公开(公告)号：US20220340875A1

公开(公告)日：2022-10-27

申请号：US17260936

申请日：2019-07-18

Applicant: IDEAYA BIOSCIENCES, INC.

Inventor： Muzaffar ALAM ,  Fred ASWAD ,  Hilary Plake BECK ,  Michael Patrick DILLON ,  Marcos GONZALEZ-LOPEZ ,  Yujiro HATA ,  Alice Chen RICO ,  James Clifford SUTTON, Jr.

IPC: C12N5/0789 ,  A61K35/28

Abstract: Provided are methods for expanding stem cells and/or lineage committed progenitor cells, such as hematopoietic stems cells and/or lineage committed progenitor cells, at least in part, by using compounds that antagonize AhR. The compounds are represented by formulae: wherein the letters and symbols a, b, c, d, e, f, g, Z, R1b, R2a and R2b have the meanings provided in the specification. Also provided are compositions comprising stem cells and/or lineage committed progenitor cells expanded by methods disclosed herein and methods for the treatment of diseases treatable by same.

公开(公告)号：US20210254006A1

公开(公告)日：2021-08-19

申请号：US16972181

申请日：2019-06-05

Applicant: IDEAYA BIOSCIENCES, INC.

Inventor： Muzaffar ALAM ,  Fred ASWAD ,  Hilary Plake BECK ,  Michael Patrick DILLON ,  Marcos GONZALEZ-LOPEZ ,  Yujiro HATA ,  James Clifford SUTTON, Jr.

IPC: C12N5/0789 ,  A61K35/28 ,  A61L29/16 ,  A61L31/16

Abstract: Provided are methods for expanding stem cells and/or lineage committed progenitor cells, at least in part, by using lactam compounds that antagonize AhR. The compounds are represented by formula (I): wherein the letters and symbols X1, X2, Z, R1b, R1c, R1d, R1e, R2a, R2b, R2c and R2d have the meanings provided below. Also provided are compositions comprising stem cells and/or lineage committed progenitor cells expanded by methods disclosed herein and methods for the treatment of diseases treatable by same.