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    Hydrogel-forming system with hydrophobic and hydrophilic components
    1.
    发明授权
    Hydrogel-forming system with hydrophobic and hydrophilic components 失效
    具有疏水和亲水组分的水凝胶形成体系

    公开(公告)号：US06709668B2

    公开(公告)日：2004-03-23

    申请号：US10369676

    申请日：2003-02-21

    Applicant: Chee-Youb Won ,  Yeli Zhang ,  Chih-Chang Chu

    Inventor： Chee-Youb Won ,  Yeli Zhang ,  Chih-Chang Chu

    IPC: C09D400

    CPC classification number: C08L5/02 ,  A61K9/205 ,  A61K47/36 ,  C08B37/0021 ,  C08G18/6484 ,  C08G18/8108 ,  C08G2210/00 ,  C08L67/07 ,  Y10S525/937 ,  C08L2666/02 ,  C08L2666/26

    Abstract: A hydrogel forming system which comprises a hydrophobic macromer with unsaturated group terminated ends and a hydrophilic polymer which is a polysaccharide (e.g., dextran) containing hydroxy groups which are reacted with unsaturated group introducing compound, is convertible by free radical polymerization to form a hydrogel containing a three dimensional crosslinked polymer network containing hydrophobic and hydrophilic components. Agent can be entrapped in the polymer network, e.g., drugs, macromolecules or synthetic or natural polymers, for controlled release therefrom.

    Abstract translation: 包含具有不饱和基团末端的疏水大分子单体和亲水性聚合物的水凝胶形成体系，其是含有与不饱和基团引入化合物反应的含羟基的多糖（例如，葡聚糖），可通过自由基聚合反应形成含有 含有疏水和亲水组分的三维交联聚合物网络。 药剂可以被捕获在聚合物网络中，例如药物，大分子或合成或天然聚合物，用于从其中控制释放。

    Hydrogel entrapping therapeutic agent and stent with coating comprising this
    2.
    发明授权
    Hydrogel entrapping therapeutic agent and stent with coating comprising this 有权
    水凝胶包埋治疗剂和含有该涂层的涂层的支架

    公开(公告)号：US07138132B2

    公开(公告)日：2006-11-21

    申请号：US11037011

    申请日：2005-01-19

    Applicant: Chee-Youb Won ,  Yeli Zhang ,  Chih-Chang Chu

    Inventor： Chee-Youb Won ,  Yeli Zhang ,  Chih-Chang Chu

    IPC: C09D4/00 ,  A61L25/00 ,  A61L27/00 ,  A61L29/00

    CPC classification number: C08L5/02 ,  A61K9/205 ,  A61K47/36 ,  C08B37/0021 ,  C08G18/6484 ,  C08G18/8108 ,  C08G2210/00 ,  C08L67/07 ,  Y10S525/937 ,  C08L2666/02 ,  C08L2666/26

    Abstract: A hydrogel forming system which comprises a hydrophobic macromer with unsaturated group terminated ends and a hydrophilic polymer which is a polysaccharide containing hydroxy groups which are reacted with unsaturated group introducing compound, is convertible by free radical polymerization to form a hydrogel containing a three dimensional crosslinked polymer network containing hydrophobic and hydrophilic components. Agent can be entrapped in the polymer network, e.g., drugs, macromolecules or synthetic or natural polymers, for controlled release therefrom. In one embodiment, a vascular stent is coated with hydrogel with therapeutic agent entrapped therein.

    Abstract translation: 包含具有不饱和基团末端的疏水大分子单体和亲水性聚合物的水凝胶形成体系，其是含有与不饱和基团导入化合物反应的羟基的多糖，可通过自由基聚合反应形成含有三维交联聚合物的水凝胶 网络含有疏水和亲水组分。 药剂可以被捕获在聚合物网络中，例如药物，大分子或合成或天然聚合物，用于从其中控制释放。 在一个实施方案中，血管支架用包封在其中的治疗剂的水凝胶包被。

    Absorbable PEG-based hydrogels
    5.
    发明授权
    Absorbable PEG-based hydrogels 有权
    可吸收PEG型水凝胶

    公开(公告)号：US08524215B2

    公开(公告)日：2013-09-03

    申请号：US13193958

    申请日：2011-07-29

    Applicant: Chee-Youb Won ,  Helen Cui

    Inventor： Chee-Youb Won ,  Helen Cui

    IPC: A61K31/74

    CPC classification number: A61K9/0024 ,  A61K9/06 ,  A61K47/10 ,  A61K47/34 ,  C08L71/02 ,  C08L2201/56

    Abstract: An absorbable PEG-based hydrogel prepared from a multi-arm-PEG-vinylsulfone having about 3 to about 8 arms and a multi-arm-PEG-R-sulfhydryl having about 3 to about 8 arms; where R is defined as an ester linkage, such as carboxylate ester, lactate ester, and isobutyrate ester have been disclosed. Additionally, sustained release compositions that are prepared from an absorbable PEG-based hydrogel and a protein have been disclosed which provide sustained release of proteins and peptides.

    Abstract translation: 由具有约3至约8个臂的多臂-PEG-乙烯基砜制备的可吸收PEG基水凝胶和具有约3至约8个臂的多臂-PEG-R-巯基; 其中R被定义为酯键，例如羧酸酯，乳酸酯和异丁酸酯。 此外，已经公开了由可吸收的基于PEG的水凝胶和蛋白质制备的持续释放组合物，其提供蛋白质和肽的持续释放。

    ABSORBABLE PEG-BASED HYDROGELS
    6.
    发明申请
    ABSORBABLE PEG-BASED HYDROGELS 有权
    可吸收的基于PEG的水凝胶

    公开(公告)号：US20120027775A1

    公开(公告)日：2012-02-02

    申请号：US13193958

    申请日：2011-07-29

    Applicant: Chee-Youb Won ,  Helen Cui

    Inventor： Chee-Youb Won ,  Helen Cui

    IPC: A61K39/395 ,  A61K47/40 ,  A61P37/00 ,  A61K47/20

    CPC classification number: A61K9/0024 ,  A61K9/06 ,  A61K47/10 ,  A61K47/34 ,  C08L71/02 ,  C08L2201/56

    Abstract: An absorbable PEG-based hydrogel prepared from a multi-arm-PEG-vinylsulfone having about 3 to about 8 arms and a multi-arm-PEG-R-sulfhydryl having about 3 to about 8 arms; where R is defined as an ester linkage, such as carboxylate ester, lactate ester, and isobutyrate ester have been disclosed. Additionally, sustained release compositions that are prepared from an absorbable PEG-based hydrogel and a protein have been disclosed which provide sustained release of proteins and peptides.

    Abstract translation: 由具有约3至约8个臂的多臂-PEG-乙烯基砜制备的可吸收PEG基水凝胶和具有约3至约8个臂的多臂-PEG-R-巯基; 其中R被定义为酯键，例如羧酸酯，乳酸酯和异丁酸酯。 此外，已经公开了由可吸收的基于PEG的水凝胶和蛋白质制备的持续释放组合物，其提供蛋白质和肽的持续释放。

    Polyalkylene glycol acid additives
    7.
    发明授权
    Polyalkylene glycol acid additives 失效
    聚亚烷基二醇酸添加剂

    公开(公告)号：US07193031B2

    公开(公告)日：2007-03-20

    申请号：US10625033

    申请日：2003-07-22

    Applicant: Pascal Sebastian Bailon ,  Chee-Youb Won

    Inventor： Pascal Sebastian Bailon ,  Chee-Youb Won

    IPC: C08G65/34

    CPC classification number: C08G65/337 ,  A61K47/60 ,  C08G65/329 ,  C08G65/3322 ,  C08L2203/02

    Abstract: A new class of activated polyalkylene glycol acids and their active ester reagents for conjugation to biopharmaceuticals such as polypeptides, sugars, proteins and therapeutically active small molecules to produce biologically active conjugates of these pharmaceuticals and methods for producing these conjugates.

    Abstract translation: 一类新的活性聚亚烷基二醇酸及其活性酯试剂，用于与生物药物如多肽，糖，蛋白质和治疗活性的小分子结合，以产生这些药物的生物活性缀合物和制备这些缀合物的方法。

    Polyalkylene glycol acid additives
    9.
    发明授权
    Polyalkylene glycol acid additives 失效
    聚亚烷基二醇酸添加剂

    公开(公告)号：US07504477B2

    公开(公告)日：2009-03-17

    申请号：US11386876

    申请日：2006-03-22

    Applicant: Chee-Youb Won

    Inventor： Chee-Youb Won

    IPC: C08G65/34 ,  C08G65/00

    CPC classification number: C08G65/337 ,  A61K47/60 ,  C08G65/329 ,  C08G65/3322 ,  C08L2203/02

    Abstract: A new class of activated polyalkylene glycol acids and their active ester reagents for conjugation to biopharmaceuticals such as polypeptides, sugars, proteins and therapeutically active small molecules to produce biologically active conjugates of these pharmaceuticals and methods for producing these conjugates.

    Abstract translation: 一类新的活性聚亚烷基二醇酸及其活性酯试剂，用于与生物药物如多肽，糖，蛋白质和治疗活性的小分子结合，以产生这些药物的生物活性缀合物和制备这些缀合物的方法。

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