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公开(公告)号：US08648196B2
公开(公告)日：2014-02-11
申请号：US13663601
申请日：2012-10-30
Applicant: AbbVie Inc.
Inventor： Anthony Haight , David M. Barnes , Geoff G. Z. Zhang
IPC: C07D215/38
CPC classification number: C07D213/74 , A01N43/40 , C07D205/04 , C07D213/73 , C07D213/75 , C07D401/14
Abstract: A process for making 1-(6-amino-3,5-difluoropyridin-2-yl)-8-chloro-6-fluoro-7-(3-hydroxyazetidin-1-yl)-4-oxo-1,4-dihydro-3-quinolinecarboxylic acid, and therapeutically acceptable salts thereof, and intermediates used in the process are disclosed.
Abstract translation: 制备1-（6-氨基-3,5-二氟吡啶-2-基）-8-氯-6-氟-7-（3-羟基吖丁啶-1-基）-4-氧代-1,4- 二氢-3-喹啉羧酸及其治疗上可接受的盐，以及该方法中使用的中间体。
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公开(公告)号：US10329276B2
公开(公告)日：2019-06-25
申请号：US15844904
申请日：2017-12-18
Applicant: AbbVie Inc.
Inventor： Geoff G. Z. Zhang , Michael F. Bradley , David M. Barnes , Rodger Henry
IPC: C07D401/14 , C07C31/26 , A61K31/4709 , A61K47/02 , A61K47/12
Abstract: A crystalline form of a drug, ways to make it, compositions containing it and methods of treatment of diseases and inhibition of adverse physiological events using it are disclosed.
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公开(公告)号：US09873681B2
公开(公告)日：2018-01-23
申请号：US15359734
申请日：2016-11-23
Applicant: AbbVie Inc.
Inventor： Geoff G. Z. Zhang , Michael F. Bradley , David M. Barnes , Rodger Henry
IPC: C07D401/14 , C07C31/26 , A61K31/4709 , A61K47/02 , A61K47/12
CPC classification number: C07D401/14 , A61K31/4709 , A61K47/02 , A61K47/12 , C07C31/26
Abstract: A crystalline form of a drug, ways to make it, compositions containing it and methods of treatment of diseases and inhibition of adverse physiological events using it are disclosed.
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Patent Agency Ranking
公开(公告)号：US09381508B2
公开(公告)日：2016-07-05
申请号：US14834420
申请日：2015-08-24
Applicant: AbbVie Inc.
Inventor： Shashank Shekhar , Thaddeus S. Franczyk , David M. Barnes , Travis B. Dunn , Anthony R. Haight , Vincent S. Chan
IPC: B01J31/18 , B01J31/24 , C07C1/30 , C07C1/32 , C07C17/093 , C07C201/10 , C07C253/14 , C07C253/30 , C07C273/18 , C07C303/36 , C07C303/40 , C07C319/14 , C07C41/01 , C07C45/68 , C07C45/71 , C07D209/12 , C07D209/34 , C07D209/42 , C07D213/76 , C07D239/54 , C07D265/30 , C07D295/033 , C07F1/02 , C07F5/02 , C07F9/40 , C07F9/50 , C07F9/6568
CPC classification number: B01J31/2423 , B01J31/189 , B01J31/2419 , B01J31/2438 , B01J31/2466 , B01J31/2485 , B01J31/249 , B01J2231/4211 , B01J2231/4227 , B01J2231/4277 , B01J2231/4283 , B01J2231/4288 , B01J2231/4294 , B01J2231/44 , B01J2531/0205 , B01J2531/0266 , B01J2531/0288 , B01J2531/824 , B01J2540/10 , B01J2540/40 , C07C1/26 , C07C1/30 , C07C1/321 , C07C17/093 , C07C17/2635 , C07C17/361 , C07C41/01 , C07C41/30 , C07C45/61 , C07C45/68 , C07C45/71 , C07C201/10 , C07C253/14 , C07C253/30 , C07C273/1854 , C07C273/1863 , C07C303/36 , C07C303/40 , C07C319/14 , C07C2531/24 , C07C2531/26 , C07D209/12 , C07D209/34 , C07D209/42 , C07D213/76 , C07D239/54 , C07D265/30 , C07D295/033 , C07F1/02 , C07F5/025 , C07F5/04 , C07F9/4021 , C07F9/4841 , C07F9/505 , C07F9/5072 , C07F9/509 , C07F9/572 , C07F9/65031 , C07F9/65583 , C07F9/65683 , C07F9/657163 , Y02P20/52 , C07C275/28 , C07C311/08 , C07C311/21 , C07C311/29 , C07C255/10 , C07C321/30 , C07C205/45 , C07C15/06 , C07C49/784
Abstract: The disclosure is directed to: (a) phosphacycle ligands; (b) catalyst compositions comprising phosphacycle ligands; and (c) methods of using such phosphacycle ligands and catalyst compositions in bond forming reactions.
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公开(公告)号：US09266913B2
公开(公告)日：2016-02-23
申请号：US14467625
申请日：2014-08-25
Applicant: AbbVie Inc.
Inventor： Shashank Shekhar , Thaddeus S. Franczyk , David M. Barnes , Travis B. Dunn , Anthony R. Haight , Vincent S. Chan
IPC: C07F9/6568 , C07F9/6571 , B01J31/24 , C07D239/54 , C07F9/6503 , C07F9/655 , C07C1/30 , C07C15/14 , C07C41/09 , C07C201/10 , C07C273/18 , C07C315/04 , C07C319/18 , C07D209/34 , C07D295/033 , C07F5/02 , C07F9/40 , C07F9/6584
CPC classification number: C07F9/657163 , B01J31/189 , B01J31/2423 , B01J31/2466 , B01J31/2485 , B01J31/249 , B01J2231/344 , B01J2231/4227 , B01J2231/4283 , B01J2231/4288 , B01J2231/4294 , B01J2531/0205 , B01J2531/0266 , B01J2531/0288 , B01J2531/824 , B01J2540/10 , B01J2540/40 , C07C1/30 , C07C1/321 , C07C15/14 , C07C17/093 , C07C17/361 , C07C41/09 , C07C45/68 , C07C201/10 , C07C253/30 , C07C273/1854 , C07C273/1863 , C07C303/40 , C07C315/04 , C07C319/14 , C07C319/18 , C07C2523/42 , C07C2523/44 , C07C2523/46 , C07C2523/52 , C07C2523/72 , C07C2523/75 , C07C2523/755 , C07C2527/14 , C07C2531/22 , C07C2531/24 , C07D209/34 , C07D239/54 , C07D295/033 , C07F5/027 , C07F9/40 , C07F9/65031 , C07F9/65515 , C07F9/6552 , C07F9/65683 , C07F9/6571 , C07F9/6584 , Y02P20/52 , C07C275/28 , C07C311/08 , C07C311/21 , C07C311/29 , C07C255/10 , C07C321/30 , C07C205/45 , C07C15/06 , C07C49/784 , C07C25/18
Abstract: The disclosure is directed to: (a) phosphacycle ligands; (b) methods of using such phosphacycle ligands in bond forming reactions; and (c) methods of preparing phosphacycle ligands.
Abstract translation: 本公开涉及：（a）磷酸基配体; （b）在成键反应中使用这种磷酸基配体的方法; 和（c）制备磷酸基配体的方法。
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公开(公告)号：US09200021B2
公开(公告)日：2015-12-01
申请号：US14611943
申请日：2015-02-02
Applicant: AbbVie Inc.
Inventor： Shashank Shekhar , Thaddeus S. Franczyk , David M. Barnes , Travis B. Dunn , Anthony R. Haight , Vincent S. Chan
IPC: C07F9/6568 , B01J31/24 , C07C303/40 , C07D209/12 , C07D213/76 , C07D239/54 , C07C253/30 , C07C201/10 , C07D209/34 , C07D265/30 , C07C1/30 , C07C17/093 , C07C41/01 , C07C45/71 , C07C253/14 , C07C273/18 , C07C303/36 , C07C319/14 , C07D209/42 , C07D295/033 , C07F5/02 , C07F9/40
CPC classification number: B01J31/2423 , B01J31/189 , B01J31/2419 , B01J31/2438 , B01J31/2466 , B01J31/2485 , B01J31/249 , B01J2231/4211 , B01J2231/4227 , B01J2231/4277 , B01J2231/4283 , B01J2231/4288 , B01J2231/4294 , B01J2231/44 , B01J2531/0205 , B01J2531/0266 , B01J2531/0288 , B01J2531/824 , B01J2540/10 , B01J2540/40 , C07C1/26 , C07C1/30 , C07C1/321 , C07C17/093 , C07C17/2635 , C07C17/361 , C07C41/01 , C07C41/30 , C07C45/61 , C07C45/68 , C07C45/71 , C07C201/10 , C07C253/14 , C07C253/30 , C07C273/1854 , C07C273/1863 , C07C303/36 , C07C303/40 , C07C319/14 , C07C2531/24 , C07C2531/26 , C07D209/12 , C07D209/34 , C07D209/42 , C07D213/76 , C07D239/54 , C07D265/30 , C07D295/033 , C07F1/02 , C07F5/025 , C07F5/04 , C07F9/4021 , C07F9/4841 , C07F9/505 , C07F9/5072 , C07F9/509 , C07F9/572 , C07F9/65031 , C07F9/65583 , C07F9/65683 , C07F9/657163 , Y02P20/52 , C07C275/28 , C07C311/08 , C07C311/21 , C07C311/29 , C07C255/10 , C07C321/30 , C07C205/45 , C07C15/06 , C07C49/784
Abstract: The disclosure is directed to: (a) phosphacycle ligands; (b) catalyst compositions comprising phosphacycle ligands; and (c) methods of using such phosphacycle ligands and catalyst compositions in bond forming reactions.
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公开(公告)号：US20150152126A1
公开(公告)日：2015-06-04
申请号：US14611943
申请日：2015-02-02
Applicant: AbbVie Inc.
Inventor： Shashank Shekhar , Thaddeus S. Franczyk , David M. Barnes , Travis B. Dunn , Anthony R. Haight , Vincent S. Chan
IPC: C07F9/6568 , C07D209/42 , C07D213/76 , C07D239/54 , C07C41/01 , C07C273/18 , C07C253/30 , C07C201/10 , C07D209/34 , C07F5/02 , C07C17/093 , C07D295/033 , C07C319/14 , C07C45/71 , C07C253/14 , C07F9/40 , B01J31/24 , C07C1/30 , C07C303/36
CPC classification number: B01J31/2423 , B01J31/189 , B01J31/2419 , B01J31/2438 , B01J31/2466 , B01J31/2485 , B01J31/249 , B01J2231/4211 , B01J2231/4227 , B01J2231/4277 , B01J2231/4283 , B01J2231/4288 , B01J2231/4294 , B01J2231/44 , B01J2531/0205 , B01J2531/0266 , B01J2531/0288 , B01J2531/824 , B01J2540/10 , B01J2540/40 , C07C1/26 , C07C1/30 , C07C1/321 , C07C17/093 , C07C17/2635 , C07C17/361 , C07C41/01 , C07C41/30 , C07C45/61 , C07C45/68 , C07C45/71 , C07C201/10 , C07C253/14 , C07C253/30 , C07C273/1854 , C07C273/1863 , C07C303/36 , C07C303/40 , C07C319/14 , C07C2531/24 , C07C2531/26 , C07D209/12 , C07D209/34 , C07D209/42 , C07D213/76 , C07D239/54 , C07D265/30 , C07D295/033 , C07F1/02 , C07F5/025 , C07F5/04 , C07F9/4021 , C07F9/4841 , C07F9/505 , C07F9/5072 , C07F9/509 , C07F9/572 , C07F9/65031 , C07F9/65583 , C07F9/65683 , C07F9/657163 , Y02P20/52 , C07C275/28 , C07C311/08 , C07C311/21 , C07C311/29 , C07C255/10 , C07C321/30 , C07C205/45 , C07C15/06 , C07C49/784
Abstract: The disclosure is directed to: (a) phosphacycle ligands; (b) catalyst compositions comprising phosphacycle ligands; and (c) methods of using such phosphacycle ligands and catalyst compositions in bond forming reactions.
Abstract translation: 本公开涉及：（a）磷酸基配体; （b）包含磷酸基配体的催化剂组合物; 和（c）在结合形成反应中使用这种磷酸基配体和催化剂组合物的方法。
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公开(公告)号：US08927723B2
公开(公告)日：2015-01-06
申请号：US14176334
申请日：2014-02-10
Applicant: AbbVie, Inc.
Inventor： Anthony Haight , David M. Barnes , Geoff G. Z. Zhang
IPC: C07D215/38 , C07D401/14 , C07D205/04 , C07D213/73 , C07D213/75
CPC classification number: C07D213/74 , A01N43/40 , C07D205/04 , C07D213/73 , C07D213/75 , C07D401/14
Abstract: A process for making 1-(6-amino-3,5-difluoropyridin-2-yl)-8-chloro-6-fluoro-7-(3-hydroxyazetidin-1-yl)-4-oxo-1,4-dihydro-3-quinolinecarboxylic acid, and therapeutically acceptable salts thereof, and intermediates used in the process are disclosed.
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