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公开(公告)号：US11472836B2
公开(公告)日：2022-10-18
申请号：US14768267
申请日：2014-02-11
Applicant: EMD Millipore Corporation
Inventor： Matthew T. Stone , Mikhail Kozlov
Abstract: The present invention provides novel and improved protein purification processes which incorporate certain types of carbonaceous materials and result in effective and selective removal of certain undesirable impurities without adversely effecting the yield of the desired protein product.
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公开(公告)号：USD853226S1
公开(公告)日：2019-07-09
申请号：US29618352
申请日：2017-09-20
Applicant: EMD Millipore Corporation
Designer： Joseph Geringer , Stephen G. Hunt , Mikhail Kozlov , Joseph Almasian , Gregory Straeffer
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公开(公告)号：US10064965B2
公开(公告)日：2018-09-04
申请号：US15691286
申请日：2017-08-30
Applicant: EMD Millipore Corporation
Inventor： Mikhail Kozlov , Wilson Moya , Gabriel Tkacik
Abstract: A method for removing microorganisms from liquid samples and a nanofiber containing liquid filtration medium that simultaneously exhibits high liquid permeability and high microorganism retention. Microorganisms such as bacteria, particularly B. Diminuta, are removed from a liquid by passing the liquid through a porous nanofiber containing filtration medium having a B. Diminuta LRV greater than about 9, and the nanofiber(s) has a diameter from about 10 nm to about 1,000 nm. Another method for removing microorganisms such as bacteria and Mycloplasma, includes passing the liquid through a porous nanofiber containing filtration medium having a microorganism LRV greater than about 8, and the nanofiber(s) has a diameter from about 10 nm to about 1,000 nm. The filtration medium can be in the form of a fibrous electro spun polymeric nanofiber liquid filtration medium mat.
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公开(公告)号：US20160272676A1
公开(公告)日：2016-09-22
申请号：US15033940
申请日：2014-11-06
Applicant: EMD MILLIPORE CORPORATION
Inventor： Mikhail Kozlov , William Cataldo , Jeffrey Caron
IPC: C07K1/34 , C07K16/00 , C08F220/56 , C08F220/54 , C08F220/18 , B01J20/289 , C08J5/22 , C08F259/08 , B01D15/10 , B01D37/00 , B01J20/26 , B01J20/288 , C07K1/18 , C08F220/58
CPC classification number: C07K1/34 , B01D15/10 , B01D37/00 , B01J20/267 , B01J20/288 , B01J20/289 , B01J20/321 , B01J20/3212 , B01J20/327 , B01J20/3276 , B01J20/3291 , B01J39/26 , B01J2220/80 , C07K1/18 , C07K16/00 , C08F220/18 , C08F220/54 , C08F220/56 , C08F220/58 , C08F259/08 , C08F2220/1825 , C08F2220/1858 , C08J5/2243 , C08J2351/00
Abstract: Novel compositions for re-moving impurities such as, protein aggregates, from a sample containing a protein of interest, e.g., an antibody. Such compositions can be used prior to the virus filtration step during protein purification, to remove aggregates and protect the virus filter from fouling, therefore improving virus filter capacity. A porous solid support including a co-polymer having at least two monomers, wherein at least one of the monomers comprises acrylamide and at least a second monomer comprises a hydrophobic binding group, where the solid support selectively binds protein aggregates, thereby to separate the monomeric protein of interest from the protein aggregates. The method can be performed under neutral to high pH and high conductivity conditions.
Abstract translation: 用于从含有目的蛋白质的样品例如抗体重新杂交诸如蛋白质聚集体的新型组合物。 这样的组合物可以在蛋白质纯化期间的病毒过滤步骤之前使用，以除去聚集体并保护病毒过滤器免于结垢，从而提高病毒过滤能力。 一种多孔固体支持物，包括具有至少两种单体的共聚物，其中所述单体中的至少一种包含丙烯酰胺，并且至少第二单体包含疏水性结合基团，其中所述固体支持物选择性地结合蛋白质聚集体，由此分离单体 来自蛋白质聚集体的目标蛋白质。 该方法可在中性至高pH和高电导条件下进行。
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15.发明申请SELECTIVE REMOVAL OF A PROTEIN FROM A MIXTURE OF PROTEINS USING ACTIVATED CARBON BY ADJUSTING SOLUTION CONDITIONS 审中-公开通过调节溶液条件，使用活性炭从蛋白质混合物中选择性去除蛋白质公开(公告)号：US20150376232A1
公开(公告)日：2015-12-31
申请号：US14768267
申请日：2014-02-11
Applicant: EMD MILLIPORE CORPORATION
Inventor： Matthew T. Stone , Mikhail Kozlov
CPC classification number: C07K1/36 , C07K1/22 , C07K16/065 , C07K2317/14
Abstract: The present invention provides novel and improved protein purification processes which incorporate certain types of carbonaceous materials and result in effective and selective removal of certain undesirable impurities without adversely effecting the yield of the desired protein product.
Abstract translation: 本发明提供新颖和改进的蛋白质纯化方法，其包含某些类型的碳质材料，并且导致有效和选择性地除去某些不需要的杂质，而不会不利地影响所需蛋白质产物的产率。
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Patent Agency Ranking
16.发明申请USE OF CHARGED FLUOROCARBON COMPOSITIONS IN METHODS FOR PURIFICATION OF BIOMOLECULES 审中-公开在生物分子纯化方法中使用充电氟化物组合物公开(公告)号：US20150125929A1
公开(公告)日：2015-05-07
申请号：US14362964
申请日：2013-03-18
Applicant: EMD Millipore Corporation
Inventor： Mikhail Kozlov , Wilson Moya , Jad Jaber , William Cataldo , Ajish Potty , Christopher Gillespie
Abstract: The present invention relates to novel and improved methods for the purification of biomolecules. In particular, the present invention relates to methods of protein purification which employ a porous solid support modified with a charged fluorocarbon composition.
Abstract translation: 本发明涉及用于纯化生物分子的新颖和改进的方法。 特别地，本发明涉及蛋白质纯化方法，该方法采用用带电的碳氟化合物组合物改性的多孔固体支持物。
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公开(公告)号：US20230123639A1
公开(公告)日：2023-04-20
申请号：US18066610
申请日：2022-12-15
Applicant: EMD Millipore Corporation
Inventor： Mikhail Kozlov , Gabriel Tkacik , Onur Y. Kas , Ajish Potty , Jigneshkumar Patel
Abstract: A porous electrospun polymeric nanofiber liquid filtration medium, such as an electrospun mats, used for the removal of viral particles (e.g., parvovirus) and other particles in the 18 nm to 30 nm size range from fluid streams, having a mean flow bubble point measured with perfluorohexane above 100 psi. The electrospun medium includes nanofibers having an average fiber diameter of about 6 nm to about 13 nm, and the nanofiber liquid filtration medium has a mean pore size ranging from about 0.01 μm to about 0.03 μm, a porosity ranging from about 80% to about 95%, a thickness ranging from about 1 μm to about 100 μm, and a liquid permeability greater than about 10 LMH/psi. The high porosity of the electrospun mats enable much higher water fluxes, thus reducing the time required to complete virus filtration steps on a fluid stream.
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公开(公告)号：US11358102B2
公开(公告)日：2022-06-14
申请号：US16918431
申请日：2020-07-01
Applicant: EMD Millipore Corporation
Inventor： Jad Jaber , Wilson Moya , Mikhail Kozlov
Abstract: The embodiments described herein relate to agarose ultrafiltration membrane composites and methods for making and using the same.
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公开(公告)号：US20200368696A1
公开(公告)日：2020-11-26
申请号：US16918431
申请日：2020-07-01
Applicant: EMD Millipore Corporation
Inventor： Jad Jaber , Wilson Moya , Mikhail Kozlov
Abstract: The embodiments described herein relate to agarose ultrafiltration membrane composites and methods for making and using the same.
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公开(公告)号：US10252199B2
公开(公告)日：2019-04-09
申请号：US15448248
申请日：2017-03-02
Applicant: EMD Millipore Corporation
Inventor： Onur Y. Kas , Mikhail Kozlov , Wilson Moya , Sherry A. Leon , Philip Goddard , Jibin Hao , Gabriel Tkacik
IPC: B01D39/16 , B01D39/18 , B01D39/14 , A61L2/02 , C12N7/00 , D01D1/02 , D01D5/00 , D01F6/96 , B01D69/02 , B01D69/10 , B01D39/04 , B01D39/00 , B01D67/00 , B01D61/14
Abstract: A method for removing retroviruses from liquid samples and a nanofiber containing liquid filtration medium that simultaneously exhibits high liquid permeability and high microorganism retention is disclosed. Retroviruses are removed from a liquid by passing the liquid through a porous nanofiber containing filtration medium having a retrovirus LRV greater than about 6, and the nanofiber(s) has a diameter from about 10 nm to about 100 nm. The filtration medium can be in the form of a fibrous electrospun polymeric nanofiber liquid filtration medium mat.
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