公开(公告)号：US06716445B2

公开(公告)日：2004-04-06

申请号：US10143572

申请日：2002-05-13

Applicant: Chee-Youb Won ,  Yeli Zhang ,  Chih-Chang Chu

Inventor： Chee-Youb Won ,  Yeli Zhang ,  Chih-Chang Chu

IPC: A61K958

CPC classification number: C08L5/02 ,  A61K9/205 ,  A61K47/36 ,  C08B37/0021 ,  C08G18/6484 ,  C08G18/8108 ,  C08G2210/00 ,  C08L67/07 ,  Y10S525/937 ,  C08L2666/02 ,  C08L2666/26

Abstract: A hydrogel forming system which comprises a hydrophobic macromer with unsaturated group terminated ends and a hydrophilic polymer which is a polysaccharide containing hydroxy groups which are reacted with unsaturated group introducing compound, is convertible by free radical polymerization to form a hydrogel containing a three dimensional crosslinked polymer network containing hydrophobic and hydrophilic components. Agent can be entrapped in the polymer network, e.g., drugs, macromolecules or synthetic or natural polymers, for controlled release therefrom. In one embodiment, a vascular stent is coated with hydrogel with therapeutic agent entrapped therein.

Abstract translation: 包含具有不饱和基团末端的疏水大分子单体和亲水性聚合物的水凝胶形成体系，其是含有与不饱和基团导入化合物反应的羟基的多糖，可通过自由基聚合反应形成含有三维交联聚合物的水凝胶 网络含有疏水和亲水组分。 药剂可以被捕获在聚合物网络中，例如药物，大分子或合成或天然聚合物，用于从其中控制释放。 在一个实施方案中，血管支架用包封在其中的治疗剂的水凝胶包被。

公开(公告)号：US20070167606A1

公开(公告)日：2007-07-19

申请号：US11724009

申请日：2007-03-14

Applicant: Chee-Youb Won

Inventor： Chee-Youb Won

IPC: C08G65/34 ,  C07C271/20 ,  C07C275/14

CPC classification number: C08G65/324 ,  C08G65/329 ,  C08G65/331

Abstract: Polyethylene glycol aldehyde compounds are provided. Methods of making and using such compounds, as well as chemical intermediates are also provided.

Abstract translation: 提供聚乙二醇醛化合物。 还提供了制备和使用这些化合物的方法以及化学中间体。

公开(公告)号：US07084261B2

公开(公告)日：2006-08-01

申请号：US10625103

申请日：2003-07-22

Applicant: Pascal S. Bailon ,  Chee-Youb Won

Inventor： Pascal S. Bailon ,  Chee-Youb Won

IPC: A61K38/12 ,  C08H1/00

CPC classification number: C07K14/005 ,  A61K38/00 ,  A61K47/60 ,  C12N2740/15022 ,  C12N2740/16122

Abstract: Pegylated T1249 polypeptide compounds are provided. Also provided are pharmaceutical compositions containing pegylated T1249 polypeptide compounds, and methods of making. Further provided are methods of inhibiting HIV infection using such compounds and compositions.

Abstract translation: 提供了聚乙二醇化的T1249多肽化合物。 还提供了含有聚乙二醇化T1249多肽化合物的药物组合物和制备方法。 还提供了使用这些化合物和组合物来抑制HIV感染的方法。

公开(公告)号：US20060167218A1

公开(公告)日：2006-07-27

申请号：US11386876

申请日：2006-03-22

Applicant: Chee-Youb Won

Inventor： Chee-Youb Won

IPC: C08G65/34 ,  C08G63/06

CPC classification number: C08G65/337 ,  A61K47/60 ,  C08G65/329 ,  C08G65/3322 ,  C08L2203/02

Abstract: A new class of activated polyalkylene glycol acids and their active ester reagents for conjugation to biopharmaceuticals such as polypeptides, sugars, proteins and therapeutically active small molecules to produce biologically active conjugates of these pharmaceuticals and methods for producing these conjugates.

公开(公告)号：US07049415B2

公开(公告)日：2006-05-23

申请号：US10623873

申请日：2003-07-21

Applicant: Pascal Sebastian Bailon ,  Chee-Youb Won

Inventor： Pascal Sebastian Bailon ,  Chee-Youb Won

IPC: A61K38/12 ,  C08H1/00

CPC classification number: C07K14/005 ,  A61K38/00 ,  C12N2740/16122

Abstract: Pegylated T20 polypeptide compounds are provided. Also provided are pharmaceutical compositions containing pegylated T20 polypeptide compounds, and methods of making and using such compounds and compositions.

Abstract translation: 提供了聚乙二醇化的T20多肽化合物。 还提供含有聚乙二醇化的T20多肽化合物的药物组合物，以及制备和使用这些化合物和组合物的方法。

公开(公告)号：US06916857B2

公开(公告)日：2005-07-12

申请号：US10733291

申请日：2003-12-12

Applicant: Chee-Youb Won ,  Yeli Zhang ,  Chih-Chang Chu

Inventor： Chee-Youb Won ,  Yeli Zhang ,  Chih-Chang Chu

IPC: A61K9/20 ,  A61K9/22 ,  A61K9/58 ,  A61K31/405 ,  A61K38/00 ,  A61K38/28 ,  A61K47/32 ,  A61K47/36 ,  A61P3/10 ,  A61P29/00 ,  C08B37/02 ,  C08F299/00 ,  C08G18/64 ,  C08G18/81 ,  C08L5/02 ,  C08L67/07 ,  C08G63/08

CPC classification number: C08L5/02 ,  A61K9/205 ,  A61K47/36 ,  C08B37/0021 ,  C08G18/6484 ,  C08G18/8108 ,  C08G2210/00 ,  C08L67/07 ,  Y10S525/937 ,  C08L2666/02 ,  C08L2666/26

Abstract: A hydrogel forming system which comprises a hydrophobic macromer with unsaturated group terminated ends and a hydrophilic polymer which is a polysaccharide (e.g. dextran) containing hydroxy groups which are reacted with unsaturated group introducing compound, is convertible by free radical polymerization to form a hydrogel containing a three dimensional crosslinked polymer network containing hydrophobic and hydrophilic components. Agent can be entrapped in the polymer network, e.g., drugs, macromolecules or synthetic or natural polymers, for controlled release therefrom.

Abstract translation: 包含具有不饱和基团末端的疏水性大分子单体和亲水性聚合物的水凝胶形成体系，其是含有与不饱和基团引入化合物反应的羟基的多糖（例如葡聚糖），可通过自由基聚合反应形成含有 含有疏水和亲水组分的三维交联聚合物网络。 药剂可以被捕获在聚合物网络中，例如药物，大分子或合成或天然聚合物，用于从其中控制释放。

公开(公告)号：US06388047B1

公开(公告)日：2002-05-14

申请号：US09531451

申请日：2000-03-20

Applicant: Chee-Youb Won ,  Yeli Zhang ,  Chih-Chang Chu

Inventor： Chee-Youb Won ,  Yeli Zhang ,  Chih-Chang Chu

IPC: A61K958

CPC classification number: C08L5/02 ,  A61K9/205 ,  A61K47/36 ,  C08B37/0021 ,  C08G18/6484 ,  C08G18/8108 ,  C08G2210/00 ,  C08L67/07 ,  Y10S525/937 ,  C08L2666/02 ,  C08L2666/26

Abstract: A hydrogel forming system which comprises a hydrophobic macromer with unsaturated group terminated ends and a hydrophilic polymer which is a polysaccharide containing hydroxy groups which are reacted with unsaturated group introducing compound, is convertible by free radical polymerization to form a hydrogel containing a three dimensional crosslinked polymer network containing hydrophobic and hydrophilic components. Preferably, the hydrophobic polymer is prepared by reacting the hydroxyls of a diol obtained by converting hydroxy of terminal carboxylic acid group of poly(lactic acid) to aminoethanol group, with an unsaturated group introducing compound which is acryloyl chloride or isocyanate having an unsaturated group at one end of the molecule. Preferably, the hydrophilic polymer is dextran wherein one or more hydroxyls in a glucose unit of the dextran is (are) reacted with an unsaturated group introducing compound which is acryloyl chloride or isocyanate having an unsaturated group at one end of a molecule. Agent can be entrapped in the polymer network, e.g., drugs, water-soluble macromolecules or synthetic or natural polymers, for controlled release therefrom.

Abstract translation: 包含具有不饱和基团末端的疏水大分子单体和亲水性聚合物的水凝胶形成体系，其是含有与不饱和基团导入化合物反应的羟基的多糖，可通过自由基聚合反应形成含有三维交联聚合物的水凝胶 网络含有疏水和亲水组分。 优选地，疏水性聚合物通过将通过将聚（乳酸）的末端羧酸基团的羟基与氨基乙醇基团的羟基与不饱和基团引入化合物（其是丙烯酰氯或具有不饱和基团的异氰酸酯） 分子的一端。 优选地，亲水性聚合物是葡聚糖，其中葡聚糖的葡萄糖单元中的一个或多个羟基与不饱和基团引入化合物反应，该化合物是分子的一端具有不饱和基团的丙烯酰氯或异氰酸酯。 药剂可以被包埋在聚合物网络中，例如药物，水溶性大分子或合成或天然聚合物，用于从其中控释。