公开(公告)号：US11246850B2

公开(公告)日：2022-02-15

申请号：US17321788

申请日：2021-05-17

Applicant: Biogen MA Inc.

Inventor： Mark Novas ,  Rui (Ray) Zhang

IPC: A61K31/225 ,  A61K31/40 ,  A61K9/00 ,  A61K9/28 ,  A61K9/48 ,  G01N33/49 ,  G09B19/00 ,  A61K47/54 ,  A61P25/00

Abstract: Provided herein are methods of treating multiple sclerosis with a fumarate, wherein the fumarate is a dialkyl fumarate, a monoalkyl fumarate, a combination of a dialkyl fumarate and a monoalkyl fumarate, a prodrug of monoalkyl fumarate, a deuterated form of any of the foregoing, or a pharmaceutically acceptable salt, clathrate, solvate, tautomer, or stereoisomer of any of the foregoing, or a combination of any of the foregoing. The methods provided herein improve the safety of treatment by informing and monitoring patients undergoing treatment regarding progressive multifocal leukoencephalopathy, and/or by monitoring lymphocyte count.

公开(公告)号：US20180000770A1

公开(公告)日：2018-01-04

申请号：US15647036

申请日：2017-07-11

Applicant: Biogen MA Inc.

Inventor： Mark Novas ,  Rui (Ray) Zhang

IPC: A61K31/225 ,  A61K9/48 ,  A61K9/00 ,  A61K9/28 ,  G09B19/00 ,  G01N33/49

CPC classification number: A61K31/225 ,  A61K9/0053 ,  A61K9/28 ,  A61K9/4808 ,  A61K9/4825 ,  A61K9/485 ,  A61K9/4858 ,  A61K9/4866 ,  A61K47/542 ,  A61K47/545 ,  G01N33/492 ,  G09B19/00 ,  Y02A50/467

Abstract: Provided herein are methods of treating multiple sclerosis with a fumarate, wherein the fumarate is a dialkyl fumarate, a monoalkyl fumarate, a combination of a dialkyl fumarate and a monoalkyl fumarate, a prodrug of monoalkyl fumarate, a deuterated form of any of the foregoing, or a pharmaceutically acceptable salt, clathrate, solvate, tautomer, or stereoisomer of any of the foregoing, or a combination of any of the foregoing. The methods provided herein improve the safety of treatment by informing and monitoring patients undergoing treatment regarding progressive multifocal leukoencephalopathy, and/or by monitoring lymphocyte count.

公开(公告)号：US20170354630A1

公开(公告)日：2017-12-14

申请号：US15527252

申请日：2015-11-16

Applicant: Biogen MA Inc.

Inventor： Mark Novas ,  Rui (Ray) Zhang

IPC: A61K31/225 ,  G01N33/49 ,  G09B19/00 ,  A61K9/48 ,  A61K9/28 ,  A61K9/00

CPC classification number: A61K31/225 ,  A61K9/0053 ,  A61K9/28 ,  A61K9/4808 ,  A61K9/4825 ,  A61K9/485 ,  A61K9/4858 ,  A61K9/4866 ,  A61K47/542 ,  A61K47/545 ,  G01N33/492 ,  G09B19/00 ,  Y02A50/467

Abstract: Provided herein are methods of treating multiple sclerosis with a fumarate, wherein the fumarate is a dialkyl fumarate, a monoalkyl fumarate, a combination of a dialkyl fumarate and a monoalkyl fumarate, a prodrug of monoalkyl fumarate, a deuterated form of any of the foregoing, or a pharmaceutically acceptable salt, clathrate, solvate, tautomer, or stereoisomer of any of the foregoing, or a combination of any of the foregoing. The methods provided herein improve the safety of treatment by informing and monitoring patients undergoing treatment regarding progressive multifocal leukoencephalopathy, and/or by monitoring lymphocyte count.