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    SYSTEM AND METHOD FOR SIMULTANEOUSLY DETECTING PHASE MODULATED OPTICAL SIGNALS
    11.
    发明申请
    SYSTEM AND METHOD FOR SIMULTANEOUSLY DETECTING PHASE MODULATED OPTICAL SIGNALS 审中-公开

    公开(公告)号：US20190150751A1

    公开(公告)日：2019-05-23

    申请号：US15939603

    申请日：2018-03-29

    Applicant: HI LLC

    Inventor： Changhuei Yang ,  Adam Marblestone ,  Jamu Alford ,  Daniel Sobek

    IPC: A61B5/00 ,  H04N5/225 ,  A61B5/1455 ,  H04N5/89

    Abstract: An optical detection method and system are provided. Sample light is delivered into an anatomical structure having a target voxel, whereby a portion of the sample light passing through the target voxel is scattered by the anatomical structure as signal light, and another portion of the sample light not passing through the target voxel is scattered by the anatomical structure as background light that is combined with the signal light to create a sample light pattern. The sample light pattern and the reference light having an M number of different phases are concurrently combined to respectively generate an M number of interference light patterns. The M number of interference light patterns are detected. M pluralities of values representative of spatial components of the respective M number of interference light patterns are generated, and a physiologically-dependent optical parameter of the target voxel is determined based on the M pluralities of values.

    Time-of-flight optical measurement and decoding of fast-optical signals
    13.
    发明授权
    Time-of-flight optical measurement and decoding of fast-optical signals 有权

    公开(公告)号：US12064208B2

    公开(公告)日：2024-08-20

    申请号：US17663992

    申请日：2022-05-18

    Applicant: HI LLC

    Inventor： Jamu Alford ,  Adam Marblestone ,  Ivo Vellekoop ,  Daniel Sobek ,  Michael Henninger ,  Brian Robinson ,  Yuecheng Shen ,  Roarke Horstmeyer

    IPC: A61B5/00 ,  A61B5/026

    CPC classification number: A61B5/0004 ,  A61B5/0066 ,  A61B5/0084 ,  A61B5/0261

    Abstract: An optical measurement system comprising an optical source configured for delivering sample light in an anatomical structure, such that the sample light is scattered by the anatomical structure, resulting in physiological-encoded signal light that exits the anatomical structure, an optical detector configured for detecting the physiological-encoded signal light, and a processor configured for acquiring a TOF profile derived from the physiological-encoded signal light, the initial TOF profile having an initial contrast-to-noise ratio (CNR) between a plurality of states of a physiological activity in the anatomical structure. The processor is further configured for applying one or more weighting functions to the initial TOF profile to generate a weighted TOF profile having a subsequent CNR greater than the initial CNR between the plurality of states of the physiological activity. The processor is further configured for processing the weighted TOF profile, and identifying one of the plurality of states of the physiological activity.

    NON-INVASIVE OPTICAL DETECTION SYSTEM AND METHOD
    14.
    发明申请
    NON-INVASIVE OPTICAL DETECTION SYSTEM AND METHOD 审中-公开

    公开(公告)号：US20190336057A1

    公开(公告)日：2019-11-07

    申请号：US16382461

    申请日：2019-04-12

    Applicant: HI LLC

    Inventor： Jamu Alford ,  Ashutosh Chaturvedi ,  Adam Marblestone

    IPC: A61B5/1455 ,  A61B5/00

    Abstract: In a non-invasive optical detection system and method, sample light is delivered into a scattering medium. A first portion of the sample light passing through a volume of interest exits the scattering medium as signal light, and a second portion of the sample light passing through a volume of non-interest exits the scattering medium as background light that is combined with the signal light to create a sample light pattern. Reference light is combined with the sample light pattern to create an interference light pattern having a holographic beat component. Ultrasound is emitted into the volume of non-interest in a manner that decorrelates the background light of the sample light pattern from the holographic beat component. The holographic beat component is detected during the measurement period. An optical parameter of the volume of interest is determined based on the detected holographic beat component.

    ULTRASOUND MODULATING OPTICAL TOMOGRAPHY USING REDUCED LASER PULSE DURATION
    15.
    发明申请
    ULTRASOUND MODULATING OPTICAL TOMOGRAPHY USING REDUCED LASER PULSE DURATION 审中-公开

    公开(公告)号：US20190269331A1

    公开(公告)日：2019-09-05

    申请号：US16266818

    申请日：2019-02-04

    Applicant: HI LLC

    Inventor： Jamu Alford ,  Adam Marblestone ,  Changhuei Yang

    IPC: A61B5/00 ,  G01B9/02

    Abstract: Sample light is delivered into the anatomical structure having a target voxel, whereby a portion of the sample light passing through the target voxel is scattered by the anatomical structure as signal light, and another portion of the sample light not passing through the target voxel is scattered by the anatomical structure as background light that is combined with the signal light to create a sample light pattern. Reference light is combined with the sample light pattern to generate an interference light pattern, such that the signal light and the reference light are combined in a heterodyne manner. Ultrasound is delivered into the target voxel, such that the signal light is frequency shifted by the ultrasound. The ultrasound and the sample light are pulsed in synchrony at the target voxel, such that at least one pulse of the sample light has a combined duration less than a pulse width of the ultrasound.

    Pulsed ultrasound modulated optical tomography with increased optical/ultrasound pulse ratio
    16.
    发明授权
    Pulsed ultrasound modulated optical tomography with increased optical/ultrasound pulse ratio 有权

    公开(公告)号：US10299682B1

    公开(公告)日：2019-05-28

    申请号：US15844398

    申请日：2017-12-15

    Applicant: HI LLC

    Inventor： Changhuei Yang ,  Adam Marblestone ,  Jamu Alford ,  Daniel Sobek

    IPC: A61B5/00 ,  G01N21/17 ,  G01N21/45 ,  A61B5/1455

    Abstract: A system and method of performing ultrasound modulated optical tomography. Ultrasound is delivered into a target voxel in an anatomical structure, and sample light is delivered into the anatomical structure, whereby a portion of the sample light passing through the target voxel is scattered by the biological tissue as signal light, and a portion of the sample light not passing through the target voxel is scattered by the anatomical structure as background light. The ultrasound and sample light are pulsed in synchrony, such that only the signal light is frequency shifted by the ultrasound. Multiple pulses of the sample light are delivered into the anatomical structure for each pulse of the ultrasound delivered into the target voxel. Reference light is combined with the signal light and background light to generate an interference light pattern, which is sequentially modulated to generate different interference light patterns, which are detected.

    PULSED ULTRASOUND MODULATED OPTICAL TOMOGRAPHY WITH INCREASED OPTICAL/ULTRASOUND PULSE RATIO
    17.
    发明申请
    PULSED ULTRASOUND MODULATED OPTICAL TOMOGRAPHY WITH INCREASED OPTICAL/ULTRASOUND PULSE RATIO 审中-公开

    公开(公告)号：US20190150744A1

    公开(公告)日：2019-05-23

    申请号：US15844398

    申请日：2017-12-15

    Applicant: HI LLC

    Inventor： Changhuei Yang ,  Adam Marblestone ,  Jamu Alford ,  Daniel Sobek

    IPC: A61B5/00 ,  G01N21/17 ,  G01N21/45 ,  A61B5/1455

    Abstract: A system and method of performing ultrasound modulated optical tomography. Ultrasound is delivered into a target voxel in an anatomical structure, and sample light is delivered into the anatomical structure, whereby a portion of the sample light passing through the target voxel is scattered by the biological tissue as signal light, and a portion of the sample light not passing through the target voxel is scattered by the anatomical structure as background light. The ultrasound and sample light are pulsed in synchrony, such that only the signal light is frequency shifted by the ultrasound. Multiple pulses of the sample light are delivered into the anatomical structure for each pulse of the ultrasound delivered into the target voxel. Reference light is combined with the signal light and background light to generate an interference light pattern, which is sequentially modulated to generate different interference light patterns, which are detected.

    TIME-OF-FLIGHT OPTICAL MEASUREMENT AND DECODING OF FAST-OPTICAL SIGNALS
    19.
    发明公开
    TIME-OF-FLIGHT OPTICAL MEASUREMENT AND DECODING OF FAST-OPTICAL SIGNALS 审中-公开

    公开(公告)号：US20230301515A1

    公开(公告)日：2023-09-28

    申请号：US17663992

    申请日：2023-05-18

    Applicant: HI LLC

    Inventor： Jamu Alford ,  Adam Marblestone ,  Ivo Vellekoop ,  Daniel Sobek ,  Michael Henninger ,  Brian Robinson ,  Yuecheng Shen ,  Roarke Horstmeyer

    IPC: A61B5/00

    CPC classification number: A61B5/0004 ,  A61B5/0084 ,  A61B5/0066 ,  A61B5/0261

    Abstract: An optical measurement system comprising an optical source configured for delivering sample light in an anatomical structure, such that the sample light is scattered by the anatomical structure, resulting in physiological-encoded signal light that exits the anatomical structure, an optical detector configured for detecting the physiological-encoded signal light, and a processor configured for acquiring a TOF profile derived from the physiological-encoded signal light, the initial TOF profile having an initial contrast-to-noise ratio (CNR) between a plurality of states of a physiological activity in the anatomical structure. The processor is further configured for applying one or more weighting functions to the initial TOF profile to generate a weighted TOF profile having a subsequent CNR greater than the initial CNR between the plurality of states of the physiological activity. The processor is further configured for processing the weighted TOF profile, and identifying one of the plurality of states of the physiological activity.

    Non-invasive optical detection system and method of multiple-scattered light with swept source illumination
    20.
    发明授权
    Non-invasive optical detection system and method of multiple-scattered light with swept source illumination 有权

    公开(公告)号：US11547303B2

    公开(公告)日：2023-01-10

    申请号：US16393002

    申请日：2019-04-24

    Applicant: HI LLC

    Inventor： Haowen Ruan ,  Adam Marblestone ,  Roarke Horstmeyer ,  Yuecheng Shen ,  Haojiang Zhou ,  Jamu Alford

    IPC: A61B5/00

    Abstract: An optical source sweeps a source light over an optical wavelength range. An interferometer splits the source light into sample light and reference light, delivers the sample light into an anatomical structure, such that the sample light is scattered by the anatomical structure, resulting in physiological-encoded signal light that exits the anatomical structure, and combines the signal light and the reference light into an interference light pattern having an array of spatial components and a plurality of oscillation frequency components. An optical detector array detects intensity values of the array of spatial components. A processor derives an array of intensity values of each oscillation frequency component from the detected spatial component intensity value array, reduces each derived oscillation frequency component intensity value array to a single frequency component intensity value, and determines a depth of a physiological event in the anatomical structure based on the reduced frequency component intensity values.

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