公开(公告)号：US20210055269A1

公开(公告)日：2021-02-25

申请号：US17045751

申请日：2018-04-06

Applicant: Agilent Technologies, Inc.

Inventor： Konstantin Shoykhet

IPC: G01N30/32 ,  G01N30/20 ,  G01N30/46

Abstract: An apparatus for separating a fluidic sample includes a fluid drive arrangement including fluid drive units for driving a mobile phase along a flow path to a sample separation unit, a sample accommodation volume for accommodating the fluidic sample and selectively fluidically coupleable with or decoupleable from the flow path, and a control unit. The control unit is configured to control pressure decoupling of at least part of at least one of the fluid drive units from the flow path, and enable the partially pressure-decoupled fluid drive unit(s) to pressurize the sample accommodation volume before fluidically coupling the sample accommodation volume with the flow path and/or to de-pressurize the sample accommodation volume after fluidically coupling the sample accommodation volume with the flow path for preparing a subsequent intake of fluidic sample in the sample accommodation volume.

公开(公告)号：US20180052141A1

公开(公告)日：2018-02-22

申请号：US15558117

申请日：2016-03-10

Applicant: Agilent Technologies, Inc.

Inventor： Dwight Robert Stoll ,  Konstantin Shoykhet ,  Klaus Witt ,  Stephan Buckenmaier

IPC: G01N30/34 ,  G01N30/20 ,  G01N30/46

Abstract: A control device for controlling at least part of a sample separation apparatus for separating a fluidic sample, the sample separation apparatus including at least two fluid accommodation volumes having different flow through properties and each being configured for temporarily accommodating fluidic sample, wherein the control device is configured for controlling operation of at least part of the sample separation apparatus for at least partially compensating sample separation artifacts resulting from the different flow through properties of the fluid accommodation volumes.

公开(公告)号：US20170131244A1

公开(公告)日：2017-05-11

申请号：US15320123

申请日：2014-06-25

Applicant: Agilent Technologies, Inc.

Inventor： Klaus Witt ,  Stephan Buckenmaier ,  Konstantin Shoykhet

IPC: G01N30/46 ,  B01D15/18

CPC classification number: G01N30/463 ,  B01D15/1878 ,  G01N30/32 ,  G01N30/465 ,  G01N30/88 ,  G01N2030/322 ,  G01N2030/8881

Abstract: A secondary stage sample separation device for separating at least a portion of a fluidic sample includes a fluidic interface configured for forming a detachable fluidic coupling between a primary stage sample separation device and the secondary separation device so that the fluidic sample separated by the primary stage sample separation device is fluidically supplyable to the secondary stage sample separation device via the fluidic interface for further separation, wherein the secondary stage sample separation device is further configured for separating at least a portion of the supplied fluidic sample independent of a flow rate of the fluidic sample supplied from the primary stage sample separation device at the fluidic interface.

公开(公告)号：US20240280546A1

公开(公告)日：2024-08-22

申请号：US18649773

申请日：2024-04-29

Applicant: Agilent Technologies, Inc.

Inventor： Clemens Plachetka ,  Manfred Berndt ,  Konstantin Shoykhet ,  Tony Ziegler ,  Joachim-Richard Wagner

IPC: G01N30/06 ,  G01N1/00 ,  G01N30/32

CPC classification number: G01N30/06 ,  G01N30/32 ,  G01N2001/002 ,  G01N2030/065 ,  G01N2030/326

Abstract: A fluid supply device for providing a mobile phase for a sample separating device includes a supply path configured to provide a fluid for forming at least a part of the mobile phase, a fluid conveying unit configured to receive and pressurize the fluid from the supply path and to convey the fluid to the sample separating device, and a sterile filter disposed in the supply path upstream of the fluid conveying unit and configured to filter the fluid. The fluid supply device may include a pre-filter pump configured to push the fluid through the sterile filter and/or a buffer unit configured to buffer the fluid.

公开(公告)号：US11933769B2

公开(公告)日：2024-03-19

申请号：US17051701

申请日：2019-04-30

Applicant: Agilent Technologies, Inc.

Inventor： Dwight Robert Stoll ,  Klaus Witt ,  Konstantin Shoykhet

IPC: G01N30/32 ,  G01N30/46

CPC classification number: G01N30/32 ,  G01N30/463 ,  G01N30/466 ,  G01N30/468

Abstract: A multidimensional sample separation apparatus includes a first separation dimension for separating a fluidic sample, a second separation dimension for further separating the fluidic sample, a switching mechanism, and a control unit. The first separation dimension includes a first fluid drive unit and a first sample separation unit. The second separation dimension includes a second fluid drive unit for driving the separated fluidic sample, and second and third sample separation units each configured for further separating the separated fluidic sample. The switching mechanism is configured for selectively switching an outlet of the first separation dimension in fluid communication with a selected one of the second sample separation unit and/or the third sample separation unit. The control unit is configured for controlling a pressure at inlets of the second sample separation unit and the third sample separation unit to be substantially the same at least at the time of the switching.

公开(公告)号：US11635065B2

公开(公告)日：2023-04-25

申请号：US17322676

申请日：2021-05-17

Applicant: Agilent Technologies, Inc.

Inventor： Klaus Witt ,  Konstantin Shoykhet

IPC: F04B11/00 ,  F04B13/02

Abstract: A solvent supply system for supplying a composite includes a first supply path with a first pump unit, the first supply path being adapted for supplying a first solvent to a mixing unit, the first pump unit operating periodically, and a second supply path with a second pump unit, the second supply path being adapted for supplying a second solvent to the mixing unit, the second pump unit operating periodically. The mixing unit is adapted for mixing the first and the second solvent and for supplying a composite solvent. The solvent supply system further includes a control unit adapted for controlling operation of the first and the second pump unit.

公开(公告)号：US20220065827A1

公开(公告)日：2022-03-03

申请号：US17446096

申请日：2021-08-26

Applicant: Agilent Technologies, Inc.

Inventor： Konstantin Shoykhet ,  Stephan Buckenmaier

IPC: G01N30/46 ,  G01N30/32 ,  G01N30/14

Abstract: A multi-dimensional liquid chromatography system includes first and second liquid chromatography systems. The first system is configured for providing a first chromatographic separation of a sample fluid comprised in a first mobile phase and to provide a first effluent including at least a portion of the separated sample fluid. The second system is configured for providing a second chromatographic separation of at least a portion of the first effluent comprised in a second mobile phase. A control unit is configured to operate the first liquid chromatography system by maintaining a first flow rate of the first mobile phase substantially constant during the first chromatographic separation, and to operate the second liquid chromatography system during the second chromatographic separation according to a control value different from the second flow rate, so that a variation in the control value can lead to a variation in the second flow rate.

公开(公告)号：US20210223216A1

公开(公告)日：2021-07-22

申请号：US17051701

申请日：2019-04-30

Applicant: Agilent Technologies, Inc.

Inventor： Dwight Robert Stoll ,  Klaus Witt ,  Konstantin Shoykhet

IPC: G01N30/32 ,  G01N30/46

Abstract: A multidimensional sample separation apparatus includes a first separation dimension for separating a fluidic sample, a second separation dimension for further separating the fluidic sample, a switching mechanism, and a control unit. The first separation dimension includes a first fluid drive unit and a first sample separation unit. The second separation dimension includes a second fluid drive unit for driving the separated fluidic sample, and second and third sample separation units each configured for further separating the separated fluidic sample. The switching mechanism is configured for selectively switching an outlet of the first separation dimension in fluid communication with a selected one of the second sample separation unit and/or the third sample separation unit. The control unit is configured for controlling a pressure at inlets of the second sample separation unit and the third sample separation unit to be substantially the same at least at the time of the switching.

公开(公告)号：US10976289B2

公开(公告)日：2021-04-13

申请号：US15691202

申请日：2017-08-30

Applicant: Agilent Technologies, Inc.

Inventor： Klaus Witt ,  Konstantin Shoykhet ,  Philip Herzog ,  Iwan Bouzid

IPC: G01N30/32 ,  G01N30/86 ,  G01N30/02 ,  G01N30/20

Abstract: To determine a corrected flow rate value of a mobile phase flowing in a liquid chromatography (LC) system, a flow rate of the mobile phase at a selected reference position in the LC system is measured to produce one or more flow rate values. A model of the LC system is applied to the flow rate value(s) to determine the corrected flow rate value(s). The model includes a distribution of capacitive elements and resistive elements arranged according to a topology of the LC system. The capacitive and resistive elements are representative of system and solvent properties affecting flow rate while operating the LC system. The system and solvent properties may be properties affecting the flow rate while operating the LC system under dynamic conditions.

公开(公告)号：US09631618B2

公开(公告)日：2017-04-25

申请号：US14677558

申请日：2015-04-02

Applicant: AGILENT TECHNOLOGIES, INC.

Inventor： Konstantin Shoykhet ,  Klaus Witt

IPC: F04B51/00 ,  F04B23/06 ,  F04B49/08 ,  F04B49/20 ,  G01N30/32 ,  G01N30/36

CPC classification number: F04B51/00 ,  F04B23/06 ,  F04B49/08 ,  F04B49/20 ,  G01N30/32 ,  G01N30/36 ,  G01N2030/326

Abstract: A device for determining a leakage of fluid in a piston pump, wherein the piston pump comprises a piston arranged in such a manner that it can reciprocate in a piston chamber for delivering fluid, wherein the device comprises a control unit for controlling the piston in such a manner that the piston executes two piston chamber evacuation processes with different evacuation times, in each case for at least partial evacuating of fluid located in the piston chamber, and a determination unit for determining the leakage based on a comparison of fluid quantities evacuated from the piston chamber in the two piston chamber evacuation processes.