公开(公告)号：US20150291642A1

公开(公告)日：2015-10-15

申请号：US14442017

申请日：2013-09-19

Applicant: GLYCOM A/S

Inventor： Martin Matwiejuk ,  Gyula Dekany

IPC: C07H3/06 ,  A23L1/29 ,  A23L1/30 ,  C07H1/06

CPC classification number: C07H3/06 ,  A23L33/10 ,  A23L33/40 ,  A23V2002/00 ,  C07H1/06

Abstract: Crystalline 3-O-fucosyllactose, useful in a pharmaceutical composition and a nutritional formulation, is disclosed.

Abstract translation: 公开了可用于药物组合物和营养制剂的结晶的3-O-岩藻糖基乳糖。

公开(公告)号：US12060594B2

公开(公告)日：2024-08-13

申请号：US16895871

申请日：2020-06-08

Applicant: Glycom A/S

Inventor： Gyula Dekany ,  Györgyi Osztrovszky ,  Martin Matwiejuk ,  Pierre Chassagne ,  Markus Jondelius Hederos

IPC: C12P19/18 ,  C07H1/06 ,  C07H3/06

CPC classification number: C12P19/18 ,  C07H1/06 ,  C07H3/06 ,  C12Y204/01069

Abstract: The invention relates to a method for selective crystallization of 2′-fucosyllactose (2′-FL) from an aqueous solution comprising 2′-FL and one or more other fucosylated carbohydrates by adding acetic acid to the solution. The aqueous solution is separated from an aqueous culture medium prior to crystallization.

公开(公告)号：US11384110B2

公开(公告)日：2022-07-12

申请号：US16346057

申请日：2017-10-31

Applicant: Glycom A/S

Inventor： Pierre Chassagne ,  Martin Matwiejuk ,  Nikolay Khanzhin ,  Markus Jondelius Hederos

IPC: C07H3/06 ,  A61K31/702 ,  F26B5/04 ,  F26B21/14 ,  C07H13/04 ,  C07H1/00 ,  A23L33/21 ,  C07H1/06

Abstract: The present invention relates to a method of removing residual organic solvent from crystalline oligosaccharides by the use of water vapour as well as the pharmaceutically and nutritionally suitable crystalline oligosaccharides obtained by said method.

公开(公告)号：US11312741B2

公开(公告)日：2022-04-26

申请号：US16094508

申请日：2017-04-19

Applicant: GLYCOM A/S

Inventor： Pierre Chassagne ,  Nikolay Khanzhin ,  Martin Matwiejuk ,  Markus Jondelius Hederos ,  Niels Banke

IPC: C07H13/04 ,  B01D61/02 ,  B01D61/14 ,  B01D61/58 ,  C07H1/06 ,  C12P19/28 ,  B01D15/36 ,  B01J41/07 ,  B01D61/16 ,  B01J39/05 ,  B01D15/18 ,  B01J20/20 ,  G01N30/96 ,  C12P19/26 ,  G01N30/02

Abstract: The invention relates to a method for obtaining an N-acetylglucosamine containing neutral oligosaccharide from a fermentation broth, wherein said oligosaccharide is produced by culturing a genetically modified microorganism capable of producing said oligosaccharide from an internalized carbohydrate precursor, comprising the steps of: i) ultrafiltration (UF), preferably to separate biomass from the broth, ii) nanofiltration (NF), preferably to concentrate said oligosaccharide in the broth and/or reduce an inorganic salt content of the broth, and iii) treating the broth with an ion exchange resin, preferably to remove charged materials, and/or subjecting the broth to chromatography, preferably to remove hydrophobic impurities.

公开(公告)号：US10005807B2

公开(公告)日：2018-06-26

申请号：US14783783

申请日：2014-04-11

Applicant: GLYCOM A/S

Inventor： Pierre Chassagne ,  Nikolay Khanzhin ,  Markus Jondelius Hederos ,  Elise Champion ,  Martin Matwiejuk ,  Gyula Dekany

IPC: C07H5/04 ,  C07H1/00

CPC classification number: C07H5/04 ,  C07H1/00

Abstract: An achemo-enzymatic synthesis of oligosaccharides of formula 1 is presented wherein R is selected from —OH, —N 3 and —OR 6 wherein R 6 is selected from allyl optionally substituted by one or more methyl, propargyl optionally substituted by one or more methyl, 2-trimethylsilyl-ethyl, —(CH 2) n —NH 2 and —(CH 2) n —N 3 wherein integer n is to 10, preferably 2 or 3, R is selected from sialyl moiety, —SO 3 H and —CH(R)—COOH wherein R is selected from H, alkyl and benzyl, R 2 is selected from H and fucosyl, R 3 is selected from H and sialyl, R 4 is selected from H and fucosyl, provided that at least one of R 3 and R 4 is H, and A is a divalent carbohydrate linker, having important biological activities and significant commercial value for the pharmaceutical and food industry.

公开(公告)号：US20150065702A1

公开(公告)日：2015-03-05

申请号：US14385624

申请日：2013-03-20

Applicant: Glycom A/S

Inventor： Christoph Röhrig ,  Gyula Dekany ,  Martin Matwiejuk ,  Sándor Demkó

IPC: C07H15/203

CPC classification number: C07H15/203 ,  C07H3/06 ,  C07H15/18

Abstract: 3-O-Fucosyllactose is made by process which includes the hydrogenolysis of a new compound of the formula 1 wherein R1 and R2 are independently a group removable by hydrogenolysis, and R3 is a group removable by hydrogenolysis or H; or a hydrate or solvate thereof.

Abstract translation: 3-O-岩藻糖基乳糖是通过以下方法制备的：其中R1和R2独立地是通过氢解除去的基团，R3是通过氢解或H可除去的基团; 或其水合物或溶剂合物。