在一个实施方案中，用于实时监测扩增过程的方法。