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公开(公告)号：US20180195037A1
公开(公告)日：2018-07-12
申请号：US15490100
申请日：2017-04-18
Applicant: Subhra Mohapatra , Shyam S. Mohapatra , Yvonne Kathleen Davis , Chunyan Wang
Inventor： Subhra Mohapatra , Shyam S. Mohapatra , Yvonne Kathleen Davis , Chunyan Wang
CPC classification number: C12N5/0062 , C12N5/0068 , C12N5/0693 , C12N2533/40 , C12N2533/72
Abstract: Provided herein is a three-dimensional scaffold composition comprising randomly oriented fibers, wherein the fibers comprise a polyethylene glycol-polylactic acid block copolymer (PEG-PLA) and a poly(lactic-co-glycolic acid) (PLGA). Also provided are methods for using the three-dimensional scaffolds described herein.
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公开(公告)号：US09624473B2
公开(公告)日：2017-04-18
申请号：US13775536
申请日：2013-02-25
Applicant: Subhra Mohapatra , Shyam S. Mohapatra , Yvonne Kathleen Davis , Chunyan Wang
Inventor： Subhra Mohapatra , Shyam S. Mohapatra , Yvonne Kathleen Davis , Chunyan Wang
CPC classification number: C12N5/0062 , C12N5/0068 , C12N5/0693 , C12N2533/40 , C12N2533/72
Abstract: Provided herein is a three-dimensional scaffold composition comprising randomly oriented fibers, wherein the fibers comprise a polyethylene glycol-polylactic acid block copolymer (PEG-PLA) and a poly(lactic-co-glycolic acid) (PLGA). Also provided are methods for using the three-dimensional scaffolds described herein.
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公开(公告)号：US20130230496A1
公开(公告)日：2013-09-05
申请号：US13775560
申请日：2013-02-25
Applicant: Subhra Mohapatra , Chunyan Wang
Inventor： Subhra Mohapatra , Chunyan Wang
IPC: A61K47/36
CPC classification number: A61K47/36 , A61K9/5161 , A61L15/44 , A61L15/46 , A61L15/60 , A61L27/443 , A61L27/52 , C08B37/003 , C08F220/54 , C08F222/1006 , C08F251/00 , C08F290/062 , C08F292/00 , C08G83/001 , C08J3/075 , C08J2387/00 , C08L5/08 , C12N5/0068 , C12N2533/20 , C12N2533/72 , C08L33/00 , C08L71/02 , C08F220/52 , C08F220/06
Abstract: Provided herein is a hydrogel composition comprising a graphene, a chitosan, and a polyethylene (glycol) diacrylate (PEGDA) (PCG hydrogel). In some embodiments, the hydrogel further comprises a N-isopropylacrylamide (NIPAM) (TPCG hydrogel). Also provided is a method for differentiating a mesenchymal stem cell comprising contacting the cell with the PCG hydrogel. Further provided herein is a method for delivering a pharmaceutical composition to a cell comprising administering to the cell a TPCG hydrogel and the pharmaceutical composition.
Abstract translation: 本文提供包含石墨烯，壳聚糖和聚乙二醇（二醇）二丙烯酸酯（PEGDA）（PCG水凝胶））的水凝胶组合物。 在一些实施方案中，水凝胶还包含N-异丙基丙烯酰胺（NIPAM）（TPCG水凝胶）。 还提供了用于分化间充质干细胞的方法，包括使细胞与PCG水凝胶接触。 本文还提供了将药物组合物递送至细胞的方法，包括向细胞施用TPCG水凝胶和药物组合物。
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公开(公告)号：US06583670B2
公开(公告)日：2003-06-24
申请号：US09794222
申请日：2001-02-28
Applicant: Chunyan Wang
Inventor： Chunyan Wang
IPC: H03F316
CPC classification number: H03F3/345
Abstract: This invention relates to a method and apparatus for amplifying an input current into an output current. An input current is first injected in or pulled out of a transimpedance stage and converted, in a linear way, into an interstage voltage. The interstage voltage is then converted into the output current. The conversion of the interstage voltage into an output current is performed by maintaining a transistor in the triode mode to obtain a linear conversion as well as adding a current which comes from a current source.
Abstract translation: 本发明涉及将输入电流放大为输出电流的方法和装置。 首先将输入电流注入或拉出跨阻级，并以线性方式将其转换为级间电压。 然后将级间电压转换为输出电流。 通过将晶体管保持在三极管模式中来实现级间电压转换为输出电流，以获得线性转换以及添加来自电流源的电流。
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公开(公告)号：US06417702B1
公开(公告)日：2002-07-09
申请号：US09617270
申请日：2000-07-17
Applicant: Chunyan Wang
Inventor： Chunyan Wang
IPC: G05I302
CPC classification number: G05F3/262
Abstract: A method and circuit are provided to perform current-to-voltage conversions. The circuit is operational in one linear mode based on channel-length-modulation effects in the saturation region and two non-linear modes based on a current operation overrunning the saturation region and a logarithmic function of drain current versus gate-to-source voltage, respectively. An adaptive process is provided to set-up the quiescent point of the circuit. The conversion gain is variable with respect to the conversion mode, the current range, and the length of the converting transistor.
Abstract translation: 提供了一种方法和电路来执行电流 - 电压转换。 基于饱和区域中的沟道长度调制效应和基于超过饱和区域的电流操作和漏极电流对栅极至源极电压的对数函数的两个非线性模式，该电路可操作在一个线性模式中， 分别。 提供自适应过程来设置电路的静态点。 转换增益相对于转换模式，电流范围和转换晶体管的长度是可变的。
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Patent Agency Ranking
公开(公告)号：US09695262B2
公开(公告)日：2017-07-04
申请号：US14000326
申请日：2012-02-24
Applicant: Subhra Mohapatra , Chunyan Wang
Inventor： Subhra Mohapatra , Chunyan Wang
CPC classification number: C08F220/06 , A61K38/00 , B82Y5/00 , C07K14/58 , G01N33/74 , G01N2333/58 , G01N2600/00 , Y10T428/24802
Abstract: The present invention concerns molecularly imprinted polymers (MIPs) having an affinity for natriuretic peptides, such as atrial natriuretic peptide (ANP). In some embodiments, the MIP is a nanoparticle (a molecularly imprinted polymeric nanoparticle (MIPNP)). Other aspects of the invention include methods of preparing an MIP having affinity for a natriuretic peptide, methods for binding a natriuretic peptide in vitro or in vivo using an MIP of the invention, methods for interfering with the binding of a natriuretic peptide with its receptor in vivo, methods for reducing inflammation, cell growth, cell differentiation, or a cell proliferation disorder, methods for detecting natriuretic peptides, and devices and kits for sequestering and/or detecting natriuretic peptides.
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公开(公告)号：US09675714B1
公开(公告)日：2017-06-13
申请号：US14186845
申请日：2014-02-21
Applicant: Subhra Mohapatra , Chunyan Wang
Inventor： Subhra Mohapatra , Chunyan Wang
CPC classification number: A61K49/1881 , A61K31/704 , A61K47/6923 , A61K48/0041 , B82Y5/00
Abstract: Disclosed herein are theranostic nanoparticles configured for simultaneous delivery of a diagnostic moiety, drug moiety, and a gene therapy moiety. In one embodiment, the theranostic nanoparticles contain a super paramagnetic iron oxide chemotherapeutic loaded on a chitosan functionalized 2D graphene sheet with a gene therapy moiety attached to the surface of the chitosan functionalized 2D graphene sheet. Also disclosed are methods for making and administering theranositic nanoparticles configured for simultaneous delivery of a diagnostic moiety, drug moiety, and a gene therapy moiety.
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公开(公告)号：US09433682B2
公开(公告)日：2016-09-06
申请号：US13775560
申请日：2013-02-25
Applicant: Subhra Mohapatra , Chunyan Wang
Inventor： Subhra Mohapatra , Chunyan Wang
IPC: A01N63/00 , A01N65/00 , A61K47/36 , A61K9/51 , A61L27/44 , A61L27/52 , A61L15/44 , A61L15/46 , A61L15/60 , C12N5/00 , C08B37/08 , C08L5/08 , C08J3/075 , C08F292/00 , C08F251/00 , C08F290/06 , C08F220/54 , C08F222/10 , C08G83/00
CPC classification number: A61K47/36 , A61K9/5161 , A61L15/44 , A61L15/46 , A61L15/60 , A61L27/443 , A61L27/52 , C08B37/003 , C08F220/54 , C08F222/1006 , C08F251/00 , C08F290/062 , C08F292/00 , C08G83/001 , C08J3/075 , C08J2387/00 , C08L5/08 , C12N5/0068 , C12N2533/20 , C12N2533/72 , C08L33/00 , C08L71/02 , C08F220/52 , C08F220/06
Abstract: Provided herein is a hydrogel composition comprising a graphene, a chitosan, and a polyethylene (glycol) diacrylate (PEGDA) (PCG hydrogel). In some embodiments, the hydrogel further comprises a N-isopropylacrylamide (NIPAM) (TPCG hydrogel). Also provided is a method for differentiating a mesenchymal stem cell comprising contacting the cell with the PCG hydrogel. Further provided herein is a method for delivering a pharmaceutical composition to a cell comprising administering to the cell a TPCG hydrogel and the pharmaceutical composition.
Abstract translation: 本文提供包含石墨烯，壳聚糖和聚乙二醇（二醇）二丙烯酸酯（PEGDA）（PCG水凝胶））的水凝胶组合物。 在一些实施方案中，水凝胶还包含N-异丙基丙烯酰胺（NIPAM）（TPCG水凝胶）。 还提供了用于分化间充质干细胞的方法，包括使细胞与PCG水凝胶接触。 本文还提供了将药物组合物递送至细胞的方法，包括向细胞施用TPCG水凝胶和药物组合物。
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公开(公告)号：US09175974B2
公开(公告)日：2015-11-03
申请号：US12518108
申请日：2009-05-08
Applicant: Chunyan Wang
Inventor： Chunyan Wang
CPC classification number: G01C21/3644 , G01C21/3476 , H04L67/18 , H04L67/36 , H04W4/02 , H04W4/026 , Y10T29/49826
Abstract: One embodiment of the present application discloses an POI displaying method for displaying information of at least one POI (point of interest) stored in a database on an electronic apparatus. The method comprises: (a) obtaining at least one POI according to a desired POI type; (b) obtaining at least one corresponding path according to the position of each obtained POI; (c) generating a POI gathering information of each corresponding path according to the at least one obtained POI; and (d) displaying the at least one corresponding path and the corresponding POI gathering information.
Abstract translation: 本申请的一个实施例公开了一种POI显示方法，用于显示存储在电子设备上的数据库中的至少一个POI（兴趣点）的信息。 该方法包括：（a）根据所需的POI类型获得至少一个POI; （b）根据每个获得的POI的位置获得至少一个对应的路径; （c）根据所述至少一个获得的POI生成每个相应路径的POI收集信息; 和（d）显示所述至少一个对应路径和相应的POI收集信息。
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公开(公告)号：US20150064116A1
公开(公告)日：2015-03-05
申请号：US14346330
申请日：2012-09-28
Applicant: Subhra Mohapatra , Chunyan Wang
Inventor： Subhra Mohapatra , Chunyan Wang
CPC classification number: A61K48/0041 , A61K47/48192 , A61K47/4823 , A61K47/48907 , A61K47/48923 , A61K47/59 , A61K47/61 , A61K47/6935 , A61K47/6939 , A61K48/0033 , A61K49/1809 , A61K49/1857 , A61K49/1863 , A61K49/1875 , C12N15/85 , C12N15/88 , C12N2800/107 , C12N2810/859
Abstract: Provided herein are compositions comprising a micelle having a hydrophobic superparmagnetic iron oxide nanoparticle (SPION) core, a first coating comprising a cationic polymer, and a second coating comprising a polynucleotide. Also provided are methods of using the compositions for transfection and/or transformation of a cell with the polynucleotide. Further provided are methods of detecting transfection of a cell with the polynucleotide.
Abstract translation: 本文提供了包含具有疏水超磁性氧化铁纳米颗粒（SPION）芯的胶束，包含阳离子聚合物的第一涂层和包含多核苷酸的第二涂层的组合物。 还提供了使用组合物用于与多核苷酸转染和/或转化细胞的方法。 还提供了用多核苷酸检测细胞转染的方法。
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