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公开(公告)号：US09732374B2
公开(公告)日：2017-08-15
申请号：US14213900
申请日：2014-03-14
Applicant: Gen-Probe Incorporated
Inventor： David A. Buse , David Opalsky , Jason F. Rhubottom , Norbert D. Hagen , Jennifer L. Tidd
CPC classification number: C12Q1/6806 , B01L3/50825 , B01L3/527 , B01L3/565 , B01L7/5255 , B01L2200/026 , B01L2200/0689 , B01L2300/046 , C12Q1/686 , G01N35/04 , G01N2035/0418 , G01N2035/0436
Abstract: A diagnostic system performs a first nucleic acid amplification reaction and a second, different nucleic acid amplification reaction. The diagnostic system includes a compartment configured to store at least a first bulk reagent container comprising a first bulk reagent for performing a sample preparation process, and a second bulk reagent container comprising a second bulk reagent for performing the first reaction. The system including a compartment configured to store at least one unit-dose pack comprising a plurality of unit-dose reagents for performing the second reaction. The diagnostic system is configured to perform the sample preparation process using the first bulk reagent on each of a plurality of samples provided to the diagnostic system. The system is configured to perform the first reaction using the second bulk reagent on a first sample subset, and perform the second reaction using the plurality of first unit-dose reagents on a second sample subset.
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12.发明授权Apparatus for transferring reaction receptacles between a plurality of receptacle-receiving structures 有权用于在多个容器接收结构之间转移反应容器的装置公开(公告)号：US09446911B2
公开(公告)日：2016-09-20
申请号：US14259041
申请日：2014-04-22
Applicant: GEN-PROBE INCORPORATED , STRATEC BIOMEDICAL AG
Inventor： Stefan Habrich , Norbert D. Hagen , Olaf Hörger , Byron J. Knight , David Opalsky , Jason F. Rhubottom , Heiko Sayer , Harald Thahedl
CPC classification number: B65G47/901 , G01N35/026 , G01N35/04 , G01N2035/0413 , G01N2035/0422 , G01N2035/0484
Abstract: An apparatus for transferring receptacles between a plurality of receptacle-receiving structures disposed at different locations adjacent a transport track. The apparatus includes a receptacle carrier operatively engaged with the transport track and adapted to carry a receptacle and translate along the transport track. The receptacle carrier is further adapted to selectively stop at a transfer station with respect to any of the receptacles-receiving structures. The receptacle carrier includes a receptacle moving mechanism adapted to move a receptacle with respect to the receptacle carrier to move a receptacle into and/or out of the receptacle carrier. The apparatus further includes a transfer position locating system to automatically determine a location of a transfer position of the receptacle carrier with respect to each of the receptacle-receiving structures, thereby enabling the receptacle carrier to transfer a receptacle between the receptacle carrier and the receptacle-receiving structures.
Abstract translation: 一种用于在设置在邻近传输轨道的不同位置处的多个插座接收结构之间传送插座的装置。 该装置包括与运输轨道可操作地接合并适于承载容器并沿着运输轨道平移的插座托架。 插座托架进一步适于相对于任何容器接收结构选择性地停在转运站。 插座托架包括插座移动机构，其适于使插座相对于插座托架移动以将插座移入和/或离开插座托架。 该装置还包括传送位置定位系统，用于相对于每个容器接收结构自动确定插座托架的传送位置的位置，从而使得插座托架能够在插座托架和插座接收结构之间传送插座， 接收结构。
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公开(公告)号：US09117192B2
公开(公告)日：2015-08-25
申请号：US14229676
申请日：2014-03-28
Applicant: GEN-PROBE INCORPORATED , STRATEC Biomedical AG
Inventor： Craig B. Clark , John M. Gilker , Norbert D. Hagen , Olaf Hörger , Tom R. Horn , Byron J. Knight , Waldemar Lukhaub , David Opalsky , Jason F. Rhubottom
CPC classification number: G06Q10/087 , B01L9/06 , B01L2200/023 , B01L2200/06 , B01L2200/141 , B01L2300/021 , G01N35/1004
Abstract: A structure for holding sample-containing receptacles includes a cover with holes formed therein through which the receptacles can be accessed with a substance transfer mechanism, such as a robotic pipettor. When the transfer mechanism is inserted into and then withdrawn from a receptacle, a string of viscous material may be suspended from the mechanism. A viscous string removal element adjacent each opening engages the string of viscous material and dislodges the string from the mechanism when the mechanism moves in a prescribed path with respect to the removal element. A sample rack configured to hold receptacles and to be inserted into the structure below the cover includes a sample rack having receptacle-receiving pockets, each with a resilient element and a positioning feature for holding receptacles of varying sizes in a predetermined position within the receptacle receiving pocket, and a cover including features for preventing a receptacle from being pulled out of its receptacle-receiving pocket when the transfer mechanism is withdrawn from the receptacle.
Abstract translation: 用于保持含有样品的容器的结构包括其中形成有孔的盖，通过该盖可以用诸如机器人移液器的物质转移机构接近容器。 当转移机构插入到容器中然后从容器中取出时，一串粘性材料可以悬挂在机构上。 邻近每个开口的粘性排除元件与该粘性材料串接合，并且当机构相对于移除元件以规定的路径移动时，将该绳从机构中移出。 被配置成保持插座并插入到盖子下面的结构中的样品架包括具有插座容纳凹部的样品架，每个具有弹性元件和用于在插座接收中的预定位置保持不同尺寸的容器的定位特征 口袋和盖子，其包括当传送机构从容器中取出时防止插座从其容器接收口袋中被拉出的特征。
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14.发明授权公开(公告)号：US12286669B2
公开(公告)日：2025-04-29
申请号：US17027363
申请日：2020-09-21
Applicant: Gen-Probe Incorporated
Inventor： David Buse , David Howard Combs , Norbert D. Hagen , David Opalsky , Bruce Richardson , Anita Prasad , Keith Moravick , Tyler Moore , Byron J. Knight
Abstract: An apparatus for performing nucleic acid amplification reactions includes a thermally-conductive receptacle holder that includes multiple receptacle wells. Each well can receive a receptacle and has a through-hole extending from an inner surface of the well to an outer surface of the holder. The apparatus includes multiple optical fibers, and each optical fiber has a first end in optical communication with an associated well and a second end in optical communication with an excitation signal source and/or an emission signal detector. The first end of each optical fiber is moveable with respect to the through-hole. A cover is movable between an open position and a closed position relative to the receptacle holder, and the first end of each optical fiber moves with respect to the through-hole of the associated well as the cover moves to the open or closed position or when the cover moves into or out of contact with any receptacles within the wells.
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公开(公告)号：US12258458B2
公开(公告)日：2025-03-25
申请号：US18516696
申请日：2023-11-21
Applicant: Gen-Probe Incorporated
Inventor： Byron J. Knight , David Opalsky
Abstract: A kit includes a vessel having a plasma-treated interior surface, solid composition adhered to the plasma-treated interior surface, and a reconstitution liquid. The solid composition has a mass ranging from about 600 micrograms to about 20 grams and is in the form of a lyophilized pellet adhered to the plasma-treated interior surface. The solid composition is macroscopic in three orthogonal dimensions, such that the solid composition is not a coating and has a length, a width, and a height of greater than 1 mm.
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Patent Agency Ranking
公开(公告)号：US12175322B2
公开(公告)日：2024-12-24
申请号：US18331027
申请日：2023-06-07
Applicant: GEN-PROBE INCORPORATED
Inventor： David Opalsky
Abstract: A method of reading machine-readable marks on a movable support and object of a sample instrument. The method includes capturing a first image of the moveable support as the moveable support moves from a first position to a second position using an image capture device; determining whether a first fiducial machine-readable mark on the moveable support is in the first image; determining, when the first fiducial machine-readable mark is in the first image, whether a first machine-readable mark on a first object coupled to the moveable support is in the first image at a predetermined position relative to the first fiducial machine-readable mark; and associating information decoded from the first machine-readable mark on the first object with a first location on the moveable support associated with the first fiducial machine-readable mark.
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公开(公告)号：US11815522B2
公开(公告)日：2023-11-14
申请号：US18111865
申请日：2023-02-20
Applicant: Gen-Probe Incorporated
Inventor： Rolf Silbert , David Opalsky , David Aaron Buse , Robert J. Rosati , Olev Tammer , Richard Capella , Matthias Merten
IPC: G01N1/28 , G01N1/31 , G01N35/10 , G01N35/02 , G01N35/00 , G01F23/263 , G01N35/04 , B67B7/00 , C40B60/12
CPC classification number: G01N35/1004 , B67B7/00 , G01F23/265 , G01N1/28 , G01N1/31 , G01N35/0099 , G01N35/00732 , G01N35/025 , G01N35/04 , G01N35/1002 , G01N35/1016 , G01N35/1079 , C40B60/12 , G01N2035/00524 , G01N2035/00752 , G01N2035/00811 , G01N2035/00831 , G01N2035/00861 , G01N2035/0405 , G01N2035/1018 , G01N2035/1046 , G01N2035/1048 , G01N2035/1051 , G01N2035/1062
Abstract: A sample processing station includes two or more container holders on a platform that is rotatable about a central axis of rotation. Each holder is configured to rotate about a secondary axis of rotation. The station includes a capping/decapping mechanism to cap or decap a container held in one of the container holders and an elevator with a chuck guide that contact the container holder as the chuck is lowered by the elevator to positon the chuck with respect to the cap of the container held in the holder and to hold jaws of the container holder in a closed position. In embodiment, the chuck guide includes a yoke with opposed arms and spindles located near distal ends of the arms that engage beveled shoulders of the container holder.
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18.发明授权公开(公告)号：US11788128B2
公开(公告)日：2023-10-17
申请号：US17029930
申请日：2020-09-23
Applicant: Gen-Probe Incorporated
Inventor： David Buse , David Howard Combs , Norbert D. Hagen , David Opalsky , Bruce Richardson , Anita Prasad , Keith Moravick , Tyler Moore
CPC classification number: C12Q1/686 , B01L7/52 , G01N21/6452 , B01L9/06 , B01L2200/141 , B01L2200/142 , B01L2300/042 , B01L2300/0654 , B01L2300/0829 , B01L2300/0851 , B01L2300/1822 , G01N2021/6482 , G01N2021/6484
Abstract: An apparatus for performing nucleic acid amplification reactions includes a thermally-conductive receptacle holder with front and back surfaces. The front surface includes a row of receptacle wells, and an outer surface of each well has a frustoconical shape, an inner surface of each well receives a receptacle, and each well has a through-hole extending between the inner and outer surfaces thereof. One or more thermal elements in contact with the back surface of the holder alter a temperature(s) of the holder. The apparatus includes multiple optical fibers, and each optical fiber provides optical communication between one of the wells and an excitation signal source and/or an emission signal detector. A first end of each optical fiber is disposed outside, within, or extends through the through-hole of a corresponding well, and a second end of each optical fiber is in optical communication with the excitation signal source and/or the emission signal detector.
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公开(公告)号：US11761026B2
公开(公告)日：2023-09-19
申请号：US17842535
申请日：2022-06-16
Applicant: Gen-Probe Incorporated
Inventor： David Opalsky , Byron J. Knight
IPC: C12Q1/6806 , C12Q1/686 , G01N35/04 , B01L3/00 , B01L7/00
CPC classification number: C12Q1/6806 , B01L3/50825 , B01L3/565 , B01L7/5255 , C12Q1/686 , G01N35/04 , B01L3/527 , B01L2200/026 , B01L2200/0689 , B01L2300/046 , G01N2035/0418 , G01N2035/0436
Abstract: A nucleic acid diagnostic system includes a unit-dose reagent compartment storing at least one unit-dose pack, one or more unit-dose pack loading stations for holding a unit-dose pack at a location that permits a substance transfer device to dispense a reconstitution reagent into each well of the pack, a unit-dose pack distributor configured to transfer a unit-dose pack from the unit-dose reagent compartment to one of the unit-dose pack loading stations, and an electrostatic generator disposed within the housing of the unit-dose reagent compartment and/or adjacent the one or more unit-dose pack loading stations. The electrostatic generator imparts an electrostatic charge to each of the wells of the unit-dose pack and/or to a lyophilized reagent pellet within each well so that the electrostatic charge positions and holds each lyophilized reagent pellet at a bottom of each respective well of the unit-dose pack.
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公开(公告)号：US20230204616A1
公开(公告)日：2023-06-29
申请号：US18111865
申请日：2023-02-20
Applicant: Gen-Probe Incorporated
Inventor： Rolf SILBERT , David Opalsky , David Aaron Buse , Robert J. Rosati , Olev Tammer , Richard Capella , Matthias Merten
CPC classification number: G01N35/1004 , G01N35/1079 , G01N35/1016 , G01F23/265 , G01N35/025 , G01N35/04 , G01N1/28 , G01N1/31 , G01N35/0099 , G01N35/00732 , G01N35/1002 , G01N2035/1018 , G01N2035/1046 , G01N2035/00524 , C40B60/12
Abstract: A sample processing station includes two or more container holders on a platform that is rotatable about a central axis of rotation. Each holder is configured to rotate about a secondary axis of rotation. The station includes a capping/decapping mechanism to cap or decap a container held in one of the container holders and an elevator with a chuck guide that contact the container holder as the chuck is lowered by the elevator to positon the chuck with respect to the cap of the container held in the holder and to hold jaws of the container holder in a closed position. In embodiment, the chuck guide includes a yoke with opposed arms and spindles located near distal ends of the arms that engage beveled shoulders of the container holder.
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