公开(公告)号：US20230355382A1

公开(公告)日：2023-11-09

申请号：US18352120

申请日：2023-07-13

Applicant: EDWARDS LIFESCIENCES CORPORATION

Inventor： Lien Huong Thi Hoang ,  Sandip Vasant Pawar ,  Taylor Michael Winters

IPC: A61F2/24

CPC classification number: A61F2/2418 ,  A61F2220/0008

Abstract: Disclosed herein are implantable prosthetic valves having outer sealing member comprising a bulge in the expanded configuration. The bulge can be configured to provide sealing against native anatomy when the valve is implanted and to assist in minimizing a paravalvular leakage. In addition, disclosed herein are methods of making the prosthetic valves.

公开(公告)号：US20230255762A1

公开(公告)日：2023-08-17

申请号：US18306740

申请日：2023-04-25

Applicant: EDWARDS LIFESCIENCES CORPORATION

Inventor： Shahram Zamani ,  Michael Bukin ,  Sandip Vasant Pawar

IPC: A61F2/24

CPC classification number: A61F2/243 ,  A61F2/2412 ,  A61F2/2418 ,  A61F2220/0075 ,  A61F2/2463 ,  A61F2/2436 ,  A61F2/2439 ,  A61F2250/0069 ,  A61F2250/0028

Abstract: A sealing member for a prosthetic heart valve includes an annular fabric body having a first circumferential portion and a second circumferential portion. The first circumferential portion extends circumferentially around the annular fabric body and is resiliently stretchable in a direction along the longitudinal axis of the annular fabric body between an expanded configuration of the prosthetic heart valve and a collapsed configuration of the prosthetic heart valve. The second circumferential portion extends around the annular fabric body and is circumferentially offset from the first circumferential portion, the second circumferential portion being resiliently stretchable in a circumferential direction between the collapsed configuration of the prosthetic heart valve and the expanded configuration of the prosthetic heart valve.

公开(公告)号：US11013595B2

公开(公告)日：2021-05-25

申请号：US16100601

申请日：2018-08-10

Applicant: Edwards Lifesciences Corporation

Inventor： Tamir S. Levi ,  Giolnara Pinhas ,  Liraz Marom ,  Elena Sherman ,  Noam Mizrahi ,  Delfin Rafael Ruiz ,  Sandip Vasant Pawar ,  Liron Tayeb

IPC: A61F2/24 ,  A61F2/00

Abstract: An implantable prosthetic valve that is radially collapsible to a collapsed configuration and radially expandable to an expanded configuration includes an annular frame having an inflow end, an outflow end, and a longitudinal axis. A leaflet structure is positioned within the frame and secured thereto, and a sealing element is secured to the frame. The sealing element includes a first woven portion extending circumferentially around the frame. The first woven portion includes a plurality of interwoven filaments. The sealing element further includes a second woven portion extending circumferentially around the frame and spaced apart from the first woven portion along the longitudinal axis of the frame. At least a portion of the filaments exit the weave of the first woven portion and form loops extending radially outwardly from the frame.

公开(公告)号：US20250114198A1

公开(公告)日：2025-04-10

申请号：US18987648

申请日：2024-12-19

Applicant: EDWARDS LIFESCIENCES CORPORATION

Inventor： Shahram Zamani ,  Michael Bukin ,  Sandip Vasant Pawar

IPC: A61F2/24 ,  A61F2/07

Abstract: A prosthetic heart valve includes a frame with a plurality of strut members, the frame being radially collapsible to a collapsed configuration and radially expandable to an expanded configuration, the frame having an inflow end and an outflow end, and defining a longitudinal axis. A leaflet structure is coupled to the frame and configured to regulate blood flow through the frame. A fabric sealing member is disposed around the frame, the sealing member being resiliently stretchable between a first state corresponding to the radially expanded configuration of the frame and a second state corresponding to the radially collapsed configuration of the frame. The sealing member has two ends, and the two ends are secured together by a seam.

公开(公告)号：US20250065597A1

公开(公告)日：2025-02-27

申请号：US18945342

申请日：2024-11-12

Applicant: EDWARDS LIFESCIENCES CORPORATION

Inventor： Radhika Vaid ,  Sandip Vasant Pawar ,  Rupesh Gajanan Nawalakhe ,  Gillian Irene Armstrong ,  Ido Halabi ,  Carmel Peleg ,  Anna Khodos ,  Yaron Herman

IPC: B32B5/24 ,  B32B5/02

Abstract: A method for use in the manufacture of a medical implant is provided. A sandwich is formed, the sandwich including a fabric layer; a coating layer comprising a polymer configured to inhibit tissue growth thereon; a binding layer sandwiched between the fabric layer and the coating layer; and at least part of a frame sandwiched between the fabric layer and the binding layer. The sandwich is heated and compressed such that the binding layer binds the fabric layer to the coating layer. Holes are then formed through the sandwich. Other implementations are also described.

公开(公告)号：US12064348B2

公开(公告)日：2024-08-20

申请号：US18311880

申请日：2023-05-03

Applicant: EDWARDS LIFESCIENCES CORPORATION

Inventor： Gil Senesh ,  Jeanette Jasmine Corona Kelly ,  Sandip Vasant Pawar

IPC: A61F2/24 ,  A61F2/00

CPC classification number: A61F2/2418 ,  A61F2/0077 ,  A61F2210/0076 ,  A61F2250/001

Abstract: A prosthetic heart valve including a frame, leaflet structure, and sealing member disposed around an outer surface of the frame is disclosed. As one example, the sealing member includes a knitted fabric layer, the knitted fabric layer comprising a base layer forming an inner surface of the knitted fabric layer, where the base layer has a mesh-like structure. The knitted fabric layer further comprises a plush outer surface comprising a plurality of pile yarns knit into loops and that extend outward from the base layer.

公开(公告)号：US20240173126A1

公开(公告)日：2024-05-30

申请号：US18431739

申请日：2024-02-02

Applicant: EDWARDS LIFESCIENCES CORPORATION

Inventor： Sandip Vasant Pawar ,  Delfin Rafael Ruiz

IPC: A61F2/24 ,  A61F2/07 ,  D02G3/04 ,  D02G3/32 ,  D02G3/36 ,  D02G3/38 ,  D03D1/00 ,  D03D13/00 ,  D03D15/283 ,  D03D15/47 ,  D03D15/56 ,  D04B1/18 ,  D04B1/22 ,  D04C1/02 ,  D04C1/06

CPC classification number: A61F2/2418 ,  D02G3/045 ,  D02G3/32 ,  D02G3/36 ,  D02G3/38 ,  D03D1/00 ,  D03D13/004 ,  D03D15/283 ,  D03D15/47 ,  D03D15/56 ,  D04B1/18 ,  D04B1/22 ,  D04C1/02 ,  D04C1/06 ,  A61F2002/077 ,  D10B2331/04 ,  D10B2331/10 ,  D10B2401/061 ,  D10B2509/00

Abstract: Disclosed herein is a textile comprising: a) a first yarn comprising one or more filaments comprising a first polymer; b) one or more additional yarns comprising a composition and/or properties different from the first yarn; wherein the first yarn exhibits an elasticity higher than an elasticity of the one or more additional yarns the textile exhibits an ultimate elongation of about 50% to about 700% and is shape-adapting and biocompatible, and wherein the textile is configured to be inserted and/or implanted in a subject's body. Also described herein are medical devices having the disclosed textiles. In addition, disclosed herein are methods of making the disclosed textiles.

公开(公告)号：US20240138975A1

公开(公告)日：2024-05-02

申请号：US18050415

申请日：2022-10-27

Applicant: Edwards Lifesciences Corporation

Inventor： Rupesh Gajanan Nawalakhe ,  Sandip Vasant Pawar ,  Chambory Chhe ,  Arpit Laddha

IPC: A61F2/24

CPC classification number: A61F2/2418 ,  A61F2/2409 ,  A61F2210/0076

Abstract: An implantable prosthetic valve may include an annular frame having an inner surface and an outer surface and the frame has an inflow end and an outflow end and a central longitudinal axis extending from the inflow end to the outflow end. A leaflet structure may be positioned within the frame. An inner skirt may be positioned along the inner surface of the frame. An outer skirt may be positioned around the outer surface of the frame. Various portions of the leaflet structure, the inner skirt, or outer skirt may incorporate a material inclusive of electrospun silk.

公开(公告)号：US20230277306A1

公开(公告)日：2023-09-07

申请号：US18195808

申请日：2023-05-10

Applicant: EDWARDS LIFESCIENCES CORPORATION

Inventor： Tamir S. Levi ,  Giolnara Pinhas ,  Liraz Marom ,  Elena Sherman ,  Noam Mizrahi ,  Delfin Rafael Ruiz ,  Sandip Vasant Pawar ,  Liron Tayeb

IPC: A61F2/24 ,  A61F2/00

CPC classification number: A61F2/2415 ,  A61F2/0077 ,  A61F2/2409 ,  A61F2/2418 ,  A61F2210/0076 ,  A61F2230/0069 ,  A61F2250/0069

Abstract: An implantable prosthetic valve that is radially collapsible to a collapsed configuration and radially expandable to an expanded configuration includes an annular frame having an inflow end, an outflow end, and a longitudinal axis. A leaflet structure is positioned within the frame and secured thereto, and a sealing element is secured to the frame. The sealing element includes a first woven portion extending circumferentially around the frame. The first woven portion includes a plurality of interwoven filaments. The sealing element further includes a second woven portion extending circumferentially around the frame and spaced apart from the first woven portion along the longitudinal axis of the frame. At least a portion of the filaments comprise a hydrophilic surface treatment.

公开(公告)号：US20230017301A1

公开(公告)日：2023-01-19

申请号：US17935891

申请日：2022-09-27

Applicant: Edwards Lifesciences Corporation

Inventor： Elena Sherman ,  Michael Bukin ,  Sandip Vasant Pawar ,  Shahram Zamani ,  Tamir S. Levi ,  Noam Nir ,  Yana Mayatskaya ,  Alexander Barash ,  Ziv Yohanan ,  Nikolay Gurovich ,  Itai Pelled

IPC: A61F2/24

Abstract: An implantable prosthetic device can include a frame movable between a radially compressed and a radially expanded configuration and a sealing member. The frame can include an inflow end portion, an outflow end portion, and a plurality of struts. The sealing member can be disposed around the frame and can include a cushioning layer comprising a plurality of texturized yarns extending along the longitudinal axis of the frame, and a base layer disposed between the cushioning layer and the frame.