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公开(公告)号：US11857316B2
公开(公告)日：2024-01-02
申请号：US16382461
申请日：2019-04-12
Applicant: HI LLC
Inventor： Jamu Alford , Ashutosh Chaturvedi , Adam Marblestone
IPC: A61B5/1455 , A61B5/00
CPC classification number: A61B5/14553 , A61B5/0042 , A61B5/0051 , A61B5/0066 , A61B5/0097 , A61B5/1455
Abstract: In a non-invasive optical detection system and method, sample light is delivered into a scattering medium. A first portion of the sample light passing through a volume of interest exits the scattering medium as signal light, and a second portion of the sample light passing through a volume of non-interest exits the scattering medium as background light that is combined with the signal light to create a sample light pattern. Reference light is combined with the sample light pattern to create an interference light pattern having a holographic beat component. Ultrasound is emitted into the volume of non-interest in a manner that decorrelates the background light of the sample light pattern from the holographic beat component. The holographic beat component is detected during the measurement period. An optical parameter of the volume of interest is determined based on the detected holographic beat component.
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公开(公告)号：US11291370B2
公开(公告)日：2022-04-05
申请号：US16422906
申请日：2019-05-24
Applicant: HI LLC
Inventor： Jamu Alford , Adam Marblestone
Abstract: Disclosed herein are devices and methods for modifying a conventional imager to have functional features similar to that of a lock-in camera. Optical mask devices are configured to be coupled to conventional imager sensors and the configuration of the mask devices can be adjusted to acquire image data in rapid succession. One variation of an optical mask device comprises a substrate comprising a pattern of light-blocking and light-transmitting regions and an attachment structure for coupling the optical mask device to the imager. The substrate is configured to adjust the position of the light-blocking regions and light-transmitting regions relative to the light-sensing region of the imager based on a set of one or more predetermined substrate configurations. In some variations, the mask device and/or the imager sensor may be mechanically moved relative to each other based on the set of one or more predetermined substrate configurations.
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公开(公告)号：US11206985B2
公开(公告)日：2021-12-28
申请号：US16299067
申请日：2019-03-11
Applicant: HI LLC
Inventor： Jamu Alford , Adam Marblestone
Abstract: A non-invasive optical detection system and method are provided. Sample light is delivered into a target volume of interest, whereby the sample light is scattered by the target volume of interest, resulting in a sample light pattern that exits the anatomical structure. Reference light is combined with the sample light pattern to generate at least one interference light pattern, each of which may have a time varying interference component that integrates to a first value in the absence of the physiological event, and that integrates to a second greater value in the presence of the physiological event. Intensities of spatial components of each interference light pattern are detected during a measurement period. A function of the detected spatial component intensities of the interference light pattern(s) is analyzed, and a presence of the physiological event in the target volume of interest is determined based on the analysis.
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公开(公告)号：US11412930B2
公开(公告)日：2022-08-16
申请号：US16533133
申请日：2019-08-06
Applicant: HI LLC
Inventor： Jamu Alford , Adam Marblestone , Ivo Vellekoop , Daniel Sobek , Michael Henninger , Brian Robinson , Yuecheng Shen , Roarke Horstmeyer
Abstract: An optical measurement system comprising an optical source configured for delivering sample light in an anatomical structure, such that the sample light is scattered by the anatomical structure, resulting in physiological-encoded signal light that exits the anatomical structure, an optical detector configured for detecting the physiological-encoded signal light, and a processor configured for acquiring a TOF profile derived from the physiological-encoded signal light, the initial TOF profile having an initial contrast-to-noise ratio (CNR) between a plurality of states of a physiological activity in the anatomical structure. The processor is further configured for applying one or more weighting functions to the initial TOF profile to generate a weighted TOF profile having a subsequent CNR greater than the initial CNR between the plurality of states of the physiological activity. The processor is further configured for processing the weighted TOF profile, and identifying one of the plurality of states of the physiological activity.
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公开(公告)号：US11058301B2
公开(公告)日：2021-07-13
申请号：US15939603
申请日：2018-03-29
Applicant: HI LLC
Inventor： Changhuei Yang , Adam Marblestone , Jamu Alford , Daniel Sobek
IPC: A61B5/1455 , A61B5/00 , H04N5/225 , H04N5/89 , H04N5/76
Abstract: An optical detection method and system are provided. Sample light is delivered into an anatomical structure having a target voxel, whereby a portion of the sample light passing through the target voxel is scattered by the anatomical structure as signal light, and another portion of the sample light not passing through the target voxel is scattered by the anatomical structure as background light that is combined with the signal light to create a sample light pattern. The sample light pattern and the reference light having an M number of different phases are concurrently combined to respectively generate an M number of interference light patterns. The M number of interference light patterns are detected. M pluralities of values representative of spatial components of the respective M number of interference light patterns are generated, and a physiologically-dependent optical parameter of the target voxel is determined based on the M pluralities of values.
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Patent Agency Ranking
公开(公告)号：US10335036B2
公开(公告)日：2019-07-02
申请号：US15844370
申请日：2017-12-15
Applicant: HI LLC
Inventor： Changhuei Yang , Adam Marblestone , Jamu Alford
IPC: A61B5/00 , G01N21/17 , G01N21/45 , A61B5/1455
Abstract: A system and method of performing ultrasound modulated optical tomography. Ultrasound is delivered into a target voxel in an anatomical structure, and sample light is delivered into the anatomical structure, whereby a portion of the sample light passing through the target voxel is scattered by the biological tissue as signal light, and a portion of the sample light not passing through the target voxel is scattered by the anatomical structure as background light. The ultrasound and sample light are pulsed in synchrony, such that only the signal light is frequency shifted by the ultrasound. Reference light is combined with the signal light and background light to generate an interference light pattern, which is sequentially modulated to generate a plurality of different interference light patterns. Spatial components of each of the different interference light patterns are simultaneously detected and stored in bins.
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公开(公告)号：US20190150743A1
公开(公告)日：2019-05-23
申请号：US15844370
申请日：2017-12-15
Applicant: HI LLC
Inventor： Changhuei Yang , Adam Marblestone , Jamu Alford
IPC: A61B5/00 , G01N21/17 , G01N21/45 , A61B5/1455
CPC classification number: A61B5/0042 , A61B5/0066 , A61B5/0073 , A61B5/0097 , A61B5/14553 , A61B5/4064 , A61B5/4875 , A61B5/6803 , A61B5/6814 , A61B5/7278 , A61B2562/04 , A61B2576/026 , G01B9/02002 , G01B9/0201 , G01B9/02031 , G01N21/1702 , G01N21/45 , G01N29/2418 , G01N2021/1706
Abstract: A system and method of performing ultrasound modulated optical tomography. Ultrasound is delivered into a target voxel in an anatomical structure, and sample light is delivered into the anatomical structure, whereby a portion of the sample light passing through the target voxel is scattered by the biological tissue as signal light, and a portion of the sample light not passing through the target voxel is scattered by the anatomical structure as background light. The ultrasound and sample light are pulsed in synchrony, such that only the signal light is frequency shifted by the ultrasound. Reference light is combined with the signal light and background light to generate an interference light pattern, which is sequentially modulated to generate a plurality of different interference light patterns. Spatial components of each of the different interference light patterns are simultaneously detected and stored in bins.
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公开(公告)号：US10881300B2
公开(公告)日：2021-01-05
申请号：US16246218
申请日：2019-01-11
Applicant: HI LLC
Inventor： Changhuei Yang , Adam Marblestone , Jamu Alford
Abstract: Described herein are systems and methods for noninvasive functional brain imaging using low-coherence interferometry (e.g., for the purpose of creating a brain computer interface with higher spatiotemporal resolution). One variation of a system and method comprises optical interference components and techniques using a lock-in camera. The system comprises a light source and a processor configured to rapidly phase-shift the reference light beam across a pre-selected set of phase shifts or offsets, to store a set of interference patterns associated with each of these pre-selected phase shifts, and to process these stored interference patterns to compute an estimate of the number of photons traveling between a light source and the lock-in camera detector for which the path length falls within a user-defined path length range.
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公开(公告)号：US20190313912A1
公开(公告)日：2019-10-17
申请号：US16299067
申请日：2019-03-11
Applicant: HI LLC
Inventor： Jamu Alford , Adam Marblestone
Abstract: A non-invasive optical detection system and method are provided. Sample light is delivered into a target volume of interest, whereby the sample light is scattered by the target volume of interest, resulting in a sample light pattern that exits the anatomical structure. Reference light is combined with the sample light pattern to generate at least one interference light pattern, each of which may have a time varying interference component that integrates to a first value in the absence of the physiological event, and that integrates to a second greater value in the presence of the physiological event. Intensities of spatial components of each interference light pattern are detected during a measurement period. A function of the detected spatial component intensities of the interference light pattern(s) is analyzed, and a presence of the physiological event in the target volume of interest is determined based on the analysis.
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公开(公告)号：US20190274548A1
公开(公告)日：2019-09-12
申请号：US16422906
申请日：2019-05-24
Applicant: HI LLC
Inventor： Jamu Alford , Adam Marblestone
Abstract: Disclosed herein are devices and methods for modifying a conventional imager to have functional features similar to that of a lock-in camera. Optical mask devices are configured to be coupled to conventional imager sensors and the configuration of the mask devices can be adjusted to acquire image data in rapid succession. One variation of an optical mask device comprises a substrate comprising a pattern of light-blocking and light-transmitting regions and an attachment structure for coupling the optical mask device to the imager. The substrate is configured to adjust the position of the light-blocking regions and light-transmitting regions relative to the light-sensing region of the imager based on a set of one or more predetermined substrate configurations. In some variations, the mask device and/or the imager sensor may be mechanically moved relative to each other based on the set of one or more predetermined substrate configurations.
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